scholarly journals Group of Investigators for ERAs Program, Russia. Allergic rhinitis and asthma in real clinical practice in Russia: multicenter clinical study

2012 ◽  
Vol 9 (1) ◽  
pp. 29-36
Author(s):  
A V Emelyanov ◽  
L A Goryachkina ◽  
N G Astafeva ◽  
R S Fassakhov ◽  
B A Chernyak ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Case Report ◽  
Clinical Study ◽  
Outpatient Visit ◽  
Asthma Control Questionnaire ◽  
Asthma Patients ◽  
Group 2 ◽  
Multicenter Clinical Study ◽  
Real Clinical Practice ◽  
Group 1

The aim of the study which included 2311 patients (aged 18—80 yrs), examined by 100 physicians (57% allergists, 37% pulmonologists and 7% general practitioner) in 18 Russian cities, was to assess the prevalence of allergic rhinitis in patients with asthma, as well as to evaluate the specifics of the course of these diseases, when concomitant or not. The study design included one outpatient visit, followed by the completion of studyspecific case report forms and Asthma Control Questionnaire (ACQ) validated for use in Russia. The vast majority (88%)of asthma patients had concomitant allergic rhinitis (Group 1). Patients with asthma only (Group 2) were older (50,6±0,78 vs 41,9±0,35 yr, p

scholarly journals Clinical Study of Sodium Hypochlorite, Polymyxin B And Limewater Effect on MMP-3,-8,-9 In Apical Periodontitis

2020 ◽  
Vol 31 (2) ◽  
pp. 116-121 ◽  
Author(s):  
Cláudio Antonio Talge Carvalho ◽  
Amjad Abu Hasna ◽  
Alessandra Sverberi Carvalho ◽  
Polyana das Graças Figueiredo Vilela ◽  
Lucas de Paula Ramos ◽  
...  
Keyword(s):  
Clinical Study ◽  
Sodium Hypochlorite ◽  
Root Canal ◽  
Polymyxin B ◽  
Apical Periodontitis ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Abstract This study aimed to evaluate sodium hypochlorite (NaOCl), limewater (LW), and Polymyxin B (PMB) as irrigants over MMP-3, MMP-8 and MMP-9. Thirty-three patients with apical periodontitis of single-rooted teeth were treated according to three-experimental groups (n=11): group-1: 2.5% NaOCl was used as irrigant; group-2: 2.5% NaOCl for the first two files and LW: [0.14% Ca(OH)2] for the last two files; group-3: 2.5% NaOCl for the first two files and PMB for the last two files. The association of Ca(OH)2 and CHX was used as an intracanal medication in all groups. Four root canal samplings (S) were collected: S1) immediately after access cavity; S2) after biomechanical preparation; S3) after EDTA application; and S4) after removal of the intracanal medication. After quantification of MMP-3, MMP-8, and MMP-9, the data were analyzed by Friedman and Kruskal-Wallis tests and completed by Dunn test (5%). Regardless the used irrigant, there was no difference in reducing MMP-3 or MMP-8 (P=0,5273, P=0,7048 respectively). However, in reducing MMP-9 (P=0,0246) the NaOCl group was the most effective followed by NaOCl+LW group and NaOCl+PMB group respectively. The intracanal medication [Ca(OH)2 + CHX] with the NaOCl and NaOCl+LW was effective in reducing MMP-8 (P<0,0001, P=0,0025) and MMP-9 (P=0,0007, P=0,0047) respectively, but not for the group of NaOCl+PMB which was not effective in reducing MMP-8 or MMP-9 (P=0,1718, P=0,1953) respectively. NaOCl and NaOCl+LW were effective in reducing MMP-9 levels, and this effectivity could be improved by the use of the intracanal medication [Ca(OH)2 + CHX] in reducing MMP-8 and MMP-9 levels.

scholarly journals Impulse oscillometry in evaluation bronchial hyperresponsivness in patients with persistent allergic rhinitis

2018 ◽  
Vol 75 (1) ◽  
pp. 39-45
Author(s):  
Dragan Koruga ◽  
Nenad Baletic ◽  
Kristina Tot-Veres ◽  
Aleksandar Peric
Keyword(s):  
Allergic Rhinitis ◽  
Lung Function ◽  
Challenge Test ◽  
Provocation Test ◽  
High Sensitivity ◽  
Poor Correlation ◽  
Impulse Oscillometry ◽  
Persistent Allergic Rhinitis ◽  
Group 2 ◽  
Group 1

