scholarly journals Plant based Indigenous Dietary Calcium supplementation on Bone turnover markers among Peri and Postmenopausal women: A Randomised Controlled Trial

2020 ◽  
Vol 32 (4) ◽  
pp. 705-712
Author(s):  
G. Gayathri ◽  
AJ Hemamalini
Keyword(s):  
Bone Resorption ◽  
Postmenopausal Women ◽  
Calcium Supplementation ◽  
Controlled Trial ◽  
Dietary Calcium ◽  
Calcium Deficiency ◽  
Food Supplement ◽  
Dietary Calcium Intake ◽  
Bone Resorption Marker ◽  
Randomised Controlled

Background: Indigenous plant based dietary supplement that is accessible and safer may help to combat the more proclaimed calcium deficiency among Indian population and improve bone strength. Aim & Objective: To formulate an indigenous calcium rich food supplement and study its impact on markers of bone resorption and formation. Settings and Design: Sixty subjects (80% power, α = 0.05) including 30 perimenopausal and postmenopausal women each were randomly assigned to control and experimental groups. Methods and Material: Experimental postmenopausal and perimenopausal women received 1200mg and 800mg per day of calcium respectively from a plant based supplement comprising Sesamum indicum, Eleusine coracana, Glycine max Vigna mungo and Sesbania grandiflora as a midmorning and evening snack. Measures like serum calcium, betacrosslaps (bone resorption marker), total P1NP (bone formation marker) were assessed at baseline, 3rd and 6th month. Results: Fifty-seven subjects were analysed with no adverse events were reported. Results showed that after supplementation betacrosslaps reduced from 0.32±0.130 ng/ml to 0.25±0.130 ng/ml and 1.11±0.290 ng/ml to 0.42±0.263 ng/ml in perimenopausal and postmenopausal subjects significant at (P=0.008) and (P=0.012) respectively. Conclusions: Adequate dietary calcium intake using locally available foods is recommended as a strategic option in reducing risk of osteoporosis.

scholarly journals Dietary Calcium Intake and Bone Loss Over 6 Years in Osteopenic Postmenopausal Women

2019 ◽  
Vol 104 (8) ◽  
pp. 3576-3584 ◽  
Author(s):  
Sarah M Bristow ◽  
Anne M Horne ◽  
Greg D Gamble ◽  
Borislav Mihov ◽  
Angela Stewart ◽  
...  
Keyword(s):  
Bone Loss ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Calcium Intake ◽  
Controlled Trial ◽  
Hormone Replacement ◽  
Dietary Calcium ◽  
Dietary Calcium Intake ◽  
Mineral Density ◽  
Total Body

Abstract Context Calcium intakes are commonly lower than the recommended levels, and increasing calcium intake is often recommended for bone health. Objective To determine the relationship between dietary calcium intake and rate of bone loss in older postmenopausal women. Participants Analysis of observational data collected from a randomized controlled trial. Participants were osteopenic (hip T-scores between −1.0 and −2.5) women, aged >65 years, not receiving therapy for osteoporosis nor taking calcium supplements. Women from the total cohort (n = 1994) contributed data to the analysis of calcium intake and bone mineral density (BMD) at baseline, and women from the placebo group (n = 698) contributed data to the analysis of calcium intake and change in BMD. BMD and bone mineral content (BMC) of the spine, total hip, femoral neck, and total body were measured three times over 6 years. Results Mean calcium intake was 886 mg/day. Baseline BMDs were not related to quintile of calcium intake at any site, before or after adjustment for baseline age, height, weight, physical activity, alcohol intake, smoking status, and past hormone replacement use. There was no relationship between bone loss and quintile of calcium intake at any site, with or without adjustment for covariables. Total body bone balance (i.e., change in BMC) was unrelated to an individuals’ calcium intake (P = 0.99). Conclusions Postmenopausal bone loss is unrelated to dietary calcium intake. This suggests that strategies to increase calcium intake are unlikely to impact the prevalence of and morbidity from postmenopausal osteoporosis.

scholarly journals Supplementation with a low–moderate dose ofn-3 long-chain PUFA has no short-term effect on bone resorption in human adults

