scholarly journals Plummer-Vinson Syndrome

2021 ◽  
pp. 1-3
Author(s):  
Mahesh S ◽  
Keyword(s):  
Weight Loss ◽  
Iron Deficiency ◽  
Children And Adolescents ◽  
Alimentary Tract ◽  
White Women ◽  
Deficiency Anemia ◽  
Clinical Aspects ◽  
Exact Data ◽  
Plummer Vinson Syndrome ◽  
Classical Triad

Plummer-Vinson syndrome is a classical triad of dysphagia, iron-deficiency anemia and esophageal webs, Plummer-Vinson or Paterson-Kelly syndrome occurs. There is no exact data on the epidemiology of the condition; the syndrome is extremely rare. Most of the patients are middle-aged white women, but the syndrome has also been identified in children and adolescents in the fourth to seventh decades of life. Over the years, dysphagia is typically painless and sporadic or incremental, restricted to solids and often related to weight loss. The association with upper alimentary tract cancers is one of the most significant clinical aspects of Plummer-Vinson syndrome. Etiopathogenesis is unknown due to Plummer-Vinson syndrome.

scholarly journals Plummer-Vinson Syndrome: A Case Report

2011 ◽  
Vol 31 (3) ◽  
pp. 254-256
Author(s):  
DS Gedam ◽  
J Mandliya ◽  
M Verma
Keyword(s):  
Case Report ◽  
Iron Deficiency ◽  
Ethnic Group ◽  
Iron Deficiency Anemia ◽  
Deficiency Anemia ◽  
White Female ◽  
Esophageal Web ◽  
Plummer Vinson Syndrome ◽  
Classical Triad

Plummer-Vinson also known as sideropenic dysphagia is a disease that is characterized by classical triad of iron deficiency anemia, dysphagia and esophageal web. It is known to mostly affect white female mainly, but cases have been reported from other ethnic group in the literature. Treatment is very promising especially when it is not associated with carcinoma. DOI: http://dx.doi.org/10.3126/jnps.v31i3.4259 J Nep Paedtr Soc 2011;31(3): 254-256

scholarly journals Gastric Cancer Accompanying Plummer-Vinson Syndrome

2020 ◽  
Vol 20 (2) ◽  
pp. 159-163
Author(s):  
Ho Joon Im ◽  
Sung Eun Kim ◽  
Moo In Park ◽  
Seun Ja Park ◽  
Won Moon ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Squamous Cell Carcinoma ◽  
Iron Deficiency ◽  
Oral Cavity ◽  
Deficiency Anemia ◽  
Iron Supplements ◽  
Precancerous Condition ◽  
Exact Data ◽  
Plummer Vinson Syndrome ◽  
Caucasian Women

Plummer-Vinson syndrome (PVS), also called sideropenic dysphagia or Paterson-Kelly syndrome, is a condition characterized by a triad of chronic iron-deficiency anemia, esophageal webs, and dysphagia. This syndrome is considered as a precancerous condition due to the occurrence of squamous cell carcinoma in the hypopharynx, upper esophagus and oral cavity. Although exact data on the prevalence of the syndrome are not evidently available, physicians need to recognize this rare syndrome. Most of the patients are elderly Caucasian women aged 40 to 70 years, but cases in children, adolescents, or men have also been described. At present, the prevalence of PVS is decreasing due to improvement in nutritional habits and intake of iron supplements. Therefore, the syndrome accompanied with gastric cancer is even more uncommon. We report a case of a 61-year-old woman with PVS who was diagnosed with gastric cancer and improved after treatment.

scholarly journals Comparative Study of the Effects of Lactoferrin versus Oral Iron Therapy in Obese Children and Adolescents with Iron Deficiency Anemia

2021 ◽  
pp. 104-114
Author(s):  
Manal Mahmoud Atia ◽  
Rasha Mohamed Gama ◽  
Mohamed Attia Saad ◽  
Mohammed Amr Hamam
Keyword(s):  
Iron Deficiency ◽  
Children And Adolescents ◽  
Iron Deficiency Anemia ◽  
Interleukin 6 ◽  
Oral Iron ◽  
Iron Therapy ◽  
Deficiency Anemia ◽  
Obese Children ◽  
Oral Iron Therapy ◽  
Serum Hepcidin

Greater prevalence of iron deficiency (ID) has been observed in overweight and obese children and adolescents. Hepcidin acts as a key regulator of iron metabolism. Hepcidin synthesis increases in response inflammatory cytokines especially Interleukin-6 (IL-6). Considering that obesity represents a low grade chronic inflammatory state, a high concentration of hepcidin has been found in obese children. Elevated hepcidin level in obese children is associated with diminished response to oral iron therapy. Lactoferrin is an iron-binding multifunctional glycoprotein and has strong capacity to modulate the inflammatory response by its capacity to reduce pro-inflammatory cytokine expression in vivo, including IL-6 and hepcidin. Aim of the Work: To compare the efficacy of lactoferrin versus oral iron therapy in treatment of obese children and adolescents with iron deficiency anemia and the effect of therapy on serum hepcidin and interleukin 6 levels. Methodology: This prospective randomized clinical trial was conducted on 40 obese children and adolescents aged between 6 –18 years suffering from iron deficiency anemia (IDA). They were equally randomized into one of 2 groups. Group A received regular oral lactoferrin in a dose of 100 mg/day. Group B received regular oral iron supplementation (Ferric hydroxide polymaltose) in a dose of 6 mg elemental iron/kg /day.Baseline investigations included complete blood count (CBC), iron profile (Serum ferritin, serum iron, total iron binding capacity (TIBC), transferrin saturation), serum Interleukin 6, and serum hepcidin. Reevaluation of CBC was done monthly while iron status parameters, serum IL-6 and serum hepcidin were reevaluated after 3 months of receiving regular therapy. Results: Significant elevations in hemoglobin, MCV, MCH, Serum ferritin, serum iron and transferrin saturation with lactoferrin therapy compared to oral iron therapy. Significantly Lower TIBC after 3 months of lactoferrin therapy while the decrease in TIBC was insignificant in the iron therapy group.Lower serum hepcidin and IL6 after 3 months of lactoferrin therapy with no significant change in serum hepcidin and IL6 after iron therapy. Conclusion: This study clearly demonstrated the superiority of lactoferrin over iron use as oral in the treatment of iron deficiency anemia in obese children not only for the better response of hematological and iron status parameters and less gastrointestinal side effects but also for its effect on decreasing inflammatory biomarkers as hepcidin and IL6.

