Prevalence of risk factors associated with ocular problems in males and females in type 1 & 2 diabetes

Background: The aim of current study was exploring the ocular abnormalities in individuals with Type 1 & 2 diabetes. Methods: Patients referred for diabetic ocular abnormalities (retinopathy, cataract, glaucoma and refractive error) on fundoscopy from LRBT eye hospital Korangi, Karachi were randomly included in the study. Retinopathy, cataract and refractive error were evaluated by slit lamp biomicroscope or indirect ophthalmoscope, & categorized into lacking, non-proliferative, proliferative retinopathy, maculopathy, capsular or sub capsular cataract, myopia and hypermetropia. While glaucoma was assessed by tonometry. Prevalence of eye complication has been seen in subjects. Outcome of substantial risk factors on the diverse phases of retinopathy, multivariate regression analysis was performed. Results: 200 diabetic subjects (106 males and 94 females) when the compared; diabetic subjects and subjects with hypertension; 28.0 % retinopathy, 9.75 % cataract, 7.31 % with glaucoma, and about 2.43% refractive error were found out among the diabetic males. 47.61 % retinopathy, 11.9% Cataract, 40.47% refractive error were found in females. In males with diabetes and hypertension were found 60.46 % retinopathy, 27.9 5% cataract, 11.62 % refractive error & in females 46.15% retinopathy, 19.23 % cataract, and 34.61 % with refractive error. Conclusions: This current study emphasizes screening of diabetic subjects regularly so as to distinguish ocular abnormalities and increasing public awareness.

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Patient-Related Risk Factors Associated With Surgical Site Complications After Elective Hand Surgery

Hand ◽

10.1177/1558944720944260 ◽

2020 ◽

pp. 155894472094426

Author(s):

Tyler Youngman ◽

Michael Del Core ◽

Timothy Benage ◽

Daniel Koehler ◽

Douglas Sammer ◽

...

Keyword(s):

Risk Factors ◽

Regression Analysis ◽

Surgical Complications ◽

Multivariate Regression ◽

Univariate Analysis ◽

Hand Surgery ◽

Multivariate Regression Analysis ◽

Class Iii ◽

Factors Associated ◽

Surgical Site Complications

Background: The purpose of this study was to identify independent risk factors associated with an increased rate of surgical site complications after elective hand surgery. Methods: This study is a retrospective review of all patients who underwent elective hand, wrist, forearm, and elbow surgery over a 10-year period at a single institution. Electronic medical records were reviewed, and information regarding patient demographics, past medical and social history, perioperative laboratory values, procedures performed, and surgical complications was collected. Surgical site complications included surgical site infections, seromas or hematomas, and delayed wound healing or wound dehiscence. A univariate analysis was then performed to identify potential risk factors, which were then included in a multivariate regression analysis. Results: A total of 3261 patients who underwent elective hand surgery and met the above inclusion and exclusion criteria were included in this study. The mean age was 57 years, with 65% female and 35% male patients. The overall surgical complication rate was 2.2%. Univariate analysis of patient factors identified male sex; number of procedures >1; history of drug, alcohol, or smoking use; American Society of Anesthesiologists (ASA) class III and IV; and serum albumin <3.5 mg/dL to be significantly associated with complications. However, multivariate regression analysis identified that only ASA class III and IV (odds ratio = 3.27) was significantly associated with surgical complications. Conclusions: Patients classified as ASA class III or IV were identified to be at a significantly increased risk of complications following elective hand surgery. Health factors which triage patients into these 2 groups may represent potentially modifiable factors to mitigate perioperative risk in the elective hand surgery population.

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Extracorporeal Life Support in Postcardiotomy Cardiogenic Shock: A View on Scenario, Outcome, and Risk Factors in 261 Patients

The Thoracic and Cardiovascular Surgeon ◽

10.1055/s-0040-1714746 ◽

2020 ◽

Author(s):

Zdenek Provaznik ◽

Alois Philipp ◽

Florian Zeman ◽

Daniele Camboni ◽

Christof Schmid ◽

...

