scholarly journals Hearing loss among patients on treatment for drug-resistant tuberculosis in Uganda

2021 ◽  
Vol 14 (3) ◽  
pp. 80-84
Author(s):  
Lodiong Jackson Dumo Lodiong ◽  
Timbine Amos ◽  
Boniface Amanee Elias Lumori ◽  
Edwin Nuwagira
Keyword(s):  
Hearing Loss ◽  
Cox Model ◽  
Hearing Threshold ◽  
P Value ◽  
Drug Resistant ◽  
Treatment Unit ◽  
Drug Resistant Tuberculosis ◽  
Regional Referral Hospital ◽  
Resistant Tuberculosis ◽  
Male Sex

Introduction: Second-line injectable therapy using aminoglycosides (AG) like kanamycin, amikacin or capreomycin is associated with irreversible hearing loss. We aimed to determine the incidence and predictors of hearing loss among patients with drug resistant tuberculosis (DR-TB) who received AG.Method: This was a retrospective cohort study conducted at the tuberculosis treatment unit of Mbarara Regional Referral Hospital (MRRH). All adult patients with a diagnosis of DR-TB between March 2016 and December 2019 were candidates for inclusion in the study. Hearing loss was defined as a hearing threshold of >20 decibels (dB) at any test frequency in at least one ear. The incidence and predictors of hearing loss were analysed using multivariable Cox model. A p-value of ≤0.05 was considered as statistically significant. Data analysis was done using STATA version 13.Results: The estimated rate of developing hearing loss was 107 per 1000 person months. Thirty-seven (52.9%) of 70 DR-TB patients experienced some degree of hearing loss, of which 25 (67.6 %) developed mild, 5 (13.5%) moderate, and 3 (8.1%) severe hearing loss. Male sex (HR 2.05, CI 1.03-4.10, p-value 0.041), increasing age (HR.5.17, CI 1.42-18.87, p-value 0.013) and high BMI (HR 3.31, CI 1.15 - 9.53, p-value 0.026) were significant predictors of new onset of hearing loss.Conclusion: The incidence of hearing loss among DR-TB patients was high, with the majority having a mild hearing loss. Patients who were male, older, overweight and/or obese were more likely to develop AG-induced hearing loss.

scholarly journals Aminoglycoside-induced Hearing Loss Among Patients Being Treated for Drug-resistant Tuberculosis in South Africa: A Prediction Model

2019 ◽  
Vol 70 (5) ◽  
pp. 917-924 ◽  
Author(s):  
Hyejeong Hong ◽  
David W Dowdy ◽  
Kelly E Dooley ◽  
Howard W Francis ◽  
Chakra Budhathoki ◽  
...  
Keyword(s):  
South Africa ◽  
Hearing Loss ◽  
Prediction Model ◽  
Predictive Value ◽  
Characteristic Curve ◽  
Hearing Threshold ◽  
Drug Resistant ◽  
Drug Resistant Tuberculosis ◽  
Tb Treatment ◽  
Resistant Tuberculosis

Abstract Background Individuals treated for drug-resistant tuberculosis (DR-TB) with aminoglycosides (AGs) in resource-limited settings often experience permanent hearing loss, yet there is no practical method to identify those at higher risk. We sought to develop a clinical prediction model of AG-induced hearing loss among patients initiating DR-TB treatment in South Africa. Methods Using nested, prospective data from a cohort of 379 South African adults being treated for confirmed DR-TB with AG-based regimens we developed the prediction model using multiple logistic regression. Predictors were collected from clinical, audiological, and laboratory evaluations conducted at the initiation of DR-TB treatment. The outcome of AG-induced hearing loss was identified from audiometric and clinical evaluation by a worsened hearing threshold compared with baseline during the 6-month intensive phase. Results Sixty-three percent of participants (n = 238) developed any level of hearing loss. The model predicting hearing loss at frequencies from 250 to 8000 Hz included weekly AG dose, human immunodeficiency virus status with CD4 count, age, serum albumin, body mass index, and pre-existing hearing loss. This model demonstrated reasonable discrimination (area under the receiver operating characteristic curve [AUC] = 0.71) and calibration (χ2[8] = 6.10, P = .636). Using a cutoff of 80% predicted probability of hearing loss, the positive predictive value of this model was 83% and negative predictive value was 40%. Model discrimination was similar for ultrahigh-frequency hearing loss (frequencies >9000 Hz; AUC = 0.81) but weaker for clinically determined hearing loss (AUC = 0.60). Conclusions This model may identify patients with DR-TB who are at highest risk of developing AG-induced ototoxicity and may help prioritize patients for AG-sparing regimens in clinical settings where access is limited.

scholarly journals Hearing loss in patients on treatment for drug-resistant tuberculosis

2012 ◽  
Vol 40 (5) ◽  
pp. 1277-1286 ◽  
Author(s):  
James A. Seddon ◽  
Peter Godfrey-Faussett ◽  
Kayleen Jacobs ◽  
Adam Ebrahim ◽  
Anneke C. Hesseling ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Drug Resistant ◽  
Drug Resistant Tuberculosis ◽  
Resistant Tuberculosis

scholarly journals Determinants Of Multidrug Resistant Tuberculosis Among Adultsundergoing Treatment For Tuberculosis In Tigray Region, Ethiopia: A Case Control Study