2010 ◽  
Vol 105 (8) ◽  
pp. 1145-1149 ◽  
Author(s):  
K. M. Appleton ◽  
W. D. Fraser ◽  
P. J. Rogers ◽  
A. R. Ness ◽  
J. H. Tobias
Keyword(s):  
Bone Resorption ◽  
Controlled Trial ◽  
Bone Resorption Marker ◽  
Serum Samples ◽  
Pufa Supplementation ◽  
Adult Men ◽  
Chain Pufa ◽  
Human Adults ◽  
Randomised Controlled ◽  
The Impact

Previous research suggests thatn-3 PUFA may play a role in bone health. The present analysis aimed to investigate the impact ofn-3 PUFA supplementation on bone resorption in adult men and women. Serum samples from 113 mild–moderately depressed individuals (twenty-six males and eighty-seven females, aged 18–67 years) randomised to receive 1·48 g EPA+DHA/d (n53) or placebo (n60) for 12 weeks as part of a large recent randomised controlled trial were assayed forn-3 PUFA status and a bone resorption marker, C-terminal cross-linking telopeptide of type 1 collagen (β-CTX). Regression analyses revealed thatn-3 PUFA status following supplementation was associated with randomisation (placebo/n-3 PUFA) (B = 3·25, 95 % CI 2·60, 3·91,P < 0·01). However, β-CTX status following supplementation was not associated with randomisation (B = − 0·01, 95 % CI − 0·03, 0·04). Change in β-CTX status was also not associated with change inn-3 PUFA status (B = − 0·002, 95 % CI − 0·01, 0·01). These findings provide no evidence for an association betweenn-3 PUFA supplementation (1·48 g EPA+DHA/d) for 12 weeks and bone resorption in humans assessed by β-CTX, and suggest thatn-3 PUFA supplementation may be unlikely to be of benefit in preventing bone loss.

Increasing child consumption of calcium through parents: A randomised controlled trial

2021 ◽  
pp. 1-26
Author(s):  
Jessica E. Bourne ◽  
Kathleen A. Martin Ginis ◽  
Andrea C. Buchholz ◽  
Skylar Schmidtke ◽  
Mary E. Jung
Keyword(s):  
Randomised Controlled Trial ◽  
Calcium Intake ◽  
Controlled Trial ◽  
Food Choices ◽  
Dietary Calcium ◽  
Dietary Calcium Intake ◽  
Dietary Advice ◽  
Randomised Controlled ◽  
Total Calcium Intake ◽  
Intervention Condition

Abstract Objectives: Approximately 25% of Canadian children aged 4-8 years fail to meet the recommended dietary allowance (RDA) of calcium. Young children’s food choices are primarily determined by their parents. No interventions have directly targeted parents as a medium through which to increase children’s calcium consumption. This study compared the effectiveness of a calcium-specific intervention targeted towards parents, to generic dietary advice on the calcium consumption of children aged 4-10 years. Design: A parallel 2-arm randomised controlled trial was conducted. Setting: The study was conducted across Canada. Both conditions received information on the RDA of calcium and an index of intake requirements. Material sent to the intervention condition included behavioural strategies to increase dietary calcium consumption, information on the benefits of dietary calcium intake, and messages addressing perceived barriers to the consumption of calcium-rich foods. Participants: A total of 239 parents (93% mothers) of children aged 4-10 years who consumed less than the RDA of calcium were randomly assigned in a 1:1 allocation ratio. Results: There was a significant increase in total calcium intake and calcium from dairy for children at weeks 8, 34 and 52 (ps ≤.001) in both conditions. Parental calcium intake and amount spent on dairy products did not significantly increase following the intervention. Conclusion: Provision of daily calcium requirements with regular reminders could impact parents’ delivery of calcium-rich foods to their children. This finding is important for public health messaging as it suggests that parents are a potent medium through which to promote calcium intake in children.

scholarly journals No Interaction Effect between Interleukin-6 Polymorphisms and Acid Ash Diet with Bone Resorption Marker in Postmenopausal Women

2021 ◽  
Vol 18 (2) ◽  
pp. 827
Author(s):  
Sook Yee Lim ◽  
Yoke Mun Chan ◽  
Vasudevan Ramachandran ◽  
Zalilah Mohd Shariff ◽  
Yit Siew Chin ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Postmenopausal Women ◽  
Interaction Effect ◽  
Interleukin 6 ◽  
Gene Polymorphisms ◽  
Bone Resorption Marker ◽  
Dietary Intakes ◽  
Dietary Acid Load ◽  
Dietary Acid ◽  
Acid Load

