scholarly journals Regulatory T cells and anti-inflammatory cytokine profile of mice fed a high-fat diet after single-bulb garlic (Allium sativum L.) oil treatment

2019 ◽  
Vol 17 (11) ◽  
pp. 2157 ◽  
Author(s):  
Sri Rahayu Lestari ◽  
Muhaimin Rifa’i
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
High Fat Diet ◽  
Inflammatory Cytokine ◽  
Allium Sativum ◽  
Cytokine Profile ◽  
High Fat ◽  
Anti Inflammatory ◽  
Anti Inflammatory Cytokine

Gum Arabic modifies anti-inflammatory cytokine in mice fed with high fat diet induced obesity

2021 ◽  
Vol 25 ◽  
pp. 100258
Author(s):  
Abdelkareem A. Ahmed ◽  
Mohammed Elmujtba Adam Essa ◽  
Adriano Mollica ◽  
Azzurra Stefanucci ◽  
Gokhan Zengin ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Inflammatory Cytokine ◽  
Gum Arabic ◽  
High Fat ◽  
Diet Induced Obesity ◽  
Anti Inflammatory ◽  
Anti Inflammatory Cytokine

Anti-inflammatory cytokine profile and mortality in febrile patients

The Lancet ◽  
1998 ◽  
Vol 351 (9107) ◽  
pp. 950-953 ◽  
Author(s):  
J VANDISSEL ◽  
P VANLANGEVELDE ◽  
R WESTENDORP ◽  
K KWAPPENBERG ◽  
M FROLICH
Keyword(s):  
Inflammatory Cytokine ◽  
Cytokine Profile ◽  
Anti Inflammatory ◽  
Anti Inflammatory Cytokine

scholarly journals Elevated vasopressin in pregnant mice induces T-helper subset alterations consistent with human preeclampsia

2018 ◽  
Vol 132 (3) ◽  
pp. 419-436 ◽  
Author(s):  
Sabrina M. Scroggins ◽  
Donna A. Santillan ◽  
Jenna M. Lund ◽  
Jeremy A. Sandgren ◽  
Lindsay K. Krotz ◽  
...  
Keyword(s):  
T Cells ◽  
Cd4 T Cells ◽  
Inflammatory Cytokine ◽  
Maternal Plasma ◽  
Hypertensive Disorder ◽  
Wild Type ◽  
T Helper ◽  
Anti Inflammatory ◽  
Immune Changes ◽  
Anti Inflammatory Cytokine

The pathogenesis of preeclampsia (PreE), a hypertensive disorder of pregnancy, involves imbalanced T helper (TH) cell populations and resultant changes in pro- and anti-inflammatory cytokine release. Elevated copeptin (an inert biomarker of arginine vasopressin (AVP)), secretion precedes the development of symptoms in PreE in humans, and infusion of AVP proximal to and throughout gestation is sufficient to initiate cardiovascular and renal phenotypes of PreE in wild-type C57BL/6J mice. We hypothesize that AVP infusion in wild-type mice is sufficient to induce the immune changes observed in human PreE. AVP infusion throughout gestation in mice resulted in increased pro-inflammatory interferon γ (IFNg) (TH1) in the maternal plasma. The TH17-associated cytokine interleukin (IL)-17 was elevated in the maternal plasma, amniotic fluid, and placenta following AVP infusion. Conversely, the TH2-associated anti-inflammatory cytokine IL-4 was decreased in the maternal and fetal kidneys from AVP-infused dams, while IL-10 was decreased in the maternal kidney and all fetal tissues. Collectively, these results demonstrate the sufficiency of AVP to induce the immune changes typical of PreE. We investigated if T cells can respond directly to AVP by evaluating the expression of AVP receptors (AVPRs) on mouse and human CD4+ T cells. Mouse and human T cells expressed AVPR1a, AVPR1b, and AVPR2. The expression of AVPR1a was decreased in CD4+ T cells obtained from PreE-affected women. In total, our data are consistent with a potential initiating role for AVP in the immune dysfunction typical of PreE and identifies putative signaling mechanism(s) for future investigation.

