Risk factors for rhabdomyolysis following doxylamine overdose

2007 ◽  
Vol 26 (8) ◽  
pp. 617-621 ◽  
Author(s):  
Young-Il Jo ◽  
Jong-Oh Song ◽  
Jung-Hwan Park ◽  
Soon-Young Koh ◽  
Seung-Min Lee ◽  
...  
Keyword(s):  
Risk Factors ◽  
Renal Failure ◽  
Predictive Value ◽  
Multivariate Regression ◽  
Laboratory Data ◽  
Multivariate Regression Analysis ◽  
University Teaching ◽  
Demographic Information ◽  
Reliable Predictor ◽  
Arterial Ph

The objective of this prospective study was to identify risk factors for developing rhabdomyolysis in patients with doxylamine overdose. Patients who were admitted to a university teaching hospital between July 2000 and September 2005 due to doxylamine overdose were recruited. Demographic information, clinical variables, and laboratory data were investigated. Twenty-seven (M/F 12/15, age 33.2 ±13.1 years) patients were enrolled. Sixteen (59%) of 27 patients developed rhabdomyolysis and three (19%) of 16 patients with rhabdomyolysis also developed acute renal failure. Patients who developed rhabdomyolysis differed from those who did not in the amount of doxylamine ingested, initial serum creatitnine and arterial pH. In multivariate regression analysis, the only reliable predictor of rhabdomyolysis was the amount of doxylamine ingested ( P = 0.039). The amount of doxylamine ingested (≥ 20 mg/kg) predicted the development of rhabdomyolysis with a sensitivity of 81%, a specificity of 82%, a positive predictive value of 87%, and a negative predictive value of 75%. In conclusion, rhabdomyolysis following doxylamine overdose was common, occurring in 87% of patients who ingested more than 20 mg/kg. The amount of doxylamine ingested was the only reliable predictor for developing rhabdomyolysis following doxylamine overdose. Human & Experimental Toxicology (2007) 26, 617—621

Patient-Related Risk Factors Associated With Surgical Site Complications After Elective Hand Surgery

Hand ◽  
2020 ◽  
pp. 155894472094426
Author(s):  
Tyler Youngman ◽  
Michael Del Core ◽  
Timothy Benage ◽  
Daniel Koehler ◽  
Douglas Sammer ◽  
...  
Keyword(s):  
Risk Factors ◽  
Regression Analysis ◽  
Surgical Complications ◽  
Multivariate Regression ◽  
Univariate Analysis ◽  
Hand Surgery ◽  
Multivariate Regression Analysis ◽  
Class Iii ◽  
Factors Associated ◽  
Surgical Site Complications

Background: The purpose of this study was to identify independent risk factors associated with an increased rate of surgical site complications after elective hand surgery. Methods: This study is a retrospective review of all patients who underwent elective hand, wrist, forearm, and elbow surgery over a 10-year period at a single institution. Electronic medical records were reviewed, and information regarding patient demographics, past medical and social history, perioperative laboratory values, procedures performed, and surgical complications was collected. Surgical site complications included surgical site infections, seromas or hematomas, and delayed wound healing or wound dehiscence. A univariate analysis was then performed to identify potential risk factors, which were then included in a multivariate regression analysis. Results: A total of 3261 patients who underwent elective hand surgery and met the above inclusion and exclusion criteria were included in this study. The mean age was 57 years, with 65% female and 35% male patients. The overall surgical complication rate was 2.2%. Univariate analysis of patient factors identified male sex; number of procedures >1; history of drug, alcohol, or smoking use; American Society of Anesthesiologists (ASA) class III and IV; and serum albumin <3.5 mg/dL to be significantly associated with complications. However, multivariate regression analysis identified that only ASA class III and IV (odds ratio = 3.27) was significantly associated with surgical complications. Conclusions: Patients classified as ASA class III or IV were identified to be at a significantly increased risk of complications following elective hand surgery. Health factors which triage patients into these 2 groups may represent potentially modifiable factors to mitigate perioperative risk in the elective hand surgery population.

