Life-time tobacco consumption and oral cancer among citizens of Karachi: one of the world’s highest reported incidence areas for oral squamous cell carcinoma

2021 ◽  
pp. 1-12
Author(s):  
Muhammad Mohiuddin Alamgir ◽  
Fouzia Shaikh
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Life Time ◽  
Tobacco Consumption ◽  
Tobacco Exposure ◽  
History Of ◽  
The Common ◽  
Cancerous Lesions

Abstract Objective: To analyze dose-response relationship between the common risk factor of tobacco consumption and oral lesions like squamous cell carcinoma and pre-cancerous lesions. Methods: The study comprises of 150 histologically confirmed OSCC cases, 100 cases of clinically diagnosed oral pre-cancerous lesions and 108 habit-matched controls. Life-time tobacco-exposures were calculated as tobacco indices, i.e., chewing index and smoking index, for comparison between cases and controls. Results: The age of OSCC cases ranged from 20-78 years and pre-cancerous cases from 16-78 years, mean 47.1 ± 12.22 and 34.17 ± 13.78, respectively. Of all OSCC patients 125 (83.33%) and 96 (96%) of PCL patients gave a positive history of tobacco use. 68.8% of all 250 cases were exclusive tobacco chewers which turned out to be the most prevalent tobacco habit. Exclusive smoking was seen in 11 (4.4%) cases, 38 (15.2%) patients had a mixed tobacco habit of chewing plus smoking while 29 (11.6%) were tobacco free. Tobacco indices (median values) in exclusive chewer’s category were found to be lower in cancers (150) as compared to matched controls (210) but were nearer to pre-cancers (144). In pre-cancers we found lower median values of tobacco indices for all chewers, exclusive chewers and all-smokers categories in comparison to controls, i.e., 144/200, 144/210, 10/21 respectively.  Conclusion: Life-time tobacco exposure indices were either comparable or lower in studied patients as compared to controls pointing towards the role of other etiological factors in addition to tobacco for malignant transformation of oral mucosa. Continuous...

Squamous Cell Carcinoma in Older Patients without Risk Factors

1992 ◽  
Vol 106 (3) ◽  
pp. 275-277 ◽  
Author(s):  
Minas S. Constantinides ◽  
Stephen G. Rothstein ◽  
Mark S. Persky
Keyword(s):  
Risk Factors ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Older Women ◽  
Squamous Cell ◽  
Field Cancerization ◽  
Tobacco Exposure ◽  
Upper Aerodigestive Tract ◽  
History Of ◽  
Distant Spread

Ten patients over sixty years of age with no history of tobacco or alcohol use were treated for squamous cell carcinoma of the upper aerodigestive tract between 1979 and 1991. Nine of these ten patients were women with lesions confined to the oral cavity and oropharynx. Modes of treatment included surgery, radiation, or a combination of surgery and radiation. Followup from 1 to 10 years revealed two deaths from local and distant spread, and eight patients with no evidence of disease. Recurrences after treatment were aggressive and occurred within the same region as the primary lesion. Although most patients with upper aerodigestive squamous cell carcinoma are men with alcohol and/or tobacco exposure, this study demonstrates findings consistent with field cancerization in a group of older women with no risk factors.

Occurrence of Squamous Cell Carcinoma in an Area of Lichen Simplex Chronicus: Case Report and Pathogenetic Hypothesis

2012 ◽  
Vol 16 (5) ◽  
pp. 350-352 ◽  
Author(s):  
Cesare Tiengo ◽  
Jenny Deluca ◽  
Anna Belloni-Fortina ◽  
Roberto Salmaso ◽  
Flavia Galifi ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Keratinocyte Proliferation ◽  
Lichen Simplex Chronicus ◽  
Proliferation And Differentiation ◽  
Common Skin ◽  
History Of ◽  
Repetitive Trauma

