scholarly journals Protective Role of Artemisia Afra Aqueous Extract on Tissue Antioxidant Defense Systems in Streptozotocin-Induced Diabetic Rats

2012 ◽  
Vol 10 (1) ◽  
Author(s):  
AJ Afolayan ◽  
TO Sunmonu
Keyword(s):  
Aqueous Extract ◽  
Antioxidant Defense ◽  
Protective Role ◽  
Diabetic Rats ◽  
Defense Systems ◽  
Antioxidant Defense Systems

scholarly journals The Role of Oxidative Stress in Cardiac Disease: From Physiological Response to Injury Factor

2020 ◽  
Vol 2020 ◽  
pp. 1-29 ◽  
Author(s):  
Rossella D’Oria ◽  
Rossella Schipani ◽  
Anna Leonardini ◽  
Annalisa Natalicchio ◽  
Sebastio Perrini ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Myocardial Injury ◽  
Antioxidant Defense ◽  
Experimental Studies ◽  
Chemical Species ◽  
Oxygen Species ◽  
Molecular Abnormalities ◽  
Defense Systems ◽  
Antioxidant Defense Systems

Reactive oxygen species (ROS) are highly reactive chemical species containing oxygen, controlled by both enzymatic and nonenzymatic antioxidant defense systems. In the heart, ROS play an important role in cell homeostasis, by modulating cell proliferation, differentiation, and excitation-contraction coupling. Oxidative stress occurs when ROS production exceeds the buffering capacity of the antioxidant defense systems, leading to cellular and molecular abnormalities, ultimately resulting in cardiac dysfunction. In this review, we will discuss the physiological sources of ROS in the heart, the mechanisms of oxidative stress-related myocardial injury, and the implications of experimental studies and clinical trials with antioxidant therapies in cardiovascular diseases.

scholarly journals Role of germanium L-cysteine α-tocopherol complex as stimulator of some antioxidant defense systems in gamma-irradiated rats

2007 ◽  
Vol 57 (1) ◽  
pp. 1-12 ◽  
Author(s):  
Mamdouh Ali ◽  
Eman Noaman ◽  
Sherien Kamal ◽  
Saaed Soliman ◽  
Dina Ismail
Keyword(s):  
Total Protein ◽  
Antioxidant Defense ◽  
Whole Body ◽  
Albino Rats ◽  
Protective Agent ◽  
Γ Irradiation ◽  
Defense Systems ◽  
Antioxidant Defense Systems ◽  
Gamma Irradiated

Role of germanium L-cysteine α-tocopherol complex as stimulator of some antioxidant defense systems in gamma-irradiated rats This study was conducted to evaluate the potency of the newly prepared germanium L-cysteine α-tocopherol complex [germanium dichloro tetrakis (L-cysteinyl-α-tocopherol amide) dichloride] as a protective agent against γ-irradiation-induced free radicals production and liver toxicity. Male Swiss albino rats were injected intraperitoneally with the germanium complex in a concentration of 75 mg kg-1 body mass per dose, for 6 successive doses, last dose administered twenty minutes pre-exposure to a single dose of whole body γ-irradiation of 6.5 Gy. Lipid peroxidation (LPx), nitric oxide (NO), glutathione (GSH) levels, and activity of the antioxidant enzymes glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase (CAT) were estimated in blood and liver. Blood total protein, cholesterol, triglyceride and α-tocopherol content were estimated as well. The results revealed that administration of germanium complex pre-irradiation resulted in significant (p < 0.001) improvement compared to the irradiated group in the level of hepatic and blood LPx. Hepatic GSH revealed a significant increase (p < 0.001), while its level showed no significant variation in blood. Also, the level of NO in blood and liver increased significantly (p < 0.001). On the other hand, pretreatment with the germanium complex normalized the activities of SOD, GPx and CAT in blood and liver when compared to the irradiated group. The study also documents a marked decrease in a blood triglyceride and cholesterol (p < 0.001) and a significant increase (p < 0.001) of α-tocopherol and total protein contents in blood. These biochemical changes were associated with marked improvement of histological status. Therefore, the germanium L-cysteine α-tocopherol complex may be a good candidate for ameliorating the changes induced by irradiation, which indicates the beneficial radio-protective role of this antioxidant agent.

scholarly journals An Overview of the Beneficial Role of Antioxidants in the Treatment of Nanoparticle-Induced Toxicities

2021 ◽  
Vol 2021 ◽  
pp. 1-21
Author(s):  
Vladimir Mihailovic ◽  
Jelena S. Katanic Stankovic ◽  
Dragica Selakovic ◽  
Gvozden Rosic
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Defense ◽  
Therapeutic Agents ◽  
Protective Mechanisms ◽  
Defense Systems ◽  
Naturally Occurring ◽  
New Findings ◽  
Antioxidant Defense Systems ◽  
Harmful Effects