scholarly journals Effectiveness of Antibiotic Treatment in Children with Lyme Neuroborreliosis - A Retrospective Study

2021 ◽  
Author(s):  
Sigurdur Arnason ◽  
Barbro H Skogman
Keyword(s):  
Regression Analysis ◽  
Retrospective Study ◽  
Clinical Outcome ◽  
Antibiotic Treatment ◽  
Multivariate Regression ◽  
Laboratory Data ◽  
Multivariate Regression Analysis ◽  
Treatment Groups ◽  
Recommended Treatment

Abstract BackgroundLyme neuroboreliosis (LNB) is a tick-borne infection caused by the spirochete Borrelia burgdorferi sensu lato complex with various neurological manifestations. The recommended treatment for LNB in Swedish children has been ceftriaxone i.v. 50-100 mg/kg x 1 (< 8 years of age) or doxycycline p.o. 4 mg/kg x 1 (≥ 8 years of age) for 10-14 days. Studies on adult LNB patients have shown equal efficacy for ceftriaxone i.v. and doxycycline p.o., but no such studies have been performed on pediatric LNB patients. The aim of this study is to retrospectively evaluate clinical outcome in children with LNB who have received ceftriaxone i.v. as compared to doxycycline p.o. ResultsClinical and laboratory data from three previously performed prospective studies on children with LNB (three cohorts, 1998-2014) were collected and retrospectively analyzed. A total of 321 Swedish children (1-19 years of age), who had received antibiotic treatment for LNB, were included. Clinical outcome at the 2-month follow-up (recovery/non-recovery) was evaluated, using Chi2 test and logistic multivariate regression analysis. Out of 321 LNB patients, 194 children (60%) had received ceftriaxone i.v. and 127 children (40%) had received doxycycline p.o.. When comparing recovery/non-recovery between treatment groups, no difference in clinical outcome was found (p=0,217). Results did not change when incorporating relevant clinical and laboratory data into the logistic multivariate regression analysis. ConclusionIn this large retrospective study, no difference in clinical outcome (recovery/non-recovery) was found, independent of age, when comparing children who received ceftriaxone i.v. with children who received doxycycline p.o., supporting an equal effectiveness for treatment of pediatric LNB patients. However, future randomized comparative treatment studies with non-inferiority design are warranted for evaluation of efficacy and safety of antibiotic treatment in pediatric LNB patients.

Extracorporeal Life Support in Postcardiotomy Cardiogenic Shock: A View on Scenario, Outcome, and Risk Factors in 261 Patients

2020 ◽  
Author(s):  
Zdenek Provaznik ◽  
Alois Philipp ◽  
Florian Zeman ◽  
Daniele Camboni ◽  
Christof Schmid ◽  
...  
Keyword(s):  
Risk Factors ◽  
Regression Analysis ◽  
Cardiac Surgery ◽  
Cardiopulmonary Bypass ◽  
Multivariate Regression ◽  
Life Support ◽  
Extracorporeal Life Support ◽  
Multivariate Regression Analysis ◽  
Weaning Failure

Abstract Background Weaning failure from cardiopulmonary bypass, postoperative low cardiac output (LCO), and cardiopulmonary resuscitation (CPR) are common scenarios preceding extracorporeal life support (ECLS) implantation after cardiac surgery. The impact of these scenarios on short- and long-term outcome are not well described. Methods Between March 2006 and December 2018, 261 patients received ECLS support after cardiac surgery. Data of patients with weaning failure (NW), postoperative LCO, and CPR leading to ECLS implantation were retrospectively analyzed regarding outcome. Risk factors for outcome after postcardiotomy ECLS were assessed by uni- or multivariate regression analysis. Results Median duration of extracorporeal support was 5.5 ± 8.5 days. Overall mortality on ECLS was 39.1%. Scenario analysis revealed weaning failure from cardiopulmonary bypass in 40.6%, postoperative LCO in 24.5%, and postoperative CPR in 34.9% leading to initiation of ECLS. Most common cause of death was refractory LCO (25.3%). Overall follow-up survival was 23.7%. Survival after weaning and during follow-up in all subgroups was 9.2% (CPR), 5.0% (LCO), and 9.6% (NW), respectively. Uni- or multivariate regression analysis revealed age, aortic surgery, and vasopressor medication level on day 1 as risk for death on support, as well as postoperative renal failure, and body mass index (BMI) as risk factors for death during follow-up. Conclusion Mortality after postcardiotomy ECLS is high. Overall, outcome after CPR, NW, weaning failure and LCO is comparable. Postoperative resuscitation does not negatively affect outcome after postcardiotomy ECLS. Neurological status of ECLS survivors is good.

