scholarly journals Effect of astaxanthin on malondialdehyde level in damaged cerebral cortex tissue in male rat (Rattus norvegicus) induced by formaldehyde orally

2021 ◽  
Vol 129 (s2) ◽  
Author(s):  
Erik Ahmad Hasyim ◽  
Virhan Novianry ◽  
Mistika Zakiah ◽  
Andriani ◽  
Dyan Roshinta Laksmi Dewi
Keyword(s):  
Oxidative Stress ◽  
Cerebral Cortex ◽  
Human Body ◽  
Rattus Norvegicus ◽  
Male Rat ◽  
Cerebral Cortex Tissue

Background: Malondialdehyde (MDA) is a dialdehyde substance that is the final product of lipids peroxidation in the human body, and it can be used as a biomarker of oxidative stress. One of the most potent antioxidants known nowadays is astaxanthin. This study aims to investigate the effect of astaxanthin on the MDA level in cerebral cortex tissue of Rattus norvegicus, which was given oral formaldehyde.

scholarly journals Radioprotective and Radiomitigative Effects of Melatonin in Tissues with Different Proliferative Activity

Antioxidants ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 1885
Author(s):  
Serazhutdin A. Abdullaev ◽  
Sergey I. Glukhov ◽  
Azhub I. Gaziev
Keyword(s):  
Oxidative Stress ◽  
Cerebral Cortex ◽  
Proliferative Activity ◽  
Nuclear Dna ◽  
Significant Proportion ◽  
Spleen Tissue ◽  
X Ray ◽  
Mouse Tissues ◽  
Baseline Values ◽  
Cerebral Cortex Tissue

We used various markers to analyze damage to mouse tissues (spleen and cerebral cortex) which have different proliferative activity and sensitivity to ionizing radiation (IR). We also assessed the degree of modulation of damages that occurs when melatonin is administered to mice prior to and after their X-ray irradiation. The data from this study showed that lesions in nuclear DNA (nDNA) were repaired more actively in the spleen than in the cerebral cortex of mice irradiated and treated with melatonin (N-acetyl-5-methoxytryptamine). Mitochondrial biogenesis involving mitochondrial DNA (mtDNA) synthesis was activated in both tissues of irradiated mice. A significant proportion of the newly synthesized mtDNA molecules were mutant copies that increase oxidative stress. Melatonin reduced the number of mutant mtDNA copies and the level of H2O2 in both tissues of the irradiated mice. Melatonin promoted the restoration of ATP levels in the tissues of irradiated mice. In the mouse tissues after exposure to X-ray, the level of malondialdehyde (MDA) increased and melatonin was able to reduce it. The MDA concentration was higher in the cerebral cortex tissue than that in the spleen tissue of the mouse. In mouse tissues following irradiation, the glutathione (GSH) level was low. The spleen GSH content was more than twice as low as that in the cerebral cortex. Melatonin helped restore the GSH levels in the mouse tissues. Although the spleen and cerebral cortex tissues of mice differ in the baseline values of the analyzed markers, the radioprotective and radiomitigative potential of melatonin was observed in both tissues.

scholarly journals PENGARUH PEMBERIAN EKSTRAK KULIT SEMANGKA (Citrullus lanatus) TERHADAP MOTILITAS DAN VIABILITAS SPERMATOZOA TIKUS (Rattus norvegicus) DENGAN PAPARAN SUHU PANAS

2020 ◽  
Vol 7 (2) ◽  
pp. 131
Author(s):  
Lailatul Rohmah ◽  
Indah Norma Triana ◽  
Agus Sunarso ◽  
Suherni Susilowati ◽  
Nove Hidajati ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Free Radicals ◽  
High Temperatures ◽  
Rattus Norvegicus ◽  
Citrullus Lanatus ◽  
Male Rat

High temperatures lead to oxidative stress which can decrease the quality of spermatozoa. Watermelon’s rind have an ability for antioxidants effect that can reduce sperm’s damages that results by role explanation of free radicals. This study aimed to determine the effect of extract of watermelon’s rind on the motility and viability of sperm on male rat exposed to heat. This experiments use rat as animals experiment with five treatments and four repetitions. Five treatments are: P0: without exposured to 40˚C of temperature and without treatment by extract watermelon’s rind, P1: was exposured to 40˚C of temperature and without treatment by extract watermelon’s rind, P2: was exposured to 40˚C of temperature and treatments by extract watermelon’s rind dosage 20 mg/rat/day, P3: was exposured to 40˚C of temperature and treatments by extract watermelon’s rind dosage 40 mg/rat/day, and P4: was exposured to 40˚C of temperature and treatments by extract watermelon’s rind dosage 80 mg/rat/day. The treatment was done for 52 days. The results, P4 have the best effect that can be increase the motility and viability of rat’s sperm (Rattus norvegicus) exposed to heat.

