EVALUATION OF PATIENT'S PERCEPTION AND HEALING, FOLLOWING CONVENTIONAL AND PARALLELING TECHNIQUE OF FRENECTOMY USING SCALPEL AND OTHER MODALITY

Background: Frenum that encroaches on the margin of the gingiva may interfere with plaque removal and can lead to gingival recession and midline diastema. Thus, to maintain proper oral hygiene and prevent gingival recession, frenectomy is done. Frenectomy can be accomplished by conventional frenectomy technique, which has certain disadvantages. To overcome those drawbacks, paralleling technique of frenectomy has been introduced. Both the techniques can be performed by using various treatment modalities. Aim: The purpose of this clinical study was to compare the bleeding during surgery, post-operative wound healing and patient's perception towards the conventional frenectomy technique with scalpel, paralleling frenectomy technique with scalpel and paralleling technique with electrocautery. Materials and method: A total of 30 subjects with gingival or papillary frenal attachment were selected and equally divided into three groups. Group 1 was treated by conventional technique with scalpel, Group 2 by paralleling technique with scalpel and Group 3 by paralleling technique with electrocautery. Various parameters such as bleeding during surgery, patient's perception towards the various techniques and post-operative wound healing were evaluated. Results: The results showed that bleeding during surgery was minimum in group 3 as compared to other two groups. Patient's perception towards paralleling technique with scalpel, was found better than the other groups. At 7th day, though there was a difference in the healing but at 21st day wound healing was almost similar in all the three groups. Conclusion: Based on our findings and clinical outcome, paralleling technique with scalpel provided better patient's perception and an efficient and satisfactory option for frenectomy.

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An approach to treatment modalities of keloids: a comparative study

International Journal of Research in Dermatology ◽

10.18203/issn.2455-4529.intjresdermatol20214911 ◽

2021 ◽

Vol 8 (1) ◽

pp. 45

Author(s):

Sweta S. Parmar ◽

Avani Modi

Keyword(s):

Side Effects ◽

Triamcinolone Acetonide ◽

Statistical Tests ◽

Treatment Modalities ◽

Complete Clearance ◽

Limited Efficacy ◽

Group 3 ◽

Group 2 ◽

Better Than ◽

Group 1

Background: In spite of the presence of such an array of treatment modalities, none of these can be claimed to be an ideal treatment option as most of them have limited efficacy, significant side effects or increased chances of recurrence. Hence the study was undertaken to search an ideal treatment for keloids which is safe, effective, and with low rate of recurrence.Methods: Total of 200 patients were recruited out of which only 160 patients were included in study. The patients were divided into three groups and administered with different modes of treatment. Patients in all the groups were followed up at 3 weekly intervals for evaluation of response. At the end of the study, the data was compiled and analysed using appropriate statistical tests.Results: In only 32 patients completed study in group 1, 2 and 3 respectively. Group 1, 2 and 3 were more or less equally efficacious with clearance rate. Complete clearance was seen in 24 patients in group 1 patients, in group 2 there were 22 patients with complete clearance and in group 3 there were 24 patients.Conclusions: Intralesional triamcinolone acetonide, intralesional triamcinolone acetonide with hyaluronidase and intralesional radiofrequency with intralesional triamcinolone acetonide are almost equally effective modalities for the treatment of keloids. But, intralesional triamcinolone acetonide with hyaluronidase fares better than other two as far as safety is concerned with least side effects.

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Comparison of Rare Types of Breast Cancer

Journal of Cancer and Tumor International ◽

10.9734/jcti/2021/v11i230146 ◽

2021 ◽

pp. 9-17

Author(s):

Osman Erdogan ◽

Alper Parlakgumus ◽

Ugur Topal ◽

Kemal Yener ◽

Umit Turan ◽

...

Keyword(s):

