Maropitant citrate as an adjunct to visceral analgesia in dogs and cats – review

2021 ◽  
Vol XXVI (150) ◽  
pp. 50-62
Author(s):  
Ana A. dos S. Cassoli ◽  
Raimundo C. Palheta Jr. ◽  
Ricardo Lola Pereira
Keyword(s):  
Quality Of Life ◽  
Substance P ◽  
Alternative Treatment ◽  
Tissue Damage ◽  
Visceral Pain ◽  
Minimum Alveolar Concentration ◽  
Neural Pathways ◽  
Potential Use

Pain is a complex multifactorial experience associated with tissue damage that causes suffering and reduces an animal’s quality of life. Maropitant citrate is a antagonist specific to the NK-1 receptor which selectively inhibits the production of substance P, a mediator involved in the signals responsible for emesis. For this reason, maropitant was initially developed for the treatment of vomiting in dogs and cats. However, substance P also has a role in the neural pathways responsible for the modulation of harmful stimuli involved in nociception and inflammation. Recent research into this role shows that maropitant citrate may be an alternative treatment for visceral pain in dogs and cats. Most of these studies have shown a reduction in the minimum alveolar concentration (MAC) of allogenated anesthetics agents with the use of maropitant citrate. This review describes studies into the potential use of maropitant citrate in anesthetic protocols in animals.

scholarly journals The immediate effect of facial candling on inflammatory mediators, substance P, symptoms severity, and quality of life in allergic rhinitis patients

Medicine ◽  
2017 ◽  
Vol 96 (30) ◽  
pp. e7511 ◽  
Author(s):  
Nor Faizatul Fatikah Ismail ◽  
Chin Fen Neoh ◽  
Siong Meng Lim ◽  
Amir Heberd Abdullah ◽  
Mohd Fahmi Mastuki ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Allergic Rhinitis ◽  
Substance P ◽  
Inflammatory Mediators

scholarly journals Pain in Decreased Consciousness Patients

2021 ◽  
Vol 5 (11) ◽  
pp. 1042-1048
Author(s):  
Masita ◽  
Rachman Toyo ◽  
Ika Erna Uly Sirait
Keyword(s):  
Quality Of Life ◽  
Disease Management ◽  
Literature Review ◽  
Treatment Period ◽  
Pain Assessment ◽  
Tissue Damage ◽  
International Association ◽  
Emotional Experience ◽  
Experience Pain

The International Association for the Study of Pain (IASP) defines pain as an unpleasant sensory and emotional experience associated with potential or tissue damage or described in terms of such damage. Pain in patients with decreased consciousness is individual and needs to consider many aspects. Following the expansion pain definition according to the IASP in 2020, the inability to communicate does not exclude the possibility that humans experience pain. Therefore, a good pain assessment in patients with decreased consciousness can increase the value of disease management and improve the patient's quality of life both during the treatment period and after hospitalization. Because of the inability of patients with decreased consciousness to verbally convey their pain, this poses a challenge for the clinician. This literature review was aimed to describe how to understand the pain in decreased consciousness patients.

scholarly journals In Chronic Spontaneous Urticaria, Comorbid Depression Linked to Higher Disease Activity, and Substance P Levels

2021 ◽  
Vol 12 ◽  
Author(s):  
Bachar Memet ◽  
Eren Vurgun ◽  
Fatma Barlas ◽  
Martin Metz ◽  
Marcus Maurer ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Substance P ◽  
Disease Activity ◽  
Chronic Spontaneous Urticaria ◽  
Healthy Controls ◽  
Comorbid Depression ◽  
Healthy Control ◽  
Severity Of Depression ◽  
Urticaria Activity Score

Background: Patients with chronic spontaneous urticaria often exhibit psychiatric comorbidities including depression that contribute to the impairment of their quality of life. How CSU and depression are linked isn't well-understood. Substance P has been shown to be increased in patients with CSU and is held to contribute to the pathogenesis of depression.Methods: We measured disease activity in 30 CSU patients without depression and 30 CSU patients with depression by using the urticaria activity score. The severity of depression was assessed with the Beck Depression Inventory. We measured SP levels in these patients as well as in 30 healthy control subjects. In patients with comorbid depression, we correlated SP levels with CSU disease activity and the severity of depression.Results: In CSU patients, disease activity and the severity of depression were positively linked. UAS7 values were higher in CSU patients with comorbid depression as compared to those without (p < 0.05). SP levels were higher in CSU patients with depression than in those without (p < 0.001), but was similar in all CSU patients compared to healthy controls. SP levels weren't correlated with UAS7 values in CSU patients with depression, whereas they were weakly but significantly correlated with BDI scores (p < 0.05).Conclusion: Our results suggest that, in CSU patients with comorbid depression, CSU disease activity affects the severity of depression. CSU patients with high disease activity should be explored for comorbid depression.