Background/Aim. Impulse oscillometry (IOS) is a method for estimating lung function which is used for early detection of bronchial hyperresponsiveness (BHR) and asthma. The aim of the study was to determine the prevalence of BHR, the correlation between spirometry and IOS and sensitivity and specificity of IOS in proving BHR in patients with persistent allergic rhinitis. Methods. The study included 81 patients with allergic rhinitis. From all of them, medical history was taken, allergy testing was done, as well as measurements of parameters of lung function by the IOS and spirometry before and after nonspecific bronchial provocation test with histamin via Aerosol provocative system. Changes of the IOS parameters to fall in FEV1 of 20% were measured and compared with changes in the spirometry parameters. After bronchial challenge test subjects were divided into two groups: the group with BHR (group 1) and that without BHR (group 2). Results. The mean age of participants was 25.7 ? 5.7 years, and 50.5% were men. Out of the total number of subjects with allergy rhinitis, 56 (58.9%) had a positive BPT. After bronchoprovocation an average increase in the group 1 was 88.15% for Rrs5, 111.98% for Fres, and for AX 819.69%. The high degree of correlation between the IOS and spirometry was proven in the group 2, while the whole group 1 had a weak correlation between parameters of these two methods. High sensitivity and low specificity for Rrs5 and Fres compared to FEV1 in diagnosing BHR was proven. Conclusion. The study demonstrated a high prevalence of BHR in the study group of patients with persistent allergic rhinitis, poor correlation in relation to the spirometric measurements in the group with BHR and a high sensitivity and low specificity of IOS for the detection of early changes in the airways.

scholarly journals Comparative characteristics of the quality of life of asthma patients with different types of airway hyperresponsiveness to physical stimules

2021 ◽  
pp. 55-61
Author(s):  
N. L. Perelman
Keyword(s):  
Quality Of Life ◽  
Airway Hyperresponsiveness ◽  
Group 4 ◽  
Sf 36 ◽  
Different Types ◽  
Asthma Patients ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Aim. To compare the nature and degree of influence of different types of airway hyperresponsiveness (AHR) on the general and specific quality of life (QoL) of patients with asthma and control over the disease.Materials and methods. 234 patients with mild-to-moderate asthma, aged from 18 to 60 years old, were interviewed and examined. Depending on the presence of one or another type of AHR, 4 groups were formed: group 1 included 60 patients with cold AHR, group 2 – 75 patients with hypoosmotic AHR, group 3 – 35 patients with hyperosmotic AHR, group 4 – 64 patients with exercise-induced bronchoconstriction (EIB). QoL and the state of the emotional sphere were assessed using the SF-36, AQLQ, HADS questionnaires. The level of asthma control was determined using the ACT questionnaire. Lung function was assessed by spirometry.Results. When comparing QoL between groups, statistical differences were obtained for most of the SF-36 scales, with the exception of the domains “Role Physical” (RP) and “Bodily Pain” (BP), and their presence and significance varied depending on the types of AHR being compared. The lowest QoL indices were found in group 1 of patients with cold AHR according to the domains “Physical Activity” (PA), RP, BP, and “Role Emotional” (RE). The lowest indices for the domains “General Health” (GH), “Vitality” (V) and “Mental health” (MH) were found in the respondents of the 2nd group. Most of the highest QoL indicators in the compared groups were found in patients of group 4 with EIB in the domains PA, RP, V, RE, and MH. When carrying out a comparative analysis, the maximum number of significant differences was found between the groups with cold AHR and EIB. A comparative study of QoL using a special AQLQ questionnaire showed the lowest indices for the “Activity” and “Symptoms” domains in groups 1 and 2 of asthma patients. In addition, in group 1, the minimum QoL values were recorded for the “General QoL” domain (3.6±0.2 points), and in group 2, for the “Environment” domain (2.9±0.3 compared with 3.9±0.2 points in group 3, p<0.01).Conclusion. This study has demonstrated the multifaceted effect of AHR on health-related QoL, dependent on sensitivity to a particular physical stimulus and the season of maximum trigger action. The subjective assessment of psychosocial functioning is most differentiated according to the GH domain of the SF-36 questionnaire. The greatest negative impact on the QoL indices is exerted by the cold and hypoosmotic AHR, the least – by the EIB. The assessment of QoL allows to get a full picture of the perception of the patient's health level at the moment and in the given conditions.

