Manganese (II) and Cobalt (II) Acetylacetonates as Antimicrobial Agents

Mn(II) and Co(II) complexes were prepared by reaction of the metal chlorides with acetylacetone in ammonical aqueous medium. The metal complexes were prepared in order to investigate their antimicrobial activity on some selected pathogens. The characterisation of the complexes was on the basis of various spectroscopic techniques like infrared and ultraviolet studies. The compounds were subjected to antimicrobial activity screening using serial broth dilution method. Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal/Fungicidal Concentration (MBC/MFC) were determined. Mn(II) complex has shown significantly both antibacterial and antifungal activity with a MIC of 1.25 μg/mL while Co(II) complex was noticeable for antifungal activity at the same concentration. Whereas Mn(II) acetylacetonate is a more potent bactericide while Co(II) acetylacetonate is a more potent fungicide, both with MBC/MFC value of 2.5 μg/mL. Antimicrobial agent of the ligand has enhanced on complexation with Mn(II) and Co(II) ions. Though, the potency of the prepared antibiotics on the tested microbes is less compared to the standard drugs (Ciprofloxacin and Fulcin).

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Synthesis, antibacterial and antifungal activity of 1-[4-(1,1,3,3-tetramethylbutyl)phenoxy]-3-dialkylamino-2-propanol quaternary salts

Farmatsevtychnyi zhurnal ◽

10.32352/0367-3057.1.15.04 ◽

2019 ◽

pp. 56-62 ◽

Cited By ~ 1

Author(s):

Y. V. Korotkii ◽

N. A. Vrynchanu ◽

M. L. Dronova ◽

Z. S. Suvorova ◽

O. A. Smertenko

Keyword(s):

Antimicrobial Activity ◽

Antifungal Activity ◽

Antimicrobial Agents ◽

Dilution Method ◽

The Novel ◽

Antibacterial And Antifungal Activity ◽

Antimicrobial Drugs ◽

Quaternary Salts ◽

Resistant Strains ◽

Antibacterial And Antifungal

The emergence and spread of resistant strains of pathogens as well as reduction of the efficacy of current antimicrobial agents requires the development of novel antimicrobial compounds. The aim of the present study was synthesis and evaluation of antimicrobial activity of new arylaliphatic aminopropanols. The objects of the present study were 1-[4-(1,1,3,3-tetramethylbutyl)phenoxy]-3-dialkylamino-2-propanol quaternary salts (compounds I–XIV). Compounds synthesis was carried out by heating of precursor epoxide and excessive amount of appropriate amines in isopropanole, followed by treatment with excess of alkyl halides. Methods of elemental analysis, IR- and PMR-spectroscopy were used for confirmation of chemical structure. Antimicrobial activity against Staphylococcus аureus АTCC 25923, Escherichia coli ATCC 25922, Pseudomonas aeruginosa АТСС 27853 and Candida albicans NCTC 885/653 was determined by a broth dilution method and evaluated via minimum inhibitory concentration (MIC). Our investigation of antibacterial and antifungal activity of 1-[4-(1,1,3,3-tetra methylbutyl)phenoxy]-3-dialkylamino-2-propanol quaternary salts showed that compounds possess narrow spectrum, as well as broad spectrum action. Significant antimicrobial activity of the novel aryl aliphatic aminoalcohols indicates their potential usage as a component of new antimicrobial drugs.

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Copper-catalyzed Convenient Synthesis and SAR Studies of Substituted-1,2,3-triazole as Antimicrobial Agents

Letters in Drug Design & Discovery ◽

10.2174/1570180815666180326153322 ◽

2018 ◽

Vol 16 (1) ◽

pp. 3-10

Author(s):

Aniket P. Sarkate ◽

Kshipra S. Karnik ◽

Pravin S. Wakte ◽

Ajinkya P. Sarkate ◽

Ashwini V. Izankar ◽

...