Background: Lichen simplex chronicus is a common skin disorder characterized by circumscribed, lichenified, pruritic plaque secondary to local repetitive trauma, notably rubbing and scratching. Objective: We describe a case of a squamous cell carcinoma arising in a patient with a long-lasting history of lichen simplex chronicus and discuss the potential role of the microenvironment in predisposing the malignant transformation. Conclusion: Here we propose a hypothesis in which rubbing and scratching contribute to an excess of inflammatory mediators, which in turn may lead to alterations in the processes of keratinocyte proliferation and differentiation. Renseignements de base: Le lichen simplex chronique est une affection cutanée courante caractérisée par une plaque pruritique lichénifiée circonscrite consécutive à des traumatismes locaux répétés, notamment le frottement et le grattage. Objectif: Nous décrivons un cas de carcinome squameux chez un patient présentant depuis longtemps des antécédents de lichen simplex chronique, et nous discutons du rôle potentiel du micro-environnement dans la prédisposition de la transformation maligne. Conclusion: Nous proposons ici une hypothèse selon laquelle le frottement et le grattage contribuent à un excès de médiateurs inflammatoires, lesquels peuvent à leur tour venir modifier les processus de prolifération et de différenciation des kératinocytes.

Squamous cell carcinoma of the maxillary antrum metastatic to the heart and skin

1994 ◽  
Vol 108 (10) ◽  
pp. 896-897 ◽  
Author(s):  
R. J. Calvert ◽  
C. M. Quinn
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Maxillary Antrum ◽  
Disease Process ◽  
Autopsy Examination ◽  
History Of ◽  
Local Disease Control ◽  
Disseminated Disease

AbstractA case of squamous cell carcinoma of the maxillary antrum is presented in which autopsy examination revealed widespread disseminated disease including metastatic deposits in the unusual sites of the myocardium and skin. Apart from the skin deposit the metastases were clinically unsuspected. This case demonstrates the role of the autopsy in the study of malignancy and the possible effects of local disease control on the natural history of the disease process.

scholarly journals Malignant and premalignant lesions of the tongue, clinical and histopathological findings for their early detection. Study of two cases

2020 ◽  
Author(s):  
Adel Martinez-Martinez ◽  
Antonio Diaz-Caballero ◽  
Natalia Quintero-Echenique
Keyword(s):  
Squamous Cell Carcinoma ◽  
Alcohol Consumption ◽  
Early Detection ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Tobacco Consumption ◽  
Premalignant Lesions ◽  
Hpv Dna ◽  
History Of ◽  
Male Patients

  Background: Squamous cell carcinoma affects subjects between the sixth and seventh decade of life. However, there are growing reports on the involvement of young adults. Clinical Cases: Two male patients aged 40 and 55, with no history of tobacco consumption and occasional alcohol consumption. They presented an exophytic ulcer and a white plaque on the lateral border of the tongue, the first diagnosed as moderately differentiated squamous cell carcinoma without HPV DNA genotypes and the second as leukoplakia without dysplasia. Conclusions: Risk factors commonly associated with potentially malign disorders and oral cancer, such as smoking and alcohol consumption, were not involved in the present cases. Therefore identify clinical, histopathological and molecular findings, allows the early detection of them, improving the prognosis of these patients.

scholarly journals Overexpression of KLF17 Predicts a Favorable Prognosis in Patients with Oral Squamous Cell Carcinoma: A Retrospective Study

Medicina ◽  
2020 ◽  
Vol 56 (2) ◽  
pp. 57 ◽  
Author(s):  
Yi-Ju Lee ◽  
Lung Chan ◽  
Chung-Min Yeh ◽  
Chien-Hsun Lee ◽  
Wen-Wei Sung
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Prognostic Value ◽  
Prognostic Role ◽  
Favorable Prognosis ◽  
Betel Quid Chewing ◽  
History Of

