scholarly journals A review of telocytes in cardiovascular tissue and their role in angiogenesis

2020 ◽  
Vol 9 (2) ◽  
pp. 1807-1815
Author(s):  
Ibsen Ongidi ◽  
Fadhila Abdulsalaam ◽  
Harry Otieno ◽  
Noel Odero ◽  
Anne Pulei ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Tissue Regeneration ◽  
Literature Search ◽  
Cardiac Tissue ◽  
Close Association ◽  
Functional Coupling ◽  
Cardiovascular Tissue ◽  
Tissue Repair And Regeneration ◽  
Cardiovascular Tissues ◽  
Online Databases

Telocytes are interstitial cells characterized by small cell bodies with very long and slender processes extending from them. They are present in most tissues and are most commonly found in close association with nerves, smooth muscle and microvascular networks in tissue interstitial space. Telocytes maintain tissue homeostasis in various ways including modulation of electrical activity, regulation of stem cell proliferation and angiogenesis. The role of telocytes in blood vessels stems from a structural and functional coupling to vascular endothelial and smooth muscle cells. This review explores the distribution of telocytes in cardiovascular tissues, their mechanisms in angiogenesis and application of this property in tissue regeneration. The literature search was conducted on PubMedTM, Science directTM and African Journals Online databases as well as Google ScholarTM search engines. The keywords used in the literature search included ‘telocytes’, ‘cardiovascular telocytes’, ‘blood vessel’, ‘cardiac tissue’, ‘(neo-)angiogenesis’ and ‘tissue regeneration’. Articles which contained the keywords and relevant citations from their reference lists were included in the study. In conclusion, telocytes display close structural relationship with cardiovascular tissues. They play an angiogenesis inducing role which may be explored as a therapeutic target in tissue repair and regeneration. Keywords : cardiovascular telocytes, interstitial Cajal-like cell, regeneration, angiogenesis

A human airway smooth muscle cell line that retains physiological responsiveness

1989 ◽  
Vol 256 (2) ◽  
pp. C329-C335 ◽  
Author(s):  
R. A. Panettieri ◽  
R. K. Murray ◽  
L. R. DePalo ◽  
P. A. Yadvish ◽  
M. I. Kotlikoff
Keyword(s):  
Smooth Muscle ◽  
Cell Line ◽  
Airway Smooth Muscle ◽  
Cytosolic Calcium ◽  
Airway Smooth Muscle Cell ◽  
Airway Smooth Muscle Cells ◽  
Functional Coupling ◽  
Functional Responses ◽  
Human Airway Smooth Muscle ◽  
Human Airway

We report the development of a nontransformed line of human airway smooth muscle cells retaining smooth muscle-specific contractile protein expression and physiological responsiveness to agonists implicated in inflammatory airway diseases. Specific responses to histamine, leukotrienes, bradykinin, platelet-activating factor, substance P, and thromboxane analogues are demonstrated as well as functional coupling to beta-adrenergic receptors. The cell line was characterized using indirect immunofluorescence, as well as electrophoretic separation and immunoblot analysis of smooth muscle-specific actin. Functional responses were assessed by measurements of cytosolic calcium and stimulation of adenosine 3',5'-cyclic monophosphate production. The cells retain their responsiveness over many population doublings and should be a useful model to examine specific receptor-effector mechanisms, as well as the effects of neurohumoral agents on the regulation of airway smooth muscle growth and differentiation.

scholarly journals Smooth muscle myosin light chain kinase expression in cardiac and skeletal muscle

2000 ◽  
Vol 279 (5) ◽  
pp. C1656-C1664 ◽  
Author(s):  
B. Paul Herring ◽  
Shelley Dixon ◽  
Patricia J. Gallagher
Keyword(s):  
Skeletal Muscle ◽  
Smooth Muscle ◽  
Light Chain ◽  
Myosin Light Chain Kinase ◽  
Myosin Light Chain ◽  
Cardiac Myocyte ◽  
Cardiac Tissue ◽  
Specific Protein ◽  
Myoblast Differentiation ◽  
Adult Skeletal Muscle

The purpose of this study was to characterize myosin light chain kinase (MLCK) expression in cardiac and skeletal muscle. The only classic MLCK detected in cardiac tissue, purified cardiac myocytes, and in a cardiac myocyte cell line (AT1) was identical to the 130-kDa smooth muscle MLCK (smMLCK). A complex pattern of MLCK expression was observed during differentiation of skeletal muscle in which the 220-kDa-long or “nonmuscle” form of MLCK is expressed in undifferentiated myoblasts. Subsequently, during myoblast differentiation, expression of the 220-kDa MLCK declines and expression of this form is replaced by the 130-kDa smMLCK and a skeletal muscle-specific isoform, skMLCK in adult skeletal muscle. These results demonstrate that the skMLCK is the only tissue-specific MLCK, being expressed in adult skeletal muscle but not in cardiac, smooth, or nonmuscle tissues. In contrast, the 130-kDa smMLCK is ubiquitous in all adult tissues, including skeletal and cardiac muscle, demonstrating that, although the 130-kDa smMLCK is expressed at highest levels in smooth muscle tissues, it is not a smooth muscle-specific protein.

