A CONTROLLED CLINICAL STUDY TO EVALUATE THE EFFICACY OF KARPASASTHYADI TAILA NASYAKARMA IN THE MANAGEMENT OF GREEVA ASTHIGATAVATA VIS- A-VIS CERVICAL SPONDYLOSIS

Asthigatavata is one among Shoola and Shosha Pradhana Vatavyadhi characterized by Asthishosha (Osteoporosis), Asthibheda (Cutting pain in bony joints), Asthishoola, Sandhishoola (Joint pain), Bedhaasthiparvanam (Splitting pain in bones and joints), Mamsabalakshaya (Loss of muscle strength), Aswapna (Insomnia) and Satata Ruk (Continuous pain). When Kupitha Vata Dosha enters in to the Asthi present in Greevapradesha causes series of changes producing symptoms and this clinical entity is named as Greeva Asthigatavata. Cervical Spondylosis is seen in the general population with the incidence rate of 83 per 100,000 and occurs mostly in fourth and fifth decades of life. More disability is seen over the age of 50years. Its prevalence is similar for both the sex, although the degree of severity is greater for males. Aim: To evaluate the therapeutic efficacy of Karpasasthyadi Taila Nasyakarma in the management of Greeva Asthigatavata vis-à-vis Cervical Spondylosis. Materials and Methods: It was a controlled clinical study with pre and posttest design. Total 100 subjects were incidentally selected and assigned into two groups viz., Group A (Control group) and Group B (Test group), with 50 subjects in each group. Subjects of Control Group were subjected with Greevabasti with Mahamasha Taila for 7 consecutive days and Astavarga Kashaya internally for 14 consecutive days from the first day of Greevabasti. Subjects of Test Group were subjected to Nasyakarma with Karpasasthyadi Taila for 7 consecutive days along with Greevabasti with Mahamasha Taila for 7 consecutive days and Astavarga Kashaya internally for 14 consecutive days from the first day of Nasyakarma. The study consisted of 3 assessments i.e on 0th day, 7th day and on 14th day. Result: In the study it was observed that Group B (CC=0.529) showed clinically and statistically highly significant results with respect to reduction of symptoms than Group A (CC=0.389) with high contingency coefficient value. Also, the overall assessment showed clinically and statistically highly significant result in both groups with p value 0.000. Conclusion: On comparing the overall effect of the study, trial group (Group B) showed better results than control group (Group A). Hence, Karpasasthyadi Taila has a better role in the management of Greeva Asthigatavata.

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A CONTROLLED CLINICAL STUDY TO EVALUATE THE EFFICACY OF KARPASASTHYADI TAILA NASYAKARMA IN THE MANAGEMENT OF GREEVA ASTHIGATAVATA VIS- A-VIS CERVICAL SPONDYLOSIS

November 2020 - International Ayurvedic Medical Journal ◽

10.46607/iamj.09012021 ◽

2021 ◽

Vol 09 (1) ◽

pp. 63-72

Author(s):

Asha Rani K ◽

Umashankar. K. S

Keyword(s):

Clinical Study ◽

Cervical Spondylosis ◽

Test Group ◽

Control Group ◽

P Value ◽

Contingency Coefficient ◽

Group A ◽

Group B ◽

B Test ◽

Controlled Clinical Study

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Evaluation of the Efficacy of Sapta Winsati Guggulu in the Management of Shushkarsha: A Comparative Clinical Study

International Journal of Health Sciences and Research ◽

10.52403/ijhsr.20210627 ◽

2021 ◽

Vol 11 (6) ◽

pp. 172-177

Author(s):

Fernando BPA ◽

Hettiarachchi GTK ◽

Kumara GUA

Keyword(s):

