scholarly journals A RANDOMIZED COMPARATIVE CLINICAL STUDY ON LODHRADHI LEPA AND ARJUN TWAK LEPA WITH JALOUKAVACHARANA IN THE MANAGEMENT OF MUKHADUSHIKA (ACNE VULGARIS)

2020 ◽  
Vol 8 (10) ◽  
pp. 4622-4625
Author(s):  
Sagar Rathod ◽  
Mashetti N. B. ◽  
Gannur P. G. ◽  
Rakeshkumar Gujjar
Keyword(s):  
Clinical Study ◽  
Acne Vulgaris ◽  
Skin Care ◽  
Assessment Criteria ◽  
Treatment Modalities ◽  
Common Skin ◽  
Comparative Clinical Study ◽  
Group 2 ◽  
Group 1

Mukhadushika is the most troublesome and most common skin care problem. The symptoms of Mukha-dushika resembles with Acne Vulgaris. Objective: The present study was to evaluate the comparative ef-fect of Lodhradilepa and Arjuna twak lepa with Jaloukavacharana in the management of Mukhadushika. Methods: 40 patients were randomly selected and divided into 2 groups. Results: Both the groups showed statistically significant results on all assessment criteria. On comparison between 2 groups, there is no sig-nificant difference in assessment criteria except in the size in which Group-2 was more effective than Group-1 and Number of pidaka in both groups found to be insignificant. Interpretation and conclusion: Jaloukavacharana serve as a Shodhana karma here as there is involvement of Rakta dhatu in the Sam-prapti & Lepa is one of the treatment modalities for Mukhadushika mentioned in classics. Both Arjuna le-pa and Lodhradi lepa along with application of Jalouka showed statistically highly significant on all the assessment criteria like vedana etc. GAGS Score and IGA criteria except in the size in which Group-2 was more effective than Group-1 and Number of Pidaka in both groups found to be insignificant.

scholarly journals A comparative clinical study on the cosmetic approach in Tarunyapidaka vis-a-vis Acne Vulgaris amongst female population through Shodhana Shamana and Lepa

2020 ◽  
Vol 5 (05) ◽  
pp. 104-110
Author(s):  
Sharanamma A ◽  
Prashanth A.S. ◽  
S.G. Chavan
Keyword(s):  
Clinical Study ◽  
Clinical Efficacy ◽  
Acne Vulgaris ◽  
Ayurvedic Medicine ◽  
Inclusion Criteria ◽  
Female Population ◽  
Common Skin ◽  
Comparative Clinical Study ◽  
Group A ◽  
Group B

Tarunyapiadaka is one of the Kshudraroga and most common skin disorders. Ayurvedic medicine plays important role in the patients who are in deep depression due to disfiguration of face and Tarunyapidaka in the field of Cosmetiology. In the present study an effort has been made to formulate an effective, economic and simple remedy to help in the total cure and preventing of Tarunyapidaka. In the present study 40 Subjects diagnosed with Tarunyapidaka w.s.r to Acne Vulgaris fulfilling the Inclusion criteria were selected for study and randomly categorized into two groups as Group A and Group B each consisting of 20 subjects from OPD and IPD of department of PG studies in Kayachikitsa department of Ayurveda Mahavidhyalaya, Hubbali have been treated with Amapachana with Guduchi Churna. In group A Sadhyosnehapana with Panchatikta Ghrita. Sarvanga Abhyanga with Elaadi Taila followed by Sarvanga Swedana. And Sneha Virechana was administered with Trivruth Lehya. After Samsarjana Krama, Navaka Kashaya given as a Shamanoushadi along with Manjista with Madhu Lepa. In Group B Sadhyosnehapana with Panchatikta Ghrita. Sarvanga Abhyanga with Elaadi Taila followed by Sarvanga Swedana and Sneha Virechana was administered with Trivruth Lehya. After Samsarjana Krama, Gopanganadi Kashaya given as a Shamanoushadi along with Manjista with Madhu Lepa for 45 days to assess the clinical efficacy of Navaka Kashaya and Gopanganadi Kashaya. Significant changes in Subjective and Objective criteria were observed.

scholarly journals A Comparative Clinical Study on Surgical Blade and Diode Laser in the Treatment of Gingival Melanin Pigmentation

