The Application Value of ApoE Gene Polymorphism in Alzheimer's Disease

2019 ◽  
Vol 9 (10) ◽  
pp. 1403-1407
Author(s):  
Cong Chen ◽  
Yuhui Zhang ◽  
Bin Chen ◽  
Chaosheng Zeng ◽  
Min Chen ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Gene Polymorphism ◽  
Apoe Genotype ◽  
Apoe Gene ◽  
Control Group ◽  
Apolipoprotein E Polymorphism ◽  
Abnormal Lipid Metabolism ◽  
And Control ◽  
Apoe Gene Polymorphism

To explore the association of apolipoprotein E polymorphism with Alzheimer's disease (AD), so as to provide possible research value for potential targeted therapy. 120 AD patients and 50 healthy volunteers were enrolled to extract fasting blood samples. ApoE gene polymorphism and blood lipids were tested in blood. ApoE gene and genotype frequency between AD group and control group were compared by PCR and sequencing methods. MMSE, CDR, and BPSD were used to determine the intelligence. ApoE genotype was detected by DNA microarray. ɛ4 carrier accounted for 45% in AD group, which was significantly elevated compared with control group (12%) (P < 0.05). TG, TC, and LDL-C levels were increased, while HDL-C was reduced in ɛ4 allele carriers (allP < 0.05). The MMSE scores of ApoEɛ4 genotype carriers in AD group were markedly lower than those of nonApoEɛ4 genotype carriers (P < 0.05) and control (P < 0.01). The proportion of dementia in ApoEɛ4 genotype carriers from AD group was apparently higher than the ɛ4 gene non-carriers (P < 0.05). The ApoEɛ4 gene is an AD risk factor. The changes of genotype and frequency of ApoEɛ4 gene are the main factors leading to abnormal lipid metabolism in AD patients, suggesting that ApoEɛ4 gene detection might be helpful for the early diagnosis and treatment of AD.

scholarly journals A CROSS-SECTIONAL ANALYSIS OF APOE GENE POLYMORPHISM AND THE RISK OF COGNITIVE IMPAIRMENTS IN THE ALZHEIMER’S DISEASE NEUROIMAGING INITIATIVE STUDY

2021 ◽  
pp. 1-6
Author(s):  
G. Wang ◽  
D.E. Vance ◽  
W. Li
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Gene Polymorphism ◽  
Cognitive Impairments ◽  
Apoe Genotype ◽  
Apoe Gene ◽  
Dependent Manner ◽  
Cross Sectional ◽  
Apoe Genotypes ◽  
Apoe Gene Polymorphism

Background: It is inconclusive on how apolipoprotein epsilon (APOE) gene polymorphism is associated with the risk of having mild cognitive impairment (MCI) or Alzheimer’s disease (AD). Objectives: To investigate how APOE genotype is associated with the risk of MCI or AD using the data collected from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) participants. Methods: A cross-sectional design was used to analyze the baseline data collected from the 1,720 ADNI participants. APOE gene polymorphism was analyzed on how they are related to the risk of cognitive impairments of either MCI or AD using a percent yield (PY) method. Then cognitive functions were compared among six different APOE genotypes using a two-way ANCOVA by controlling possible confounding factors. Results: The prevalence of six APOE genotypes in 1,720 participants is as following: e2/e2 (0.3%), e2/e3 (7.4%), e3/e3 (45.4%), e2/e4 (2%), e3/e4 (35%) and e4/e4 (9.9%). The e2/e2 and e4/e4 genotypes were associated with the lowest and the highest risk respectively for cognitive impairments of either MCI or AD. Further, a worse cognitive diagnosis was associated with an increasing number of APOE e4 allele in a dose dependent manner. Participants with genotype e3/e3 had a better memory measure than those with the genotype of e3/e4. Conclusions: APOE gene polymorphism is associated with different level of risks for cognitive impairments. The heterozygous genotype e3/e4 is associated with a worse memory function compared to the genotype of e3/e3. Further investigations are needed to intervene the cognitive deteriorations in those with at risk APOE genotypes.

scholarly journals Apolipoprotein E gene polymorphism influenced glycemic status among Malaysians

2019 ◽  
Vol 6 (7) ◽  
pp. 3307-3314
Author(s):  
K. M. Hafizur Rahman ◽  
Md. Sanower Hossain ◽  
Nazmul Haque ◽  
Tariq Bin Abdul Razak ◽  
Hussain Ahmad
Keyword(s):  
Gene Polymorphism ◽  
Apolipoprotein E ◽  
Predictive Analytics ◽  
Fasting Blood Glucose ◽  
Apoe Gene ◽  
Control Group ◽  
Glycemic Status ◽  
Diabetes Group ◽  
And Control ◽  
Apoe Gene Polymorphism