Clinical Study ◽

Varicose Veins ◽

Control Group ◽

P Value ◽

Lower Rectum ◽

Remarkable Effect ◽

Key Words Hemorrhoids ◽

Internal Hemorrhoids ◽

Group A ◽

Group B

Introduction: Hemorrhoids, also called piles, co-related with Arsha in Ayurveda, are swollen veins in the anus and the lower rectum, similar to varicose veins. Hemorrhoids can develop inside the rectum known as internal hemorrhoids or under the skin around the anus known as external hemorrhoids. Worldwide, the prevalence of symptomatic hemorrhoids is estimated at 4.4% in the general population. Objectives: This is a clinical study was conducted to evaluate the efficacy of the Sapta Winshati Guggulu in the management of Shushkarsha. Methodology: 40 patients diagnosed with Shushkarsha were randomly selected to this study and they were randomly divided into two groups and was named as the Group-A (Tested group) and the Group-B (Control group). All the patients (both A and B groups) were treated by Abhayarishta, Chirabilwa Kwatha and Sukumara Churna. Only Group-A (testing group) was additionally treated with Sapta Winshati Guggulu. Data collection: Subjective parameters such as pain and Objective parameters such as circumference of the pile and distance of the prolapse were collected. Data analysis: All the subjective and objective parameters were entered by using reputed methods and were analyzed by using graphs and figures and SPSS Statistical Software. Results: p-value and t-value of Group-A and Group-B were statistically significant. But, Significant level of Group-A was higher than Group-B. Conclusion: According to the findings, finally it can be concluded that the Sapta Winshati Guggulu has remarkable effect in the management of the Shushkarsha. Key words: Hemorrhoids, Piles, Shushkarsha, Chirabilwa Kwatha, Sapta Winshati Guggulu.

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A CONTROLLED CLINICAL STUDY TO EVALUATE THE EFFECT OF KETAKI NIRUHA BASTI IN MADHUMEHA WITH SPECIAL REFERENCE TO DIABETES MELLITUS-II

November 2020 - International Ayurvedic Medical Journal ◽

10.46607/iamj1109102021 ◽

2021 ◽

Vol 9 (10) ◽

pp. 2360-2370

Author(s):

Akshatha. M ◽

Ananta S Desai

Keyword(s):

Diabetes Mellitus ◽

Clinical Study ◽

Special Reference ◽

Control Group ◽

Open Label ◽

Medical College ◽

Before And After ◽

Group A ◽

Group B ◽

Controlled Clinical Study

Introduction: A controlled clinical study to evaluate the effect of Ketaki Niruha Basti in Madhumeha with special reference to Diabetes mellitus-ii with Madhutailika Basti being the controlled group. Methods: It was an open- label controlled parallel-group study at a government Ayurveda medical college and hospital in South India. 41 subjects fulfilling inclusion criteria were selected through a convenient sampling method. Group A (study group) 21 subjects were included and 1 dropped out and in Group B (control group) 20 subjects were included. Group A was administered with Ketaki Niruha Basti and Group B was administered with Madhutailika Basti in Yoga Basti pattern. Both the groups were given Murchita Taila for Anuvasana. Results: The effect of the therapy was assessed by analyzing subjective and objective parameters before and after the treatment. While comparing the effect between the groups of Ketaki Niruha Basti and Madhutailika Basti, it showed no significant statistical difference. Conclusion: Ketaki Niruha Basti showed marginally better results in polyphagia, polydipsia, FBS and PPBS while Madhutailika Basti showed better results in polyuria day, polyuria night, tiredness and BMI. Keywords: Basti, Diabetes Melitus-II, Ketaki Niruha Basti, Madhumeha, Madhutailika Basti.

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Therapeutic efficacy and safety of Unani formulation in patients of Fasaad-e-tashahhum-e-dam (dyslipidemia): a randomized open standard controlled clinical study

International Journal of Advances in Medicine ◽

10.18203/2349-3933.ijam20212772 ◽

2021 ◽

Author(s):

Syed Sabahat ◽

Naquib Ul-Islam

Keyword(s):

