scholarly journals КOMPLEKSI ZLATA KAO POTENCIJALNI SUPLEMENTI SA ANTIKANCEROGENIM I ANTIVIRUSNIM DELOVANJEM

2021 ◽  
Author(s):  
Marko Antonijevic ◽  
◽  
Jelena Đorovic Jovanovic ◽  
Ana Kesic ◽  
Dejan Milenkovic ◽  
...  
Keyword(s):  
19Th Century ◽  
Inhibitory Activity ◽  
Chemotherapeutic Agents ◽  
Gold Complexes ◽  
Square Planar ◽  
Gold Compounds ◽  
Antitumor Properties ◽  
Approved Drugs ◽  
The 19Th Century ◽  
Fda Approved Drugs

The pharmacologic properties of gold compounds have been known since the end of the 19th century. They have been used for different studies, even though they are usually used for the treatment of arthritis. In the last decade, gold complexes have received increased attention due to the variety of their applications. Primary, they have been investigated as potential anticancer and chemotherapeutic agents. It is well known that gold(III) complexes are very similar to platinum(II) compounds, so they could exhibit prospective anticancer, cytotoxic and antitumor properties. In this paper, were investigated the interactions of the gold(III) complexes, [Au(DPP)Cl2]+ and [Au(DMP)Cl3] where DPP=4,7-diphenyl-1,10-phenanthroline and DMP=2,9-dimethyl-1,10-phenanthroline) with SARS-CoV2 protease. The obtained results indicate that the square-planar [Au(DPP)Cl2]+ complex shows good inhibitory activity, compared to FDA approved drugs, cinanserin and chloroquine.

scholarly journals Targeting SARS-CoV-2 Polymerase with New Nucleoside Analogues

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3461
Author(s):  
Vasiliki Daikopoulou ◽  
Panagiotis Apostolou ◽  
Sofia Mourati ◽  
Ioanna Vlachou ◽  
Maria Gougousi ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Drug Repositioning ◽  
Nucleoside Analogues ◽  
In Vitro Assays ◽  
Rna Dependent Rna Polymerase ◽  
Sugar Moiety ◽  
The Family ◽  
Approved Drugs ◽  
Fda Approved Drugs

Despite the fact that COVID-19 vaccines are already available on the market, there have not been any effective FDA-approved drugs to treat this disease. There are several already known drugs that through drug repositioning have shown an inhibitory activity against SARS-CoV-2 RNA-dependent RNA polymerase. These drugs are included in the family of nucleoside analogues. In our efforts, we synthesized a group of new nucleoside analogues, which are modified at the sugar moiety that is replaced by a quinazoline entity. Different nucleobase derivatives are used in order to increase the inhibition. Five new nucleoside analogues were evaluated with in vitro assays for targeting polymerase of SARS-CoV-2.

scholarly journals Computational studies by molecular docking of some antiviral drugs with COVID-19 receptors are an approach to medication for COVID-19

2021 ◽  
Vol 19 (1) ◽  
pp. 245-264
Author(s):  
Magda H. Abdellatiif ◽  
Amena Ali ◽  
Abuzer Ali ◽  
Mostafa A. Hussien
Keyword(s):  
Molecular Docking ◽  
Antiviral Drug ◽  
Chemotherapeutic Agents ◽  
The Novel ◽  
Drug Molecules ◽  
Study Results ◽  
Promising Treatment ◽  
Novel Coronavirus ◽  
Approved Drugs ◽  
Fda Approved Drugs

Abstract The COVID-19 outbreak is a matter of concern worldwide due to unavailability of promising treatment comprising medication or vaccination till date. The discovery of antiviral drug is of immense importance in the existing spread of novel coronavirus. The goal of the present study was to evolve an opposite antiviral drug against the novel COVID-19 virus. A directly succeeding perspective would be to use the prevailing influential drugs from several antimicrobial and chemotherapeutic agents. The encouraging approach is to identify promising drug molecules and compounds through virtual screening via molecular docking of FDA-approved drugs and some previously synthesized pyridone and coumarin derivatives for probable therapeutic outcome. In this conceptual milieu, an effort has been made to propose a computational in silico relationship among FDA-approved drugs and coronavirus-associated receptors and proteins. The study results were evaluated on the basis of a dock score by using molecular operating environment. Out of 15 compounds screened, the compounds with the best docking scores toward their targets was 3d. Therefore, compound 3d deserves further investigations and clinical trials as a possible therapeutic inhibitor of the COVID-19 caused by the novel SARS-CoV-2.

Grammatical Descriptions in Manchu Grammar Books from the Qing Dynasty

2019 ◽  
Vol 41 (1) ◽  
pp. 39-55
Author(s):  
Takashi Takekoshi
Keyword(s):  
19Th Century ◽  
Qing Dynasty ◽  
The Qing Dynasty ◽  
Chinese Scholars ◽  
High Degree ◽  
The 19Th Century

In this paper, we analyse features of the grammatical descriptions in Manchu grammar books from the Qing Dynasty. Manchu grammar books exemplify how Chinese scholars gave Chinese names to grammatical concepts in Manchu such as case, conjugation, and derivation which exist in agglutinating languages but not in isolating languages. A thorough examination reveals that Chinese scholarly understanding of Manchu grammar at the time had attained a high degree of sophistication. We conclude that the reason they did not apply modern grammatical concepts until the end of the 19th century was not a lack of ability but because the object of their grammatical descriptions was Chinese, a typical isolating language.