Aim: In the last decade Apolipoprotein E (APOE) gene polymorphism has been identified as one of the risk factors of type 2 diabetes mellitus (T2DM). Though more than 11% population of Malaysia are suffering from T2DM, there is inadequate data on the correlation between the APOE gene polymorphism and pathogenesis of diabetes among Malaysians. Hence, in this study we aimed to find out the association between the frequencies of APOE allele and fasting blood glucose (FBG) concentration among subjects with T2DM. Methods: A total of 102 subjects were recruited into two distinct groups, 51 in diabetes (cases) and 51 in non-diabetes (control) group. Their fasting blood sample was tested for FBG, while APOE genotyping was carried out using restriction fragment length polymorphism technique. Predictive Analytics Software (PASW) statistics, version 18.0, was used for statistical analyses. Results: There was no association between APOE alleles and T2DM; odd ratios for the e2, e3 and e4 alleles were 1.51 (95%CI: 0.615-3.706), 0.77 (95%CI: 0.431-1.375) and 1.12 (95%CI: 0.584-2.131) respectively. The highest mean FBG was found in subjects with e2 alleles, followed by e4 and e3 alleles in both cases and control groups. Both e2 and e4 alleles were significantly linked to higher mean FBG (p=0.03 and 0.04 for the respectively) compared to e3 allele in diabetes group. Conclusions: Although the APOE gene was not found to be associated with T2DM, it may influence glycemic status among subjects.  

scholarly journals Apolipoprotein E Polymorphism and Alzheimer’s Risk in Kashmiri Population

2021 ◽  
Vol 18 (4) ◽  
pp. 673-680
Author(s):  
Kamran Nissar ◽  
Arshad Hussain ◽  
Bashir Ahmad Ganai
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Gene Polymorphism ◽  
Apoe Gene ◽  
Gene Variation ◽  
Variant Genotype ◽  
Apolipoprotein E Polymorphism ◽  
Survey Results ◽  
Kashmiri Population

Background: Although the cause of Alzheimer's disease is unknown, most experts feel that the disease is caused by a combination of circumstances rather than a single cause. Age, gene polymorphism, diabetes, and other conditions are all risk factors for Alzheimer's disease. Given the importance of gene polymorphism in different diseases, we intended to find out the association of APOE gene polymorphism with Alzheimer's risk in the Kashmiri population. Method: Out of 300 patients who were referred to the memory clinic of the hospital, to evaluate the probable relation of APOE gene variation in Alzheimer's disease, we conducted the study on 59 clinically confirmed Alzheimer's patients and 52 age and ethnicity-matched healthy controls found in a community survey. Results: Our data revealed a statistically significant association of ε4 variant genotype of the APOE gene with AD susceptibility in the Kashmiri population. Conclusions: The current study's findings provided insight into the role of APOE polymorphisms in Alzheimer's disease susceptibility. The identified susceptibility variant may become a marker genotype for AD.

scholarly journals Interleukinų IL1A ir IL6 genų polimorfizmas: sąsajų su APOE genotipu ir sporadinės Alzheimerio ligos klinikine eiga paieška Interleukin IL1a and IL6 gene polymorphism: search for association with APOE genotype and clinical course of sporadic Alzheimer’s disease

2020 ◽  
Vol 23 (81) ◽  
pp. 130-139
Author(s):  
G. Pšemeneckienė ◽  
K. Petrikonis ◽  
D. Rastenytė
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Gene Polymorphism ◽  
Clinical Course ◽  
Apoe Genotype ◽  
Sporadic Alzheimer’S Disease ◽  
Apoe Ε4 ◽  
Il6 Gene

