scholarly journals Effect of Ethanol Extract of Leaves of Chrysophyllum albidum on the Reproductive Hormones of Lead-Exposed Female Wistar Albino Rats

2018 ◽  
Vol 22 (9) ◽  
pp. 1503
Author(s):  
CC Obi ◽  
KC Patrick-Iwuanyanwu ◽  
EN Onyeike
Keyword(s):  
Ethanol Extract ◽  
Reproductive Hormones ◽  
Albino Rats ◽  
Wistar Albino Rats

scholarly journals Cardioprotective Potential of Ethanol Extract of Sonchus Arvensis L. Leaves on Isoproterenol-Induced Myocardial Infarction in Rat

2018 ◽  
Vol 16 (1) ◽  
pp. 20
Author(s):  
Neng Fisheri Kurniati ◽  
Elin Yulinah Sukandar ◽  
Rian Pardilah ◽  
Nova Suliska ◽  
Dhyan Kusuma Ayuningtyas
Keyword(s):  
Myocardial Infarction ◽  
Creatine Kinase ◽  
Ethanol Extract ◽  
Wistar Rat ◽  
Positive Control ◽  
Negative Control ◽  
Albino Rats ◽  
Creatine Kinase Mb ◽  
Wistar Albino Rats ◽  
Sonchus Arvensis

Sonchus arvensis L. leaves have been used traditionally to treat various disease conditions. This study is designed to evaluate cardioprotective potential of ethanol extract of S. arvensis leaves on isoproterenol-induced myocardial infarction in Wistar rat. Male Wistar albino rats were divided into three main groups: negative control (saline only), positive control (isoproterenol only), and S. arvensis extract treated groups. S. arvensis extract was administered in three doses; 50, 100, and 200 mg/kg b.w. p.o for 14 days. On day 13 and 14, isoproterenol (85 mg/kg bw) was given intraperitoneally to positive control and extract treated groups. The parameters studied were cardiac biomarker enzymes which were Creatine Kinase (CK), Creatine Kinase-MB (CK-MB), Aspartate Transaminase (AST), Alanine Transaminase (ALT) and Lactate Dehydrogenase (LDH). The results showed that S. arvensis at dose of 50 mg/kg b.w. could significantly (P<0.05) reduce the level of CK, CK-MB, AST, ALT, and LDH in myocardial infarcted rats compared to positive control. The increase of the dose of S. arvensis extract was not followed by an increase of its cardioprotective activity. In conclusion, Sonchus arvensis L. leaves extract at dose of 50 mg/kg b.w. has potential to be developed as cardioprotective drug.

scholarly journals ANTIDIABETIC ACTIVITY OF BACOLEPIS NERVOSA (WIGHT AND ARN.) DECNE. EX MOQ. EXTRACT ON ALLOXAN INDUCED DIABETIC RATS

2016 ◽  
Vol 8 (11) ◽  
pp. 320
Author(s):  
Arockia Jenecius Alphonse A. ◽  
Mohan V. R. ◽  
Doss A.
Keyword(s):  
Blood Glucose ◽  
Ethanol Extract ◽  
Diabetic Rats ◽  
Serum Enzymes ◽  
Antidiabetic Activity ◽  
Albino Rats ◽  
Ethanol Extracts ◽  
Wistar Albino Rats ◽  
Alloxan Monohydrate ◽  
Lipid Parameters

Objective: The aim of this study was to investigate the effect of ethanol extracts of stem and leaf of Bacolepis nervosa as antihyperglycemic, anti-hyperlipidemic and antioxidant activity in alloxan-induced diabetic rats. Methods: Diabetes was induced in wistar albino rats by administration of alloxan monohydrate (150 mg/kg). The ethanol extract of B. nervosa leaf and stem at a dose of 150 and 300 mg/kg body weight was administrated at a single dose per day to diabetes-induced rats for a period of 14 d. The effect of ethanol extract of B. nervosa leaf and stem on blood glucose, insulin, urea, creatinine, HbA1C, serum protein, albumin, globulin, serum enzymes, serum lipid profiles, lipid peroxidase (LPO) and antioxidant enzymes like superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and reduced glutathione (GSH) were measured in the diabetic rats.Results: The ethanol extract of B. nervosa stem and leaf elicited significant reduction in blood glucose (p<0.001), serum enzymes (SGPT, SGOT, ALP) (p<0.01), lipid parameters (TC, TG, VLDL-LDL, PL) (p<0.01) except HDL-C and significantly increased insulin (p<0.01), HDL-C (p<0.05),, GPx, GSH, SOD and CAT (p<0.05) at the dose of 300 mg/kg when compared with the diabetic-induced control.Conclusion: From the above results, it is concluded that ethanol extracts of B. nervosa leaf and stem possesses significant antihyperglycemic, antihyperlipidemic and antioxidant effect in alloxan induced diabetic rats.

Evaluation of the Effect of Subchronic Administration of the 70% Ethanol Extract of Millettiea ferruginea (Hochst) Bak (Fabaceae) Seeds on Biochemical, Haematological and Histopathological Parameters in Albino Wistar Rats

2020 ◽  
Vol 36 (1) ◽  
pp. 49-60
Author(s):  
Mekonnen Debebe ◽  
Molla Getu ◽  
Mekbeb Afework ◽  
Aster Tsegaye ◽  
Eyasu Makonnen ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Haemoglobin Concentration ◽  
Ethanol Extract ◽  
Chronic Administration ◽  
Female Rats ◽  
Male Rats ◽  
Albino Rats ◽  
Blood Levels ◽  
Male And Female Rats ◽  
Wistar Albino Rats

Millettiea ferruginea (Hochst) Bak (Fabaceae) is an indigenous plant, traditionally used for the treatment of various disease conditions in Ethiopia  without substantiating its safety. This study, therefore, evaluated its toxicity in albino Wistar rats. The hydroalcoholic extract of M. ferruginea was prepared by maceration of the powdered seeds in 70% ethanol. The effect of extract administration to albino Wistar albino rats for 90 days at doses of 125 mg/kg and 250 mg/kg b/w was investigated. Subchronic administration of the extract at a dose of 250 mg/kg decreased mean corpuscular haemoglobin concentration (MCHC) and monocytes in female rats. The blood levels of alkaline phosphatase (ALP), alanine transaminase (ALT), creatine kinase (CK) and urea in the female, and CK in male rats treated with the extract at 250 mg/kg were significantly increased. Histopathological investigation of the liver revealed signs of blood congestions in portal vein and hepatic artery at 125 mg/kg, and minor inflammation, congestions and focal hepatocellular necrosis at 250 mg/kg in both sexes. The extract produced atrophy of the glomeruli, widened urinary space andinflammation of the kidney at both doses, and also caused minor tubular necrosis and peritubular blood congestions at 250 mg/kg in both male and female rats. In the heart of extract treated rats, there were congestions of blood vessels and necrosis of myocardium at both doses, and inflammation at 250 mg/kg. Desquamation and infiltration of the mucosa at both doses, and submucosal atrophy at 125 mg/kg and blood congestions at 250 mg/kg were observed in the small intestine of extract treated rats. The present findings suggest that the extract is relatively safe at therapeutic dose, although some signs of toxicity occurred mainly at the higher dose in female rats. Additional investigations on chronic administration of the extract is recommended to further substantiate the safety of the plant. Keywords: Millettia ferruginea, ethanol seed extract, toxicity, histopathology, Wistar albino rats 

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