Effet des prétraitements de semences du prunier des savanes (vitex doniana sweet) sur la germination et la croissance des plantules

2011 ◽  
Vol 15 (1) ◽  
Author(s):  
LE Ahoton ◽  
JB Adjakpa ◽  
M Gouda ◽  
O Daïnou ◽  
EL Akpo
Keyword(s):  
Vitex Doniana

scholarly journals Proximate and Acute Toxicity Profile of Vitex doniana (Black Plum) Fruit

2021 ◽  
Vol 46 (2) ◽  
Author(s):  
C. Imoisi ◽  
J.U. Iyasele ◽  
S.E. Okhale
Keyword(s):  
Acute Toxicity ◽  
Potable Water ◽  
Oral Treatment ◽  
Control Group ◽  
Toxicity Profile ◽  
North East ◽  
Capability Analysis ◽  
Edo State ◽  
Ld50 Value ◽  
Vitex Doniana

The fresh fruits of Vitex doniana sweet were collected from several randomly selected trees in a farm site in Uromi metropolis, Esan North-East Local Government Area of Edo state and then processed into an extract in form of syrup. The proximate composition and acute toxicity profile of Vitex doniana sweet fruit were investigated to ascertain its safety and nutritional capability. Analysis of the fruit showed it to be a highly nutritious food containing moisture of about, 9.90%, ash content: 21.5%, fat: 0.75%, fiber: Not detected (ND), protein: 0.006% and carbohydrate: 67.84%. Twenty mice were randomized based on body weight into five groups of four mice each. Three mice in each group were given syrup volumes of 100, 200, 300, 400 and 500 mg/ml respectively, corresponding to 1000, 2000, 3000, 4000 and 5000 mg/kg doses. In contrast, mice in the control group received potable water (10 mL/kg). The mice in all the groups were observed closely for mortality, toxicity signs and abnormalities in gross behaviour at 15 min, 30 min, 1, 2, 4 and 8 h, and then daily for 14 days. Based on the model used, the fruit was acutely safe in mice, since no death was observed within 24 hours after oral treatment and on extrapolation gave a high predictive value in humans. The LD50 value of black plum fruit was also found to be greater than 5000 mg/kg. Therefore, Vitex doniana fruit should be considered a source of edible syrup bearing in mind the safety, quantity and variety of nutrients it contains.

scholarly journals In vivo and In vitro Antioxidant Activities of Aqueous and Ethanol Stem Bark Extracts of Vitex doniana on Doxorubicin-induced Oxidative Stress in Rats

2021 ◽  
pp. 44-55
Author(s):  
Mohammed Aliyu Sulaiman ◽  
Daniel Dahiru ◽  
Mohammed Auwal Ibrahim ◽  
Ahmed Ibrahim Hayatu
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Activities ◽  
Ischemia Reperfusion ◽  
Oral Treatment ◽  
Stem Bark ◽  
Albino Rats ◽  
Associated Diseases ◽  
Vitex Doniana

Background: Oxidative stress is involved in the pathogenesis of hypertension, myocardial ischemia-reperfusion injury, atherosclerosis, muscular dystrophy, aging and other associated diseases. Vitex doniana is used in Adamawa, northern Nigeria to treat oxidative stress associated diseases. However, the antioxidative effects of the plant have not been scientifically examined in oxidative stress experimental animal models. The aim of this study is to investigate the in vitro and in vivo antioxidant activities of aqueous and ethanol stem bark extracts of Vitex doniana in oxidative stress model of rats. Methods: The study used 35 adult albino rats weighing 175 ± 25 g, of which 30 were induced with oxidative stress by intraperitoneal injection of doxorubicin (10 mg/kg) for three consecutive days. Animals were treated by oral administration of silymarin (100 mg/kg) and Vitex doniana aqueous or ethanol extract (100 mg/kg and 200 mg/kg) for 14 consecutive days before they were sacrificed on the 15th day and blood was analyzed for biochemical indices of oxidative stress. Results: The results of the phytochemistry showed the presence of alkaloids, tannins, flavonoids, steroids, phenols, saponins, terpenoids, glycosides: and total flavonoids (52.70 ± 1.60 mg/ml and 75.40 ± 0.80 mg/ml), total phenols (21.45 ± 1.54 mg/ml and 26.50 ± 1.22 mg/ml) for aqueous and ethanol stem bark extracts respectively. The extracts scavenged DPPH radical, reduced Fe3+ and inhibited lipid peroxidation. Doxorubicin significantly (p<0.05) lowered the levels of SOD, CAT, GR and TAS and significantly (p<0.05) but, increased the level of LPO. Oral treatment with Vitex doniana extracts significantly (p<0.05) increased the activities of CAT, GR, SOD and TAS while LPO was significantly (p<0.05) lowered. Vitex doniana stem bark extracts significantly (p<0.05) improved the biochemical derangements observed in the induced untreated animals in comparable manner to that of Silymarin. Conclusion: The present study provides the scientific rationale for the use of Vitex doniana stem bark in traditional medicine and has a viable antioxidative capacity both in vitro and in vivo.

