scholarly journals Efficacy of Shankhapushpi Choorna on Borderline IQ in School Going Children - A Randomized Placebo Controlled Clinical Study

2020 ◽  
Vol 11 (3) ◽  
pp. 433-440
Author(s):  
Aswathi P Murali ◽  
Prathviraj Puranik ◽  
Nagaratna S Jartarghar
Keyword(s):  
Clinical Study ◽  
Objective Assessment ◽  
Indian Children ◽  
Post Test ◽  
Group A ◽  
Detailed Assessment ◽  
Group B ◽  
Trial Drug ◽  
Borderline Iq ◽  
Controlled Clinical Study

Objective: To study the concepts regarding Medha, Medhya and IQ. Detailed assessment of IQ level of school going children with 6-8 years of age group. To study the efficacy of Shankhapushpi Choorna in the enhancement of IQ of school going children with Borderline IQ. Design: Open randomized placebo controlled clinical study with pre and post-test design. Setting: O.P.D. of Sri Dharmasthala Manjunatheshwara College of Ayurveda and Hospital, Udupi and also nearby schools of Udupi. Interventions: A minimum of 40 children under borderline IQ were selected based on the inclusion and exclusion criteria. The selected children were randomly divided into 2 groups of 20 each. Group A (Trial Group) were treated with Shankhapushpi Choorna with dose of 5grams daily at night, after food with lukewarm milk for a duration of 60 days and Group B was administered with Placebo. The follow up period was 30 days after the intervention. Main outcome measures: The subjective criteria were based on the parameters of Grasping power, Memory power, Courage & Activity.  The values obtained using Malin’s Intelligence Scale for Indian Children (MISIC) were considered for objective assessment. Results: Over the duration of the study, the trial drug Shankhapushpi Choorna was seen to have a positive effect on all the subjective and objective parameters with statistically highly significant results. Conclusion: Shankhapushpi Choorna with the proper dosage according to the age definitely improves the Medha of children with borderline IQ. The drug can be used as both promotive as well as curative aspects in accordance with intelligence.

A Randomised, Controlled Clinical Study on Total Hip Arthroplasty Using 4 Different Bearings: Results after 10 Years

2016 ◽  
Vol 27 (1) ◽  
pp. 96-103
Author(s):  
Arne Borgwardt ◽  
Bo Zerahn ◽  
Sandra D. Fabricius ◽  
Tine H. Bertelsen ◽  
Henrik Daugaard ◽  
...  
Keyword(s):  
Clinical Study ◽  
Total Hip Arthroplasty ◽  
Hip Arthroplasty ◽  
Total Hip ◽  
Metal On Metal ◽  
Group A ◽  
Group B ◽  
Randomised Controlled ◽  
Group D ◽  
Controlled Clinical Study

Purpose To compare 4 different bearings in total hip arthroplasty (THA) in a randomised controlled clinical study on clinical performance. Methods 393 patients with osteoarthritis of the hip or avascular necrosis were included and allocated to 1 of the head-and-cup couples zirconia-on-polyethylene (group A), metal-on-metal (group B), zirconia-on-polyethylene with the liner moulded into the shell (group C), or alumina-on-alumina (group D). In the individual case the surgeon could choose other implants if indicated. Results 299 patients were operated with the allocated prosthesis. The estimated cumulated prosthesis survival percentages and 95% confidence interval after 10 years were: group A 84.6 (75.8-93.4); group B 95.0 (89.5-100); group C 93.2 (86.7-99.7); group D 66.1 (54.5-77.7). The patients' physical function was significantly improved and remained equally good in all 4 groups, however slightly declining with ageing. The luxation rate was initially high, and equal between the groups, but was reduced by improving the surgical procedure introducing capsule repair by reinsertion of the short external hip rotators. Conclusions The metal-on-metal or zirconia-on-polyethylene prostheses had high 10-year survival percentages. The longevity of these bearing couples by themselves was not related to the combination of materials. The zirconia-on-polyethylene prosthesis with the liner mounted peroperatively possibly exhibited cases of backside wear which the corresponding bearing couple with moulded polyethylene (Asian) did not. The alumina-on-alumina bearing performed poorly - it was redesigned after our study initiation and later withdrawn from the market.