Breast Cancer ◽

Lymph Nodes ◽

Radical Mastectomy ◽

Treatment Modalities ◽

Breast Carcinomas ◽

Term Survival ◽

Prognostic Features ◽

Group 3 ◽

Group 2 ◽

Group 1

Aims: Mucinous, medullary, and papillary carcinomas are rarely encountered types of breast cancer. This study aims to contribute to the literature by comparing the clinical and prognostic features and treatment alternatives of rare breast carcinomas. Study Design: Thirty-four patients with rare breast cancer out of a total of 1368 patients who underwent surgery for breast cancer in our clinic between January 2011 and December 2020 were included in the study. Methodology: The patients were assigned into three groups, i.e., medullary carcinoma group (Group 1), mucinous carcinoma group (Group 2) and papillary carcinoma group (Group 3). Demographic and clinical features, treatment modalities used, surgical approaches, pathological features of tumors and survival were compared between the groups. Results: Thirty-four patients were included in the study. The mean age of the patients in Group 3 was higher, though it was not statistically significant. Modified radical mastectomy was more frequently performed in all the groups. The number of the lymph nodes removed through axillary dissections and the number of the positive lymph nodes were similar in all the groups. The tumors in all the groups were also of comparable sizes (30 mm in Group 1, 42.5 mm in Group 2 and 30 mm in Group 3; p:0.464). Estrogen receptors were negative in a significantly higher rate of Group 1(66.7% of Group 1, p<0,001). A significantly higher rate of Group 1 received postoperative chemotherapy (93,3% of Group 1,p:0.001), but the rate of the patients receiving hormonotherapy in this group was significantly lower (26.7% of Group, p<0,001). The patients with medullary cancer had significantly longer survival than those with mucinous cancer and those with papillary cancer (76.2 in Group 1, 54.5 in Group 2 and 58.4 in Group 3; p:0.005). Conclusion: While rare subtypes of breast carcinoma did not affect opting for surgical treatment, selection of oncological therapy was affected depending on the hormone receptor status of these tumors. The long-term survival differed between rare breast tumors. In view of the unique clinical pictures of the tumors, the patients should be evaluated individually, and the evaluation should be associated with theevidence-based principles available for more common breast carcinomas.

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Latent Learning in White Rats with and without Reinforcement by Presentation of Videotaped Stimuli

Perceptual and Motor Skills ◽

10.2466/pms.1978.46.3c.1331 ◽

1978 ◽

Vol 46 (3_suppl) ◽

pp. 1331-1337 ◽

Cited By ~ 1

Author(s):

Jonathan Kahane ◽

Robert J. Robinson

Keyword(s):

Albino Rats ◽

Correlated Response ◽

Latent Learning ◽

White Rats ◽

Theoretical Support ◽

Wistar Strain ◽

Group 3 ◽

Group 2 ◽

Better Than ◽

Group 1

The effect of videotaped presentation of a maze, with and without reinforcement during correct “trials,” was investigated to determine whether learning could occur without the correlated response being manifested. Three groups of 10, female albino rats of the Wistar strain, 120 days old, were employed. The stimuli were presented on a monitor during acquisition. Group 1 received the film and reinforcement during correct “trials” and performed significantly better than Group 2, which received the film but no reinforcement and Group 3 which received neither film nor reinforcement on test trials in the actual maze. Empirical and theoretical support were obtained for the notion that learning would occur without responding.

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Is electrosurgery fulguration a better procedure for Bartholin’s gland cyst?

Revista da Associação Médica Brasileira ◽

10.1590/1806-9282.66.2.201 ◽

2020 ◽

Vol 66 (2) ◽

pp. 201-209

Author(s):

Marcia Farina Kamilos ◽

Celso Luiz Borrelli ◽

Ruben Sciuto ◽

Fernanda Pereira Cotrim ◽

Eduardo Carvalho de Arruda Veiga ◽

...

Keyword(s):

Conventional Technique ◽

Treatment Session ◽

Complete Healing ◽

Lower Percentage ◽

Control Group ◽

Bartholin’S Gland ◽

Surgical History ◽

Group 3 ◽

Group 2 ◽

Group 1

SUMMARY OBJECTIVE To evaluate the effectiveness of electrosurgery fulguration as a treatment for Bartholin’s gland cysts. DESIGN Retrospective study with a comparative control group performed on Hospital Brigadeiro and in the Disciplina de Ginecologia do Departamento de Obstetrícia e Ginecologia, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo from February 2005 to March 2009. Patients: Patients with Bartholin’s gland cyst were divided into three treatment groups: group 1 electrosurgery (n=169 cases); group 2 - gland excision with the conventional technique using a cold scalpel (n = 51 cases); group 3 - marsupialization (n=11 cases). We reviewed the clinical and surgical history, physical examination, description of the surgical technique, postoperative results (success and complications), and follow-up data. RESULTS There is no difference between groups in relation to intraoperative bleeding, hematoma, and complete healing in a single treatment session. However, electrosurgery shows the lower percentage of recurrences 18 (10,7%) compared to the Marsupialization technique (group 3, p=.031). Recurrences occurred in 18 (10,7%), 3 (5,9%), and 4 (36,4%) cases. After retreatment by the same technique, there was a complete cure rate of 90% (152/169) for group 1, and 98% (50/51) for group 2. The cost of group 1 was lower than that of other groups. CONCLUSION The fulguration with electrosurgery of the capsule of Bartholin’s cyst is an effective method of treatment, andthe cost of this technique is lower than the conventional technique and marsupialization.