scholarly journals A Clinical Study to assess the Efficacy of Commonly Available Denture Adhesive Materials in Mandibular Dentures

2013 ◽  
Vol 3 (4) ◽  
pp. 125-130 ◽  
Author(s):  
Bhupender Yadav ◽  
Puja Malhotra ◽  
Harish Yadav ◽  
Sumit Singh Phukela
Keyword(s):  
Clinical Study ◽  
Adhesive Bond ◽  
Mean Value ◽  
Denture Adhesive ◽  
Denture Adhesives ◽  
Group 2 ◽  
Edentulous Patients ◽  
Age Range ◽  
Adhesive Materials ◽  
Group 1

ABSTRACT Retention in mandibular dentures has always been a challenge for the treating dentist. Denture adhesives are known to improve the adhesive bond between the denture and the underlying tissues. However, denture adhesives still remain unexplored and not much is known about the efficacy of these materials in mandibular dentures especially in patients with poor foundations. The present study was carried out to compare the efficacy of different commercially available denture adhesives in relation to their retentive ability in patients with good well formed mandibular ridges and in patients with resorbed and flat mandibular ridges. Seventy edentulous patients, age range between 50 to 70 years, were selected. The patients were divided into 2 groups; group 1 comprised of 35 patients with good well formed mandibular ridges and group 2 consisted of 35 patients having low well rounded mandibular ridges. The adhesion and cohesion that developed between the dentures and the underlying tissues when the various materials were interposed between them was evaluated with the help of a test apparatus in newtons. Mean value of retention in denture without adhesive was 9.93 N and 24.53 N in resorbed and well formed ridges respectively. Use of denture adhesive materials led to a higher value of retention as opposed to when the dentures were used without adhesives. This was true for patients with good well formed mandibular ridges as well as for patients with poor foundations. Among the various denture adhesive powders tested, Fittydent showed better results, i.e. 29.56 and 33.05 in resorbed and well-formed ridges respectively as opposed to fixon which showed values of 16.47 and 27.70 respectively. How to cite this article Malhotra P, Yadav B, Yadav H, Phukela SS. A Clinical Study to assess the Efficacy of Commonly Available Denture Adhesive Materials in Mandibular Dentures. Int J Prosthodont Restor Dent 2013;3(4):125-130.

Assessment of Sensory Perceptions and Patient Preference for Intranasal Corticosteroid Sprays in Allergic Rhinitis

2005 ◽  
Vol 19 (3) ◽  
pp. 316-321 ◽  
Author(s):  
Puneet Khanna ◽  
Ashok Shah
Keyword(s):  
Allergic Rhinitis ◽  
Efficacy And Safety ◽  
Intranasal Corticosteroid ◽  
Point Scale ◽  
Nasal Sprays ◽  
Safety Compliance ◽  
Group 2 ◽  
Single Blind ◽  
Group 1

Background Long-term intranasal corticosteroid sprays (INCSs), the mainstay of therapy in allergic rhinitis, differ little in efficacy and safety. Compliance to therapy is strongly influenced by patients’ perceptions and preferences. We evaluated the acceptability, based on sensory perceptions, of beclomethasone, budesonide, fluticasone propionate (FP), and mometasone furoate (MF) nasal sprays. Methods A single-blind (patient), crossover study was performed; 114 patients with allergic rhinitis, categorized as “sneezers and runners” (group 1) and “blockers” (group 2) were assessed for their sensory perceptions (nasal spray evaluation questionnaire, 14 sensory attributes, and 100-point scale). Results Significantly more patients preferred MF because of its less irritation, liking of odor, more moistness, and less aftertaste. FP rated significantly higher odor strength and amount of irritation. Seventy-two (63%) patients were in group 1 and 42 (37%) patients were in group 2. MF was the most preferred drug in both group 1 (40 patients, 56%; p < 0.05) and group 2 (21 patients, 50%). Liking the odor was the strongest attribute that affected choice in group 1 (52 patients, 58%), and strength of aftertaste in group 2 (13 patients, 31%). Significantly more patients in group 1 (55 patients, 76%) could appreciate differences in attributes than in group 2 (27 patients, 64%). Ninety-one (80%) patients predicted a better compliance with their preferred drug. Conclusion MF was the most preferred INCS in our patients. This was ascribed to less irritation, odor, and aftertaste along with superior moistness. “Sneezers and runners” appreciated significant differences in INCS. In patients with allergic rhinitis, assessment of sensory perceptions could play a crucial role in promoting compliance with therapy.

scholarly journals Clinical Effect of Azeptin on Allergic Rhinitis. A Multicenter Clinical Study in Kagawa Prefecture.