Overtraining of aerobic physical exercise reduce rats (Rattus norvegicus) memory

2020 ◽  
Vol 14 (1) ◽  
Author(s):  
Ni Made Ridla Parwata
Keyword(s):  
Body Weight ◽  
Physical Exercise ◽  
Rattus Norvegicus ◽  
Research Method ◽  
Male Rat ◽  
Control Group ◽  
Adult Male Rat ◽  
The Subject ◽  
Heavy Training

Overtraining syndrome is a decrease in physical capacity, emotions and immunity due to training that is too often without adequate periods of rest. Overtraining is often experienced by athletes who daily undergo heavy training with short break periods. This research aims to look at the effect of overtraining aerobic physical exercise on memory in mice. The research method was experimental in vivo with the subject of adult male rat (Rattus Norvegicus) Winstar strain aged 8-10 weeks, body weight 200-250 gr. Divided into three groups, namely the control group, aerobic group and overtraining group. The results of memory tests with water E Maze showed an increase in the duration of travel time and the number of animal errors made by the overtraining group (p = 0.003). This study concludes that overtraining aerobic physical exercise can reduce memory in rat hippocampus.

Effect of Acute Administration of 3-Butyl-1-Phenyl-2-(Phenyltelluro)Oct-En-1-One on Oxidative Stress in Cerebral Cortex, Hippocampus, and Cerebellum of Rats

2010 ◽  
Vol 30 (7) ◽  
pp. 1135-1142 ◽  
Author(s):  
Cláudia Funchal ◽  
Carlos Augusto Souza Carvalho ◽  
Tanise Gemelli ◽  
Andressa S. Centeno ◽  
Robson Brum Guerra ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cerebral Cortex ◽  
Acute Administration

scholarly journals Histopathological Assessment of the Effect of Pregabalin Toxicity on Cerebrum and Cerebellum of Adult Albino Rats

2021 ◽  
Author(s):  
Wael Abdou Hassan ◽  
Shaimaa Shehata ◽  
Ahmad ElBana
Keyword(s):  
Cerebral Cortex ◽  
Acute Toxicity ◽  
Chronic Toxicity ◽  
Control Group ◽  
Albino Rats ◽  
Histopathological Study ◽  
Addictive Behaviors ◽  
Group 3 ◽  
Group 2 ◽  
Cerebral Cortex Tissue

Abstract Background: Pregabalin (PGB) used as analgesic in treatment of neurogenic pains of chronic diseases, is considered as one of the most abused anti-epileptic drugs worldwide and it has been proved that it induces addictive behaviors. The present histopathological study aimed to identify the effect of PGB administration on cerebral cortex and cerebellar cortex, in both acute and chronic toxicity. Seventy-two male and non-pregnant female adult albino rats’ 6- to 8-week-old divided into 3 main groups of 24 rats each were studied. Group 1 represented the control group and group 2 represented the acute toxicity group, in which rats were given a single dose of PGB (5000 mg/kg) orally by gavage and after 24 hours, rats were sacrificed and examined. Group 3 represented the chronic toxicity group; were given PGB 500 mg/kg orally by gavage for 12 weeks, after which rats were sacrificed and examined. Result: Cerebral cortex tissue of acute toxicity group displayed astrocytosis and dystrophic changes, while in chronic group showed degeneration, necrosis and cellular infiltrates. The cerebellum of chronic groups showed degeneration and shrunken of Purkinje cells. Conclusion: Acute and chronic intoxication with pregabalin adversely altered the structure of cerebral cortex and cerebellum.

scholarly journals Colorimetry-Based Detection of Nitric Oxide from Exhaled Breath for Quantification of Oxidative Stress in Human Body

Healthcare ◽  
2021 ◽  
Vol 9 (8) ◽  
pp. 1055
Author(s):  
Muni Raj Maurya ◽  
Haseena Onthath ◽  
Hagar Morsy ◽  
Najam-US-Sahar Riyaz ◽  
Muna Ibrahim ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Human Body ◽  
Ph Effect ◽  
High Sensitivity ◽  
Fast Response ◽  
The Body ◽  
Bromophenol Blue ◽  
Exhaled Breath ◽  
Vis Spectroscopy

Monitoring exhaled breath is a safe, noninvasive method for determining the health status of the human body. Most of the components in our exhaled breath can act as health biomarkers, and they help in providing information about various diseases. Nitric oxide (NO) is one such important biomarker in exhaled breath that indicates oxidative stress in our body. This work presents a simple and noninvasive quantitative analysis approach for detecting NO from exhaled breath. The sensing is based on the colorimetric assisted detection of NO by m-Cresol Purple, Bromophenol Blue, and Alizaringelb dye. The sensing performance of the dye was analyzed by ultraviolet–visible (UV–Vis) spectroscopy. The study covers various sampling conditions like the pH effect, temperature effect, concentration effect, and selective nature of the dye. The m-Cresol Purple dye exhibited a high sensitivity towards NO with a detection limit of ~0.082 ppm in the linear range of 0.002–0.5 ppm. Moreover, the dye apprehended a high degree of selectivity towards other biocompounds present in the breath, and no possible interfering cross-reaction from these species was observed. The dye offered a high sensitivity, selectivity, fast response, and stability, which benchmark its potential for NO sensing. Further, m-Cresol Purple dye is suitable for NO sensing from the exhaled breath and can assist in quantifying oxidative stress levels in the body for the possible detection of COVID-19.

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