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Retrospective analysis of outcomes in patients with non metastatic cholangiocarcinoma: A single network experience.

Journal of Clinical Oncology ◽

10.1200/jco.2019.37.15_suppl.e15643 ◽

2019 ◽

Vol 37 (15_suppl) ◽

pp. e15643-e15643

Author(s):

Jyothika Mamadgi ◽

Kristina Lundeen ◽

Shaakir Hasan ◽

Sunita Patruni ◽

Ahmed Khattab ◽

...

Keyword(s):

Adjuvant Chemotherapy ◽

Adjuvant Therapy ◽

Adjuvant Treatment ◽

Therapy Group ◽

Progression Free Survival ◽

Distant Recurrence ◽

Treatment Modalities ◽

Group 3 ◽

Group 2 ◽

Group 1

e15643 Background: Biliary tract cancers are rare cancers with an annual incidence of about 8,000. In resected non-metastatic BTCs (NM-BTCs), cure rates decrease significantly due to local and distant recurrence. However, guidelines to use adjuvant therapies are not well established due to the lack of well-structured phase three randomized trials, given the rarity of the disease. We present a retrospective study analyzing outcomes of NM-BTCs managed within Allegheny Health Network (AHN) with specific focus on patients who underwent resection and received different adjuvant treatment modalities. Methods: Data of all patients with NM-BTCs treated at AHN from January 2012 to December 2017 was collected and outcomes analyzed for patients treated with surgery vs no surgery We then sub-stratified the patients who received surgery into three groups based on the modality of adjuvant therapy. Group 1 included patients with no additional therapy , Group 2 with adjuvant chemotherapy and Group 3 with adjuvant chemotherapy+radiation. We compared Mean Progression-Free Survival (PFS) and Overall Survival (OS) in these three groups. Results: Of the 59 NM-BTCs treated at AHN, 32(52.4%) underwent surgery. The OS for surgical vs non-surgically treated patients was 23 vs 17 months (p = 0.008) and PFS 26 vs 19 months (P = 0.06) respectively. Of the resected –patients, PFS for patients in Group1 vs Group2 vs Group3 was 16 vs 21 vs 34 months (pooled P = 0.05) and OS was 19 vs 22 vs 19 months respectively (pooled P = 0.5). PFS for patients in Group1 vs Group (2+3),i.e, patients treated surgery only vs surgery+ any adjuvant treatment was 16 vs 28 months (P = 0.1), OS was 19 vs 22 months (P = 0.7)respectively. PFS in patients in Group 3 vs Group (1+2),i.e, patients treated with adjuvant chemotherapy+radiation vs others was 34 vs 19 months. (p = 0.0183) respectively. Conclusions: This analysis revealed a statistically significant improvement in OS in patients with NM-BTCs who received surgery. There was a trend towards improvement in PFS/OS in patients who received adjuvant therapy, though not statistically-significant. Use of adjuvant chemotherapy+radiation resulted in statistically significant improvements in PFS as compared to other treatment modalities.

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Effect of Timing of Pulmonary Metastases Identification on Prognosis of Patients With Osteosarcoma: The Japanese Musculoskeletal Oncology Group Study

Journal of Clinical Oncology ◽

10.1200/jco.2002.11.028 ◽

2002 ◽

Vol 20 (16) ◽

pp. 3470-3477 ◽

Cited By ~ 107

Author(s):

Hiroyuki Tsuchiya ◽

Yoshimitsu Kanazawa ◽

Mohamed E. Abdel-Wanis ◽

Naohiro Asada ◽

Satoshi Abe ◽

...