Įvadas. Yra duomenų, kad IL1α ir IL6, kaip vienų svarbiausių citokinų, dalyvaujančių neurouždegimo procesuose, genų polimorfizmai yra susiję su Alzheimerio ligos (AL) rizika. Šiame tyrime siekėme įvertinti IL1A -889C>T ir IL6 -174G>C polimorfizmų sąsajas su sporadinės AL rizika APOE ε4 nešiotojams ir APOE rizikos alelio neturintiems asmenims. Taip pat tyrėme IL1A -889C>T ir IL6 -174G>C polimorfizmų sąsajas su AL progresavimo pobūdžiu. Tiriamieji ir tyrimo metodai. Tyrime dalyvavo 110 sergančiųjų sporadine AL ir 115 sutapatintų pagal amžių ir lytį sveikų kontrolinių tiriamųjų, kurių pažinimo funkcijos nesutrikusios (Lietuvos populiacija). IL1A -889C>T (rs1800587) ir IL6 -174G>C (rs1800795, Intro- no tipo) genotipavimas atliktas tikro laiko PGR (TL-PGR) metodu. Rezultatai. IL1A -889C>T genotipų dažniai APOE4+ grupėje (C/C – 52,9 %, C/T – 41,2 %, T/T – 5,9 %), lyginant su APOE4- sergančiaisiais AL (C/C – 55,6 %, C/T – 37,0 %, T/T – 7,4 %), nesiskyrė (p = 0,887). Sergantiems AL pacientams IL6 -174G>C genotipai APOE4+ grupėje (G/G – 11,8 %, G/C – 62,7 %, C/C – 25,5 %) ir APOE4- grupėje (G/G – 14,8 %, G/C – 61,1 %, C/C – 24,1 %) buvo pasiskirstę panašiai (p = 0,898). Genotipų dažniai reikšmingai nesiskyrė sergantiesiems greitai progresuojančia AL, lyginant su lėtai progresuojančia AL (p (IL1A -889C>T) = 0,638; p (IL6 -174G>C) = 0,118). IL1A -889C>T ir IL6 -174G>C polimorfizmų paveldėjimas (dominantinio, overdominantinio ir recesyvinio modeli0), atsižvelgiant į APOE genotipą, reikšmingai nekeitė galimybių santykio sirgti AL (p < 0,05). Lėtai ir greitai progresuojančios AL grupėse IL1A -889C>T ir IL6 -174G>C polimorfizmų paveldėjimas AL galimybei reikšmingos įtakos neturėjo (p < 0,05). Išvados. IL1A -889C>T ir IL6 -174G>C genotipų pasiskirstymas grupėse pagal APOE ε4 ir grupėse pagal AL progresavimo pobūdį reikšmingai nesiskyrė. Reikšmingų IL1A -889C>T ir IL6 -174G>C polimorfizmų sąsajų su AL rizika nei APOE4+, nei APOE4- tiriamiesiems nenustatyta. Mūsų duomenimis, IL1A -889C>T ir IL6 -174G>C polimorfizmų paveldėjimas nesusijęs su spartesniu AL progresavimu.

scholarly journals Prevalence of Comorbidities in Individuals Diagnosed and Undiagnosed with Alzheimer’s Disease in León, Spain and a Proposal for Contingency Procedures to Follow in the Case of Emergencies Involving People with Alzheimer’s Disease

2020 ◽  
Vol 17 (10) ◽  
pp. 3398
Author(s):  
Macrina Tortajada-Soler ◽  
Leticia Sánchez-Valdeón ◽  
Marta Blanco-Nistal ◽  
José Alberto Benítez-Andrades ◽  
Cristina Liébana-Presa ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Disorders ◽  
Cross Sectional Study ◽  
Control Group ◽  
Cross Sectional ◽  
Emergency Procedures ◽  
And Control ◽  
Similar Incidence

Background: Alzheimer’s disease (AD) which is the most common type of dementia is characterized by mental or cognitive disorders. People suffering with this condition find it inherently difficult to communicate and describe symptoms. As a consequence, both detection and treatment of comorbidities associated with Alzheimer’s disease are substantially impaired. Equally, action protocols in the case of emergencies must be clearly formulated and stated. Methods: We performed a bibliography search followed by an observational and cross-sectional study involving a thorough review of medical records. A group of AD patients was compared with a control group. Each group consisted of 100 people and were all León residents aged ≥65 years. Results: The following comorbidities were found to be associated with AD: cataracts, urinary incontinence, osteoarthritis, hearing loss, osteoporosis, and personality disorders. The most frequent comorbidities in the control group were the following: eye strain, stroke, vertigo, as well as circulatory and respiratory disorders. Comorbidities with a similar incidence in both groups included type 2 diabetes mellitus, glaucoma, depression, obesity, arthritis, and anxiety. We also reviewed emergency procedures employed in the case of an emergency involving an AD patient. Conclusions: Some comorbidities were present in both the AD and control groups, while others were found in the AD group and not in the control group, and vice versa.

scholarly journals Case-control study of apoE gene polymorphism in young CHD patients and controls in the Serbian population

2011 ◽  
Vol 63 (1) ◽  
pp. 89-98 ◽  
Author(s):  
I. Djan ◽  
Edita Stokic ◽  
D. Sakac ◽  
Mihajla Djan ◽  
Dragana Obreht ◽  
...  
Keyword(s):  
Waist Circumference ◽  
Gene Polymorphism ◽  
Biochemical Parameters ◽  
Case Control Study ◽  
Apoe Genotype ◽  
Case Control ◽  
Apoe Gene ◽  
E4 Allele ◽  
Apoe Gene Polymorphism ◽  
Control Study