2021 ◽  
Vol 10 (10) ◽  
pp. 689-693
Author(s):  
Somit Kumar Jain ◽  
Nina Shenoy ◽  
Mehul Kumar Chourasia ◽  
Amitha Ramesh
Keyword(s):  
Wound Healing ◽  
Clinical Study ◽  
Diode Laser ◽  
Pain Perception ◽  
Rank Test ◽  
Side Group ◽  
Melanin Pigmentation ◽  
Comparative Clinical Study ◽  
Group 2 ◽  
Group 1

BACKGROUND Gingival melanin pigmentation (GMP) is a common aesthetic concern. The gold standard for depigmentation, is surgery. Recently soft tissue lasers have gained popularity. The purpose of this study was to compare and evaluate the clinical efficacy of surgical blade and laser treatment in terms of pain perception and wound healing outcomes, 7 and 14 days following the procedures for the treatment of gingival depigmentation. METHODS This 14 day follow up comparative clinical study, utilized a split mouth design, in the anterior region. Fifteen patients with moderate to heavy bilateral gingival pigmentation were included as per the criteria by Dummett et al. The patients’ right side (group 1) was treated with surgical blade and the left side (group 2) with diode laser (Picasso, AMD LASERS™) by a trained clinician. Pain perception was assessed using Visual Analog Scale (VAS) and wound healing was assessed using clinical parameters. RESULTS Data was analysed using paired t test and Wilcoxon’s signed rank test. P value of < 0.05 was considered statistically significant. On day 7, more than 70 % patients had slight pain in group 1. Whereas, 47 % experienced no pain in group 2. The mean difference in VAS scores between the groups at day 7, was statistically significant. No statistically significant distinction in wound healing was observed 7 days following both procedures. No pain, and complete epithelialisation was noted in both groups on day 14. CONCLUSIONS Pain experienced by the patients was slightly more in the scalpel group compared to laser. There was no difference in wound healing between both groups. KEY WORDS GMP, Gingival Melanin Pigmentation, VAS Scale, Depigmentation, Wound Healing, Laser, Surgical Blade, Split Mouth Design

scholarly journals Comparison of Rare Types of Breast Cancer

2021 ◽  
pp. 9-17
Author(s):  
Osman Erdogan ◽  
Alper Parlakgumus ◽  
Ugur Topal ◽  
Kemal Yener ◽  
Umit Turan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Nodes ◽  
Radical Mastectomy ◽  
Treatment Modalities ◽  
Breast Carcinomas ◽  
Term Survival ◽  
Prognostic Features ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Aims: Mucinous, medullary, and papillary carcinomas are rarely encountered types of breast cancer. This study aims to contribute to the literature by comparing the clinical and prognostic features and treatment alternatives of rare breast carcinomas. Study Design: Thirty-four patients with rare breast cancer out of a total of 1368 patients who underwent surgery for breast cancer in our clinic between January 2011 and December 2020 were included in the study. Methodology: The patients were assigned into three groups, i.e., medullary carcinoma group (Group 1), mucinous carcinoma group (Group 2) and papillary carcinoma group (Group 3). Demographic and clinical features, treatment modalities used, surgical approaches, pathological features of tumors and survival were compared between the groups. Results: Thirty-four patients were included in the study. The mean age of the patients in Group 3 was higher, though it was not statistically significant. Modified radical mastectomy was more frequently performed in all the groups. The number of the lymph nodes removed through axillary dissections and the number of the positive lymph nodes were similar in all the groups. The tumors in all the groups were also of comparable sizes (30 mm in Group 1, 42.5 mm in Group 2 and 30 mm in Group 3; p:0.464). Estrogen receptors were negative in a significantly higher rate of Group 1(66.7% of Group 1, p<0,001). A significantly higher rate of Group 1 received postoperative chemotherapy (93,3% of Group 1,p:0.001), but the rate of the patients receiving hormonotherapy in this group was significantly lower (26.7% of Group, p<0,001). The patients with medullary cancer had significantly longer survival than those with mucinous cancer and those with papillary cancer (76.2 in Group 1, 54.5 in Group 2 and 58.4 in Group 3; p:0.005). Conclusion: While rare subtypes of breast carcinoma did not affect opting for surgical treatment, selection of oncological therapy was affected depending on the hormone receptor status of these tumors. The long-term survival differed between rare breast tumors. In view of the unique clinical pictures of the tumors, the patients should be evaluated individually, and the evaluation should be associated with theevidence-based principles available for more common breast carcinomas.