Cancer Risk Factors in SLE: Multivariate Regression Analysis in 16,409 Patients

2014 ◽  
Vol 2 (3) ◽  
pp. 100-103
Author(s):  
Sasha Bernatsky ◽  
◽  
Rosalind Ramsey-Goldman ◽  
Jean-François Jean-François ◽  
Lawrence Joseph ◽  
...  
Keyword(s):  
Risk Factors ◽  
Regression Analysis ◽  
Cancer Risk ◽  
Multivariate Regression ◽  
Multivariate Regression Analysis ◽  
Cancer Risk Factors

scholarly journals Cancer risk factors in systemic lupus erythematosus: multivariate regression analysis in 16,409 patients

2014 ◽  
Vol 16 (Suppl 1) ◽  
pp. A35
Author(s):  
Sasha Bernatsky ◽  
Rosalind Ramsey-Goldman ◽  
Jean-François Boivin ◽  
Lawrence Joseph ◽  
Michelle A Petri ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systemic Lupus Erythematosus ◽  
Regression Analysis ◽  
Cancer Risk ◽  
Lupus Erythematosus ◽  
Multivariate Regression ◽  
Multivariate Regression Analysis ◽  
Systemic Lupus ◽  
Cancer Risk Factors

Risk factors for venous thromboembolism (VTE) in outpatients with pancreatic cancer.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e14578-e14578
Author(s):  
Joshua Michael Ruch ◽  
Michelle A Anderson ◽  
Suman Lata Sood
Keyword(s):  
Risk Factors ◽  
Pancreatic Cancer ◽  
Regression Analysis ◽  
Cohort Study ◽  
Platelet Count ◽  
Multivariate Regression ◽  
Multivariate Regression Analysis ◽  
Comprehensive Cancer Center ◽  
Vein Thrombosis

e14578 Background: The incidence of VTE is increased in pancreatic cancer. Predictive models for cancer-associated VTE have been developed, but none specific for the pancreas. Our primary objective was to identify risk factors for VTE in outpatients with pancreatic cancer. Secondary objective was to develop a predictive model. Methods: Patients seen at the University of Michigan Comprehensive Cancer Center (UMCC) and previously consented and enrolled in a prospective cohort study were eligible. Inclusion criteria included a diagnosis of pancreatic adenocarcinoma, evaluation at UMCC, and follow up in the Electronic Medical Record (EMR) at least every 6 months. Demographics, clinical data, and VTE events (defined as deep vein thrombosis [DVT], portal vein thrombosis [PVT], or pulmonary embolism [PE]) were obtained from the EMR. A retrospective cohort study was performed including univariate and multivariate regression analysis. Results: Between 2005 and 2011, 92 patients were eligible for analysis. Median follow-up was 263.5 (18-2433) days. Twenty (21.7%) patients had a VTE; 10 (50%) DVT, 2 (10%) PE, 4 (20%) PVT, and 4 (20%) multiple VTEs. Mean (SD) age was 63.4 (8.9) with and 65.6 (11.8) without VTE. 55% of patients with and 47% without VTE were women. Higher body mass index (BMI) (median 28.8 [21.2-44.7] vs. 25.5 [16.4-43.3], p=0.02) and lower platelet count (median 241 [145-323] vs. 288 [75-645], p=0.04) were associated with VTE in univariate analysis. In multivariate regression analysis, lower platelet count (β -0.01, SE 0.004) and lower hemoglobin (β -0.44, SE 0.20) were predictive of VTE after adjusting for BMI, tumor location, and treatment with surgery, chemotherapy or radiation (area under the ROC curve 0.78). Conclusions: Pancreatic cancer outpatients with higher BMI, lower platelet count, and lower hemoglobin were more likely to develop VTE. Other clinical variables did not add additional predictive information. Given the small magnitude of difference, basic clinical criteria alone may be inadequate to identify patients at highest risk for developing VTE who may benefit from thromboprophylaxis. Additional studies are warranted to further define risk factors for VTE in this population, including novel biomarkers.

