scholarly journals The Covid-19 Effects on the Cardiovascular System; A Focus on Myocarditis

2021 ◽  
pp. 1-4
Author(s):  
Praise Chovwen ◽  
◽  
Ibukunoluwa Oshobu ◽  
Keyword(s):  
Cardiovascular System ◽  
Preventive Care ◽  
Cardiac Injury ◽  
Cardiovascular Effects ◽  
System A ◽  
Global Pandemic ◽  
Care And Treatment ◽  
The Relationship

The WHO declared COVID 19 a global pandemic on March 11, 2020. The effect the virus has created in various aspects of our lives has made it of primary importance that we understand its pathophysiology, complication, preventive care, and treatment. A significant number of COVID patients develop some form of cardiac injury, whether while infected or after recovery. In this article, we aim to discuss these aspects and expand further on the cardiovascular effects seen in COVID 19 infected patients, emphasizing myocarditis. We discuss the case of a patient who developed cardiac injuries while infected with COVID 19, which she contacted 18 days after receiving the first dose of the COVID mRNA vaccine. This article provides more understanding of the relationship between COVID-19 and the heart.

Cardiovascular disease in the literature: A selection of recent original research papers (Preprint)

2020 ◽  
Author(s):  
Fadi Hage
Keyword(s):  
Cardiovascular Disease ◽  
Cardiovascular System ◽  
Respiratory Infections ◽  
Current Knowledge ◽  
Cardiac Injury ◽  
Cardiovascular Effects ◽  
Health Science ◽  
World Health ◽  
Original Research ◽  
Investigational Therapies

UNSTRUCTURED Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been declared a pandemic with devastating effects on the entire world. Madjid et al. from the University of Texas Health Science, Houston, Texas review current information on the virus and COVID-19 and its effects on the cardiovascular system. Coronaviruses, classified in 4 groups, were first identified in humans in the 1960s with 4 types (all from the α and β classes) are endemic in humans usually causing mild and self-limiting upper respiratory infections accounting for 15-30% of common colds. Both SARS (caused by SARS-CoV) and Middle East respiratory syndrome (MERS, caused by MERS-CoV) caused outbreaks (in 2002 and 2012, respectively) that had higher fatality rates but were much less widespread than COVID-19. SARS-CoV-2 is genetically more similar to SARS-CoV (82%) than MERS-CoV (50%). The virus has a mean incubation period of 5.2 days (95%CI, 4.1-7.0 days), with the 95th percentile of the distribution at 12.5 days according to one study and up to 14 days according to another. The World Health Organization reported a global mortality rate of 3.4% but importantly, this rate varies by location, intensity of transmission, variations of care, presence of comorbidities (including cardiovascular disease), advanced age, and likely other factors. The primary symptoms of COVID-19 are fever, cough, and shortness of breath. Acute cardiac injury determined by elevated high-sensitivity troponin levels is commonly observed in severe cases and is strongly associated with mortality, complications such as acute respiratory distress syndrome, arrhythmia, renal injury, and coagulopathy. There has been reported cases of viral infiltration of the myocardium causing myocarditis. Myocardial injury can also be caused by ischemia. It is important to note that COVID-19 in addition to inducing new cardiac pathologies (such as myocarditis) may also exacerbate pre-existing cardiovascular disease. Finally, some of the investigational therapies for COVID-19 may have cardiovascular effects. Current treatment, until investigational therapies have been shown to be effective, is supportive care and treatment of complications. The article offers a wonderful review of current knowledge on COVID-19 as well as a review of SARS and MERS which provide further insights on the effects of coronaviruses on the cardiovascular system.