scholarly journals TO EVALUATE THE EFFECT OF UPANAHA SWEDA IN JANUSANDHIGATA VATA WITH VACHADI AND KOLADI YOGAS A COMPARATIVE CLINICAL STUDY

2021 ◽  
Vol 9 (8) ◽  
pp. 1675-1682
Author(s):  
Desai Sucheta ◽  
Desai Ananta ◽  
Borannavar Shaila
Keyword(s):  
Clinical Study ◽  
Elderly Population ◽  
Functional Disability ◽  
Signs And Symptoms ◽  
Walking Distance ◽  
Treatment Modalities ◽  
Age Factor ◽  
Comparative Clinical Study ◽  
Group A

The present scenario of lifestyle is prone to cause many lives deteriorating conditions. Sandhigatavata is one among the Vatavyadhi and the commonest articular disorder affecting the middle-aged, obese, and elderly population. The advancement in working pattern, lifestyle & age-factor, all together have become a prime cause for aggravation of Vata, which accelerates Dhatukshaya (depletion of tissues). Sandhigatavata can be correlated with osteoarthritis (OA) which is one such chronic, degenerative, inflammatory disease that has a great impact on the quality of the life of an individual. OA poses a huge hindrance in the day-to-day activities of the sufferer like walking, dressing, bathing etc. As per Ayurveda, it is caused due to localized accumulation of aggravated Vata in joints, which leads to Shula, Sotha, Vatapoornadritisparsha and functional disability of affected Sandhis. If not treated in time, the disease makes man disable. According to epidemiology the prevalence of osteoarthritis in India is 22-39%. Different treatment modalities like Snehana, Swedana, Lepa, Bandhana, Agni Karma and Raktamokshana are emphasized in Ayurveda to provide better relief from the pain and swelling and restore mobility; for the management of these symptoms, Swedana is the most convenient & best procedure. So, the present study was aimed to assess clinically the effect of Upanaha Swedas in the management of Janusandhigatavata. Objectives: To evaluate and compare the efficacy of Vachadi Upanaha Sweda and Koladi Upanaha Sweda in the management of Janusandhigatavata. Materials and Methods: It was a randomized comparative clinical study; total 40 patients were divided into 2 groups as 20 in each. In Group A, patients were treated with only Vachadi Upanaha Sweda and other group patients were treated with Koladi Upanaha Sweda. Results: Statistical analysis revealed that both the interventions wereeffective in reducing all the signs and symptoms of Janusandhigatavata, however in parameters Shotha, tenderness and walking distance, Koladi Upanaha Sweda showed better response than Vachadi Upanaha Sweda. Conclusion: There is a significant effect of Koladi Upanaha Sweda over Vachadi Upanaha Sweda in Janusandhigatavata both clinically and statistically. Keywords: Janusandhigatavata, knee osteoarthritis, Koladi Upanaha, Vachadi Upanaha, Swedana.

Early Response to a Short Course of Induction Chemotherapy Overcomes the Prognostic Role of IPI in Patients with Aggressive NHL. Preliminary Results of the GISL LA05 Trial.

Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 2434-2434 ◽  
Author(s):  
Nicola Di Renzo ◽  
Stefano Luminari ◽  
Antonella Montanini ◽  
Mario Petrini ◽  
Maura Brugiatelli ◽  
...  
Keyword(s):  
Induction Chemotherapy ◽  
Early Response ◽  
Treatment Modalities ◽  
Prognostic Role ◽  
Preliminary Results ◽  
Non Hodgkin Lymphoma ◽  
Group 2 ◽  
Bulky Mass ◽  
Group 1