scholarly journals Pain in Decreased Consciousness Patients

2021 ◽  
Vol 5 (4) ◽  
pp. 953-959
Author(s):  
Masita ◽  
Rachman Toyo ◽  
Ika Erna Uly Sirait
Keyword(s):  
Quality Of Life ◽  
Disease Management ◽  
Literature Review ◽  
Treatment Period ◽  
Pain Assessment ◽  
Tissue Damage ◽  
International Association ◽  
Emotional Experience ◽  
Experience Pain

The International Association for the Study of Pain (IASP) defines pain as an unpleasant sensory and emotional experience associated with potential or tissue damage or described in terms of such damage. Pain in patients with decreased consciousness is individual and needs to consider many aspects. Following the expansion pain definition according to the IASP in 2020, the inability to communicate does not exclude the possibility that humans experience pain. Therefore, a good pain assessment in patients with decreased consciousness can increase the value of disease management and improve the patient's quality of life both during the treatment period and after hospitalization. Because of the inability of patients with decreased consciousness to verbally convey their pain, this poses a challenge for the clinician. This literature review was aimed to describe how to understand the pain in decreased consciousness patients.

scholarly journals Improvement of sulphur mustard-induced chronic pruritus, quality of life and antioxidant status by curcumin: results of a randomised, double-blind, placebo-controlled trial

2011 ◽  
Vol 108 (7) ◽  
pp. 1272-1279 ◽  
Author(s):  
Yunes Panahi ◽  
Amirhossein Sahebkar ◽  
Mojtaba Amiri ◽  
Seyyed Masoud Davoudi ◽  
Fatemeh Beiraghdar ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Placebo Group ◽  
Substance P ◽  
Controlled Trial ◽  
Life Quality ◽  
Serum Concentrations ◽  
Double Blind ◽  
Sulphur Mustard ◽  
Chronic Pruritus

Skin is among the first and most heavily damaged organs upon sulphur mustard (SM) exposure. Pruritus is the most common chronic skin complication of SM, which adversely affects the quality of life (QoL). However, current therapies for the management of SM-induced pruritus are very limited and associated with side effects. The present trial investigated the efficacy of curcumin in the alleviation of SM-induced chronic pruritic symptoms. A total of ninety-six male Iranian veterans (age 37–59 years) were randomised to receive either curcumin (1 g/d, n 46) or placebo (n 50) for 4 weeks. Serum concentrations of substance P and activities of antioxidant enzymes were measured at baseline and at the end of the trial. Assessment of pruritus severity was performed using the pruritus score, visual analogue scale (VAS) and scoring atopic dermatitis (SCORAD) index. QoL was evaluated using the Dermatology Life Quality Index (DLQI) questionnaire. Serum concentrations of substance P (P < 0·001) as well as activities of superoxide dismutase (P = 0·02), glutathione peroxidase (P = 0·006) and catalase (P < 0·001) were significantly reduced in the curcumin group, while no significant change was observed in the placebo group. Curcumin supplementation was also associated with significant reductions in measures of pruritus severity including the pruritus score (P < 0·001), VAS score (P < 0·001), overall (P < 0·001) and objective SCORAD (P = 0·009), and DLQI's first question (P < 0·001). None of these measures was significantly changed in the placebo group. As for the QoL, although DLQI scores decreased in both groups (P < 0·001 and P = 0·003 in the curcumin and placebo groups, respectively), the magnitude of reduction was significantly greater in the curcumin group (P < 0·001). In conclusion, curcumin may be regarded as a natural, safe, widely available and inexpensive treatment for the management of SM-induced chronic pruritus.