Background and Objectives: Patients with oral squamous cell carcinoma (OSCC), a common malignancy in Asian countries, have a poor prognosis. We investigated the role of Krüppel-like factor 17 (KLF17) and its prognostic significance in OSCC. Materials and Methods: KLF17 expression was measured by immunohistochemical staining of specimens from 283 patients with OSCC. We analyzed correlations between KLF17 expression and clinicopathologic features and between KLF17 expression and overall survival. The prognostic value of KLF17 was tested using Kaplan–Meier analysis and Cox proportional hazard models. Results: Among the 283 patients, high KLF17 expression was significantly associated with an early OSCC stage and low T-value (p = 0.033 and p = 0.036, respectively). The five-year survival rates were better in patients with high KLF17 expression than with low expression (66.5% and 49.6%, respectively). The prognostic role of KLF17 was further confirmed through multivariate analysis (hazard ratio 1.506, 95% confidence interval 1.034–2.191, p = 0.033). The prognostic value was more significant in patients with a history of betel quid chewing or with a low T-value. Conclusions: High KLF17 expression can serve as a marker for a favorable prognosis in patients with OSCC. The prognostic role of KLF17 is more significant in patients with a history of betel quid chewing or a low T-value.

Squamous cell carcinoma arising in a suprasellar epidermoid cyst

1983 ◽  
Vol 59 (3) ◽  
pp. 538-541 ◽  
Author(s):  
Anthony J. Lewis ◽  
Perry W. Cooper ◽  
Edward E. Kassel ◽  
Michael L. Schwartz
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Epidermoid Cyst ◽  
Ct Scanning ◽  
Content Type ◽  
History Of ◽  
Temporal Lesion ◽  
Intracranial Epidermoid

✓ A case is presented in which a squamous cell carcinoma developed in an intracranial epidermoid cyst. The patient was a 54-year-old woman with a 3-year history of depression and amblyopia; no focal findings were noted and she was diagnosed as having psychiatric disorders. On her final admission she showed clinical evidence of a rapidly growing intracranial mass. Computerized tomography (CT) identified a right parasellar and temporal lesion which was then incompletely removed. The literature on primary intracranial squamous cell carcinoma is reviewed, and the role of CT scanning in preoperative diagnosis of this lesion is discussed.

scholarly journals Diagnosis dan Penatalaksanaan Karsinoma Sel Skuamosa Glotis Stadium Dini

2016 ◽  
Vol 5 (2) ◽  
Author(s):  
Sukri Rahman ◽  
Bestari Jaka Budiman ◽  
Delva Swanda
Keyword(s):  
Squamous Cell Carcinoma ◽  
Head And Neck Cancer ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Laryngeal Squamous Cell Carcinoma ◽  
Early Stage ◽  
Cure Rate ◽  
History Of ◽  
The Common ◽  
Anatomical Pathology

Abstrak           Karsinoma laring merupakan tumor ganas kepala leher yang banyak dijumpai. Lebih dari 90% dari seluruh tumor ganas laring adalah karsinoma sel skuamosa, jika terdeteksi lebih dini maka angka keberhasilan pengobatan menjadi lebih baik. Radioterapi merupakan modalitas pilihan pada penatalaksanaan karsinoma laring stadium dini untuk mempreservasi organ dan suara. Diagnosis ditegakkan berdasarkan riwayat perjalanan penyakit, pemeriksaan fisik dan pemeriksaan patologi anatomi. Dilaporkan satu kasus laki-laki berusia 61 tahun dengan diagnosis karsinoma sel skuamosa glotis keratin berdiferensiasi baik stadium IB (T1bN0M0) yang ditatalaksana dengan radioterapi.                                                                                                                                               Kata kunci: Karsinoma sel skuamosa glotis, stadium dini, radioterapi. AbstractLaryngeal carsinoma is the common head and neck cancer. More than 90% of laryngeal cancers are squamous cell carcinoma, if the early detected the cure rate can the better. Radiotherapy is the modality for treatment of laryngeal carcinoma in the early stages to preserve the organ and voice of the patient. The clinical diagnosis is made based on history of illness, physical examination and anatomical pathology examination. Reported One case, man 61 year old, diagnosed with laryngeal squamous cell carcinoma keratinized well differiamted stage IB (T1bN0M0) treated by radiotherapy. Keywords:  Glottic squamous cell carsinoma, early stage, radiotherapy.