scholarly journals Synergistic Effect of Docetaxel Plus Saponin Fraction of Vitex doniana on Prostate Specific Antigen and p53 in Nitrsobis (2-oxopropyl) Amine-induced Prostate Toxicity

2021 ◽  
pp. 17-22
Author(s):  
Ifeanacho Ezeteonu Abireh ◽  
Godson Emeka Anyanwu
Keyword(s):  
Synergistic Effect ◽  
Prostate Specific Antigen ◽  
Wistar Rats ◽  
Specific Antigen ◽  
P53 Expression ◽  
Male Wistar Rats ◽  
Saponin Fraction ◽  
Vitex Doniana ◽  
Dose Dependent ◽  
Group 1

Aim: This study investigated the synergistic effect of docetaxel plus saponin fraction of Vitex doniana on prostate specific antigen and p53 in nitrsobis (2-oxopropyl) amine-induced prostate toxicity in Wistar rat. Methodology: Twenty-four (24) male Wistar rats with elevated serum prostate specific antigen level were selected from a group of sixty (60) rats pretreated with subcutaneous Nitrosobis (2-oxopropyl) amine 5 mg/kg daily for 4 weeks. The selected 24 male Wistar rats were then grouped into 6 groups of four (4) rats each. Group 1 was given 1ml normal saline daily from day 1-28. Groups 2, 3, 4, 5, and 6 further received subcutaneous nitrosobis (2-oxopropyl) amine 5 mg/kg daily from day 1-28. In addition, groups 3, 4, 5, and 6 were given weekly intravenous docetaxel 8 mg/kg on day 15 and 22. In addition to docetaxel, groups 4, 5, and 6 were further treated with oral saponin at 250 mg/kg, 500 mg/kg, and 750 mg/kg, respectively, daily, from day 15-28. Immunoenzymometric assay method was used for analysis of blood sample for prostate specific antigen. The prostate tissues were subjected to immuno study using the ImmunoCruz Staining System (Lab Vision Corporation, Fremont, CA, USA). The quantitative evaluation of p53 was done by calculating the percentages of p53-immunostained nuclei (labeling index). Results: Significant increase in prostate specific antigen and p53 expression were observed in group 2 (treated with Nitrsobis (2-oxopropyl) amine alone) when compared with group 1 (control). Dose dependent decrease in prostate specific antigen and p53 expression were observed in groups 4, 5, and 6, treated with docetaxel 8 mg/kg plus 250 mg/kg, 500 mg/kg, and 750 mg/kg of saponin respectively. Conclusion: Docetaxel plus Saponin fraction of Vitex doniana significantly reduced the serum prostate specific antigen concentration and p53 expression in a dose dependent manner, with the group treated with 750 mg/kg showing the highest decrease in the parameters tested.

scholarly journals First Report of the Rust Fungus Olivea scitula on Vitex doniana in Zambia

Plant Disease ◽  
2005 ◽  
Vol 89 (4) ◽  
pp. 431-431 ◽  
Author(s):  
R. G. Kapooria ◽  
M. C. Aime
Keyword(s):  
Sierra Leone ◽  
Rust Fungus ◽  
Central Africa ◽  
Cattle Feed ◽  
First Report ◽  
Traditional Medicines ◽  
Plant Parts ◽  
On Line ◽  
Vitex Doniana ◽  
Mycology Laboratory