COVID-19: Update on Pathogenesis and Treatment Strategies

2020 ◽  
Vol 16 (1) ◽  
pp. 1-5
Author(s):  
Rakesh K. Chauhan ◽  
Pramod K. Sharma ◽  
Shikha Srivastava
Keyword(s):  
Monoclonal Antibody ◽  
Plasma Membrane ◽  
Human Monoclonal Antibody ◽  
Cardiac Injury ◽  
Treatment Strategies ◽  
Severe Pneumonia ◽  
Ground Glass Opacity ◽  
Golgi Membrane ◽  
Virus Particles ◽  
Global Pandemic

COVID-19 (Coronavirus disease) is the most contagious virus, which has been characterized as a global pandemic by WHO. The pathological cycle of COVID-19 virus can be specified as RNAaemia, severe pneumonia, along with the Ground-glass opacity (GGO), and acute cardiac injury. The S protein of Coronavirus has been reported to be involved in the entry of the virus into the host cell, which can be accomplished by direct membrane fusion between the virus and plasma membrane. In the endoplasmic reticulum or Golgi membrane, the newly formed enveloped glycoproteins are introduced. The spread of disease occurs due to contact and droplets unleashed by the vesicles holding the virus particles combined with the plasma membrane to the virus released by the host. The present manuscript describes the pathogenesis of COVID-19 and various treatment strategies that include drugs such as chloroquine and hydroxychloroquine, an anti-malarial drug, antibodies: SARS-CoV-specific human monoclonal antibody CR3022 and plasma treatment facilitate the therapeutic effect.

scholarly journals Stabilizing interventional instruments in the cardiovascular system: A classification of mechanisms

2021 ◽  
Vol 89 ◽  
pp. 22-32
Author(s):  
Awaz Ali ◽  
Dimitra Dodou ◽  
Gerwin Smit ◽  
Ruben Rink ◽  
Paul Breedveld
Keyword(s):  
Cardiovascular System ◽  
System A

scholarly journals ACE2 Is an Adjacent Element of Atherosclerosis and COVID-19 Pathogenesis

2021 ◽  
Vol 22 (9) ◽  
pp. 4691
Author(s):  
Anastasia V. Poznyak ◽  
Evgeny E. Bezsonov ◽  
Ali H. Eid ◽  
Tatyana V. Popkova ◽  
Ludmila V. Nedosugova ◽  
...  
Keyword(s):  
Cardiovascular System ◽  
Renin Angiotensin System ◽  
Myocardial Damage ◽  
Angiotensin Converting Enzyme 2 ◽  
Adjacent Element ◽  
Chinese Province ◽  
Coronavirus Infection ◽  
First Time ◽  
The Relationship ◽  
Interspecies Barrier

COVID-19 is a highly contagious new infection caused by the single-stranded RNA Sars-CoV-2 virus. For the first time, this infection was recorded in December 2019 in the Chinese province of Wuhan. The virus presumably crossed the interspecies barrier and passed to humans from a bat. Initially, the disease was considered exclusively in the context of damage to the respiratory system, but it quickly became clear that the disease also entails serious consequences from various systems, including the cardiovascular system. Among these consequences are myocarditis, myocardial damage, subsequent heart failure, myocardial infarction, and Takotsubo syndrome. On the other hand, clinical data indicate that the presence of chronic diseases in a patient aggravates the course and outcome of coronavirus infection. In this context, the relationship between COVID-19 and atherosclerosis, a condition preceding cardiovascular disease and other disorders of the heart and blood vessels, is particularly interesting. The renin-angiotensin system is essential for the pathogenesis of both coronavirus disease and atherosclerosis. In particular, it has been shown that ACE2, an angiotensin-converting enzyme 2, plays a key role in Sars-CoV-2 infection due to its receptor activity. It is noteworthy that this enzyme is important for the normal functioning of the cardiovascular system. Disruptions in its production and functioning can lead to various disorders, including atherosclerosis.

scholarly journals Relations Between Safety and Security in Technical Systems

2007 ◽  
Vol 3 (1) ◽  
pp. 63-73 ◽  
Author(s):  
Zbigniew Smalko
Keyword(s):  
Decision Maker ◽  
Machine System ◽  
System A ◽  
The Subject ◽  
Technical Systems ◽  
Machine Control ◽  
The Relationship

Relations Between Safety and Security in Technical Systems The subject of this paper deals with the relationship between safety and security of the man - machine system. In the above system a man can act both as a decision - maker and operator. His desired psychophysical efficiency lies in the undertaking the correct decisions as well as in the skilful machine control and operating.