Keyword(s):

Risk Factors ◽

Regression Analysis ◽

Cardiac Surgery ◽

Cardiopulmonary Bypass ◽

Multivariate Regression ◽

Life Support ◽

Extracorporeal Life Support ◽

Multivariate Regression Analysis ◽

Weaning Failure

Abstract Background Weaning failure from cardiopulmonary bypass, postoperative low cardiac output (LCO), and cardiopulmonary resuscitation (CPR) are common scenarios preceding extracorporeal life support (ECLS) implantation after cardiac surgery. The impact of these scenarios on short- and long-term outcome are not well described. Methods Between March 2006 and December 2018, 261 patients received ECLS support after cardiac surgery. Data of patients with weaning failure (NW), postoperative LCO, and CPR leading to ECLS implantation were retrospectively analyzed regarding outcome. Risk factors for outcome after postcardiotomy ECLS were assessed by uni- or multivariate regression analysis. Results Median duration of extracorporeal support was 5.5 ± 8.5 days. Overall mortality on ECLS was 39.1%. Scenario analysis revealed weaning failure from cardiopulmonary bypass in 40.6%, postoperative LCO in 24.5%, and postoperative CPR in 34.9% leading to initiation of ECLS. Most common cause of death was refractory LCO (25.3%). Overall follow-up survival was 23.7%. Survival after weaning and during follow-up in all subgroups was 9.2% (CPR), 5.0% (LCO), and 9.6% (NW), respectively. Uni- or multivariate regression analysis revealed age, aortic surgery, and vasopressor medication level on day 1 as risk for death on support, as well as postoperative renal failure, and body mass index (BMI) as risk factors for death during follow-up. Conclusion Mortality after postcardiotomy ECLS is high. Overall, outcome after CPR, NW, weaning failure and LCO is comparable. Postoperative resuscitation does not negatively affect outcome after postcardiotomy ECLS. Neurological status of ECLS survivors is good.

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Diabetic Ketoacidosis at Onset of Type 1 Diabetes: Rates and Risk Factors Today to 15 Years Ago

Global Pediatric Health ◽

10.1177/2333794x19870394 ◽

2019 ◽

Vol 6 ◽

pp. 2333794X1987039 ◽

Cited By ~ 2

Author(s):

Shana Rose Mencher ◽

Graeme Frank ◽

Joanna Fishbein

Keyword(s):

Diabetes Mellitus ◽

Risk Factors ◽

Type 1 Diabetes ◽

Type 1 Diabetes Mellitus ◽

Diabetic Ketoacidosis ◽

Public Awareness ◽

Retrospective Chart Review ◽

Late Presentation ◽

New Onset

Diabetic ketoacidosis (DKA) is a serious, potentially lethal complication of type 1 diabetes mellitus that may be present at diagnosis. The aim of this study was to determine factors associated with presentation in DKA in new-onset youth and compare the rate of DKA and risk factors to a similar study 15 years prior. This study was a retrospective chart review of newly diagnosed patients with type 1 diabetes mellitus from 2010 to 2013. Of the 276 patients, 29% presented in DKA, compared with 38% 15 years prior ( P < .002). Those with Medicaid, those misdiagnosed at initial encounter, and those not evaluated by a pediatrician initially were more likely to present in DKA ( P = .002, P = .002, P < .001, respectively). The diagnosis of diabetes was not elicited in one third of patients who ultimately presented in DKA. Pediatricians should be reeducated to ask about polyuria and polydipsia in routine encounters. Furthermore, public awareness initiatives are needed to reduce late presentation in DKA.

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Cancer Risk Factors in SLE: Multivariate Regression Analysis in 16,409 Patients

Journal of Autoimmune Diseases and Rheumatology ◽

10.12970/2310-9874.2014.02.03.4 ◽

2014 ◽

Vol 2 (3) ◽

pp. 100-103

Author(s):

Sasha Bernatsky ◽

◽

Rosalind Ramsey-Goldman ◽

Jean-François Jean-François ◽

Lawrence Joseph ◽

...