scholarly journals Sandifer Syndrome

2021 ◽  
Vol 3 (1) ◽  
pp. 30-32
Author(s):  
Juan Gomez
Keyword(s):  
Iron Deficiency ◽  
Gastroesophageal Reflux ◽  
Children And Adolescents ◽  
Hiatal Hernia ◽  
Iron Deficiency Anemia ◽  
Gastrointestinal Disorder ◽  
Deficiency Anemia ◽  
Neurological Manifestations ◽  
Upper Gastrointestinal

Sandifer syndrome, named after neurologist Paul Sandifer, was first reported by Marcel Kinsbourne in 1962, who noted an upper gastrointestinal disorder that occurs in children and adolescents with neurological manifestations. Sandifer syndrome is a neurobehavioral disorder that causes a series of paroxysmal dystonic movements in association with gastroesophageal reflux and, in some cases, with hiatal hernia. It is characterized by esophagitis, iron deficiency anemia, and is often mistaken for a seizure of epileptic origin.

scholarly journals Estimation of iron deficiency anemia in Iranian children and adolescents: a systematic review and meta-analysis

Hematology ◽  
2016 ◽  
Vol 22 (4) ◽  
pp. 231-239 ◽  
Author(s):  
Maryam Akbari ◽  
Mahmood Moosazadeh ◽  
Reza Tabrizi ◽  
Seyed Reza Khatibi ◽  
Mahmoud Khodadost ◽  
...  
Keyword(s):  
Systematic Review ◽  
Iron Deficiency ◽  
Children And Adolescents ◽  
Iron Deficiency Anemia ◽  
Meta Analysis ◽  
Deficiency Anemia ◽  
Iranian Children

scholarly journals A Rare Case Report on Plummer-Vinson Syndrome with a Complication of Oral Cancer in a South-Asian Woman

2020 ◽  
Vol 14 (1) ◽  
Author(s):  
Ayisha Ayisha ◽  
Sheema Masood Ali
Keyword(s):  
Squamous Cell Carcinoma ◽  
Case Report ◽  
Iron Deficiency ◽  
Cell Carcinoma ◽  
Iron Deficiency Anemia ◽  
Squamous Cell ◽  
Whole Body ◽  
Deficiency Anemia ◽  
Plummer Vinson Syndrome ◽  
Increased Risk

Plummer-Vinson syndrome (PVS), also called "Paterson-Brown-Kelly syndrome“, is a rare medical syndrome generally affecting middle-aged women. Iron deficiency anemia is the prime etiological factor and other probable factors include malnutrition, genetic predisposition, or autoimmune processes characterized by three distinctive features: iron deficiency anemia, dysphagia, and esophageal web. The dysphagia is generally painless and intermittent or progressive over years, restricted to solids, and associated with weight loss. The exact pathogenesis of PVS is still indistinguishable, but it is interconnected with iron deficiency anemia. Plummer-Vinson syndrome, if left untreated, carries an increased risk of developing squamous cell carcinoma of the upper alimentary tract.In this case report, a 40-year-old female patient presented long-standing dysphagia for months, which progressively developed to postcricoid squamous cell carcinoma by the time she approached to medical treatment. Diagnosis was confirmed through laboratory tests, showing iron deficiency anemia and whole-body positron emission tomography-computed tomography (PET-CT) presenting squamous cell carcinoma in postcricoid region (hypopharynx).

Anemia ferropénica crónica: síndrome de Plummer-Vinson (Paterson-Brown-Kelly)

2021 ◽  
Vol 64 (2) ◽  
pp. 22-25
Author(s):  
Adriana Zapata González ◽  
María Elena Uc Miam ◽  
Felipe Irineo Hernández Rosales ◽  
Alberto Mandujano González ◽  
Karime Berenice Ramos Santos
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Clinical History ◽  
Deficiency Anemia ◽  
Precancerous Condition ◽  
Esophageal Web ◽  
Squamous Cell Esophageal Cancer ◽  
Plummer Vinson Syndrome ◽  
History Of ◽  
First Contact

Plummer-Vinson syndrome (Paterson-Brown-Kelly) is a rare entity, characterized by dysphagia, esophageal web formation, and iron deficiency anemia. We present the case of a 46-year-old woman with a clinical history of iron deficiency anemia who subsequently presents dysphagia and odynophagia. A subcricoid web that was successfully broken with the endoscope was found. First contact doctors should be familiar with the symptoms of Plummer-Vinson syndrome, and take them into account, when addressing a patient with the classic triad. Since the syndrome is a precancerous condition with high malignant potential, early diagnosis and treatment is of utmost importance for better prognosis. Keywords: Plummer-Vinson syndrome; chronic iron deficiency anemia; esophageal membrane; squamous cell esophageal cancer; Paterson-Brown-Kelly syndrome.

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