Keyword(s):

Antimicrobial Activity ◽

Antifungal Activity ◽

Antimicrobial Agents ◽

Cycloaddition Reaction ◽

Dipolar Cycloaddition ◽

One Pot ◽

Triazole Derivatives ◽

Sar Studies ◽

Convenient Synthesis ◽

Antibacterial And Antifungal

Background:A novel copper-catalyzed synthesis of substituted-1,2,3-triazole derivatives has been developed and performed by Huisgen 1,3-dipolar cycloaddition reaction of azides with alkynes. The reaction is one-pot multicomponent.Objective:We state the advancement and execution of a methodology allowing for the synthesis of some new substituted 1,2,3-triazole analogues with antimicrobial activity.Methods:A series of triazole derivatives was synthesized by Huisgen 1,3-dipolar cycloaddition reaction of azides with alkynes. The structures of the synthesized compounds were elucidated and confirmed by 1H NMR, IR, MS and elemental analysis. All the synthesized compounds were tested for their antimicrobial activity against a series of strains of Bacillus subtilis, Staphylococcus aureus and Escherichia coli for antibacterial activity and against the strains of Candida albicans, Aspergillus flavus and Aspergillus nigar for antifungal activity, respectively.Results and Conclusion:From the antimicrobial data, it was observed that all the newly synthesized compounds showed good to moderate level of antibacterial and antifungal activity.

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Synthesis and Biological Activity of 1,2,4-Triazolo-[3,4-b]Thiadiazole as Antimicrobial Agents

International Letters of Chemistry Physics and Astronomy ◽

10.18052/www.scipress.com/ilcpa.26.45 ◽

2014 ◽

Vol 26 ◽

pp. 45-52

Author(s):

Piyush B. Vekariya ◽

Jalpa R. Pandya ◽

Vaishali Goswami ◽

Hitendra S. Joshi

Keyword(s):

Antimicrobial Activity ◽

Antibacterial Activity ◽

Spectral Analysis ◽

Biological Activity ◽

Antimicrobial Agents ◽

Dilution Method ◽

Mass Spectral Analysis ◽

Mass Spectral ◽

Broth Dilution

Some novel 6-fluoro chroman derivatives having 1,2,4-triazolo-[3,4-b]thiadiazole were synthesized and characterized by IR, NMR and mass spectral analysis. All synthesized compounds were screened for antimicrobial activity using broth dilution method. All the compounds showed good antimicrobial activity and compound 5e showed significant antibacterial activity.

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UJI AKTIVITAS ANTIJAMUR INFUSA UMBI BAWANG PUTIH (Allium sativum L.) TERHADAP Candida albicans SERTA PROFIL KROMATOGRAFINYA

Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) ◽

10.22487/j24428744.2016.v2.i1.7087 ◽

2016 ◽

Vol 2 (1) ◽

pp. 49-58

Author(s):

Khusnul Diana

Keyword(s):

Candida Albicans ◽

Antifungal Activity ◽

Allium Sativum ◽

Activity Concentration ◽

Inhibitory Concentration ◽

Dilution Method ◽

Minimum Fungicidal Concentration ◽

Tube Test ◽

Antibacterial And Antifungal ◽

Layer Chromatography

As traditional medicine, bawang putih or garlic ( Allium sativum L.) can cure as antibacterial and antifungal beside on can restorative as antihypertension, antacid, carminativa (in the dyspepsia), expectorancia and anticolesterol. This research was conducted in order to know the antifungal activity of infusion of Allium sativum against Candida albicans and to identify chemical component’s of this infusion. The antifungal activity was done by liquid dilution method. The MIC (Minimal Inhibitory Concentration) and MFC (Minimal Fungicidal Concentration) value were used as parameter to determine the antifungal activity. Concentration used in this reseach were 17,5%; 16,25%; 15%; 13,75% ; 12,5% dan 11,25% v/v for Candida albicans. The activity was done by incubating the infusion with fungal in CYG DS media of 37ºC for 18-24 hours. Identification of chemical component was carried out by paper chromatography and thin layer chromatography. The result showed that the MIC (Minimum Inhibitor Concentration) for Candida albicans could not be observed because the mixture was turbid. The MFC (Minimum Fungicidal Concentration) for Candida albicans was 15% v/v. The tube test and chromatogram showed that the infusion of Allium sativum contained flavonoid, and saponin.