Keyword(s):

Risk Factors ◽

Regression Analysis ◽

Cancer Risk ◽

Multivariate Regression ◽

Multivariate Regression Analysis ◽

Cancer Risk Factors

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Daily insulin requirement of children and adolescents with type 1 diabetes: effect of age, gender, body mass index and mode of therapy.

Acta Endocrinologica ◽

10.1530/eje-07-0904 ◽

2008 ◽

Vol 158 (4) ◽

pp. 543-549 ◽

Cited By ~ 28

Author(s):

Susanna Wiegand ◽

Klemens Raile ◽

Thomas Reinehr ◽

Sabine Hofer ◽

Andrea Näke ◽

...

Keyword(s):

Type 1 Diabetes ◽

Body Weight ◽

Regression Analysis ◽

Children And Adolescents ◽

Multivariate Regression ◽

Insulin Delivery ◽

Insulin Injection ◽

Multivariate Regression Analysis ◽

Insulin Requirement

DesignThe purpose of this study was to generate insulin dose (ID) percentiles for children and adolescents with type 1 diabetes mellitus (DM1) having the opportunity to assess this important parameter in relation to age and sex.MethodsDaily IDs per weight (ID/kg) were recorded in 22 177 patients with DM1 (3–25 years of age, DM1 duration of more than 2 years, 48% female) and ID percentiles (ID-Perc) were created statistically. The ID-Perc were compared between male and female, and between multiple insulin injection therapy (MIT) and continuous s.c. insulin infusion (CSII). A multivariate regression analysis was performed for ID in the third year of DM1 with ID/kg, body weight, age, gender, and insulin delivery regimen as variables.ResultsThe 50th ID-Perc (P50) varied among 0.67 IU/kg (age 3 years), 0.93 IU/kg (13 years), and 0.70 IU/kg (23 years) increasing from early childhood to adolescence and decreasing toward adulthood. Highest P50 ID was found at 12 years in females (0.94 IU/kg) and at 14 years in males (0.92 IU/kg). Using ICT, the ID was significantly higher compared with CSII (P50: 0.94 IU/kg versus 0.79 IU/kg at 13 years). In multivariate regression analysis, ID was significantly (P>0.001) associated with age, gender, and insulin delivery regime.ConclusionThe ID-Perc were significantly different during various periods of childhood and were influenced by gender, body weight, and insulin injection regimes. Therefore, the presented data 1) provide evidence to interpret individual ID in children and adolescents with DM1 and 2) more specifically identify children with unusually high (insulin resistance and non-compliance) or low (MODY and persistent remission) insulin requirement.

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Risk factors for rhabdomyolysis following doxylamine overdose

Human & Experimental Toxicology ◽

10.1177/0960327107077507 ◽

2007 ◽

Vol 26 (8) ◽

pp. 617-621 ◽

Cited By ~ 15

Author(s):

Young-Il Jo ◽

Jong-Oh Song ◽

Jung-Hwan Park ◽

Soon-Young Koh ◽

Seung-Min Lee ◽

...

Keyword(s):

Risk Factors ◽

Renal Failure ◽

Predictive Value ◽

Multivariate Regression ◽

Laboratory Data ◽

Multivariate Regression Analysis ◽

University Teaching ◽

Demographic Information ◽

Reliable Predictor ◽

Arterial Ph

The objective of this prospective study was to identify risk factors for developing rhabdomyolysis in patients with doxylamine overdose. Patients who were admitted to a university teaching hospital between July 2000 and September 2005 due to doxylamine overdose were recruited. Demographic information, clinical variables, and laboratory data were investigated. Twenty-seven (M/F 12/15, age 33.2 ±13.1 years) patients were enrolled. Sixteen (59%) of 27 patients developed rhabdomyolysis and three (19%) of 16 patients with rhabdomyolysis also developed acute renal failure. Patients who developed rhabdomyolysis differed from those who did not in the amount of doxylamine ingested, initial serum creatitnine and arterial pH. In multivariate regression analysis, the only reliable predictor of rhabdomyolysis was the amount of doxylamine ingested ( P = 0.039). The amount of doxylamine ingested (≥ 20 mg/kg) predicted the development of rhabdomyolysis with a sensitivity of 81%, a specificity of 82%, a positive predictive value of 87%, and a negative predictive value of 75%. In conclusion, rhabdomyolysis following doxylamine overdose was common, occurring in 87% of patients who ingested more than 20 mg/kg. The amount of doxylamine ingested was the only reliable predictor for developing rhabdomyolysis following doxylamine overdose. Human & Experimental Toxicology (2007) 26, 617—621