Carbon nanotubes for cardiac tissue regeneration: State of the art and perspectives

Carbon ◽  
2021 ◽  
Vol 184 ◽  
pp. 641-650
Author(s):  
Myriam Barrejón ◽  
Silvia Marchesan ◽  
Nuria Alegret ◽  
Maurizio Prato
Keyword(s):  
Carbon Nanotubes ◽  
Tissue Regeneration ◽  
Cardiac Tissue ◽  
State Of The Art

Functional coupling between the Na+/Ca2+ exchanger and nonselective cation channels during histamine stimulation in guinea pig tracheal smooth muscle

2007 ◽  
Vol 293 (1) ◽  
pp. L191-L198 ◽  
Author(s):  
Paola Algara-Suárez ◽  
Catalina Romero-Méndez ◽  
Tom Chrones ◽  
Sergio Sánchez-Armass ◽  
Ulises Meza ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Guinea Pig ◽  
Force Measurement ◽  
Isometric Force ◽  
Sustained Response ◽  
Functional Coupling ◽  
Channel Activation ◽  
Histamine Stimulation ◽  
Nonselective Cation Channels ◽  
Intracellular Ca

Airway smooth muscle (ASM) contracts partly due to an increase in cytosolic Ca2+. In this work, we found that the contraction caused by histamine depends on external Na+, possibly involving nonselective cationic channels (NSCC) and the Na+/Ca2+ exchanger (NCX). We performed various protocols using isometric force measurement of guinea pig tracheal rings stimulated by histamine. We observed that force reached 53 ± 1% of control during external Na+ substitution by N-methyl-d-glucamine+, whereas substitution by Li+ led to no significant change (91 ± 1%). Preincubation with KB-R7943 decreased the maximal force developed (52.3 ± 5.6%), whereas preincubation with nifedipine did not (89.7 ± 1.8%). Also, application of the nonspecific NCX blocker KB-R7943 and nifedipine on histamine-precontracted tracheal rings reduced force to 1 ± 3%, significantly different from nifedipine alone (49 ± 6%). Moreover, nonspecific NSCC inhibitors SKF-96365 and 2-aminoethyldiphenyl borate reduced force to 1 ± 1% and 19 ± 7%, respectively. Intracellular Ca2+ measurements in isolated ASM cells showed that KB-R7943 and SKF-96365 reduced the peak and sustained response to histamine (0.20 ± 0.1 and 0.19 ± 0.09 for KB-R, 0.43 ± 0.16 and 0.47 ± 0.18 for SKF, expressed as mean of differences). Moreover, Na+-free solution only inhibited the sustained response (0.54 ± 0.25). These data support an important role for NSCC and NCX during histamine stimulation. We speculate that histamine induces Na+ influx through NSCC that promotes the Ca2+ entry mode of NCX and CaV1.2 channel activation, thereby causing contraction.

scholarly journals 0190 : Ephrin-B1 blocks adult cardiomyocyte proliferation and cardiac tissue regeneration

2015 ◽  
Vol 7 (2) ◽  
pp. 198-199
Author(s):  
Celine Mias ◽  
Gael Genet ◽  
Celine Guilbeau-Frugier ◽  
Marie-Helene Seguelas ◽  
Denis Calise ◽  
...  
Keyword(s):  
Tissue Regeneration ◽  
Cardiac Tissue ◽  
Cardiomyocyte Proliferation

scholarly journals A nanopillar array on black titanium prepared by reactive ion etching augments cardiomyogenic commitment of stem cells

Nanoscale ◽  
2019 ◽  
Vol 11 (43) ◽  
pp. 20766-20776 ◽  
Author(s):  
Lopamudra Das Ghosh ◽  
Jafar Hasan ◽  
Aditi Jain ◽  
Nagalingam R. Sundaresan ◽  
Kaushik Chatterjee
Keyword(s):  
Stem Cells ◽  
Cell Therapy ◽  
Tissue Repair ◽  
Smooth Surface ◽  
Cardiac Tissue ◽  
Ex Vivo ◽  
Reactive Ion Etching ◽  
Ion Etching ◽  
Tissue Repair And Regeneration

The array highly efficiently promotes cardiomyogenic commitment of stem cells via integrin-mediated signalling compared to the smooth surface and is a potential platform for ex vivo differentiation of stem cells for cell therapy in cardiac tissue repair and regeneration.

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