scholarly journals The predictive value of soluble osteoclast-associated receptor for the prognosis of acute coronary syndrome

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Rong Wang ◽  
Jing Wang ◽  
Ling Xie ◽  
Hong-li Cai ◽  
Yi Zhang ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Coronary Syndrome ◽  
Predictive Value ◽  
Multivariate Regression ◽  
Multivariate Regression Analysis ◽  
St Segment Elevation ◽  
Coronary Syndrome ◽  
Segment Elevation Myocardial Infarction ◽  
St Segment ◽  
History Of

AbstractAt present, prognostic biomarkers of acute coronary syndrome (ACS) are fewer. The aim of this study was to explore the predictive value of soluble osteoclast-associated receptor (sOSCAR) level for the major adverse cardiovascular events (MACE) occurring within 30 days after ACS. From January to August 2020, a total of 108 patients with ACS who were admitted to our hospital, were enrolled in this study. Of the 108 patients, 79 were men and 29 women. Patient-related data, including age, sex, body mass index, history of type 2 diabetes, history of hyperlipidemia and serum sOSCAR level, were collected. All patients were followed up for 30 days. Based on MACE occurrence, the 108 patients were divided into MACE group (n = 17) and non-MACE group (n = 91). The baseline data were compared between the two groups, MACE-independent risk factors were identified by multivariate regression analysis, and the predictive value of sOSCAR for MACE occurring within 30 days after CAS was analyzed using receiver operating characteristic (ROC) curve. At the same time, according to the type of ACS, the 108 patients with ACS were divided into unstable angina (UA) group (n = 29), non ST-segment elevation myocardial infarction (USTEMI) group (n = 45) and ST-segment elevation myocardial infarction (STEMI) group (n = 34), and then the sOSCAR level and MACE incidence were observed in each group. The serum sOSCAR level was significantly lower in the MACE group [130(100,183)] than in the non-MACE group [301(220,370)] (P = 0.000). The area under ROC curve of sOSCAR level for MACE occurring within 30 days after CAS was 0.860 with 95%CI 0.782–0.919, P < 0.001. Multivariate regression analysis indicated that the sOSCAR level was an independent risk factor for the MACE occurring within 30 days after CAS (OR 0.26, 95%CI 0.087–0.777, P = 0.04). The MACE incidence (0%) was the lowest but the sOSCAR level was the highest in the UA group, while in the STEMI group, the MACE incidence (23.53%) was the higest but the sOSCAR level was the lowest among the UA, STEMI and NSTEMI groups. Serum sOSCAR level may be used as a predictor of MACE occurring within the short-term after ACS. The higher the sOSCAR level, the lower the MACE incidence.

scholarly journals Proximal deep vein thrombosis among hospitalised medical and obstetric patients in Rwandan university teaching hospitals: prevalence and associated risk factors: a cross-sectional study