Clinical Study ◽

Lipoprotein Metabolism ◽

Test Group ◽

Control Group ◽

P Value ◽

Standard Drug ◽

Control Drug ◽

Open Standard ◽

Controlled Clinical Study ◽

Lipid Parameters

Background: Hyperlipidemia which is interchangeably used with the term dyslipidemia essentially refers to the condition of abnormality of lipid levels measured in the blood typically due to the disorder of lipoprotein metabolism. The objective of this study was to determine the therapeutic effect and safety of newly formulated drug on patients with Fasaad-e-Tashahhum-e-Dam (dyslipidemia) and compare it with the effect of Unani formulation and rosavastatin.Methods: The present study was open randomized controlled clinical study. The study subjects were divided in two groups, one group was given test drug (test group) and another group was given control drug (control group). All the patients who qualified the inclusion criteria were randomly placed in either test or control group.Results: In the present study we observed that both the groups were comparable with respect to age, sex lifestyle, family history and mizaj. We found that both Unani formulated drug and standard drug rosavastatin significantly improves the lipid parameters after the treatment with a p value of (<0.001*).Conclusions: We concluded that the overall effect of the proposed Unani formulated drug was found quite fascinating in the treatment of dyslipidemia. Apart from drug safety, visible improvements were evident in objective parameters like cholesterol, triglyceride and LDL, VLD. However, the present study did not revealed that Unani drug is superior to standard drug instead both the treatments are equally effective on the improvement of lipid profile parameters.

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The Bone Buttress Theory: The Effect of the Mechanical Loading of Bone on the Osseointegration of Dental Implants

Biology ◽

10.3390/biology10010012 ◽

2020 ◽

Vol 10 (1) ◽

pp. 12

Author(s):

David Chavarri-Prado ◽

Aritza Brizuela-Velasco ◽

Ángel Álvarez-Arenal ◽

Markel Dieguez-Pereira ◽

Esteban Pérez-Pevida ◽

...

Keyword(s):

Dental Implants ◽

Mechanical Loading ◽

Bone Growth ◽

Bone Matrix ◽

Test Group ◽

Control Group ◽

Group A ◽

Bone To Implant Contact ◽

The Stability ◽

Group B

Objectives: To determine the effect of mechanical loading of bone on the stability and histomorphometric variables of the osseointegration of dental implants using an experimental test in an animal model. Materials and Methods: A total of 4 human implants were placed in both tibiae of 10 New Zealand rabbits (n = 40). A 6-week osseointegration was considered, and the rabbits were randomly assigned to two groups: Group A (Test group) included 5 rabbits that ran on a treadmill for 20 min daily during the osseointegration period; Group B (Controls) included the other 5 that were housed conventionally. The monitored variables were related to the primary and secondary stability of the dental implants (implant stability quotient—ISQ), vertical bone growth, bone to implant contact (BIC), area of regenerated bone and the percentage of immature matrix. Results: The results of the study show a greater vertical bone growth (Group A 1.26 ± 0.48 mm, Group B 0.32 ± 0.47 mm, p < 0.001), higher ISQ values (Group A 11.25 ± 6.10 ISQ, 15.73%; Group B 5.80 ± 5.97 ISQ, 7.99%, p = 0.006) and a higher BIC (Group A 19.37%, Group B 23.60%, p = 0.0058) for implants in the test group, with statistically significant differences. A higher percentage of immature bone matrix was observed for implants in the control group (20.68 ± 9.53) than those in the test group (15.38 ± 8.84) (p = 0.108). A larger area of regenerated bone was also observed for the test implants (Group A 280.50 ± 125.40 mm2, Group B 228.00 ± 141.40 mm2), but it was not statistically significant (p = 0.121). Conclusions: The mechanical loading of bone improves the stability and the histomorphometric variables of the osseointegration of dental implants.

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Resorbable Collagen Barrier Impeding the Extrusion of Obturating Material in Primary Molars Undergoing Resorption – A Randomized Clinical Trial

Journal of Clinical Pediatric Dentistry ◽

10.17796/1053-4625-45.5.4 ◽

2021 ◽

Vol 45 (5) ◽

pp. 312-316

Author(s):

Mishra Neha Sanjeev ◽

Harsimran Kaur ◽

Sandeep Singh Mayall ◽

Rishika ◽

Ramakrishna Yeluri

Keyword(s):

Test Group ◽

Primary Molars ◽

Control Group ◽

Chi Square ◽

Significance Level ◽

Significant Difference ◽

Chi Square Test ◽

Group A ◽

Group B ◽

And Control

Objective: To evaluate the effectiveness of placing a resorbable collagen barrier in impeding the extrusion of obturation material in primary molars undergoing resorption. Study design: All the 94 canals in 47 mandibular molars were allocated to 2 groups- Group ‘A’- 47 canals with collagen barrier (Test group) and Group ‘B’- 47 canals without collagen barrier (Control group) based on randomization protocol. Pulpectomy was performed and obturation of both test and control canals were radiographically assessed. Pearson’s chi – square test was applied to analyze the results. The significance level was predetermined at p < 0.05. Results: Among the test group, 93.6% of the canals showed no extrusion while, 6.4% showed visible extrusion of the material outside the apex. In the control group, 83% showed no extrusion whereas 17% of the canals showed visible extrusion outside the apex. But no significant difference was noted (p>0.05). Conclusion: The placement of resorbable collagen barrier in the apical third of the canal prevented the extrusion of obturating material beyond the apex in resorbing primary molars.