Nanoparticles (NPs) are used in many products and materials for humans such as electronics, in medicine for drug delivery, as biosensors, in biotechnology, and in agriculture, as ingredients in cosmetics and food supplements. Besides that, NPs may display potentially hazardous properties on human health and the environment as a consequence of their abundant use in life nowadays. Hence, there is increased interest of researchers to provide possible therapeutic agents or dietary supplements for the amelioration of NP-induced toxicity. This review summarizes the new findings in the research of the use of antioxidants as supplements for the prevention and alleviation of harmful effects caused by exposure of organisms to NPs. Also, mechanisms involved in the formation of NP-induced oxidative stress and protective mechanisms using different antioxidant substances have also been elaborated. This review also highlights the potential of naturally occurring antioxidants for the enhancement of the antioxidant defense systems in the prevention and mitigation of organism damage caused by NP-induced oxidative stress. Based on the presented results of the most recent studies, it may be concluded that the role of antioxidants in the prevention and treatment of nanoparticle-induced toxicity is unimpeachable. This is particularly important in terms of oxidative stress suppression.

scholarly journals The Protective Role of Toll-like Receptors Agonist Monophosphoryl Lipid A against Vaccinated Murine Schistosomiasis

2019 ◽  
Author(s):  
Ibrahim Aly ◽  
Essam H. Ibrahim ◽  
Rabab S. Hamad ◽  
Hoda EL Sayed ◽  
Sama M.N. Attiyah ◽  
...  
Keyword(s):  
Lipid A ◽  
Significant Degree ◽  
Protective Role ◽  
Oxidative Stress Marker ◽  
Defense Systems ◽  
Monophosphoryl Lipid A ◽  
Monophosphoryl Lipid ◽  
Antioxidant Defense Systems ◽  
Egg Antigen

Schistosomiasis, a crippling ailment that afflicts over 220 million people worldwide. Yet or up till now, there is no vaccine for schistosomiasis, and chemotherapy relies heavily on a single drug, the praziquantel. The present study was undertaken to investigate the therapeutic effect of Monophosphoryl Lipid A (MPLA) as an adjuvant in soluble egg antigen (SEA) vaccinated mice against the deleterious pathological impacts induced in hepatic tissues of mice by Schistosoma mansoni infection. In addition, to study the associated parasitological, immunological and biochemical parameters. Parasitological parameters showed that intraperitoneal injection of MPLA into SEA-vaccinated and S. mansoni-infected mice was effective to a significant degree in reducing the worm and egg burden, granuloma count and diameter as well as the total area of infection in their livers versus SEA-untreated but infected ones. In addition, MPLA showed ameliorative action on the elevated liver oxidative stress marker, including malondialdehyde (MDA) and decrease in the level of the antioxidant enzymes, reduced glutathione (GSH) and catalase (CAT) which may have a role in the liver damage and fibrosis due to S. mansoni infection. In conclusion, treatment with MPLA has multi-functions in attenuating the deleterious impacts of S. mansoni infection in mice livers. Its effects are mediated through a reduction of ova count, worm burden, granuloma diameter and amelioration of antioxidant defense systems, and liver function biomarkers.

Chrysin treatment improves diabetes and its complications in liver, brain, and pancreas in streptozotocin-induced diabetic rats

2016 ◽  
Vol 94 (4) ◽  
pp. 388-393 ◽  
Author(s):  
Saeed Samarghandian ◽  
Mohsen Azimi-Nezhad ◽  
Fariborz Samini ◽  
Tahereh Farkhondeh
Keyword(s):  
Total Protein ◽  
Antioxidant Defense ◽  
Diabetic Rats ◽  
Dependent Manner ◽  
Protective Effects ◽  
Significant Elevation ◽  
Glutathione S Transferase ◽  
Defense Systems ◽  
Antioxidant Defense Systems ◽  
Dose Dependent

Chrysin (CH) is a natural flavonoid with pharmacological influences. The purpose of the current study was the assessment of possible protective effects of CH against oxidative damage in the serum, liver, brain, and pancreas of streptozotocin (STZ)- induced diabetic rats. In the present study, the rats were divided into the following groups of 8 animals each: control, untreated diabetic, 3 CH (20, 40, 80 mg/kg/day)-treated diabetic groups. To find out the modulations of cellular antioxidant defense systems, malondialdehyde (MDA) level and antioxidant enzymes including glutathione-S-transferase (GST), superoxide dismutase (SOD), and catalase (CAT) activities were determined in the serum, liver, brain, and pancreas. STZ caused an elevation of glucose, MDA, TG, TC, LDL-C and with reduction of HDL-C, total protein, SOD, CAT, and GST in the serum, liver, brain, and pancreas (p < 0.01). The findings showed that the significant elevation in the glucose, MDA, TG, TC, LDL-C and reduction of HDL-C, total protein, SOD, CAT, and GST were ameliorated in the CH-treated diabetic groups versus to the untreated groups, in a dose dependent manner (p < 0.05). The current study offers that CH may be recovered diabetes and its complications by modification of oxidative stress.

Role of rat adrenal antioxidant defense systems in the aldosterone turn-off phenomenon

2000 ◽  
Vol 73 (1-2) ◽  
pp. 71-78 ◽  
Author(s):  
Tetsuya Suwa ◽  
Tomoatsu Mune ◽  
Hiroyuki Morita ◽  
Hisashi Daido ◽  
Masanao Saio ◽  
...  
Keyword(s):  
Antioxidant Defense ◽  
Defense Systems ◽  
Antioxidant Defense Systems
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