scholarly journals C - reactive protein and urinary tract infection due to Gram-negative bacteria in a pediatric population at a tertiary hospital, Mwanza, Tanzania

1970 ◽  
Vol 19 (4) ◽  
pp. 3217-3224
Author(s):  
Martha F Mushi ◽  
Vaileth G Alex ◽  
Mwanaisha Seugendo ◽  
Vitus Silago ◽  
Stephen E Mshana
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Enteric Bacteria ◽  
Gram Negative Bacteria ◽  
C Reactive Protein ◽  
Gram Negative ◽  
Reactive Protein ◽  
Significant Bacteriuria ◽  
Tract Infections

Introduction: Gram-negative bacteria are the major cause of urinary tract infections (UTI) in children. There is limited data on UTI systemic response as measured using C-reactive protein (CRP). Here, we report the association of CRP and UTI among children attending the Bugando Medical Centre, Mwanza, Tanzania.Methods: A cross-sectional study was conducted between May and July 2017. Urine and blood were collected and processed within an hour of collection. Data were analyzed using STATA version 13.Results: Of 250 enrolled children, 76(30.4%) had significant bacteriuria with 56(22.4%, 95%CI; 11.5-33.3) having gram-negative bacteria infection. There was dual growth of gram-negative bacteria in 3 patients. Escherichia coli (32.2%, 19/59) was the most frequently pathogen detected. A total of 88/250(35.2%) children had positive CRP on qualitative assay. By multinomial logistic regression, positive CRP (RRR=4.02, 95%CI: 2.1-7.7, P<0.001) and age ≤ 2years (RRR=2.4, 95%CI: 1.23-4.73, P<0.01) significantly predicted the presence of significant bacteriuria due to gram-negative enteric bacteria. Conclusion: C-reactive protein was significantly positive among children with UTI due to gram-negative bacteria and those with fever. In children with age ≤ 2 years, positive CRP indicates UTI due to gram-negative enteric bacteria.Keywords: C - reactive protein, urinary tract infection, Gram-negative bacteria, Mwanza, Tanzania.

scholarly journals Clinical and laboratory features of urinary tract infections in young infants

2018 ◽  
Vol 40 (1) ◽  
pp. 66-72
Author(s):  
Denise Swei Lo ◽  
Larissa Rodrigues ◽  
Vera Hermina Kalika Koch ◽  
Alfredo Elias Gilio
Keyword(s):  
Escherichia Coli ◽  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
C Reactive Protein ◽  
Blood Cell Count ◽  
Group Culture ◽  
Reactive Protein ◽  
Young Infants ◽  
Laboratory Features

ABSTRACT Introduction: Urinary tract infection (UTI) is the most common serious bacterial infection in young infants. Signs and symptoms are often nonspecific. Objectives: To describe clinical, demographic and laboratory features of UTI in infants ≤ 3 months old. Methods: Cross-sectional study of infants ≤ 3 months old with UTI diagnosed in a pediatric emergency department, for the period 2010-2012. UTI was defined as ≥ 50,000 colony-forming units per milliliter of a single uropathogen isolated from bladder catheterization. Paired urinalysis and urine culture from group culture-positive and group culture-negative were used to determine the sensitivity and specificity of pyuria and nitrite tests in detecting UTI. Results: Of 519 urine cultures collected, UTI was diagnosed in 65 cases (prevalence: 12.5%); with male predominance (77%). The most common etiologies were Escherichia coli (56.9%), Klebsiella pneumoniae (18.5%) and Enterococcus faecalis (7.7%). Frequent clinical manifestations were fever (77.8%), irritability (41.4%) and vomiting (25.4%). The median temperature was 38.7°C. The sensitivity of the nitrite test was 30.8% (95%CI:19.9-43.4%), specificity of 100% (95%CI:99.2-100%). Pyuria ≥ 10,000/mL had a sensitivity of 87.7% (95%CI:77.2-94.5%), specificity of 74.9% (95%CI:70.6 -78.8%). The median peripheral white blood cell count was 13,150/mm3; C-reactive protein levels were normal in 30.5% of cases. Conclusions: The male: female ratio for urinary tract infection was 3.3:1. Non-Escherichia coli etiologies should be considered in empirical treatment. Fever was the main symptom. Positive nitrite is highly suggestive of UTI but has low sensitivity; whereas pyuria ≥ 10,000/mL revealed good sensitivity, but low specificity. Peripheral white blood cell count and C-reactive protein concentration have limited usefulness to suggest UTI.

Urinary Tract Infections

2012 ◽  
pp. 267-273
Author(s):  
Walter C Hellinger
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Renal Involvement ◽  
Asymptomatic Bacteriuria ◽  
Flank Pain ◽  
Recent Onset ◽  
Significant Bacteriuria ◽  
Tract Infections ◽  
Abnormal Urinary Tract

There are several terms important to a discussion of urinary tract infection (UTI). Bacteriuria is bacteria in the urine. Significant bacteriuria is at least 105 bacteria/mL of voided urine. Asymptomatic bacteriuria is bacteria in the urine without symptoms associated with urinary tract infection. Urinary tract infection is bacteriuria (or funguria) and symptoms associated with upper UTI or lower UTI (or both). UTI s are sometimes characterized as asymptomatic or symptomatic, in which case asymptomatic UTI is synonymous with asymptomatic significant bacteriuria. Uncomplicated UTI is infection of a physiologically and anatomically normal urinary tract. Complicated UTI is infection of a physiologically or anatomically abnormal urinary tract. Cystitis is lower UTI typically associated with urinary frequency, dysuria, or urgency. Acute pyelonephritis is upper UTI of recent onset with renal involvement, often associated with fever, chills, flank pain, or nausea. Diagnosis and treatment of specific infections are also reviewed.

scholarly journals Prevalence of Extended Spectrum B-Lactamases in Hospitalized Patents and Community Patients

2019 ◽  
Vol 5 (2) ◽  
pp. 61-64
Author(s):  
Md Badrul Islam ◽  
Md Abdullah Yusuf ◽  
Samia Afrin ◽  
Md Abul Bashar
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Hospitalized Patients ◽  
Urine Samples ◽  
Gram Negative Bacteria ◽  
Gram Negative ◽  
Medical College ◽  
National Medical ◽  
Community Patients

Objectives: This study was carried out to detect extended spectrum B-lactamases (ESBLs) among Gram negative bacteria isolated from hospitalized patients and community patients (OPD) by double disc synergy test and phenotypic confirmatory test. Methodology: This cross-sectional, prospective study was carried out in the Department of Microbiology. Dhaka National Medical College, over a period of 1 (one) year 2016. Urine samples were collected from patients. Urine samples were from hospitalized patients and community patients. Samples were collected from in-patient and outpatient department of Dhaka National Medical College Hospital having clinical symptoms of microbial infection. Samples were collected from both sexes and different age groups. Result: Total 220 urine samples were collected from suspected cases of urinary tract infection. Total 132 (60%) Gram negative bacteria were isolated from these patients as causative agents. Among the isolates, 88 (75.86%) in hospitalized patients and 44 (42.31%) in community patients were isolated. Out of 132 Gram negative bacteria, 31 (23.48%) were ESBL producers. The percentage of ESBL producing bacteria was (31.81%) in hospitalized patients and (6.82%) in community patients. Conclusion: In the present study, it was observed that considerable numbers of ESBL producing bacteria were detected from urinary tract infection cases. These cases indicate ESBLs will be major threat for antibiotic therapy. Bangladesh Journal of Infectious Diseases, December 2018;5(2):61-64

Sign in / Sign up

Export Citation Format

Share Document