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Comparative analysis of the chemical composition and antimicrobal activities of some of Lamiaceae family species and Eucaliptus (Eucaliptus globules M)

Acta periodica technologica ◽

10.2298/apt1445201p ◽

2014 ◽

pp. 201-213

Author(s):

Danijela Pecarski ◽

Zorica Knezevic-Jugovic ◽

Suzana Dimitrijevic-Brankovic ◽

Katarina Mihajilovski ◽

Slobodan Jankovic

Keyword(s):

Antimicrobial Activity ◽

Essential Oils ◽

Aromatic Hydrocarbons ◽

Inhibitory Concentration ◽

Diffusion Method ◽

Dilution Method ◽

Agar Diffusion Method ◽

Main Components ◽

Oil Gas ◽

Broth Dilution

The aim of this study was to evaluate and compare the antimicrobial activity of four essential oils that belong to Lamiaceae family (sage, oregano, thyme) and eucalyptus oil. Gas chromatography coupled with mass spectrometry (GC-MS) revealed that the highest percent of essential oils 98.93% include three classes of compounds - monoterpene hydrocarbons, aromatic hydrocarbons and oxidized monoterpenes. The main components are oxidized monoterpenes: carvacrol (59.03%); thymol (36.12%), eucalyptol (20.66%), hydrocarbon monoterpenes: limonene (30.96%) and ?-pinene (12.21%) and aromatic monoterpene, p-cymene (22.25%) All essential oils showed great potential of antimicrobial activity against several bacteria and yeast C. albicans, using the agar diffusion method with wells. Minimum inhibitory concentration (MIC) for the essential oils has been determined by the broth dilution method and valued in the range from 1 to 5 ?L/m, depending on the essential oil and bacteria tested, and up to 100 ?L/ml for C. albicans. The essential oils of Lamiaceae family exhibited a strong antibacterial activity for tested microorganisms, while the essential oils of thyme were especially recognized.

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EVALUATION OF POTENTIAL ANTIMICROBIAL ACTIVITY OF SYNTHETIC FLAVONOIDS

Journal of Biomedical and Pharmaceutical Research ◽

10.32553/jbpr.v10i1.841 ◽

2021 ◽

Vol 10 (1) ◽

pp. 76-82

Author(s):

Prabhulingayya S Bhixavatimath ◽

Yasmeen Maniyar ◽

Akram Naikawadi ◽

Vijayakumar D

Keyword(s):

Antimicrobial Activity ◽

Antifungal Activity ◽

Antimicrobial Agents ◽

Oxidative Cyclization ◽

In Vivo Studies ◽

Diffusion Method ◽

Flavonoid Compounds ◽

Antibacterial And Antifungal

Introduction: In recent times, most of the currently available antimicrobial agents have developed resistance. Extensive pharmacological activities including bactericidal and bacteriostatic nature of flavonoids, made them as priority agents in this aspect of research study. Synthetic flavonoids such as hydroxy thiophen derivatives were considered to evaluate for antimicrobial activity in this study. Objective: The present study involves the analysis for antimicrobial activity of thiophen substituted synthetic flavonoids. Methods: Claisen-Schmidt method of condensation fallowed by oxidative cyclization reactions from substituted hydroxyacetophenone with aromatic aldehydes were used to synthesize the various analogues of flavonoid compounds. Then these compounds after their FTIR, 1H NMR, MS spectral characterization and elemental analysis, were screened for in vitro antibacterial and antifungal activity by using disc diffusion method followed by determining their respective zone of inhibitions. Results: All the synthesized test flavonoid compounds exhibited the good antibacterial and antifungal spectrum activity over B. subtilis, S. aureus, E. coli and P. aeurugenosa bacteria and Candida albicans and Aspergillus niger fungal microbes. However compounds such as F1, F2 and F4 showed moderately significant antibacterial activity against P. aerugenosa organism than the other test compounds and the same F1 and F2 test compounds exhibited significant antifungal activity at100µg concentration. Conclusion: The present study demonstrated that the novel thiophen substituted flavonoids (F1, F2, F3 and F4 ) found to have promising antimicrobial and antifungal activity which needs to be confirmed by in vivo studies.