scholarly journals A CLINICAL STUDY FOR THE EVALUATION OF THE EFFECT OF BALA MOOLA CHURNA IN ASRIGDARA

2022 ◽  
Vol 12 (6) ◽  
pp. 17-20
Author(s):  
Manasi PS ◽  
Kavitha BK ◽  
Manju Parvathy
Keyword(s):  
Clinical Study ◽  
Tranexamic Acid ◽  
Well Being ◽  
Randomized Clinical Study ◽  
Nulliparous Women ◽  
Multiparous Women ◽  
Normal Menstrual Cycle ◽  
Group A ◽  
Group B ◽  
Trial Drug

Menstruation is a physiological function that denotes a healthy reproductive system in a woman. A normal menstrual cycle is vital for every woman's physical and psychological well-being. Asrigdara is a condition where there is excessive or prolonged bleeding. Considering the symptoms, it can be related to Dysfunctional Uterine Bleeding, a state of abnormal bleeding without any clinically detectable organic, systemic or iatrogenic causes. It is common in multiparous women than in nulliparous women. Bala Moola mentioned in Chakradutta is undertaken for the present study to evaluate its efficacy in Asrigdara. A randomized clinical study consisting of two groups, with 20 patients in each group were selected. Group A was given trial drug Bala Moola Churna with milk and honey in the dose of 6 gms twice daily after food for three consecutive cycles. Group B was given Tranexamic acid one tablet twice after food for three-cycle. Both the drugs were given till the bleeding stopped or a maximum of 15 days. The study showed that both the drugs, Bala Moola Churna and Tranexamic acid, were equally effective in reducing the symptoms of Asrigdara at the end of treatment.

scholarly journals Efficacy of two soft-bristle toothbrushes in plaque removal. A randomized controlled trial

2020 ◽  
Vol 33 (3) ◽  
pp. 174-180
Author(s):  
Gerson Langa ◽  
Francisco Gomes Muniz ◽  
Harry Rivera Oballe ◽  
Juliano Cavagni ◽  
Stephanie Anagnostopoulos Friedrich ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Clinical Study ◽  
Controlled Trial ◽  
Percent Reduction ◽  
Plaque Removal ◽  
Randomized Controlled ◽  
Supragingival Plaque ◽  
Group A ◽  
Group B ◽  
Controlled Clinical Study

The aim of the present examiner-blind randomized controlled clinical study was to compare the efficacy two soft-bristle toothbrushes in terms of plaque removal. Seventy volunteers were randomly allocated to Group A (tapered-tip toothbrush) or Group B (end-rounded toothbrush). At baseline appointment (Day 0), volunteers underwent plaque examination using the Improved Plaque Identification Index. Under supervision, they brushed their teeth for 1 minute with their assigned toothbrushes and the plaque examination was repeated. Volunteers continued the oral hygiene regimen (assigned toothbrush and a regular dentifrice provided by the researchers) for 7 days. The experimental procedures of Day 0 were then repeated. Separate statistical analyses were performed for mean percent reduction of plaque in the whole-mouth, interproximal and gumline scores at both times, using Mann-Whitney test, p0.05). In conclusion, on Day 0, Group A presented higher efficacy in supragingival plaque removal than Group B, as reflected by whole-mouth, gumline and interproximal plaque scores.

scholarly journals A CLINICAL STUDY TO EVALUATE THE EFFECT OF GUDUCHYADI SYRUP IN ENHANCEMENT OF MEDHA IN SCHOOL GOING CHILDREN