BMJ Open ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. e032604
Author(s):  
Regine Mugeni ◽  
Eugene Nkusi ◽  
Eric Rutaganda ◽  
Sanctus Musafiri ◽  
Florence Masaisa ◽  
...  
Keyword(s):  
Risk Factors ◽  
Clinical Features ◽  
Multivariate Regression ◽  
Univariate Analysis ◽  
Cross Sectional Study ◽  
University Teaching ◽  
Teaching Hospitals ◽  
Cross Sectional ◽  
Vein Thrombosis ◽  
Tertiary Hospitals

ObjectivesTo determine the prevalence of proximal deep vein thrombosis (DVT) by ultrasound scanning, as well as associated clinical features and known risk factors, among medical and obstetrics–gynaecology inpatients in two Rwandan tertiary hospitals.DesignCross-sectional study.SettingsRwanda teaching hospitals: Kigali and Butare University Teaching Hospitals.Participants901 adult patients admitted to the Departments of Internal Medicine and Obstetrics–Gynecology (O&G) who were at least 21 years of age and willing to provide a consent.OutcomesPrevalence of proximal DVT, clinical features and known risk factors associated with DVT.MethodsBetween August 2015 and August 2016, participants were screened for DVT by compressive ultrasound of femoral and popliteal veins, conducted as a monthly cross-sectional survey of all consenting eligible inpatients. Patients completed a self-report survey on DVT risk factors. Prevalence of proximal DVT by compression ultrasonography was the primary endpoint, with univariate and multivariate regression analyses performed to assess associated clinical features and risk factors.ResultsProximal DVT was found in 5.5% of the study population, with similar rates in medical and O&G inpatients. The mean age was 41±16 SD (range, 21–91), 70% were female and 7% were pregnant. Univariate analysis showed active malignancy, immobilisation, prolonged recent travel and history of DVT to be significant risk factors for proximal DVT (all p values <0.05); while only active malignancy was an independent risk factor on multivariate regression (OR 5.2; 95% CI 2.0 to 13). Leg pain or tenderness, increased calf circumference, unilateral limb swelling or pitting oedema were predictive clinical features of DVT on both univariate analysis and multivariate regression (all p values <0.05).ConclusionProximal DVT prevalence is high among hospitalised medical and O&G patients in two tertiary hospitals in Rwanda. For reducing morbidity and mortality, research to develop Africa-specific clinical prediction tools for DVT and interventions to increase thromboprophylaxis use in the region are urgently needed.

scholarly journals Risk factors for progression of solitary plasmacytoma of bone to multiple myeloma in the spine: A population-based study

2020 ◽  
Author(s):  
Lin Xie ◽  
Hongli Wang ◽  
Jianyuan Jiang ◽  
Chaojun Zheng
Keyword(s):  
Risk Factors ◽  
Multiple Myeloma ◽  
Regression Analysis ◽  
Multivariate Regression ◽  
Multivariate Regression Analysis ◽  
Population Based ◽  
Solitary Plasmacytoma ◽  
Aged Patients ◽  
Factors Associated ◽  
Risk Of Progression

Abstract Background: Spine SBP is a primary spinal malignant tumor. Risk factors associated with progression of solitary plasmacytoma of bone (SBP) to multiple myeloma in spine remains unknown. This study therefore aimed to identify the risk factors associated with progression of solitary plasmacytoma of bone (SBP) to multiple myeloma in the spine.Methods: Data of 1543 patients diagnosed with spine SBP between 1992 and 2013 was obtained from the Surveillance, Epidemiology, and End Results (SEER) database for analysis. Risk factors associated with progression of SBP to multiple myeloma (MM) were then identified using univariate and multivariate regression analysis methods.Results: Out of the 1543 patients diagnosed with spine SBP, 659 of them progressed to MM. The overall rate of progression to MM was 42.51%. Univariate and multivariate regression analysis revealed that age, race, gender and chemotherapy were independent risk factors associated with SBP progression to MM.Conclusion: Old aged patients, patients belonging to the white race, female patients and those undergoing chemotherapy were identified to be at a high risk of progression to MM. This information will assist clinicians in evaluating patients’ risk of SBP progression to MM at the point of diagnosis and advise them accordingly.

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