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Effect of acupuncture TENS versus conventional TENS on post cesarean section incision pain

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20183786 ◽

2018 ◽

Vol 7 (9) ◽

pp. 3738

Author(s):

Priti A. Mehendale ◽

Mayur T. Revadkar

Keyword(s):

Pain Intensity ◽

Rating Scale ◽

Control Group ◽

P Value ◽

Random Allocation ◽

Lower Segment Caesarean Section ◽

Post Operative Pain ◽

Group A ◽

Group B ◽

Pain Rating Scale

Background: There is evidence regarding beneficial use of Transcutaneous Electrical Nerve Stimulation (TENS) on post Lower Segment Caesarean Section (LSCS) incision pain. However, efficacy of different types of TENS following C section pain has not yet been explored adequately.Methods: 96 women who had recently undergone LSCS were included for the study. The subjects were in the age group of 20 to 40 years (25.84±3.96); having pain intensity 4 or more on Numerical Pain Rating Scale (NPRS). They were divided into three groups by random allocation method; namely Group A: Acupuncture (Low/Motor) TENS, Group B: Conventional (High/Sensory) TENS and Group C: Control group. Group A and B received specific type of TENS twice a day for 15 minutes. Control group C did not receive any TENS intervention. All subjects received standard post-operative medications and physiotherapy. Pain intensity was recorded on NPRS pre and post intervention.Results: Both Acupuncture TENS and Conventional TENS significantly decreased post-operative pain intensity as compared to control group (p value <0.0001).Conclusions: Both, acupuncture and conventional TENS are equally effective in reducing post LSCS incision pain at a strong and non-painful intensity.

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Effects of Aqueous Extract of Basella alba L. leaves on Blood Cell Count in Rats

Bangladesh Pharmaceutical Journal ◽

10.3329/bpj.v22i1.40077 ◽

2019 ◽

Vol 22 (1) ◽

pp. 73-78

Author(s):

Farhana Sabrin ◽

AF Mohammed Shafiqul Alam ◽

Muhammad Rashedul Islam ◽

Md Elias Al Mamun ◽

Jakir Ahmed Chowdhury

Keyword(s):

Blood Cell ◽

Cell Count ◽

Aqueous Extract ◽

Control Group ◽

P Value ◽

Blood Cell Count ◽

Basella Alba ◽

Group A ◽

Group B ◽

Group D

The effect of aqueous extract of Basella alba (puishak) leaves on blood cell count of rats was studied. Forty rats of both sexes weighing between 100-150 gm were used. The rats were divided into four groups (7 rats in each group), with group A as the control group and experimental groups were denoted as B, C and D. With all aseptic precautions, aqueous extract of Basella alba (Puishak) leaves was administered into the three different doses (For group B: 60 mg/kg bw, group C: 80 mg/kg bw and group D: 100 mg/kg bw). Control group A also received distilled water as a placebo at the dose of 10 mg/kg bw for 14 days. At day 15, blood samples were collected and sent for haematological analysis. Data analysis of blood count profile of 28 rats revealed that there is an increased number of RBC, WBC and platelet count in experimental groups than in control group. ANOVA test revealed that increased blood cell counts following administration of aqueous leaves extract of keeves of B. alba were statistically significant (p value for each case was .0001<.05) than control group. Paired samples t test was performed to compare between baseline hematological parameters and parameters after 14 days of intervention. Then comparison between Group A & Group B, between Group A & Group C and between Group A & Group D were done. In all cases, probability (p) value < 0.05 was considered as statistically significant.This it is clearly evident that aqueous extract of B.alba has positive stimulant effect on blood cells count of rats. Moreover, it was found that increment of doses also increases the cell count that is positively correlated with the hypothesis. Bangladesh Pharmaceutical Journal 22(1): 73-78, 2019

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A Randomised, Controlled Clinical Study on Total Hip Arthroplasty Using 4 Different Bearings: Results after 10 Years

Hip International ◽

10.5301/hipint.5000428 ◽

2016 ◽

Vol 27 (1) ◽

pp. 96-103

Author(s):

Arne Borgwardt ◽

Bo Zerahn ◽

Sandra D. Fabricius ◽

Tine H. Bertelsen ◽

Henrik Daugaard ◽

...