2020 ◽  
Vol 8 (9) ◽  
pp. 4368-4374
Author(s):  
Navya. N. P ◽  
Sharada. M. K ◽  
Jithesh Chowta
Keyword(s):  
Clinical Study ◽  
Modern Medicine ◽  
School Factors ◽  
Sugar Syrup ◽  
Scholastic Backwardness ◽  
Group A ◽  
Group B ◽  
Controlled Clinical Study ◽  
Intellectual Power

Academic underachievement of children is a big concern among parents and teachers in present day competitive society. It is reported that around 20% of school children have scholastic backwardness include physical illness, below average Intelligence, Learning Disabilities, Attention Deficit Hyperactive Disorder, Psychiatric Disorder, family and school factors. Intelligence is usually said to involve mental capabilities such as the ability to reason, plan, solve problems, think abstractly, comprehend ideas and language, and learn. In spite of advancement in modern medicine, its success is very limited in context with the enhancement of Intellectual power and memory. Objectives: 1) To select subject with IQ ranging from 70 – 89 and study in detail about the factors influencing the Intelligence. 2) To evaluate the effect of Guduchyadi Syrup in the enhancement of Medha in school going children. Materials and Methods: An interventional Randomized Placebo Controlled Clinical study was conducted, in which 30 subjects were assigned in both Group A and Group B and given with Guduchyadi syrup and Sugar syrup respectively, with a dose of 5ml thrice a day after food for duration of 3 months. Follow up was done on 30th day after completion of the treatment. Interpretation and Result: Both the groups showed significant result in Subjective and Objective parameters. Conclusion: Both Guduchyadi syrup and Sugar syrup are having significant effect on Medha. The effect is considered to be consistent or improved even after follow up. But the change was less for the group given with Sugar syrup compared to the effect of Guduchyadi syrup.

scholarly journals A CONTROLLED CLINICAL STUDY TO EVALUATE THE EFFICACY OF KARPASASTHYADI TAILA NASYAKARMA IN THE MANAGEMENT OF GREEVA ASTHIGATAVATA VIS- A-VIS CERVICAL SPONDYLOSIS

2021 ◽  
Vol 09 (1) ◽  
pp. 63-72
Author(s):  
Asha Rani K ◽  
Umashankar. K. S
Keyword(s):  
Clinical Study ◽  
Cervical Spondylosis ◽  
Test Group ◽  
Control Group ◽  
P Value ◽  
Contingency Coefficient ◽  
Group A ◽  
Group B ◽  
B Test ◽  
Controlled Clinical Study

Asthigatavata is one among Shoola and Shosha Pradhana Vatavyadhi characterized by Asthishosha (Osteoporosis), Asthibheda (Cutting pain in bony joints), Asthishoola, Sandhishoola (Joint pain), Bedhaasthiparvanam (Splitting pain in bones and joints), Mamsabalakshaya (Loss of muscle strength), Aswapna (Insomnia) and Satata Ruk (Continuous pain). When Kupitha Vata Dosha enters in to the Asthi present in Greevapradesha causes series of changes producing symptoms and this clinical entity is named as Greeva Asthigatavata. Cervical Spondylosis is seen in the general population with the incidence rate of 83 per 100,000 and occurs mostly in fourth and fifth decades of life. More disability is seen over the age of 50years. Its prevalence is similar for both the sex, although the degree of severity is greater for males. Aim: To evaluate the therapeutic efficacy of Karpasasthyadi Taila Nasyakarma in the management of Greeva Asthigatavata vis-à-vis Cervical Spondylosis. Materials and Methods: It was a controlled clinical study with pre and posttest design. Total 100 subjects were incidentally selected and assigned into two groups viz., Group A (Control group) and Group B (Test group), with 50 subjects in each group. Subjects of Control Group were subjected with Greevabasti with Mahamasha Taila for 7 consecutive days and Astavarga Kashaya internally for 14 consecutive days from the first day of Greevabasti. Subjects of Test Group were subjected to Nasyakarma with Karpasasthyadi Taila for 7 consecutive days along with Greevabasti with Mahamasha Taila for 7 consecutive days and Astavarga Kashaya internally for 14 consecutive days from the first day of Nasyakarma. The study consisted of 3 assessments i.e on 0th day, 7th day and on 14th day. Result: In the study it was observed that Group B (CC=0.529) showed clinically and statistically highly significant results with respect to reduction of symptoms than Group A (CC=0.389) with high contingency coefficient value. Also, the overall assessment showed clinically and statistically highly significant result in both groups with p value 0.000. Conclusion: On comparing the overall effect of the study, trial group (Group B) showed better results than control group (Group A). Hence, Karpasasthyadi Taila has a better role in the management of Greeva Asthigatavata.