Vitex doniana Sweet (Verbenaceae) is a semideciduous tree that occurs throughtout Africa from Senegal to the Sudan and in Somalia, Angola, Botswana, South Africa, and most provinces of Zambia. Wood from V. doniana is used in construction, making boxes and furniture; jam and wine are made from the vitamin-rich fruits; the leaves provide cattle feed; and other plant parts are used in traditional medicines. The tree itself is a favorite for hanging bark beehives. In September 2004, leaves of V. doniana trees (20 km southeast of Lusaka) were found bearing brown uredinia, which were subsequently identified as the rust fungus, Olivea scitula Syd. The following description is based on the Zambian material that has slightly smaller spores than those of the original published description (2). Uredinia were hypophyllous, brown, round, at first scattered irregularly in the interveinal areas, then coalescing to form a continuous erumpent covering on the base, margin, or middle of the leaflet. Urediniospores were yellow brown, verrucose, globose, triangular or oval, 20 to 25 × 20 μm, with densely filled oil globules, and the wall 2 to 2.5 μm thick. Paraphyses were peripheral, incurved, basally united, and 50 to 75 × 5 to 6.25 μm. The pathogen has been reported previously from Sierra Leone, Uganda, and Nigeria (1). To our knowledge, this is the first report of Olivea spp. in Zambia and the first report of O. scitula from Central Africa. References: (1) D. F. Farr et al. Fungal Databases. Systematic Botany and Mycology Laboratory, On-line publication. ARS, USDA, 2004. (2) A. H. Sydow. Ann. Mycol. 35:251, 1937.

scholarly journals In vivo antioxidant effect of aqueous root bark, stem bark and leaves extracts of Vitex doniana in CCl4 induced liver damage rats

2013 ◽  
Vol 3 (5) ◽  
pp. 395-400 ◽  
Author(s):  
Kadejo Olubukola Adetoro ◽  
James Dorcas Bolanle ◽  
Sallau Balarebe Abdullahi ◽  
Ozigi Abdulrahaman Ahmed
Keyword(s):  
Liver Damage ◽  
Stem Bark ◽  
Antioxidant Effect ◽  
Root Bark ◽  
Vitex Doniana ◽  
In Vivo Antioxidant Effect

scholarly journals BITTER HERBS OF EASTERN NIGERIA (GONGRONEMA LATIFOLIUM, VERNONIA AMYGDALINA AND VITEX DONIANA): A REVIEW

2018 ◽  
Vol 15 (3) ◽  
pp. 47
Author(s):  
Asuzu Chinwe U.
Keyword(s):  
Key Words ◽  
Traditional Method ◽  
Human Consumption ◽  
Vernonia Amygdalina ◽  
South Eastern ◽  
Electronic Search ◽  
Anti Cancer ◽  
Large Audience ◽  
Vitex Doniana ◽  
Gongronema Latifolium

Background: The article is a review of three bitter vegetables consumed in South-eastern Nigeria (Gongronema latifolium, Vernonia amygdalina and Vitex doniana). These vegetables are not very palatable to taste but are highly famed because of the myriad of illnesses that they are reputed to cure and manage. The different aspects of these vegetables reviewed are their ethnobotany, zoo pharmacology, bioactivity, phytochemistry and toxicity. Materials and method: The literatures consulted were searched using electronic search engines (Google, Google scholar and Pubmed). Substantial amount of literature was consulted but only those directly related to the main review were selected. Result: The review revealed that the three bitter vegetables possessed phytochemicals like saponins, flavonoids, alkaloids among others that justify the claims of curing and managing many of the illnesses that traditional folks attribute to them. From literature, antimicrobial, antinflammatory, antidiabetic, antioxidant and anti cancer activities were attributed to these three bitter herbs. Antinutritional substances like phytate and oxalate reported in these herbs were not regarded as harmful for human consumption because of the traditional method of processing the vegetables by squeeze washing in several changes of water. Conclusion: The three bitter herbs are regarded as beneficial for human consumption and the information should be disseminated to a large audience. Key words: V. amygdalina, V. doniana, G.

Antihyperglycemic and Antihyperlipidemic Effects of Aqueous and Ethanolic Leaf Extracts of Vitex doniana in Streptozotocin-induced Diabetic Rats

2014 ◽  
Vol 8 (4) ◽  
pp. 178-186
Author(s):  
Okpe Oche ◽  
Ibrahim Sani ◽  
Njoku Godwin Chiaka ◽  
Ndidi Uche Samuel
Keyword(s):  
Diabetic Rats ◽  
Leaf Extracts ◽  
Vitex Doniana
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