Abstract The achievement of a clinical response to the first part of induction chemotherapy has been considered for predicting survival in patients with aggressive non Hodgkin lymphoma (NHL). In April 2000, the Gruppo Italiano Studio Linfomi (GISL) started the LA05 trial with the aim of assessing different treatment modalities according to response to 4 initial courses of chemotherapy (CT) assessed according to the international response criteria for NHL. Untreated Patients younger than 65 years with histologically confirmed diagnosis of aggressive NHLs were eligible to the study. All stages and all IPI groups were allowed. After 4 courses of CT patients achieving at least a PR >75% were to be treated with two additional courses of CT (group 1); those achieving PR <75% were randomized to receive either additional 4 courses of the same CT or a modified HDS program followed by autologous stem cell support (group 2); patients with SD or PD were to be assigned to salvage programs (group 3). The study CT regimen was ProMECE-CytaBOM; in July 2005, the protocol was amended allowing the use of other CT regimens, including CHOP and MACOP-B, and recommending the addition of Rituximab for B-cell NHL. D The study is still ongoing and we are not yet able to provide data about the efficacy of HDS in patients of group 2. We present the preliminary results of efficacy of the LA05 trial, in particular focused on the outcome of group 1 patients. As of June 2006, 341 patients were enrolled. Eighty percent of cases had DLBCL, 12% PTCL, 5% GIII FL and 3% MCL. Median age at diagnosis was 49 years (range 18–67). Sixty percent had stage III–IV disease and 38% had a bulky mass. IPI was low (0–1) in 52%, intermediate (2) in 22% and high (3+) in 26% of cases. After 4 courses of CT, 265 patients were evaluable for response; one-hundred and seventy patients (64%) achieved a CR or a PR >75%, 49 (19%) achieved a PR <75% and 46 (17%) had SD or PD. The probability of achieving a CR or a PR >75% was 74%, 62% and 42%, for patients with an initial IPI of 0–1, 2 or 3+. At the end of treatment program, a CR was achieved in 57% of cases and a PR in 14%. After a median follow-up of 21 months (range 1–73), the 2-year OS was 69% (IC 95% 62–75), being 85%, 65% and 25% for group 1, 2 and 3 respectively (p<0.001). Two-year OS was 88%, 78% and 78% for patient in group 1 with and IPI of 0–1, 2 and 3+ respectively (p=NS). The achievement of a CR or a PR >75% after the first part of initial CT overcomes the prognostic role of IPI in patients with aggressive NHL.

scholarly journals EVALUATION OF PATIENT'S PERCEPTION AND HEALING, FOLLOWING CONVENTIONAL AND PARALLELING TECHNIQUE OF FRENECTOMY USING SCALPEL AND OTHER MODALITY

2020 ◽  
Vol 6 (1) ◽  
pp. 21-27
Author(s):  
Dr. Ira Gupta ◽  
Saranik Sarkar ◽  
Rohit Gupta ◽  
Nidhi Gupta ◽  
Janardhana Amaranath B. J. ◽  
...  
Keyword(s):  
Wound Healing ◽  
Gingival Recession ◽  
Conventional Technique ◽  
Treatment Modalities ◽  
Group 3 ◽  
Group 2 ◽  
Patient’S Perception ◽  
Better Than ◽  
Group 1 ◽  
Operative Wound

Background: Frenum that encroaches on the margin of the gingiva may interfere with plaque removal and can lead to gingival recession and midline diastema. Thus, to maintain proper oral hygiene and prevent gingival recession, frenectomy is done. Frenectomy can be accomplished by conventional frenectomy technique, which has certain disadvantages. To overcome those drawbacks, paralleling technique of frenectomy has been introduced. Both the techniques can be performed by using various treatment modalities. Aim: The purpose of this clinical study was to compare the bleeding during surgery, post-operative wound healing and patient's perception towards the conventional frenectomy technique with scalpel, paralleling frenectomy technique with scalpel and paralleling technique with electrocautery. Materials and method: A total of 30 subjects with gingival or papillary frenal attachment were selected and equally divided into three groups. Group 1 was treated by conventional technique with scalpel, Group 2 by paralleling technique with scalpel and Group 3 by paralleling technique with electrocautery. Various parameters such as bleeding during surgery, patient's perception towards the various techniques and post-operative wound healing were evaluated. Results: The results showed that bleeding during surgery was minimum in group 3 as compared to other two groups. Patient's perception towards paralleling technique with scalpel, was found better than the other groups. At 7th day, though there was a difference in the healing but at 21st day wound healing was almost similar in all the three groups. Conclusion: Based on our findings and clinical outcome, paralleling technique with scalpel provided better patient's perception and an efficient and satisfactory option for frenectomy.  

scholarly journals Updates on acne in adult females

2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Nicole L. Bort ◽  
Margaret A. Bobonich
Keyword(s):  
Patient Education ◽  
Psychological Factors ◽  
Acne Vulgaris ◽  
Treatment Selection ◽  
Skin Care ◽  
Treatment Modalities ◽  
Successful Management ◽  
Adult Females ◽  
Assessment And Diagnosis