scholarly journals A Comparative Clinical Study on the Effect of Dhanyaka Kalka and Dhanyaka Avalehya with Anupana of Sharkara mixed Tandulodaka in Garbhini Chardi

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Upasana Nath ◽  
Kalpana Sharma
Keyword(s):  
Clinical Study ◽  
Large Scale ◽  
Symptomatic Relief ◽  
First Trimester ◽  
Comparative Clinical Study ◽  
Group A ◽  
Group B ◽  
Rice Water ◽  
Trial Drug ◽  
In Pregnancy

Garbhini Chardi (vomiting in pregnancy) is a blazing issue in obstetric enactment. About 50-60% of all pregnant females agonize from vomiting in pregnancy most apparently in first trimester. If not tackled effectively before or in time, it may affect the quality of life of pregnant woman and pregnancy consequences. Ayurvedic classics have described many formulations for management of Garbhini Chardi. In this study Dhanyaka kalka and Dhanyaka Avaleha was taken both with Anupana of Sharkara mixed Tandulodaka. Aim: To compare the effect of Dhanyaka Kalka and Dhanyaka Avaleha with Anupana of Sharkara mixed with Tandulodaka in Garbhini Chardi. Materials and Methods: Single blind clinical study with pre‑test and post‑test was designed. 60 patients complaining of Chardi in 1st trimester were randomly divided into the two groups: Group A and Group B, each comprising of 30 patients. Medicine used for Group A was Dhanyaka Kalka with Anupana of Sharkara Mixed Tandulodaka (rice, water or gruel) and medicine used for Group B was Dhanyaka Avaleha with Anupana of Sharkara mixed Tandulodaka. Those cases, which were in regular follow ups for 5 weeks were taken for clinical study. The criteria of assessment were mainly on the symptomatic relief. Intermediate follow ups were recorded at interval of two weeks. Results: In Group A, overall percentage relief in chief complains was calculated as 59.44% whereas in Group B this value was 66.5%. Conclusion: In present clinical study efficacy of Dhanyaka Avaleha has been proven beneficial in comparison to Dhanyaka Kalka. The trial drug is highly significant in the management of Garbhini Chardi. This study needs to be done on large scale and for longer duration.

scholarly journals A CONTROLLED CLINICAL STUDY TO EVALUATE THE EFFECT OF KETAKI NIRUHA BASTI IN MADHUMEHA WITH SPECIAL REFERENCE TO DIABETES MELLITUS-II

2021 ◽  
Vol 9 (10) ◽  
pp. 2360-2370
Author(s):  
Akshatha. M ◽  
Ananta S Desai
Keyword(s):  
Diabetes Mellitus ◽  
Clinical Study ◽  
Special Reference ◽  
Control Group ◽  
Open Label ◽  
Medical College ◽  
Before And After ◽  
Group A ◽  
Group B ◽  
Controlled Clinical Study