Fear, history, stigma, and bias in the COVID-19 pandemic

2020 ◽  
Vol 18 (7) ◽  
pp. 177-182
Author(s):  
Kevin Kupietz, PhD ◽  
Lesley Gray, MPH
Keyword(s):  
Emergency Management ◽  
Disease Outbreaks ◽  
Social Effects ◽  
Evidence Based ◽  
Stigma And Discrimination ◽  
Emergency Managers ◽  
Global Pandemic ◽  
New Concepts ◽  
History Of ◽  
The Relationship

Introduction: The greatest enemy of a global pandemic is not the virus itself, but the fear, rumor, and stigma that envelopes people. This article explores the context and history of fear and stigma relating to pandemic, summarizing key actions to mitigate the harms during an active pandemic.Method: Our article draws from accounts in literature and journalist accounts documenting the relationship between infectious diseases and major disease outbreaks that have garnered fear and stigmatization. Results: Fear, stigma, and discrimination are not new concepts for pandemics. These social effects run the risk of diverting attention from the presenting disease and government responses. Reactions to fear, stigma, and discrimination risk sabotaging effective efforts to contain, manage, and eradicate the disease.Conclusion: Emergency managers have an important role in dispelling myths, disseminating appropriate and evidence-based information without exacerbating fears. Knowledge about the roots of fear and bias along with a good understanding of historical plagues and pandemics is vital to ensure those in the field of emergency management can effectively manage irrational fears.

scholarly journals Evaluation of laparoscopic vs robotic partial nephrectomy using the margin, ischemia and complications score system: a retrospective single center analysis

2015 ◽  
Vol 87 (1) ◽  
pp. 49 ◽  
Author(s):  
Stefano Ricciardulli ◽  
Qiang Ding ◽  
Xu Zhang ◽  
Hongzhao Li ◽  
Yuzhe Tang ◽  
...  
Keyword(s):  
Partial Nephrectomy ◽  
Risk Groups ◽  
Matched Pair ◽  
P Value ◽  
Robotic Partial Nephrectomy ◽  
Score System ◽  
Operative Outcomes ◽  
System A ◽  
Binary Regression Analysis ◽  
The Relationship

Objective: To evaluate differences between Laparoscopic Partial Nephrectomy (LPN) and Robot-Assisted Partial Nephrectomy (RAPN) using the Margin, Ischemia and Complications (MIC) score system and to evaluate factors related with MIC success. Materials and Methods: Single centre retrospective study on 258 LPN and 58 RAPN performed between January 2012 and January 2014. Success was defined when surgical margins was negative, Warm Ischemia Time (WIT) was ≤ 20 minutes and no major complications occurred. Mann-Whitney-U and Pearson χ2 correlation were used to compare LPN and RAPN. A matched pair comparison was also performed. Spearman correlation (Rho) was used to evaluate the relationship between clinical, intra and post-operative and pathological patients characteristics with MIC score. A binary regression analysis was also performed to evaluate independent factors associated with MIC success. Results: The MIC rate in LPN and RAPN was 55% and 65.5% respectively. No differences in clinical, intra and post-operative outcomes between groups were found. Clinical tumor size (p-value: < 0.001; OR: 0.829; 95% CI: 0.697-0.987), PADUA score (p-value: < 0.001; OR: 0.843; 95% CI: 0.740-0.960), PADUA risk groups (intermediate; p-value: < 0.001; OR: 0.416; 95% CI: 0.238- 0.792; high: p-value: < 0.001; OR: 0.356; 95% CI: 0.199- 0.636), WIT (p-value: < 0.001; OR: 0.598; 95% CI: 0.530- 0.675) were independently associated with MIC. eGFR (< 60 vs ≥ 60 ml/min per 1.73 m2: p-value: < 0.001; OR: 3.356; 95% CI: 1.701-6.621) and Fuhrman nuclear grade (p-value: 0.014; OR: 1.798; 95% CI:1.129-2.865) were also independently associated with MIC. Conclusions: MIC score system is a simple and useful tool to report and to compare different surgical approach.

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