1991 ◽  
Vol 84 (6) ◽  
pp. 825-835 ◽  
Author(s):  
Mamoru Kimura ◽  
Shunichi Sakai ◽  
Yasuki Watanabe ◽  
Hiroyuki Kishimoto
Keyword(s):  
Allergic Rhinitis ◽  
Clinical Study ◽  
Clinical Effect ◽  
Multicenter Clinical Study

scholarly journals Thyroid and pituitary-adrenal activity in patients with asthma and endemic subclinical hypothyroidism in response of respiratory tract to a cold stimulus

2021 ◽  
pp. 62-69
Author(s):  
A. B. Pirogov ◽  
A. G. Prikhodko ◽  
Т. A. Мalʹtseva ◽  
V. P. Kolosov
Keyword(s):  
Respiratory System ◽  
Subclinical Hypothyroidism ◽  
Control Level ◽  
Cold Climate ◽  
Stress Factors ◽  
Free T4 ◽  
Cold Stimulus ◽  
Asthma Patients ◽  
Group 2 ◽  
Group 1

Introduction. In patients with uncontrolled asthma, the stress-induced production of glucocorticosteroids in response to a cold bronchoprovocation test is increased, which is associated with an increase in the level of thyroidstimulating hormone (TSH), characteristic of the syndrome of subclinical hypothyroidism (SH). The peculiarities of thyroid hormone metabolism and changes in pituitary-adrenal homeostasis that develop in asthma in a goiter-endemic region under the influence of cold stress factors on the respiratory system are poorly studied.Aim. To assess the activity of the pituitary-thyroid and pituitary-adrenal systems in response to bronchoprovocation with cold air in asthma patients with cold airway hyperresponsiveness (CAHR) and SH living in conditions of goiter endemic in the Amur Region.Materials and methods. In 34 asthma patients with CAHR, without symptoms of thyroid diseases, the level of disease control was assessed using the Asthma Control Test (ACT) questionnaire. Lung function and airway reaction to a cold stimulus (ΔFEV1IHCA) during 3-minute isocapnic hyperventilation with cold (-20ºC) air (IHCA) were measured. Methods of immunological diagnostics in the blood of patients before and after the IHCA test were used to measure the concentrations of thyroid-stimulating (TSH) and adrenocorticotropic (ACTH) hormones, common and active forms of thyroxine (T4) and triiodothyronine (T3), thyroglobulin (TG), autoantibodies to thyroperoxidase (AB-TPO), cortisol. The content of cyclic adenosine monophosphate (cAMP) was determined in leukocytes.Results. The patients were divided into two groups: group 1 included 25 patients with an initially low (<4.0) TSH level (2.39±0.18 mU/L), group 2 included 9 patients with an initially high (>4, 0) TSH level (4.80±0.46 mU/L, p<0.0001). The ACT control level in groups 1 and 2 was 16.6±1.0 and 15.3±1.5 points (p>0.05), base FEV1 was 95.8±3.3 and 81.0±5.4% (p=0.026), ΔFEV1IHCA -11.9±0.96 and -13.5±2.7 (p>0.05), respectively. In group 1, in response to IHCA, the level of free T4 increased from 14.2±0.70 to 15.2±0.71 pmol/L (p<0.05), free T3 from 3.73±0.24 to 4.15±0.21 nmol/L (p<0.05). In group 2, a lower level of free T4 was recorded, both before (12.2±1.52 pmol/L) and after IHCA (11.6±1.60 pmol/L, p=0.041). In addition, in group 2 patients, the cortisol concentration at baseline and after IHCA (516.6±31.6 and 397.4±40.4 nmol/L, p<0.05) was significantly lower than in group 1 (628.3±27.5 and 608.3±34.1 nmol/L, p=0.042; p=0.002, respectively). A close correlation was found between ΔFEV1 and the T4 level before (r=0.54; p<0.01) and after the test (r=0.41; p<0.05), with the amount of cAMP up to (r=0.58; p=0.008) and after the test (r=0.47; p=0.009), as well as the correlation between ΔМEF50 and the initial level of cortisol in the blood serum (r=0.50; p=0.002).Conclusion. In asthma patients with CAHR living in the region of cold climate and goiter endemic, the presence of SH can be considered as a prognostic sign of the development of dysadaptation of the respiratory system to cold exposure.