Introduction: A controlled clinical study to evaluate the effect of Ketaki Niruha Basti in Madhumeha with special reference to Diabetes mellitus-ii with Madhutailika Basti being the controlled group. Methods: It was an open- label controlled parallel-group study at a government Ayurveda medical college and hospital in South India. 41 subjects fulfilling inclusion criteria were selected through a convenient sampling method. Group A (study group) 21 subjects were included and 1 dropped out and in Group B (control group) 20 subjects were included. Group A was administered with Ketaki Niruha Basti and Group B was administered with Madhutailika Basti in Yoga Basti pattern. Both the groups were given Murchita Taila for Anuvasana. Results: The effect of the therapy was assessed by analyzing subjective and objective parameters before and after the treatment. While comparing the effect between the groups of Ketaki Niruha Basti and Madhutailika Basti, it showed no significant statistical difference. Conclusion: Ketaki Niruha Basti showed marginally better results in polyphagia, polydipsia, FBS and PPBS while Madhutailika Basti showed better results in polyuria day, polyuria night, tiredness and BMI. Keywords: Basti, Diabetes Melitus-II, Ketaki Niruha Basti, Madhumeha, Madhutailika Basti.

scholarly journals Comparing the efficacy of Budesonide and Montelukast in children with asthma: a prospective interventional open label controlled clinical study

2017 ◽  
Vol 4 (5) ◽  
pp. 1682
Author(s):  
Sachin S. Jangam ◽  
Anupama Mauskar
Keyword(s):  
Clinical Study ◽  
Tertiary Care ◽  
Emergency Department Visits ◽  
Secondary Outcome ◽  
Open Label ◽  
Systemic Steroids ◽  
Significant Difference ◽  
Group A ◽  
Group B ◽  
Controlled Clinical Study

Background: Bronchial asthma is a chronic inflammatory airway disease and is more prevalent in children. Inhaled corticosteroids (Budesonide) and leukotriene receptor antagonist (Montelukast) are the drugs of choice for asthma in children. The present study was aimed to compare the efficacy of these drugs in childhood asthma at tertiary care center.Methods: This is a prospective interventional open label controlled clinical study carried out from January 2012 to December 2014. Children recently diagnosed with mild persistent asthma that attended Asthma clinic or admitted in ward of department of paediatrics LTMMC and Hospital, Sion, Mumbai was participated in the study. A total of 70 patients were selected for the study and are categorized into two groups consisting of 35 in each group. Group A patients were given metered dose inhaler (MDI) Budesonide 200 mcg 1 puff twice a day (with MDI spacer and mask for children <5 years and without mask for children >5 years. Group B patients were given Montelukast 4 mg (<5 years) and 5 mg (>5 years) tablet as once a daily in the evening for 1 year. Primary and secondary outcome measures were calculated and analysed.Results: No significant difference on the basis of age and gender was observed among both groups. The complaints of cough, wheeze and breathlessness, lesser emergency department visits, nebulization and lesser number of systemic steroids (days/year) was significantly lesser in patients of group A (p<0.05) compared to group B. Group A subjects had lesser number of acute exacerbations, required lesser number of systemic steroids courses and the frequency of hospitalization. Statistically significant (p<0.05) difference was observed in episode free days in a year among both groups.Conclusions: The findings of the study prove that Budesonide had better efficacy over Montelukast in control of asthma. 

scholarly journals A CONTROLLED CLINICAL STUDY TO EVALUATE THE EFFICACY OF KARPASASTHYADI TAILA NASYAKARMA IN THE MANAGEMENT OF GREEVA ASTHIGATAVATA VIS- A-VIS CERVICAL SPONDYLOSIS

2021 ◽  
Vol 09 (1) ◽  
pp. 63-72
Author(s):  
Asha Rani K, ◽  
Umashankar. K. S
Keyword(s):  
Clinical Study ◽  
Cervical Spondylosis ◽  
Test Group ◽  
Control Group ◽  
P Value ◽  
Contingency Coefficient ◽  
Group A ◽  
Group B ◽  
B Test ◽  
Controlled Clinical Study