2019 ◽  
Author(s):  
Kidane Zereabruk ◽  
Tensay Kahsay ◽  
Hiyab Teklemichael ◽  
Woldu Aberhe ◽  
Abrha Hailay ◽  
...  
Keyword(s):  
Multidrug Resistant ◽  
Multi Drug Resistance ◽  
P Value ◽  
Rural Residence ◽  
Drug Resistant ◽  
Drug Resistant Tuberculosis ◽  
Tigray Region ◽  
Resistant Tuberculosis ◽  
Multidrug Resistant Tuberculosis ◽  
Multi Drug Resistant Tuberculosis

Abstract Background Multidrug-resistant tuberculosis is a type of tuberculosis that is resistant to at least the first line anti-tuberculosis drugs namely, Rifampicin and Isoniazid. Multidrug-resistant tuberculosis has continued to be a challenge for tuberculosis control globally. Globally 600,000 people were newly eligible for Multidrug-resistant tuberculosis treatment with an estimated 240,000 deaths annually. There are few numbers of multi drug resistant tuberculosis studies in different regions of Ethiopia. However, most of these studies were restricted only to a single hospital and there is no published information regarding multi drug resistant tuberculosis in Tigray region. Therefore, the aim of this study was to assess the determinants of multidrug resistant tuberculosis among adults undergoing treatment for tuberculosis in Tigray region, Ethiopia.Methods A hospital based unmatched case control study was conducted from April to June, 2019. Simple random sampling method was used to select 85 cases and 169 controls. Primary data was collected by face-to-face interview and secondary data by reviewing patients’ charts using pretested structured questionnaires. The data were entered and cleaned using Epi data manager then exported to SPSS for analysis. Binary Logistic regression model was used to test the association between independent and dependent variables. Model fitness was checked using Hosmer-Lemeshow goodness-of-fit and Variance inflation factor was used to assess multi collinearity between the independent variables. Variables at p-value less than 0.25 in bivariate analysis was entered into a multivariable analysis to identify the determinant factors of multi drug resistant tuberculosis. Finally, level of significance was declared at p-value <0.05.Results A total of 254 participants with 85 cases and 169 controls were included in this study. Of the respondents, 62 (36.7%) among the controls and 48 (56.5%) among the cases were living in rural residence. Rural residence [AOR=2.54;95%CI=1.34,4.83], HIV[AOR=4.5;95%CI=1.4,14.2], relapse [AOR=3.86;95%CI;1.98,7.5], return after lost follow up [AOR=6.29;95% 1.64,24.2], treatment failure [AOR=5.87; CI=1.39,24.8] were among the determinants of Multi drug resistance tuberculosis.Conclusion Rural residence, HIV, relapse, return after lost follow up and treatment failure were the identified determinant factors of Multi drug resistance tuberculosis.

scholarly journals Pharmacokinetics and other risk factors for kanamycin-induced hearing loss in patients with multi-drug resistant tuberculosis

2019 ◽  
Vol 59 (3) ◽  
pp. 219-223
Author(s):  
Nazanin Ghafari ◽  
Richard Court ◽  
Maxwell Tawanda Chirehwa ◽  
Lubbe Wiesner ◽  
Lucretia Petersen ◽  
...  
Keyword(s):  
Risk Factors ◽  
Hearing Loss ◽  
Drug Resistant ◽  
Drug Resistant Tuberculosis ◽  
Resistant Tuberculosis ◽  
Multi Drug Resistant Tuberculosis

scholarly journals Prevalence of aminoglycoside-induced hearing loss in drug-resistant tuberculosis patients: A systematic review

2021 ◽  
Author(s):  
Lauren K. Dillard ◽  
Ricardo X. Martinez ◽  
Lucero Lopez Perez ◽  
Amanda M. Fullerton ◽  
Shelly Chadha ◽  
...  
Keyword(s):  
Systematic Review ◽  
Hearing Loss ◽  
Drug Resistant ◽  
Drug Resistant Tuberculosis ◽  
Tuberculosis Patients ◽  
Resistant Tuberculosis

scholarly journals The study of adverse drug reactions in indoor patients of tuberculosis taking standardized antitubercular therapy (directly observed treatment short-course and programmatic management of drug resistant tuberculosis) in a tertiary care hospital at Surat

2021 ◽  
Vol 10 (5) ◽  
pp. 507
Author(s):  
Payal P. Naik ◽  
Arvindsingh Panwar ◽  
Swati Patel
Keyword(s):  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
P Value ◽  
Care Hospital ◽  
Drug Resistant ◽  
Drug Reactions ◽  
Drug Resistant Tuberculosis ◽  
Resistant Tuberculosis ◽  
Short Course ◽  
Directly Observed Treatment