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Antimicrobial Activity of Some Novel 1-(3-(4-Chlorophenylimino)-3,4- dihydroquinoxalin-2-yl)-3-substituted phenyl-1H-pyrazole-4-carbaldehyde

Anti-Infective Agents ◽

10.2174/2211352517666190117143604 ◽

2020 ◽

Vol 18 (2) ◽

pp. 128-134

Author(s):

Dhanapal Visagaperumal ◽

Vineeth Chandy

Keyword(s):

Antimicrobial Activity ◽

Antifungal Activity ◽

Dilution Method ◽

Significant Activity ◽

Antibacterial And Antifungal Activity ◽

Reference Drug ◽

Mass Spectral ◽

Diffusion Technique ◽

Elemental Analyses ◽

Antibacterial And Antifungal

Background: In this study, synthesis of some novel 1-(3-(4-chlorophenylimino)-3,4- dihydroquinoxalin-2-yl)-3-substituted phenyl-1H-pyrazole-4-carbaldehyde were done by cyclization of dehydrated hemiketal using VilsmeierHaack reaction. The structures of synthesized compounds were in accordance of the basis of IR, 1HNMR, Mass spectral data and elemental analyses. The synthesized compounds had given good yields and high purity. Methods: The antimicrobial activity of the synthesized compounds was preliminarily screened by paper disc diffusion technique. The determination of minimum inhibitory concentrations (MIC) of the synthesized compounds were done by using tube dilution method. Results and Conclusion: All the screened compounds showed antibacterial and antifungal activity against selected strains of Gram positive and Gram negative bacteria and two strains of fungus, respectively but exhibited considerably less activity when compared to the reference drug ciprofloxacin and Fluconazole for antibacterial and antifungal activity, respectively. Among the synthesized compounds VV5 exhibited significant activity.

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Hybrid Quinoline-Sulfonamide Complexes (M2+) Derivatives with Antimicrobial Activity

Molecules ◽

10.3390/molecules25122946 ◽

2020 ◽

Vol 25 (12) ◽

pp. 2946 ◽

Cited By ~ 1

Author(s):

Dumitrela Diaconu ◽

Violeta Mangalagiu ◽

Dorina Amariucai-Mantu ◽

Vasilichia Antoci ◽

Cristian Levente Giuroiu ◽

...

Keyword(s):

Antimicrobial Activity ◽

Antibacterial Activity ◽

Antifungal Activity ◽

Inhibitory Concentration ◽

X Ray Diffraction ◽

Metal Acetate ◽

X Ray ◽

Good Antibacterial Activity ◽

Inhibition Zones ◽

Antibacterial And Antifungal

Two new series of hybrid quinoline-sulfonamide complexes (M2+: Zn2+, Cu2+, Co2+ and Cd2+) derivatives (QSC) were designed, synthesized and tested for their antimicrobial activity. The synthesis is straightforward and efficient, involving two steps: acylation of aminoquinoline followed by complexation with metal acetate (Cu2+, Co2+ and Cd2+) or chloride (Zn2+). The synthesized QSC compounds were characterized by FTIR and NMR spectroscopy and by X-ray diffraction on single crystal. The QSC compounds were preliminary screened for their antibacterial and antifungal activity and the obtained results are very promising. In this respect, the hybrid N-(quinolin-8-yl)-4-chloro-benzenesulfonamide cadmium (II), considered as leading structure for further studies, has an excellent antibacterial activity against Staphylococcus aureus ATCC25923 (with a diameters of inhibition zones of 21 mm and a minimum inhibitory concentration (MIC) of 19.04 × 10−5 mg/mL), a very good antibacterial activity against Escherichia coli ATCC25922 (with a diameters of inhibition zones of 19 mm and a MIC of 609 × 10−5 mg/mL), and again an excellent antifungal activity against Candida albicans ATCC10231 (with a diameters of inhibition zones of 25 mm and a MIC of 19.04 × 10−5 mg/mL).