Apolipoprotein E displays polymorphism with three common alleles, e2, e3, and e4. The aim of this research was to determine apoE gene polymorphism in a group of healthy patients and a group of patients with CHD, and to reveal the relation between anthropometric and biochemical parameters and the apoE genotype. In CHD group significantly higher values of blood pressure, waist circumference, BMI and fat %, triglycerides, insulin (HOMA IR) and CRP were found. A statistically significant higher presence of the e3e4 genotype and e4 allele was detected in the CHD group. Statistically significant differences between waist circumference, BMI, insulin and HOMA IR were found between subjects with e3e3 and e3e4 genotypes.

scholarly journals Effects of Hand Exercise on Eating Action in Patients With Alzheimer’s Disease

2018 ◽  
Vol 34 (1) ◽  
pp. 57-62 ◽  
Author(s):  
Li-Li Chen ◽  
Hong Li ◽  
Xiao-Huan Chen ◽  
Shuang Jin ◽  
Qiu-Hua Chen ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Nursing Home ◽  
Exercise Group ◽  
Effective Intervention ◽  
Control Group ◽  
Daily Routine ◽  
Control Groups ◽  
And Control

We aim to investigate whether a popular hand exercise could be used to improve the action of eating in patients with Alzheimer’s disease (AD). A 6-month intervention was conducted in 60 patients with AD who live in a nursing home. They were divided into hand exercise and control groups. Patients of the control group maintained their daily routine. The improvement of Edinburgh Feeding Evaluation in Dementia scale in hand exercise group was significantly greater than in the control group ( P = .003). Significant differences in time of autonomous eating and time of simulated eating between patients in the hand exercise and control groups ( P < .05) were noted. The improvements in accuracy of eating action and coordination of eating action from baseline were significant in hand exercise group compared to the control group ( P = .020 and .014, respectively). Hand exercise is a safe and effective intervention to improve the feeding and eating of people with AD.

Promoter polymorphism (-491A/T) in the APOE gene of Finnish Alzheimer's disease patients and control individuals

1999 ◽  
Vol 246 (9) ◽  
pp. 821-824 ◽  
Author(s):  
S. Helisalmi ◽  
Mikko Hiltunen ◽  
Piia Valonen ◽  
Arto Mannermaa ◽  
Anne Maria Koivisto ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Promoter Polymorphism ◽  
Apoe Gene ◽  
And Control

scholarly journals Association of ApoE Gene Polymorphisms With Cardio-cerebrovascular Complications in Type 2 Diabetes Mellitus in the Chinese Population

2020 ◽  
Author(s):  
Lulu Kong ◽  
Yinting Gao ◽  
Wei Li ◽  
Bimin Shi
Keyword(s):  
Type 2 Diabetes ◽  
Apoe Genotype ◽  
Apoe Gene ◽  
Control Group ◽  
Case Group ◽  
Cerebrovascular Complications ◽  
E4 Allele ◽  
Apoe Genotypes ◽  
Apoe Gene Polymorphism

Abstract Objective To analyze and study the relationship between ApoE gene polymorphism and cardio-cerebrovascular complications in type 2 diabetes mellitus(T2DM) in the Chinese Population. Methods From January 2018 to January 2019, 1140 patients with type 2 diabetes admitted to the Department of Endocrinology, the Affiliated Hospital of Xuzhou Medical University were selected as the case group, including 590 patients with coronary heart disease(CHD) and 550 patients with cerebral infarction(CI), and 1198 patients with type 2 diabetes without complications during the same period were selected as the control group. General baseline data of the two groups were collected, such as gender, age, course of disease, lipid profile, HbA1C, BMI, blood pressure, carotid plaque and complications. ApoE genotypes were identified in all participants who participated in the study. Results This study showed that the ApoE genotypes in both the case group and the control group had the highest frequency of E3/E3. The E3/E4 genotype frequency and E4 allele frequency in the case group were higher than those in the control group (P < 0.05). In the case group, the frequency of E2/E3 and E3/E4 genotypes of CI group was lower than that of CHD group, while the frequency of E3/E3 genotype was higher than that of CHD group. TC and LDL-c levels were significantly increased in patients with ApoE E3/E4 genotype(P < 0.05). ApoE genotype E3/E4 was more associated with carotid plaque than E2/E3. ApoE genotype and ApoE allele were positively correlated with TC and LDL-c levels (P < 0.05).Logistic regression results show that ApoE gene polymorphism is associated with cardio-cerebrovascular complications in T2DM patients. ApoE E3/E4 genotype and allele E4 may be risk factors for T2DM patients with cardio-cerebrovascular complications. Conclusion ApoE E3/E4 genotypes and T2DM patients carrying E4 allele have a higher risk of cardio-cerebrovascular complications than other genotypes. E4 allele may be a risk factor for cardio-cerebrovascular complications in T2DM patients, and its mechanism may be related to the effect of ApoE gene on lipid metabolism.

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