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Cancer risk factors in systemic lupus erythematosus: multivariate regression analysis in 16,409 patients

Arthritis Research & Therapy ◽

10.1186/ar4651 ◽

2014 ◽

Vol 16 (Suppl 1) ◽

pp. A35

Author(s):

Sasha Bernatsky ◽

Rosalind Ramsey-Goldman ◽

Jean-François Boivin ◽

Lawrence Joseph ◽

Michelle A Petri ◽

...

Keyword(s):

Risk Factors ◽

Systemic Lupus Erythematosus ◽

Regression Analysis ◽

Cancer Risk ◽

Lupus Erythematosus ◽

Multivariate Regression ◽

Multivariate Regression Analysis ◽

Systemic Lupus ◽

Cancer Risk Factors

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Risk factors for venous thromboembolism (VTE) in outpatients with pancreatic cancer.

Journal of Clinical Oncology ◽

10.1200/jco.2012.30.15_suppl.e14578 ◽

2012 ◽

Vol 30 (15_suppl) ◽

pp. e14578-e14578

Author(s):

Joshua Michael Ruch ◽

Michelle A Anderson ◽

Suman Lata Sood

Keyword(s):

Risk Factors ◽

Pancreatic Cancer ◽

Regression Analysis ◽

Cohort Study ◽

Platelet Count ◽

Multivariate Regression ◽

Multivariate Regression Analysis ◽

Comprehensive Cancer Center ◽

Vein Thrombosis

e14578 Background: The incidence of VTE is increased in pancreatic cancer. Predictive models for cancer-associated VTE have been developed, but none specific for the pancreas. Our primary objective was to identify risk factors for VTE in outpatients with pancreatic cancer. Secondary objective was to develop a predictive model. Methods: Patients seen at the University of Michigan Comprehensive Cancer Center (UMCC) and previously consented and enrolled in a prospective cohort study were eligible. Inclusion criteria included a diagnosis of pancreatic adenocarcinoma, evaluation at UMCC, and follow up in the Electronic Medical Record (EMR) at least every 6 months. Demographics, clinical data, and VTE events (defined as deep vein thrombosis [DVT], portal vein thrombosis [PVT], or pulmonary embolism [PE]) were obtained from the EMR. A retrospective cohort study was performed including univariate and multivariate regression analysis. Results: Between 2005 and 2011, 92 patients were eligible for analysis. Median follow-up was 263.5 (18-2433) days. Twenty (21.7%) patients had a VTE; 10 (50%) DVT, 2 (10%) PE, 4 (20%) PVT, and 4 (20%) multiple VTEs. Mean (SD) age was 63.4 (8.9) with and 65.6 (11.8) without VTE. 55% of patients with and 47% without VTE were women. Higher body mass index (BMI) (median 28.8 [21.2-44.7] vs. 25.5 [16.4-43.3], p=0.02) and lower platelet count (median 241 [145-323] vs. 288 [75-645], p=0.04) were associated with VTE in univariate analysis. In multivariate regression analysis, lower platelet count (β -0.01, SE 0.004) and lower hemoglobin (β -0.44, SE 0.20) were predictive of VTE after adjusting for BMI, tumor location, and treatment with surgery, chemotherapy or radiation (area under the ROC curve 0.78). Conclusions: Pancreatic cancer outpatients with higher BMI, lower platelet count, and lower hemoglobin were more likely to develop VTE. Other clinical variables did not add additional predictive information. Given the small magnitude of difference, basic clinical criteria alone may be inadequate to identify patients at highest risk for developing VTE who may benefit from thromboprophylaxis. Additional studies are warranted to further define risk factors for VTE in this population, including novel biomarkers.