Comparing the Metabolome of a Caribbean Sponge to 420 FDA Approved Drugs, a Molecular Networking Approach

Planta Medica ◽  
2013 ◽  
Vol 79 (10) ◽  
Author(s):  
H Houson ◽  
J Schlesser ◽  
J Beverage ◽  
V Macherla ◽  
E Esquenazi
Keyword(s):  
Molecular Networking ◽  
Approved Drugs ◽  
Fda Approved Drugs

Immigrant Arab Women in Chile during the Renaissance (Nahda), 1910s-1920s

1970 ◽  
pp. 47-55
Author(s):  
Sarah Limorté
Keyword(s):  
20Th Century ◽  
19Th Century ◽  
Thematic Analysis ◽  
New World ◽  
Arab Women ◽  
Arab Woman ◽  
The Subject ◽  
The 19Th Century

Levantine immigration to Chile started during the last quarter of the 19th century. This immigration, almost exclusively male at the outset, changed at the beginning of the 20th century when women started following their fathers, brothers, and husbands to the New World. Defining the role and status of the Arab woman within her community in Chile has never before been tackled in a detailed study. This article attempts to broach the subject by looking at Arabic newspapers published in Chile between 1912 and the end of the 1920s. A thematic analysis of articles dealing with the question of women or written by women, appearing in publications such as Al-Murshid, Asch-Schabibat, Al-Watan, and Oriente, will be discussed.

THE IDEA OF «COMMUNITY» IN THE GOVERNMENT CONCEPTS OF GALICIA OF THE XIX – BEGINNING OF THE XX CENTURY

2019 ◽  
pp. 15-21
Author(s):  
Liubomyr Ilyn
Keyword(s):  
Nineteenth Century ◽  
19Th Century ◽  
Practical Significance ◽  
Distinctive Features ◽  
Legal Studies ◽  
Legal Principle ◽  
General Scientific ◽  
The Government ◽  
The Right ◽  
The 19Th Century

Purpose. The purpose of the article is to analyze and systematize the views of social and political thinkers of Galicia in the 19th - beginning of the 20th centuries. on the right and manner of organizing a nation-state as a cathedral. Method. The methodology includes a set of general scientific, special legal, special historical and philosophical methods of scientific knowledge, as well as the principles of objectivity, historicism, systematic and comprehensive. The problem-chronological approach made it possible to identify the main stages of the evolution of the content of the idea of catholicity in Galicia's legal thought of the 19th century. Results. It is established that the idea of catholicity, which was borrowed from church terminology, during the nineteenth century. acquired clear legal and philosophical features that turned it into an effective principle of achieving state unity and integrity. For the Ukrainian statesmen of the 19th century. the idea of catholicity became fundamental in view of the separation of Ukrainians between the Russian and Austro-Hungarian empires. The idea of unity of Ukrainians of Galicia and the Dnieper region, formulated for the first time by the members of the Russian Trinity, underwent a long evolution and received theoretical reflection in the work of Bachynsky's «Ukraine irredenta». It is established that catholicity should be understood as a legal principle, according to which decisions are made in dialogue, by consensus, and thus able to satisfy the absolute majority of citizens of the state. For Galician Ukrainians, the principle of unity in the nineteenth century. implemented through the prism of «state» and «international» approaches. Scientific novelty. The main stages of formation and development of the idea of catholicity in the views of social and political figures of Halychyna of the XIX – beginning of the XX centuries are highlighted in the work. and highlighting the distinctive features of «national statehood» that they promoted and understood as possible in the process of unification of Ukrainian lands into one state. Practical significance. The results of the study can be used in further historical and legal studies, preparation of special courses.

Book reviews

2017 ◽  
Vol 5 (2) ◽  
pp. 215-226
Author(s):  
Kurdish Studies
Keyword(s):  
19Th Century ◽  
Spatial Control ◽  
Cornell University ◽  
South Eastern ◽  
Turkish State ◽  
The 19Th Century

Andrea Fischer-Tahir and Sophie Wagenhofer (edsF), Disciplinary Spaces: Spatial Control, Forced Assimilation and Narratives of Progress since the 19th Century, Bielefeld: Transcript Verlag, 2017, 300 pp., (ISBN: 978-3-8376-3487-7).Ayşegül Aydın and Cem Emrence, Zones of Rebellion: Kurdish Insurgents and the Turkish State, Ithaca and London: Cornell University Press, 2015, 192 pp., (ISBN: 978-0-801-45354-0).Evgenia I. Vasil’eva, Yugo-Vostochniy Kurdistan v XVI-XIX vv. Istochnik po Istorii Kurdskikh Emiratov Ardelan i Baban. [South-Eastern Kurdistan in the XVI-XIXth cc. A Source for the Study of Kurdish Emirates of Ardalān and Bābān], St Petersburg: Nestor-Istoria, 2016. 176 pp., (ISBN 978-5-4469-0775-5).Karin Mlodoch, The Limits of Trauma Discourse: Women Anfal Survivors in Kurdistan-Iraq, Berlin: Klaus Schwarz Verlag, 2014, 541 pp., (ISBN: 978-3-87997-719-2). 

Sign in / Sign up

Export Citation Format

Share Document