New Technique for Application of Fibrin Sealant: Rubbing Method Devised to Prevent Cerebrospinal Fluid Leakage from Dura Mater Sites Repaired with Expanded Polytetrafluoroethylene Surgical Membranes

Neurosurgery ◽  
2001 ◽  
Vol 49 (1) ◽  
pp. 117-123 ◽  
Author(s):  
Satoshi Nakajima ◽  
Tadaharu Fukuda ◽  
Masamichi Hasue ◽  
Yuichi Sengoku ◽  
Jo Haraoka ◽  
...  
Keyword(s):  
Experimental Study ◽  
Cerebrospinal Fluid ◽  
Clinical Study ◽  
Fibrin Sealant ◽  
Cerebrospinal Fluid Leakage ◽  
Fluid Leakage ◽  
Pressure Elevation ◽  
Spray Method ◽  
Group 2 ◽  
Group 1

Abstract OBJECTIVE The effectiveness of a strong, pressure-tight method for fibrin sealant application was experimentally and clinically evaluated, using expanded polytetrafluoroethylene (ePTFE) surgical membranes. METHODS Two application methods were examined in two groups. For Group 1, 1 ml each of Solutions A and B was simply sprayed over the surface (spray method). For Group 2, a small amount of Solution A was rubbed into the sutured site and then Solutions A and B were sprayed over the surface (rubbing method). In the experimental study, a moment pressure elevation test and a continuous stepwise pressure elevation test were performed for both groups. The clinical study was conducted using 350 patients undergoing craniotomies. The ePTFE surgical membrane was used for 180 patients but not the other 170 patients. RESULTS In the experimental study, the bursting pressures were 51.4 ± 13.0 cm H2O for Group 1 and 129 ± 35.0 cm H2O for Group 2 in the moment pressure elevation test and 27.0 ± 6.7 cm H2O and 100 ± 31.9 cm H2O, respectively, in the continuous stepwise pressure elevation test. The sealing effect was significantly greater for Group 2 than for Group 1 in both tests (P &lt; 0.001). In the clinical study using ePTFE surgical membranes, the rubbing method significantly reduced the incidence of postoperative cerebrospinal fluid leakage (1.4%), compared with the spray method (18.3%), when external decompression was not concomitantly used (P &lt; 0.01). CONCLUSION The sealing effect of fibrin sealant on cerebrospinal fluid leakage was significantly greater with the rubbing method than with the spray method. The strong sealing effect obtained with the rubbing method is thought to result from firm linkage between the ePTFE surgical membrane and the fibrin sealant and also from fibrin being formed even in needle holes and spaces in the sutured site.

scholarly journals Specificities of small airways dysfunction development in patients with mild asthma

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Elena E. Mineeva ◽  
Marina V. Antonyuk ◽  
Alla V. Yurenko ◽  
Tatyana A. Gvozdenko ◽  
Oksana Yu. Kytikova
Keyword(s):  
Family History ◽  
Allergic Diseases ◽  
Mild Asthma ◽  
Control Group ◽  
Bronchial Obstruction ◽  
Small Airways ◽  
Asthma Patients ◽  
History Of ◽  
Group 2 ◽  
Group 1

The study goal was to identify specificities of small airways dysfunction development (SAD) in patients with mild asthma. Material and Methods — The study involved 114 patients with mild asthma. Depending on the condition of their small airways, the patients were split among two groups: Group 1 of 94 patients with asthma without SAD (82.5%); Group 2 of 20 patients with asthma and SAD (17.5%). The control group consisted of 25 volunteers. SAD was diagnosed by the presence of air trapping and hyperinflation. Results — SAD was diagnosed in 17.5% of patients with mild asthma. The development of SAD was observed in 80% of asthma patients with ailment duration of over 5 years and family history of asthma. Obesity was diagnosed 1.7 times more often in patients with SAD compared with those without it. Food allergy, allergic rhinitis, allergic conjunctivitis, urticaria and bronchial obstruction were identified two or more times more often in patients with SAD compared with those without it. Among all patients with mild asthma and SAD, bronchial obstruction was detected in 55% of cases. Conclusion — The development of SAD in the presence of mild asthma is characteristic for patients with ailment duration over 5 years, family history of asthma, obesity, predominant sensitization to food allergens, and concomitant non-pulmonary allergic diseases. Bronchial obstruction is not the obligatory feature of SAD development in presence of mild asthma.

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