Acne vulgaris is one of the most commonly treated dermatologic diseases in adult females, but treatment selection and patient education should be tailored specifically to this population. Acne in women has a known association with both physical and psychological factors. There are often genetic, hormonal, and skin care routines that play a role in the etiopathogenesis, and maintenance is often required for many years. Taking into consideration appropriate assessment and diagnosis of severity for acne and having knowledge about available treatment modalities will facilitate successful management.

scholarly journals Clinical Study of Sodium Hypochlorite, Polymyxin B And Limewater Effect on MMP-3,-8,-9 In Apical Periodontitis

2020 ◽  
Vol 31 (2) ◽  
pp. 116-121 ◽  
Author(s):  
Cláudio Antonio Talge Carvalho ◽  
Amjad Abu Hasna ◽  
Alessandra Sverberi Carvalho ◽  
Polyana das Graças Figueiredo Vilela ◽  
Lucas de Paula Ramos ◽  
...  
Keyword(s):  
Clinical Study ◽  
Sodium Hypochlorite ◽  
Root Canal ◽  
Polymyxin B ◽  
Apical Periodontitis ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Abstract This study aimed to evaluate sodium hypochlorite (NaOCl), limewater (LW), and Polymyxin B (PMB) as irrigants over MMP-3, MMP-8 and MMP-9. Thirty-three patients with apical periodontitis of single-rooted teeth were treated according to three-experimental groups (n=11): group-1: 2.5% NaOCl was used as irrigant; group-2: 2.5% NaOCl for the first two files and LW: [0.14% Ca(OH)2] for the last two files; group-3: 2.5% NaOCl for the first two files and PMB for the last two files. The association of Ca(OH)2 and CHX was used as an intracanal medication in all groups. Four root canal samplings (S) were collected: S1) immediately after access cavity; S2) after biomechanical preparation; S3) after EDTA application; and S4) after removal of the intracanal medication. After quantification of MMP-3, MMP-8, and MMP-9, the data were analyzed by Friedman and Kruskal-Wallis tests and completed by Dunn test (5%). Regardless the used irrigant, there was no difference in reducing MMP-3 or MMP-8 (P=0,5273, P=0,7048 respectively). However, in reducing MMP-9 (P=0,0246) the NaOCl group was the most effective followed by NaOCl+LW group and NaOCl+PMB group respectively. The intracanal medication [Ca(OH)2 + CHX] with the NaOCl and NaOCl+LW was effective in reducing MMP-8 (P<0,0001, P=0,0025) and MMP-9 (P=0,0007, P=0,0047) respectively, but not for the group of NaOCl+PMB which was not effective in reducing MMP-8 or MMP-9 (P=0,1718, P=0,1953) respectively. NaOCl and NaOCl+LW were effective in reducing MMP-9 levels, and this effectivity could be improved by the use of the intracanal medication [Ca(OH)2 + CHX] in reducing MMP-8 and MMP-9 levels.

scholarly journals Group of Investigators for ERAs Program, Russia. Allergic rhinitis and asthma in real clinical practice in Russia: multicenter clinical study

2012 ◽  
Vol 9 (1) ◽  
pp. 29-36
Author(s):  
A V Emelyanov ◽  
L A Goryachkina ◽  
N G Astafeva ◽  
R S Fassakhov ◽  
B A Chernyak ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Case Report ◽  
Clinical Study ◽  
Outpatient Visit ◽  
Asthma Control Questionnaire ◽  
Asthma Patients ◽  
Group 2 ◽  
Multicenter Clinical Study ◽  
Real Clinical Practice ◽  
Group 1

The aim of the study which included 2311 patients (aged 18—80 yrs), examined by 100 physicians (57% allergists, 37% pulmonologists and 7% general practitioner) in 18 Russian cities, was to assess the prevalence of allergic rhinitis in patients with asthma, as well as to evaluate the specifics of the course of these diseases, when concomitant or not. The study design included one outpatient visit, followed by the completion of studyspecific case report forms and Asthma Control Questionnaire (ACQ) validated for use in Russia. The vast majority (88%)of asthma patients had concomitant allergic rhinitis (Group 1). Patients with asthma only (Group 2) were older (50,6±0,78 vs 41,9±0,35 yr, p

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