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Design, Synthesis, and Antibacterial and Antifungal Activities of Novel Trifluoromethyl and Trifluoromethoxy Substituted Chalcone Derivatives

Pharmaceuticals ◽

10.3390/ph13110375 ◽

2020 ◽

Vol 13 (11) ◽

pp. 375

Author(s):

Surendra Babu Lagu ◽

Rajendra Prasad Yejella ◽

Richie R. Bhandare ◽

Afzal B. Shaik

Keyword(s):

Antimicrobial Activity ◽

Bacillus Subtilis ◽

Fungal Infections ◽

Normal Liver ◽

Dilution Method ◽

Spectroscopic Techniques ◽

Normal Liver Cell ◽

Olefinic Carbon ◽

Antibacterial And Antifungal Activities ◽

Antibacterial And Antifungal

Despite the availability of many drugs to treat infectious diseases, the problems like narrow antimicrobial spectrum, drug resistance, hypersensitivities and systemic toxicities are hampering their clinical utility. Based on the above facts, in the present study, we designed, synthesized and evaluated the antibacterial and antifungal activity of novel fluorinated compounds comprising of chalcones bearing trifluoromethyl (A1–A10) and trifluoromethoxy (B1–B10) substituents. The compounds were characterized by spectroscopic techniques and evaluated for their antimicrobial activity against four pathogenic Gram-positive (Staphylococcus aureus and Bacillus subtilis) and Gram-negative (Escherichia coli and Bacillus subtilis) bacterial and fungal (Candida albicans and Aspergillus niger) strains. In this study, the compounds with trifluoromethoxy group were more effective than those with trifluoromethyl group. Among the 20 fluorinated chalcones, compound A3/B3 bearing an indole ring attached to the olefinic carbon have been proved to possess the most antimicrobial activity compared to the standard drugs without showing cytotoxicity on human normal liver cell line (L02). Further, the minimum inhibitory concentration (MIC) for A3/B3 was determined by serial tube dilution method and showed potential activity. These results would provide promising access to future study about the development of novel agents against bacterial and fungal infections.

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Synthesis of modified pyridine and bipyridine substituted coumarins as potent antimicrobial agents

Journal of the Serbian Chemical Society ◽

10.2298/jsc140804004l ◽

2015 ◽

Vol 80 (6) ◽

pp. 739-747 ◽

Cited By ~ 4

Author(s):

Hemali Lad ◽

Rakesh Giri ◽

Yogita Chovatiya ◽

Dinkar Brahmbhatt

Keyword(s):

Antimicrobial Activity ◽

Antibacterial Activity ◽

Antimicrobial Agents ◽

Molecular Hybridization ◽

Dilution Method ◽

Gram Negative ◽

Comparable Activity ◽

Broth Dilution ◽

Substituted Coumarins

In search for new antimicrobial agents a series of new modified pyridine and bipyridine substituted coumarins 5a-y was designed and synthesized by adopting molecular hybridization strategy. All the synthesized compounds were evaluated for their in vitro antimicrobial activity using broth dilution method against selected bacterial (Gram-positive and Gram-negative) and fungal strains. Compounds 5a, 5f, 5g, 5n, 5r, 5t, 5w, 5x and 5y demonstrated promising antibacterial activity while other derivatives showed comparable activity to standard drugs used as reference.

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