Association of the ApoE gene polymorphism and dietary factors with cerebral infarction and circulating lipid concentrations

To explore the association of apolipoprotein E polymorphism with Alzheimer's disease (AD), so as to provide possible research value for potential targeted therapy. 120 AD patients and 50 healthy volunteers were enrolled to extract fasting blood samples. ApoE gene polymorphism and blood lipids were tested in blood. ApoE gene and genotype frequency between AD group and control group were compared by PCR and sequencing methods. MMSE, CDR, and BPSD were used to determine the intelligence. ApoE genotype was detected by DNA microarray. ɛ4 carrier accounted for 45% in AD group, which was significantly elevated compared with control group (12%) (P < 0.05). TG, TC, and LDL-C levels were increased, while HDL-C was reduced in ɛ4 allele carriers (allP < 0.05). The MMSE scores of ApoEɛ4 genotype carriers in AD group were markedly lower than those of nonApoEɛ4 genotype carriers (P < 0.05) and control (P < 0.01). The proportion of dementia in ApoEɛ4 genotype carriers from AD group was apparently higher than the ɛ4 gene non-carriers (P < 0.05). The ApoEɛ4 gene is an AD risk factor. The changes of genotype and frequency of ApoEɛ4 gene are the main factors leading to abnormal lipid metabolism in AD patients, suggesting that ApoEɛ4 gene detection might be helpful for the early diagnosis and treatment of AD.

Download Full-text

Case-control study of apoE gene polymorphism in young CHD patients and controls in the Serbian population

Archives of Biological Sciences ◽

10.2298/abs1101089d ◽

2011 ◽

Vol 63 (1) ◽

pp. 89-98 ◽

Cited By ~ 3

Author(s):

I. Djan ◽

Edita Stokic ◽

D. Sakac ◽

Mihajla Djan ◽

Dragana Obreht ◽

...

Keyword(s):

Waist Circumference ◽

Gene Polymorphism ◽

Biochemical Parameters ◽

Case Control Study ◽

Apoe Genotype ◽

Case Control ◽

Apoe Gene ◽

E4 Allele ◽

Apoe Gene Polymorphism ◽

Control Study

Apolipoprotein E displays polymorphism with three common alleles, e2, e3, and e4. The aim of this research was to determine apoE gene polymorphism in a group of healthy patients and a group of patients with CHD, and to reveal the relation between anthropometric and biochemical parameters and the apoE genotype. In CHD group significantly higher values of blood pressure, waist circumference, BMI and fat %, triglycerides, insulin (HOMA IR) and CRP were found. A statistically significant higher presence of the e3e4 genotype and e4 allele was detected in the CHD group. Statistically significant differences between waist circumference, BMI, insulin and HOMA IR were found between subjects with e3e3 and e3e4 genotypes.

Download Full-text

Influence of APOE Gene Polymorphism on Interindividual and Interethnic Warfarin Dosage Requirement: A Systematic Review and Meta-Analysis

Cardiovascular Therapeutics ◽

10.1111/1755-5922.12186 ◽

2016 ◽

Vol 34 (5) ◽

pp. 297-307 ◽

Cited By ~ 3

Author(s):

Wan-ying Yu ◽

Xue Sun ◽

Mia Wadelius ◽

Lihua Huang ◽

Chen Peng ◽

...

Keyword(s):

Systematic Review ◽

Gene Polymorphism ◽

Meta Analysis ◽

Apoe Gene ◽

Warfarin Dosage ◽

Dosage Requirement ◽

Apoe Gene Polymorphism

Download Full-text

Apolipoprotein E gene polymorphism influenced glycemic status among Malaysians

Biomedical Research and Therapy ◽

10.15419/bmrat.v6i7.557 ◽

2019 ◽

Vol 6 (7) ◽

pp. 3307-3314

Author(s):

K. M. Hafizur Rahman ◽

Md. Sanower Hossain ◽

Nazmul Haque ◽

Tariq Bin Abdul Razak ◽

Hussain Ahmad

Keyword(s):

Gene Polymorphism ◽

Apolipoprotein E ◽

Predictive Analytics ◽

Fasting Blood Glucose ◽

Apoe Gene ◽

Control Group ◽

Glycemic Status ◽

Diabetes Group ◽

And Control ◽

Apoe Gene Polymorphism

Aim: In the last decade Apolipoprotein E (APOE) gene polymorphism has been identified as one of the risk factors of type 2 diabetes mellitus (T2DM). Though more than 11% population of Malaysia are suffering from T2DM, there is inadequate data on the correlation between the APOE gene polymorphism and pathogenesis of diabetes among Malaysians. Hence, in this study we aimed to find out the association between the frequencies of APOE allele and fasting blood glucose (FBG) concentration among subjects with T2DM. Methods: A total of 102 subjects were recruited into two distinct groups, 51 in diabetes (cases) and 51 in non-diabetes (control) group. Their fasting blood sample was tested for FBG, while APOE genotyping was carried out using restriction fragment length polymorphism technique. Predictive Analytics Software (PASW) statistics, version 18.0, was used for statistical analyses. Results: There was no association between APOE alleles and T2DM; odd ratios for the e2, e3 and e4 alleles were 1.51 (95%CI: 0.615-3.706), 0.77 (95%CI: 0.431-1.375) and 1.12 (95%CI: 0.584-2.131) respectively. The highest mean FBG was found in subjects with e2 alleles, followed by e4 and e3 alleles in both cases and control groups. Both e2 and e4 alleles were significantly linked to higher mean FBG (p=0.03 and 0.04 for the respectively) compared to e3 allele in diabetes group. Conclusions: Although the APOE gene was not found to be associated with T2DM, it may influence glycemic status among subjects.

Download Full-text