Background: Evidence is growing that a high-acid diet might accelerate the rate of bone loss, and gene polymorphisms such as Interleukin 6 (IL6) -174G/C and -572G/C are related to bone deterioration. However, no study of the interaction between diet and IL6 polymorphisms has been conducted among Asians. Thus, the objective of this study was to determine whether IL6 gene polymorphisms modified the association between dietary acidity and the rate of bone resorption. Methods: This cross-sectional study recruited 203 postmenopausal women (age ranged from 51 to 85 years old) in community settings. The dietary intakes of the participants were assessed using a validated interviewer-administered semi-quantitative food frequency questionnaire (FFQ), while dietary acid load (DAL) was estimated using net endogenous acid production (NEAP). Agena® MassARRAY genotyping analysis and serum collagen type 1 cross-linked C-telopeptide (CTX1) were used to identify the IL6 genotype and as a bone resorption marker, respectively. The interactions between diet and single-nucleotide polymorphisms (SNPs) were assessed using linear regressions. Results: A total of 203 healthy postmenopausal women aged between 51 and 85 years participated in this study. The mean BMI of the participants was 24.3 kg/m2. In IL6 -174 G/C, all the participants carried the GG genotype, while the C allele was absent. Approximately 40% of the participants had a high dietary acid load. Dietary acid load (B = 0.15, p = 0.031) and the IL6 -572 CC genotype group (B = 0.14, p = 0.044) were positively associated with a higher bone resorption. However, there was no moderating effect of the IL6 genetic polymorphism on the relationship between and acid ash diet and bone resorption markers among the postmenopausal women (p = 0.79). Conclusion: High consumption of an acid ash diet and the IL6 -572 C allele seem to attribute to high bone resorption among postmenopausal women. However, our finding does not support the interaction effect of dietary acidity and IL6 (-174G/C and -572G/C) polymorphisms on the rate of bone resorption. Taken together, these results have given scientific research other candidate genes to focus on which may interact with DAL on bone resorption, to enhance planning for preventing or delaying the onset of osteoporosis among postmenopausal women.

scholarly journals Dietary Calcium Intake and Calcium Supplementation in Hungarian Patients with Osteoporosis

2013 ◽  
Vol 2013 ◽  
pp. 1-8
Author(s):  
Gábor Speer ◽  
Pál Szamosujvári ◽  
Péter Dombai ◽  
Katalin Csóré ◽  
Kinga Mikófalvi ◽  
...  
Keyword(s):  
Dietary Intake ◽  
Calcium Intake ◽  
Calcium Supplementation ◽  
Dietary Calcium ◽  
Dietary Calcium Intake ◽  
Current Recommendation ◽  
High Calcium Intake ◽  
Osteoporosis Therapy ◽  
Average Intake ◽  
High Calcium

Purpose. Adequate calcium intake is the basis of osteoporosis therapy—when this proves insufficient, even specific antiosteoporotic agents cannot exert their actions properly.Methods. Our representative survey analyzed the dietary intake and supplementation of calcium in 8033 Hungarian female and male (mean age: 68 years) (68.01 (CI95: 67.81–68.21)) patients with osteoporosis.Results. Mean intake from dietary sources was665±7.9 mg (68.01 (CI95: 67.81–68.21)) daily. A significant positive relationship could be detected between total dietary calcium intake and lumbar spine BMD (P=0.045), whereas such correlation could not be demonstrated with femoralT-score. Milk consumption positively correlated with femur (P=0.041), but not with lumbar BMD. The ingestion of one liter of milk daily increased theT-score by 0.133. Average intake from supplementation was558±6.2 mg (68.01 (CI95: 67.81–68.21)) daily. The cumulative dose of calcium—from both dietary intake and supplementation—was significantly associated with lumbar (r=0.024,P=0.049), but not with femur BMD (r=0.021,P=0.107). The currently recommended 1000–1500 mg total daily calcium intake was achieved in 34.5% of patients only. It was lower than recommended in 47.8% of the cases and substantially higher in 17.7% of subjects.Conclusions. We conclude that calcium intake in Hungarian osteoporotic patients is much lower than the current recommendation, while routinely applied calcium supplementation will result in inappropriately high calcium intake in numerous patients.

scholarly journals Randomised controlled trial to investigate the effectiveness of local oestrogen treatment in postmenopausal women undergoing pelvic organ prolapse surgery (LOTUS): a pilot study to assess feasibility of a large multicentre trial