scholarly journals High-fat diet-induced hypertension is associated with a proinflammatory T cell profile in male and female Dahl salt-sensitive rats

2018 ◽  
Vol 315 (6) ◽  
pp. H1713-H1723 ◽  
Author(s):  
Lia E. Taylor ◽  
Ellen E. Gillis ◽  
Jacqueline B. Musall ◽  
Babak Baban ◽  
Jennifer C. Sullivan
Keyword(s):  
T Cells ◽  
T Cell ◽  
Regulatory T Cells ◽  
High Fat Diet ◽  
Female Rats ◽  
Male Rats ◽  
High Fat ◽  
Male And Female ◽  
The Impact ◽  
Cell Profile

Evidence supports a sex difference in the impact of a high-fat diet (HFD) on cardiovascular outcomes, with male experimental animals exhibiting greater increases in blood pressure (BP) than female experimental animals. The immune system has been implicated in HFD-induced increases in BP, and there is a sex difference in T-cell activation in hypertension. The goal of this study was to determine the impact of HFD on BP and aortic and renal T cell profiles in male and female Dahl salt-sensitive (DSS) rats. We hypothesized that male DSS rats would have greater increases in BP and T cell infiltration in response to a HFD compared with female DSS rats. BP was measured by tail-cuff plethysmography, and aortic and renal T cells were assessed by flow cytometric analysis in male and female DSS rats on a normal-fat diet (NFD) or HFD from 12 to 16 wk of age. Four weeks of HFD increased BP in male and female DSS rats to a similar degree. Increases in BP were accompanied by increased percentages of CD4+ T cells and T helper (Th)17 cells in both sexes, although male rats had more proinflammatory T cells. Percentages of renal CD3+ and CD4+ T cells as well as Th17 cells were increased in both sexes by the HFD, although the increase in CD3+ T cells was greater in male rats. HFD also decreased the percentage of aortic and renal regulatory T cells in both sexes, although female rats maintained more regulatory T cells than male rats regardless of diet. In conclusion, both male and female DSS rats exhibit BP sensitivity to a HFD; however, the mechanisms mediating HFD-induced increases in BP may be distinct as male rats exhibit greater increases in the percentage of proinflammatory T cells than female rats. NEW & NOTEWORTHY Our study demonstrates that male and female Dahl salt-sensitive rats exhibit similar increases in blood pressure to a high-fat diet and an increase in aortic and renal T cells. These results are in contrast to studies showing that female rats remain normotensive and/or upregulate regulatory T cells in response to hypertensive stimuli compared with male rats. Our data suggest that a 4-wk high-fat diet has sex-specific effects on the T cell profile in Dahl salt-sensitive rats.

Islet allograft survival and anti-inflammatory cytokine profile are provided by circulating transgenic lung-specific alpha-1-antitrypsin

Cytokine ◽  
2009 ◽  
Vol 48 (1-2) ◽  
pp. 105
Author(s):  
Galit Shahaf ◽  
Nathaniel DeFelice ◽  
Chad Ficek ◽  
Frida Friedman ◽  
Charles A. Dinarello ◽  
...  
Keyword(s):  
Inflammatory Cytokine ◽  
Cytokine Profile ◽  
Allograft Survival ◽  
Islet Allograft ◽  
Anti Inflammatory ◽  
Alpha 1 Antitrypsin ◽  
Anti Inflammatory Cytokine

scholarly journals Pro- and anti-inflammatory cytokine production by autoimmune T cells against preproinsulin in HLA-DRB1*04, DQ8 Type 1 diabetes

Diabetologia ◽  
2004 ◽  
Vol 47 (3) ◽  
pp. 439-450 ◽  
Author(s):  
I. Durinovic-Belló ◽  
M. Schlosser ◽  
M. Riedl ◽  
N. Maisel ◽  
S. Rosinger ◽  
...  
Keyword(s):  
T Cells ◽  
Type 1 Diabetes ◽  
Inflammatory Cytokine ◽  
Cytokine Production ◽  
Inflammatory Cytokine Production ◽  
Anti Inflammatory ◽  
Anti Inflammatory Cytokine
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