Background: Tuberculosis is a serious public health issue in India. The treatment regimen followed is Directly observed treatment short-course (DOTS) and Programmatic Management of Drug resistant Tuberculosis (PMDT) approach. In a long period of treatment adverse drug reactions (ADRs) can be an important programmatic issue. Thus, study was undertaken to assess the ADRs caused by antitubercular therapy in indoor patients in a tertiary care hospital at Surat.Methods: The Observational, prospective study was carried out for one year period. The causality was determined by WHO UMC scale and severity was determined by Modified Hartwig and Siegel scale. Chi square test was applied for statistical analysis.Results: Among 255 tuberculosis patients, 85 (33.3%) patients developed ADRs. Occurrence of ADRs was more among females (46.6%). The commonly involved systems are gastrointestinal (40.6%) followed by haematological (17.9%). The most common ADRs observed were nausea and vomiting (21.7%). High percentage of ADRs causing drugs were isoniazid (30.6%) followed by rifampicin (26.1%). Causality assessment showed 60.4% ADRs were possible, 37.7% ADRs were probable and 1.9% ADRs was certain. Severity assessment scale showed 81.1% of moderate, 12.3% of mild and 6.6% of severe grading. Occurrence of ADRs was more among PMDT (60%) in comparison to DOTS therapy (31.06%) [p value = 0.0084 (significant p value < 0.05)].Conclusions: Antitubercular treatment is safer but early detection, management and reporting of ADRs is required to prevent it at initial stage and helps to decrease default rate.

scholarly journals Ototoxicity of Non-aminoglycoside Antibiotics

2021 ◽  
Vol 12 ◽  
Author(s):  
Leonard P. Rybak ◽  
Vickram Ramkumar ◽  
Debashree Mukherjea
Keyword(s):  
Hearing Loss ◽  
Animal Studies ◽  
Developing Nations ◽  
Aminoglycoside Antibiotics ◽  
Drug Resistant ◽  
Drug Resistant Tuberculosis ◽  
Resistant Tuberculosis ◽  
Polypeptide Antibiotic

It is well-known that aminoglycoside antibiotics can cause significant hearing loss and vestibular deficits that have been described in animal studies and in clinical reports. The purpose of this review is to summarize relevant preclinical and clinical publications that discuss the ototoxicity of non-aminoglycoside antibiotics. The major classes of antibiotics other than aminoglycosides that have been associated with hearing loss in animal studies and in patients are discussed in this report. These antibiotics include: capreomycin, a polypeptide antibiotic that has been used to treat patients with drug-resistant tuberculosis, particularly in developing nations; the macrolides, including erythromycin, azithromycin and clarithromycin; and vancomycin. These antibiotics have been associated with ototoxicity, particularly in neonates. It is critical to be aware of the ototoxic potential of these antibiotics since so much attention has been given to the ototoxicity of aminoglycoside antibiotics in the literature.

scholarly journals Hearing thresholds in patients with drug-resistant tuberculosis: baseline audiogram configurations and associations

2017 ◽  
Vol 43 (3) ◽  
pp. 195-201 ◽  
Author(s):  
Olusola Ayodele Sogebi ◽  
Muse Olatunbosun Fadeyi ◽  
Bolanle Olufunlola Adefuye ◽  
Festus Olukayode Soyinka
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Pure Tone ◽  
Pure Tone Audiometry ◽  
Male Gender ◽  
Sensorineural Hearing ◽  
Drug Resistant ◽  
Drug Resistant Tuberculosis ◽  
Resistant Tuberculosis ◽  
Antituberculosis Treatment

ABSTRACT Objective: To use baseline audiogram parameters in order to ascertain whether drug-resistant tuberculosis (DR-TB) has effects on hearing, as well as to describe the configurations of the audiograms and to determine whether there are parameters that can be associated with those configurations. Methods: This was a prospective study involving patients diagnosed with DR-TB at a tuberculosis treatment center in the state of Ogun, in Nigeria. The patients included in the study were submitted to pure tone audiometry at baseline (within two weeks after treatment initiation). For comparative analyses, data regarding demographic and clinical characteristics were collected from the medical records of the patients. Results: The final sample comprised 132 patients. The mean age of the patients was 34.5 ± 12.6 years (range, 8-82 years), and the male:female ratio was 2:1. Of the 132 patients, 103 (78.0%) resided in neighboring states, 125 (94.7%) had previously experienced antituberculosis treatment failure, and 18 (13.6%) were retroviral-positive. Normal audiograms were found in 12 patients (9.1%), whereas sensorineural hearing loss was identified in 104 (78.8%), the two most common configurations being ascending, in 54 (40.9%), and sloping, in 26 (19.7%). Pure-tone averages at low frequencies (0.25-1.0 kHz) and high frequencies (2.0-8.0 kHz) were 33.0 dB and 40.0 dB, respectively. Regarding the degree of hearing loss in the better ear, 36 patients (27.3%) were classified as having normal hearing and 67 (50.8%) were classified as having mild hearing loss (26-40 dB), whereas 29 (21.9%) showed moderate or severe hearing loss. Among the variables studied (age, gender, retroviral status, previous treatment outcome, and weight at admission), only male gender was associated with audiometric configurations. Conclusions: In this sample of patients with DR-TB, most presented with bilateral, mild, suboptimal sensorineural hearing loss, and ascending/sloping audiometric configurations were associated with male gender.

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