BMJ Open ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. e025141
Author(s):  
Tina Sara Verghese ◽  
Lee Middleton ◽  
Versha Cheed ◽  
Lisa Leighton ◽  
Jane Daniels ◽  
...  
Keyword(s):  
Pelvic Organ Prolapse ◽  
Randomised Controlled Trial ◽  
Postmenopausal Women ◽  
Controlled Trial ◽  
Pilot Trial ◽  
Pelvic Organ ◽  
Oestrogen Treatment ◽  
Pop Surgery ◽  
Randomised Controlled ◽  
Oestrogen Supplementation

ObjectiveTo evaluate the feasibility of a multicentre randomised controlled trial (RCT) comparing oestrogen treatment with no oestrogen supplementation in women undergoing pelvic organ prolapse (POP) surgery.Design and settingA randomised, parallel, open, external pilot trial involving six UK urogynaecology centres (July 2015–August 2016).ParticipantsPostmenopausal women with POP opting for surgery, unless involving mesh or for recurrent POP in same compartment.InterventionWomen were randomised (1:1) to preoperative and postoperative oestrogen or no treatment. Oestrogen treatment (oestradiol hemihydrate 10 μg vaginal pessaries) commenced 6 weeks prior to surgery (once daily for 2 weeks, twice weekly for 4 weeks) and twice weekly for 26 weeks from 6 weeks postsurgery.Outcome measuresThe main outcomes were assessment of eligibility and recruitment rates along with compliance and data completion. To obtain estimates for important aspects of the protocol to allow development of a definitive trial.Results325 women seeking POP surgery were screened over 13 months and 157 (48%) were eligible. Of these, 100 (64%) were randomised, 50 to oestrogen and 50 to no oestrogen treatment, with 89 (44/45 respectively) ultimately having surgery. Of these, 89% (79/89) returned complete questionnaires at 6 months and 78% (32/41) reported good compliance with oestrogen. No serious adverse events were attributable to oestrogen use.ConclusionsA large multicentre RCT of oestrogen versus no treatment is feasible, as it is possible to randomise and follow up participants with high fidelity. Four predefined feasibility criteria were met. Compliance with treatment regimens is not a barrier. A larger trial is required to definitively address the role of perioperative oestrogen supplementation.Trial registration numberISRCTN46661996.

scholarly journals Resistance training decreases plasma levels of adipokines in postmenopausal women

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Liam J. Ward ◽  
Sigrid Nilsson ◽  
Mats Hammar ◽  
Lotta Lindh-Åstrand ◽  
Emilia Berin ◽  
...  
Keyword(s):  
Resistance Training ◽  
Postmenopausal Women ◽  
Sex Hormones ◽  
Plasma Levels ◽  
Controlled Trial ◽  
Venous Blood ◽  
Sex Hormone Binding Globulin ◽  
Vasomotor Symptoms ◽  
Lipocalin 2 ◽  
Randomised Controlled

AbstractPhysical inactivity and the onset of menopause increase the risk of cardiovascular disease amongst postmenopausal women. We aim to investigate the effect of resistance training (RT) on plasma levels of selected cytokines, adipokines, myokines, and sex hormones in postmenopausal women with vasomotor symptoms. This was a sub-study of a randomised controlled trial investigating the effects of RT on vasomotor symptoms in postmenopausal women. Women were randomised to join a 15-week RT program (n = 26) or remain sedentary as control (n = 29). Venous blood samples were taken at week-0 and week-15 for all participants. Enzyme-linked immunosorbent assays and multiple bead assays were used to measure cytokines, adipokines, myokines, and sex hormones in plasma. Plasma measurements of 16 of 33 analytes were within detectable limits. After adjusting for good compliance in the RT group (58% of RT participants), after 15 weeks, significantly lower plasma levels of adiponectin (p < 0.001), lipocalin-2 (p < 0.01) and resistin (p = 0.04) were found. Comparing control and RT women, using change-over-time values, significant increases in median testosterone and sex hormone binding globulin levels were seen in RT women. RT intervention lowers the levels of adipokines, particularly adiponectin, in postmenopausal women with vasomotor symptoms. These results were secondary outcomes of a clinical trial, and further investigations in a larger cohort are essential with the additional control of diet control and body composition analyses. Nevertheless, our study shows RT may be a beneficial intervention in reducing inflammation amongst postmenopausal women.

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