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Risk factors for progression of solitary plasmacytoma of bone to multiple myeloma in the spine: A population-based study

10.21203/rs.2.17500/v2 ◽

2020 ◽

Author(s):

Lin Xie ◽

Hongli Wang ◽

Jianyuan Jiang ◽

Chaojun Zheng

Keyword(s):

Risk Factors ◽

Multiple Myeloma ◽

Regression Analysis ◽

Multivariate Regression ◽

Multivariate Regression Analysis ◽

Population Based ◽

Solitary Plasmacytoma ◽

Aged Patients ◽

Factors Associated ◽

Risk Of Progression

Abstract Background: Spine SBP is a primary spinal malignant tumor. Risk factors associated with progression of solitary plasmacytoma of bone (SBP) to multiple myeloma in spine remains unknown. This study therefore aimed to identify the risk factors associated with progression of solitary plasmacytoma of bone (SBP) to multiple myeloma in the spine.Methods: Data of 1543 patients diagnosed with spine SBP between 1992 and 2013 was obtained from the Surveillance, Epidemiology, and End Results (SEER) database for analysis. Risk factors associated with progression of SBP to multiple myeloma (MM) were then identified using univariate and multivariate regression analysis methods.Results: Out of the 1543 patients diagnosed with spine SBP, 659 of them progressed to MM. The overall rate of progression to MM was 42.51%. Univariate and multivariate regression analysis revealed that age, race, gender and chemotherapy were independent risk factors associated with SBP progression to MM.Conclusion: Old aged patients, patients belonging to the white race, female patients and those undergoing chemotherapy were identified to be at a high risk of progression to MM. This information will assist clinicians in evaluating patients’ risk of SBP progression to MM at the point of diagnosis and advise them accordingly.

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The Pulmonary Hypertension in Newborn Suffer from Congenital Diaphragmatic Hernia at Viet Nam National Children Hospital

VNU Journal of Science Medical and Pharmaceutical Sciences ◽

10.25073/2588-1132/vnumps.4090 ◽

2017 ◽

Vol 33 (2) ◽

Author(s):

Trinh Xuan Long ◽

Pham Thi Thu Phuong ◽

Tran Minh Dien ◽

Pham Hong Son

Keyword(s):

Risk Factors ◽

Pulmonary Hypertension ◽

Regression Analysis ◽

Risk Factor ◽

Congenital Diaphragmatic Hernia ◽

Endotracheal Intubation ◽

Diaphragmatic Hernia ◽

Multivariate Regression ◽

Significant Risk ◽

Multivariate Regression Analysis

Objectives: To evaluate the outcome and risk factors related to persistent pulmonary hypertension in newborn of congenital diaphragmatic hernia. Subjects and methods: Descriptive study, patients with congenital diaphragmatic hernia (HDH) treated at the Vietnam National Children’s Hospital, the period of this study was from 01/01/2012 to 30/06/2015, assessed pulmonary hypertension (PAH) by Doppler ultrasonography, divided the level of PAH from light to severe PAH. The risk factors taken on admission and during treatment. Data were analyzed on SPSS 20.0, multivariate regression analysis to find factors related to pulmonary hypertension. Results: Mean pulmonary arterial pressure during 24-hour of admission was 46 ± 20 mmHg (10-88 mmHg). The rate of PAH in CDH was 72,6%, with of 58.9% patients were moderate to severe PAH. Moderate to severe PAH was a significant risk factor for mortality in CHD with OR: 20.05; 95%CI: 7.2-70.3. Multivariate regression analysis of factors related to moderate to severe PAH was statistically significant: hospitalization age less than 24 hours < 24 hours (OR: 3.93; 95% CI: 1.23-12.53); endotracheal intubation postpartum (OR: 3.09; 95% CI: 1.26-7.56); and administration of more than 2 vasopressures/inotrops before surgery (OR: 11.09; 95% CI: 2.44-50.37). Conclusion: The rate of PAH in patient’s CDH is 72,6%. Moderate and severe PAH is a risk factor for mortality of CDH. Factors related to moderate to severe PAH in CDH were hospitalization age less than 24 hours, endotracheal intubation postpartum and administration of more than 2 vasopressures/inotrops before surgery.

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