Keyword(s):

Clinical Study ◽

Total Hip Arthroplasty ◽

Hip Arthroplasty ◽

Total Hip ◽

Metal On Metal ◽

Group A ◽

Group B ◽

Randomised Controlled ◽

Group D ◽

Controlled Clinical Study

Purpose To compare 4 different bearings in total hip arthroplasty (THA) in a randomised controlled clinical study on clinical performance. Methods 393 patients with osteoarthritis of the hip or avascular necrosis were included and allocated to 1 of the head-and-cup couples zirconia-on-polyethylene (group A), metal-on-metal (group B), zirconia-on-polyethylene with the liner moulded into the shell (group C), or alumina-on-alumina (group D). In the individual case the surgeon could choose other implants if indicated. Results 299 patients were operated with the allocated prosthesis. The estimated cumulated prosthesis survival percentages and 95% confidence interval after 10 years were: group A 84.6 (75.8-93.4); group B 95.0 (89.5-100); group C 93.2 (86.7-99.7); group D 66.1 (54.5-77.7). The patients' physical function was significantly improved and remained equally good in all 4 groups, however slightly declining with ageing. The luxation rate was initially high, and equal between the groups, but was reduced by improving the surgical procedure introducing capsule repair by reinsertion of the short external hip rotators. Conclusions The metal-on-metal or zirconia-on-polyethylene prostheses had high 10-year survival percentages. The longevity of these bearing couples by themselves was not related to the combination of materials. The zirconia-on-polyethylene prosthesis with the liner mounted peroperatively possibly exhibited cases of backside wear which the corresponding bearing couple with moulded polyethylene (Asian) did not. The alumina-on-alumina bearing performed poorly - it was redesigned after our study initiation and later withdrawn from the market.

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Efficacy of Tamsulosin and Alfuzosin in Management of Distal Ureteral Stones

Med Phoenix ◽

10.3126/medphoenix.v6i1.36352 ◽

2021 ◽

Vol 6 (1) ◽

pp. 10-13

Author(s):

Bimochan Piya ◽

Abhishek Bhattarai

Keyword(s):

Urinary Tract ◽

Side Effects ◽

Diclofenac Sodium ◽

Study Groups ◽

Ureteral Stones ◽

Control Group ◽

P Value ◽

Expulsion Rate ◽

Group A ◽

Group B

Introduction: Urinary tract calculi are the most frequent condition in urology clinics worldwide. The overall prevalence is about 5 % and lower urinary tract stones account for 70% among them. Medical expulsive therapy has been used to treat distal ureteric stone as it reduces symptoms and facilitates stone expulsion. The aim of this study is to evaluate and compare the efficacy of tamsulosin and alfuzosin as medical therapy in ureteric stones. Materials and Methods: A total of 87 patients with distal ureteral stones of size ≤10 mm were randomly divided into 3 groups. Group A patients (n-30) received 0.4 mg of tamsulosin daily, group B patients (n-29) received 10 mg of alfuzosin daily and group C patients (n-28) received 75 mg of diclofenac sodium. Patients in all groups received diclofenac sodium for one week and then as required. Follow-up was done on a weekly basis for 4 weeks. The stone expulsion rate, time for stone expulsion, and side-effects were recorded in each group. Results: The mean stone size (5.66, 5.79, 5.67) mm and age (29.1, 30.31, 29.4) were comparable in each group. The stone expulsion rate was 83.3%, 79.3%, and 50% in groups A, B, and C respectively. It showed that both the study groups (Group A and Group B) were effective than the control group (p-value 0.006 and 0.02 respectively) but there was no difference between tamsulosin and alfuzosin (p-value 0.69). The duration of stone expulsion was 11.5 days, 11.8 days, and 17.3 days for Group A, B, and C respectively. The drugs related side effects reported by patients were mild and transient. Conclusion: The use of tamsulosin and alfuzosin for the medical treatment of ureteric stones proved to be safe and effective and neither did have any significant benefits over the other.

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