scholarly journals Treatment of chronic pain in dentistry using anticonvulsants

2016 ◽  
Vol 64 (4) ◽  
pp. 447-452 ◽  
Author(s):  
Daniele Coelho DOURADO ◽  
Edielson Felipe e Silva GONÇALVES ◽  
Reinan de Oliveira MELO FILHO ◽  
Luana Ceccagno POLTRONIERI ◽  
Viviane Coelho DOURADO ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Chronic Pain ◽  
Liver Function ◽  
Tissue Damage ◽  
Emotional Experience ◽  
Scientific Evidence ◽  
Pharmaceutical Market ◽  
Gingival Enlargement ◽  
Pros And Cons

ABSTRACT Pain can be characterized as a sensorial and emotional experience in an unpleasant and personal way. It is usually associated with real tissue damage and may be caused by the involvement of chemical and physical agents or by subjective and psychological aspects. This study aimed to review the literature regarding the use of anticonvulsants in the treatment of chronic pain, the most used drugs, the efficacy of each one of them, the pros and cons of their use and the pathologies associated with chronic pain. Orofacial pains are considered complex and multifactorial and often do not respond well to treatment with common analgesics. The carbamazepine is used since the 60s, but their prolonged use can alter liver function. Phenytoin when consumed by more than three months cause gingival enlargement and clonazepam reduces patient symptomatology up to70%. Therefore, in order to improve the quality of life of patients suffering with chronic pain, the anticonvulsant drugs were introduced to the pharmaceutical market. As this problem is extremely subjective and individual, there must be scientific evidence to correctly perform the diagnosis and treatment of this condition.

POTENTIAL OF NON-DRUG METHODS IN THE TREATMENT OF ANXIETY IN ELDERLY PATIENTS

2020 ◽  
pp. 25-30
Author(s):  
Medvedev D.S. ◽  
Yushkova I.D. ◽  
Sevrukov V.V. ◽  
Makarenko S.V.
Keyword(s):  
Quality Of Life ◽  
Elderly Patients ◽  
Social Functioning ◽  
Anxiety Symptoms ◽  
Stress Factors ◽  
Cardiovascular Pathology ◽  
Somatic Disease ◽  
Role Based ◽  
Potential Use

The results of a study aimed at assessing the potential use of millimeter therapy in the treatment of anxiety in elderly patients are presented. The aim of the study was to assess the potential use of millimeter therapy in the treatment of anxiety in elderly patients. Materials and methods. A comparative study of the effectiveness of EHF-therapy in the treatment of elderly patients with anxiety, against the background of chronic forms of coronary heart disease in the form of angina of tension of the first-third functional classes and arterial hypertension of the first or second degree of the fourth class of risk of cardiovascular complications. The total number of patients was 92 people. (men – 44, women – 48). Patients were divided into 2 groups. Patients of the clinical observation group (n = 45) during treatment of the main somatic disease additionally received EHF-therapy sessions, patients of the control group (n = 47) received only drug therapy for the somatic disease and phytotherapeutic drugs to alleviate anxiety symptoms. To assess the dynamics of anxiety and quality of life, a brief questionnaire SF-36 was used. Results and discussion. Before treatment, patients in the main group had reduced quality of life indicators on the scales: general health (GH) by 31.3 ± 2.0 points, role-based functioning (RP) - by 24.2 ± 3.1 points, pain (P) - by 20.6 ± 4.2 points, physical functioning (PF) - by 23.8 ± 2.0 points, vitality (VT) - by 26.1 ± 4.2 points, psychological health (MH) - by 37 , 8 ± 3.8 points, role-based emotional functioning (RE) - by 30.6 ± 3.5 points and social functioning (SF) - by 32.2 ± 2.1 points. At the end of treatment, there was a positive trend in the quality of life. It was noted that with concomitant alarming symptoms of cardiovascular pathology, the severity of cardiac pain syndrome was significantly (p < 0.05) compared with the value of the indicator before treatment, and indicators of physical and social functioning increased. Findings. It is shown that the inclusion of millimeter therapy in the treatment of anxiety in elderly patients with cardiovascular pathology contributes to a significant improvement in symptoms and quality of life. The inclusion of millimeter therapy in treatment programs improves their effectiveness, which consists in reducing the severity of anxiety symptoms in older people, and increases resistance to stress factors by forming an adequate behavioral stereotype.

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