Keyword(s):

Lung Metastasis ◽

Lung Metastases ◽

Survival Rates ◽

Treatment Modalities ◽

Oncology Group ◽

Group 4 ◽

Group 3 ◽

Group 2 ◽

Musculoskeletal Oncology ◽

Group 1

PURPOSE: The prognostic value of the time of identification of lung metastasis was investigated in 280 patients with metastatic lung osteosarcoma as a multi-institutional study of the Japanese Musculoskeletal Oncology Group. PATIENTS AND METHODS: The 280 patients with lung metastasis were divided into four groups: group 1, patients with lung metastasis identified at initial presentation; group 2, those with lung metastasis identified during preoperative chemotherapy; group 3, those with lung metastasis identified during postoperative chemotherapy, and group 4, those with lung metastasis identified after completion of treatment. Survivals of the four groups were compared. Additionally, the effects of number of metastatic nodules, metastasectomy, and the effect of chemotherapy on the primary tumor on survival of the four groups were analyzed. RESULTS: There were 46 patients in group 1, 30 in group 2, 94 in group 3, and 110 in group 4. The overall 2-year survival rates from the time of identification of lung metastasis were 33%, 31%, 24%, and 40% for groups 1, 2, 3, and 4, respectively, whereas the 5-year survival rates were 18%, 0%, 6%, and 31%, respectively. Patients in group 4 thus demonstrated significantly better prognosis than any of the other patients (P < .0001). CONCLUSION: Time of identification of lung metastasis is an important prognostic factor. In terms of clinical behavior, groups 2 and 3 are completely different than group 4. These data ensure the need to stratify stage III osteosarcomas into subgroups according to the time of diagnosis of lung metastases. To improve the survival of osteosarcoma patients, new treatment modalities should be introduced into the treatment armamentarium for lung metastasis from osteosarcoma, especially in groups 1, 2, and 3.

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Effects of photobiomodulation on wound contraction in rats undergoing doxorubicin extravasation: a histomorphometric analysis

Revista da Escola de Enfermagem da USP ◽

10.1590/1980-220x-reeusp-2020-0527 ◽

2021 ◽

Vol 55 ◽

Author(s):

Karina Alexandra Batista da Silva Freitas ◽

Noeme Sousa Rocha ◽

Eliana Maria Minicucci ◽

Valéria Flávia Batista da Silva ◽

Hélio Langoni ◽

...

Keyword(s):

Wound Healing ◽

Acute Inflammation ◽

Wound Contraction ◽

Female Rats ◽

Histological Evaluation ◽

Group 4 ◽

Group 3 ◽

Group 2 ◽

Morphometric Evaluation ◽

Group 1

ABSTRACT Objective: To analyze wound contraction and histomorphometric pattern of lesions in Wistar rats undergoing doxorubicin extravasation. Method: Sixty adult female rats were used, divided into four groups of fifteen animals: Group 1 (Control, without antidote); Group 2 (Hyaluronidase); Group 3 (Photobiomodulation), and Group 4 (Hyaluronidase + Photobiomodulation). Doxorubicin 1mg (0.5 ml) was applied subcutaneously on the animals’ back, inducing the wound. Macroscopic and morphometric evaluation of the lesions was performed every two days for 28 days. On the 30th day, euthanasia was performed and the material was collected for histological evaluation. Results: The animals in the photobiomodulation and photobiomodulation + Hyaluronidase groups presented regeneration tissue with neovascularization and acute inflammation, with improvement in wound healing, which did not occur in the other groups. The contraction rates were better in those treated with photobiomodulation and photobiomodulation + Hyaluronidase, with healing percentages of 76.6% and 72.1%, respectively. Conclusion: The combination of photobiomodulation (660 nm–1 J) with topical hyaluronidase (65 UTR) proved to be effective in the process of wound healing due to extravasation of doxorubicin, and can be incorporated into the practice of clinical oncology.

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Allogeneic marrow transplantation for acute nonlymphoblastic leukemia after first relapse

Blood ◽

10.1182/blood.v61.5.949.bloodjournal615949 ◽

1983 ◽

Vol 61 (5) ◽

pp. 949-953 ◽

Cited By ~ 2

Author(s):

FR Appelbaum ◽

RA Clift ◽

CD Buckner ◽

P Stewart ◽

R Storb ◽

...