Asthigatavata is one among Shoola and Shosha Pradhana Vatavyadhi characterized by Asthishosha (Osteoporosis), Asthibheda (Cutting pain in bony joints), Asthishoola, Sandhishoola (Joint pain), Bedhaasthiparvanam (Splitting pain in bones and joints), Mamsabalakshaya (Loss of muscle strength), Aswapna (Insomnia) and Satata Ruk (Continuous pain). When Kupitha Vata Dosha enters in to the Asthi present in Greevapradesha causes series of changes producing symptoms and this clinical entity is named as Greeva Asthigatavata. Cervical Spondylosis is seen in the general population with the incidence rate of 83 per 100,000 and occurs mostly in fourth and fifth decades of life. More disability is seen over the age of 50years. Its prevalence is similar for both the sex, although the degree of severity is greater for males. Aim: To evaluate the therapeutic efficacy of Karpasasthyadi Taila Nasyakarma in the management of Greeva Asthigatavata vis-à-vis Cervical Spondylosis. Materials and Methods: It was a controlled clinical study with pre and posttest design. Total 100 subjects were incidentally selected and assigned into two groups viz., Group A (Control group) and Group B (Test group), with 50 subjects in each group. Subjects of Control Group were subjected with Greevabasti with Mahamasha Taila for 7 consecutive days and Astavarga Kashaya internally for 14 consecutive days from the first day of Greevabasti. Subjects of Test Group were subjected to Nasyakarma with Karpasasthyadi Taila for 7 consecutive days along with Greevabasti with Mahamasha Taila for 7 consecutive days and Astavarga Kashaya internally for 14 consecutive days from the first day of Nasyakarma. The study consisted of 3 assessments i.e on 0th day, 7th day and on 14th day. Result: In the study it was observed that Group B (CC=0.529) showed clinically and statistically highly significant results with respect to reduction of symptoms than Group A (CC=0.389) with high contingency coefficient value. Also, the overall assessment showed clinically and statistically highly significant result in both groups with p value 0.000. Conclusion: On comparing the overall effect of the study, trial group (Group B) showed better results than control group (Group A). Hence, Karpasasthyadi Taila has a better role in the management of Greeva Asthigatavata.

Clinical Study to evaluate the concept of Samanyam Vriddhi Karanam with reference to Jeevanti in Stanya Kshaya

2018 ◽  
Vol 3 (3) ◽  
Author(s):  
Pushpa A. Biradar ◽  
Umapati C. Baragi ◽  
Gangadhar Timmapur
Keyword(s):  
Clinical Study ◽  
Breast Milk ◽  
Clinical Symptoms ◽  
Statistical Significance ◽  
Normal Weight ◽  
Child Feeding ◽  
Group A ◽  
Group B ◽  
Controlled Clinical Study ◽  
Single Blind

Breast milk is the best nutrition a mother can give to her child. Feeding the child is the most fulfilling and gratifying experience for a mother. The child should be breastfed exclusively for first six months after birth. But when amount of breast milk decreases or is inadequate, it becomes very worrying. Ayurveda describes decreased breast milk as ‘Stanya Kshaya’. Adequate lactation is being defined as secretion of 300 ml daily by 5th day and 480 ml by 10th day, if this amount are not achieved, a baby of normal weight will not be adequately fed and such a situation is termed clinically as ‘Agalactia’ or ‘Agalactorrhoea’. In Asian and tropical countries like India, prevalence of lactational deficiency may be 30 - 40%. Hence a clinical study has been designed to evaluate the Stanya Janana action of Jeevanti based on the principle of Samanyam Vruddhi Karanam. Randomized single blind standard controlled clinical study was conducted in 60 patients attending OPD of Department of Prasuti andStree Roga, BLDEA’s AVS Ayurveda Mahavidyalaya Hospital andResearch Centre, Vijayapur, Karnataka, and grouped into two. Group A patients were administered with Jeevanti Churna 6 gms bd orally with Ushna Jala for 30 days and Group B patients were administered with Shatavari Churna 6 gms bd orally with Ushna Jala for 30 days. The patients were followed up for 15 days, 51 patients had completed the treatment and no adverse effects were reported during the treatment. Both groups had improved in the clinical symptoms and overall statistical significance was observed.

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