Zinc α-2 Glycoprotein (ZAG) a Novel Biomarker for the Detection of Oral Squamous Cell Carcinoma

2020 ◽  
Author(s):  
Mehwish Feroz Ali
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cancer ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Malignant Lesion ◽  
Tobacco Consumption ◽  
Constant Stimulus ◽  
Dysplastic Lesion ◽  
Cancerous Lesion

Oral cancer, the most challenging and life threatening disease in the field of dentistry, may start as a reactive lesion due to constant stimulus from tobacco consumption, transform into a pre-malignant lesion (dysplastic lesion) and ultimately develop into a cancerous lesion (Invasive carcinoma). There is a fundamental revolution taking place in the analyzing methods; extraction of biological protein from the saliva rather than from tissues or blood. Several of the biomarkers have been studied with pro-carcinogenic effects like Interleukins (ILs), tumor necrosis factor (TNF) and leptin, but only a few have been stated in the literature, which show anti-cancer characteristics like adiponectin and zinc alpha-2 glycoprotein. This review explored the diagnostic and prognostic values of a biomarkers zinc alpha-2 glycoprotein (ZAG) in adults suspected of oral squamous cell carcinoma (OSCC). The PubMed, EMBASE and Google Scholar were searched for scientific studies reported on the potential mechanism of zinc alpha-2 glycoprotein. All the research articles were selected in which ZAG is applied solely or in conjunction with other biomarkers in oral cancer and other cancers. These literatures were carefully assessed to find out and compile the diagnostic and prognostic values and to inquire therapeutic action of ZAG in the process of carcinogenesis.

Rediscussing the Role of Traditional Risk Factors in Young Adults With Oral Squamous Cell Carcinoma

2020 ◽  
Vol 40 (12) ◽  
pp. 6987-6995
Author(s):  
NORBERT NECKEL ◽  
MARCO MICHAEL ◽  
DANIEL TROELTZSCH ◽  
JONAS WÜSTER ◽  
STEFFEN KOERDT ◽  
...  
Keyword(s):  
Risk Factors ◽  
Squamous Cell Carcinoma ◽  
Young Adults ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Traditional Risk Factors

Primary squamous cell carcinoma of the ampulla of Vater: management and review of the literature

2021 ◽  
Vol 14 (1) ◽  
pp. e236477
Author(s):  
Subhash Soni ◽  
Poonam Elhence ◽  
Vaibhav Kumar Varshney ◽  
Sunita Suman
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Survival Rates ◽  
Ampulla Of Vater ◽  
Metallic Stent ◽  
Biological Behaviour ◽  
Curative Intent ◽  
Term Survival ◽  
History Of

Squamous cell carcinoma (SCC) of the ampulla of Vater is a rare pathology and only few cases are reported in the literature. With limited experience of primary SCC in the ampulla of Vater, its biological behaviour, prognosis and long-term survival rates are not well known. A 38-year-old woman presented with a history of painless progressive jaundice for which self-expending metallic stent was placed 3 years back. She was evaluated and initially diagnosed as probably periampullary adenocarcinoma. She underwent pancreaticoduodenectomy and histopathology with immunohistochemistry was suggestive of SCC of ampulla of Vater. She received adjuvant chemotherapy and doing well with no recurrence after 1 year of follow-up. In conclusion, SCC of the ampulla is an unusual pathology that should be kept as a differential diagnosis for periampullary tumours. Surgical treatment with curative intent should be performed whenever feasible even in the setting of bulky tumour to improve the outcome.

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