Keyword(s):

Marrow Transplantation ◽

Optimal Time ◽

Allogeneic Marrow Transplantation ◽

First Relapse ◽

Group 3 ◽

Group 2 ◽

Acute Nonlymphoblastic Leukemia ◽

Allogeneic Marrow ◽

Better Than ◽

Group 1

Sixty-two patients with acute nonlymphoblastic leukemia in first relapse or second remission were treated with allogeneic marrow transplantation from HLA-matched siblings. In 17 patients (group 1), no attempt at reinduction of remission was made prior to transplantation. In 20 patients (group 2), attempts at inducing a second remission prior to transplantation were unsuccessful; and in 25 patients (group 3), a second remission was achieved. Five of 17 patients (29%) in group 1, 2 of 20 (10%) in group 2, and 5 of 25 (20%) in group 3 are surviving disease-free 2–6 yr after grafting. Early mortality from nonleukemic causes was equal in the 3 groups, but the risk of recurrent leukemia after transplantation was less in patients transplanted without attempts at reinduction (group 1). Among patients transplanted in relapse, those in early relapse (less than 30% blast cells in the marrow) appeared to do better than patients in florid relapse. The results obtained in group 1 are as good as or better than those achieved in patients transplanted in second or subsequent remission. Thus, for patients with acute nonlymphoblastic leukemia not transplanted in first remission, the optimal time for transplantation would appear to be as soon as possible after the first relapse.

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Allogeneic marrow transplantation for acute nonlymphoblastic leukemia after first relapse

Blood ◽

10.1182/blood.v61.5.949.949 ◽

1983 ◽

Vol 61 (5) ◽

pp. 949-953 ◽

Cited By ~ 102

Author(s):

FR Appelbaum ◽

RA Clift ◽

CD Buckner ◽

P Stewart ◽

R Storb ◽

...

Keyword(s):

Marrow Transplantation ◽

Optimal Time ◽

Allogeneic Marrow Transplantation ◽

First Relapse ◽

Group 3 ◽

Group 2 ◽

Acute Nonlymphoblastic Leukemia ◽

Allogeneic Marrow ◽

Better Than ◽

Group 1

Abstract Sixty-two patients with acute nonlymphoblastic leukemia in first relapse or second remission were treated with allogeneic marrow transplantation from HLA-matched siblings. In 17 patients (group 1), no attempt at reinduction of remission was made prior to transplantation. In 20 patients (group 2), attempts at inducing a second remission prior to transplantation were unsuccessful; and in 25 patients (group 3), a second remission was achieved. Five of 17 patients (29%) in group 1, 2 of 20 (10%) in group 2, and 5 of 25 (20%) in group 3 are surviving disease-free 2–6 yr after grafting. Early mortality from nonleukemic causes was equal in the 3 groups, but the risk of recurrent leukemia after transplantation was less in patients transplanted without attempts at reinduction (group 1). Among patients transplanted in relapse, those in early relapse (less than 30% blast cells in the marrow) appeared to do better than patients in florid relapse. The results obtained in group 1 are as good as or better than those achieved in patients transplanted in second or subsequent remission. Thus, for patients with acute nonlymphoblastic leukemia not transplanted in first remission, the optimal time for transplantation would appear to be as soon as possible after the first relapse.

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Wound Healing Activity of Propolis of West Algeria

Phytothérapie ◽

10.3166/phyto-2018-0075 ◽

2018 ◽

Vol 17 (4) ◽

pp. 206-210

Author(s):

M. Debab ◽

F. Toumi-Benali ◽

H. Salem

Keyword(s):

Wound Healing ◽

Traditional Medicine ◽

Skin Diseases ◽

Cure Rate ◽

Important Place ◽

Ancient Times ◽

Group 3 ◽

Group 2 ◽

Wound Healing Activity ◽

Group 1

Propolis is a resinous substance that bees use todefend their colonies against any pathogen. It has beenused in traditional medicine since ancient times because ofits therapeutic properties. Pollen analysis of propolis of AinTrid has shown that the region of Ain Trid is rich in plantspecies visited by bees (31 genus identified) and that themajority of these species are considered as medicinal plants,which gives propolis an important place in wound healing.The study of the wound healing activity is carried out in vivoon theWistar rats divided into 3 groups: group 1 treated withpropolis ointment, group 2 treated with commercial cream,and group 3 considered as untreated. The duration of treatmentwas estimated to be 23 days. The results obtainedshowed that the group treated by propolis ointment showeda high cure rate, in which the percentage of wound closurereached up to 94.93% ± 5.29 in the group 1, while in thegroup 2 arrived to 79.97% ± 13.01, and in group 3 was72.55% ± 19.94. The results demonstrated also that the numberof days required to contract 50% of wound area wasdifferent among the groups, in the 12th day in group 1,16th day in group 2, and 18th day post wounding in group 3.These results have shown that propolis can be prepared andused in traditional medicine as a natural ointment for thetreatment of skin diseases in our region.

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