Next Generation Tissue Engineering Strategies by Combination of Organoid Formation and 3D Bioprinting

Over the past decades, a number of bone tissue engineering (BTE) approaches have been developed to address substantial challenges in the management of critical size bone defects. Although the majority of BTE strategies developed in the laboratory have been limited due to lack of clinical relevance in translation, primary prerequisites for the construction of vascularized functional bone grafts have gained confidence owing to the accumulated knowledge of the osteogenic, osteoinductive, and osteoconductive properties of mesenchymal stem cells and bone-relevant biomaterials that reflect bone-healing mechanisms. In this review, we summarize the current knowledge of bone-healing mechanisms focusing on the details that should be embodied in the development of vascularized BTE, and discuss promising strategies based on 3D-bioprinting technologies that efficiently coalesce the abovementioned main features in bone-healing systems, which comprehensively interact during the bone regeneration processes.

Download Full-text

3D bioprinting for lung and tracheal tissue engineering: Criteria, advances, challenges, and future directions

Bioprinting ◽

10.1016/j.bprint.2020.e00124 ◽

2021 ◽

Vol 21 ◽

pp. e00124

Author(s):

Seyed Hossein Mahfouzi ◽

Seyed Hamid Safiabadi Tali ◽

Ghassem Amoabediny

Keyword(s):

Tissue Engineering ◽

3D Bioprinting ◽

Future Directions ◽

Tracheal Tissue

Download Full-text

Key advances of carboxymethyl cellulose in tissue engineering & 3D bioprinting applications

Carbohydrate Polymers ◽

10.1016/j.carbpol.2020.117561 ◽

2021 ◽

Vol 256 ◽

pp. 117561

Author(s):

Allen Zennifer ◽

Praseetha Senthilvelan ◽

Swaminathan Sethuraman ◽

Dhakshinamoorthy Sundaramurthi

Keyword(s):

Tissue Engineering ◽

Carboxymethyl Cellulose ◽

3D Bioprinting

Download Full-text

107 The Role of Tissue Engineering in Auricular Reconstruction: A Critical Review

British Journal of Surgery ◽

10.1093/bjs/znab259.689 ◽

2021 ◽

Vol 108 (Supplement_6) ◽

Author(s):

F Moura ◽

R Varley ◽

C Yao

Keyword(s):

Mechanical Properties ◽

Tissue Engineering ◽

Immune Response ◽

Critical Review ◽

3D Bioprinting ◽

Short Term ◽

Auricular Reconstruction ◽

Cartilage Reconstruction ◽

Promising Solution

Abstract Aim Despite several decades of research in tissue engineering, reconstructing a 3D human-sized ear that can stand the test of time has remained a challenge. Autologous cartilage reconstruction remains the main treatment choice despite the associated morbidity. Progress in the field has been made and several studies have used tissue-engineered implants in immunocompetent animals with promising results. Method This study critically reviews and assesses the characteristics that make auricular reconstruction so challenging and how far research has come in addressing the following: mechanical properties; vascularisation; immune response; cell sourcing; surgical attachments; allografts; and cost. Results The question is whether tissue engineering will realistically replace autologous cartilage reconstruction in the short-term, or will advances in other areas, outlined in this article, manage to provide suitable and aesthetically accurate scaffolds. Conclusions Advances in tissue engineering are slowly progressing and utilise advances in both biomaterial design and 3D bioprinting to try and address the challenges of auricular reconstruction. Tissue engineering is still a promising solution to auricular reconstruction but still requires further research before becoming a reality.

Download Full-text

Tissue engineering, 3D-Bioprinting, morphogenesis modelling and simulation of biostructures: Relevance, underpinning biological principles and future trends

Bioprinting ◽

10.1016/j.bprint.2021.e00171 ◽

2021 ◽

pp. e00171

Author(s):

Diego Alejandro Sánchez Rodríguez ◽

Ana Isabel Ramos-Murillo ◽

Rubén Darío Godoy-Silva

Keyword(s):

Tissue Engineering ◽

Modelling And Simulation ◽

Future Trends ◽

3D Bioprinting

Download Full-text

Hydrogel-Based Bioinks for Three-Dimensional Bioprinting: Patent Analysis

Materials Proceedings ◽

10.3390/iocps2021-11239 ◽

2021 ◽

Vol 7 (1) ◽

pp. 3

Author(s):

Ahmed Fatimi

Keyword(s):

Tissue Engineering ◽

Detailed Analysis ◽

State Of The Art ◽

Three Dimensional ◽

Patent Analysis ◽

The State ◽

Driving Factors ◽

3D Bioprinting ◽

Preparation Methods

There are a variety of hydrogel-based bioinks commonly used in three-dimensional bioprinting. In this study, in the form of patent analysis, the state of the art has been reviewed by introducing what has been patented in relation to hydrogel-based bioinks. Furthermore, a detailed analysis of the patentability of the used hydrogels, their preparation methods and their formulations, as well as the 3D bioprinting process using hydrogels, have been provided by determining publication years, jurisdictions, inventors, applicants, owners, and classifications. The classification of patents reveals that most inventions intended for hydrogels used as materials for prostheses or for coating prostheses are characterized by their function or properties Knowledge clusters and expert driving factors show that biomaterials, tissue engineering, and biofabrication research is concentrated in the most patents.

Download Full-text

Vascular Tissue Engineering: The Role of 3D Bioprinting

Tissue-Engineered Vascular Grafts ◽

10.1007/978-3-030-05336-9_11 ◽

2020 ◽

pp. 321-338

Author(s):

Yu Shrike Zhang ◽

Ali Khademhosseini

Keyword(s):

Tissue Engineering ◽

Vascular Tissue ◽

Vascular Tissue Engineering ◽

3D Bioprinting

Download Full-text

Clinical Approaches of Biomimetic: An Emerging Next Generation Technology

10.5772/intechopen.97148 ◽

2021 ◽

Author(s):

Kirti Rani

Keyword(s):

Tissue Engineering ◽

Close Contact ◽

The Body ◽

Next Generation ◽

Biochemical Engineering ◽

Security Systems ◽

Material Sciences ◽

Reported Data ◽

Generation Technology

Biomimetic is the study of various principles of working mechanisms of naturally occurring phenomena and their further respective integrations in to such a modified advanced mechanized instruments/models of digital or artificial intelligence protocols. Hence, biomimetic has been proposed in last decades for betterment of human mankind for improving security systems by developing various convenient robotic vehicles and devices inspired by natural working phenomenon of plants, animals, birds and insects based on biochemical engineering and nanotechnology. Hence, biomimetic will be considered next generation technology to develop various robotic products in the fields of chemistry, medicine, material sciences, regenerative medicine and tissue engineering medicine, biomedical engineering to treat various diseases and congenital disorders. The characteristics of tissue engineered scaffolds are found to possess multifunctional cellular properties like biocompatibility, biodegradability and favorable mechanized properties when comes in close contact with the body fluids in vivo. This chapter will provide overall overview to the readers for the study based on reported data of developed biomimetic materials and tools exploited for various biomedical applications and tissue engineering applications which further helpful to meet the needs of the medicine and health care industries.

Download Full-text