scholarly journals A CLINICAL STUDY FOR THE EVALUATION OF THE EFFECT OF BALA MOOLA CHURNA IN ASRIGDARA

2022 ◽  
Vol 12 (6) ◽  
pp. 17-20
Author(s):  
Manasi PS ◽  
Kavitha BK ◽  
Manju Parvathy
Keyword(s):  
Clinical Study ◽  
Tranexamic Acid ◽  
Well Being ◽  
Randomized Clinical Study ◽  
Nulliparous Women ◽  
Multiparous Women ◽  
Normal Menstrual Cycle ◽  
Group A ◽  
Group B ◽  
Trial Drug

Menstruation is a physiological function that denotes a healthy reproductive system in a woman. A normal menstrual cycle is vital for every woman's physical and psychological well-being. Asrigdara is a condition where there is excessive or prolonged bleeding. Considering the symptoms, it can be related to Dysfunctional Uterine Bleeding, a state of abnormal bleeding without any clinically detectable organic, systemic or iatrogenic causes. It is common in multiparous women than in nulliparous women. Bala Moola mentioned in Chakradutta is undertaken for the present study to evaluate its efficacy in Asrigdara. A randomized clinical study consisting of two groups, with 20 patients in each group were selected. Group A was given trial drug Bala Moola Churna with milk and honey in the dose of 6 gms twice daily after food for three consecutive cycles. Group B was given Tranexamic acid one tablet twice after food for three-cycle. Both the drugs were given till the bleeding stopped or a maximum of 15 days. The study showed that both the drugs, Bala Moola Churna and Tranexamic acid, were equally effective in reducing the symptoms of Asrigdara at the end of treatment.

Effects of Tailored Motor Control Rehabilitation Vs Standard Exercise Program in Management Of Chronic Nonspecific LBP

2021 ◽  
Vol 15 (11) ◽  
pp. 3219-3221
Author(s):  
Maryam Liaquat ◽  
Wajida Perveen ◽  
Danish Hassan ◽  
Misbah Amanat Ali ◽  
Muhammad Akhtar ◽  
...  
Keyword(s):  
Low Back Pain ◽  
Motor Control ◽  
Back Pain ◽  
Clinical Study ◽  
Exercise Program ◽  
Low Back ◽  
Randomized Clinical Study ◽  
Lower Back ◽  
Group A ◽  
Group B

Lower back pain is one of the most common problems in adults all over the world, and chances of having back pain increases with the age. Objectives: To determine the effect of tailored motor control rehabilitation versus standard exercise program in chronic nonspecific lower back pain. Study Design: Non randomized clinical study. Methodology: A non randomized clinical study was conducted in six-month during 2018 after ethical approval. 40 patients were enrolled through non-probability purposive sampling technique and allocated into two groups (Group A & B). Informed consent was obtained. Individuals between twenty to forty years with chronic nonspecific low back pain with intensity at least 3 on a 10cm visual analog scale (VAS) were included and individuals with past history of trauma of the spine and hip and with any red flags were excluded. Outcomes were measures by Modified Oswestry Disability Index (MODI) and Visual Analogue Scale (VAS). Statistical analysis: Data was analyzed by SPSS software, version 19 as qualitative variables were expressed as mean ± SD. Independent sample T test was also applied. Results: The mean age Group A was 29.05±8.58 and Group B, was 32.05±6.53 years. The result shows that there was a significant difference in outcomes among tailored motorcontrol rehabilitation (Group A) and standard exercise program (Group B). Conclusion: We concluded that motor control rehabilitation was more effective than standard exercise program in decreasing low back pain and improving quality of life. Key Words: Low Back Pain, Tailored Motor Control Rehabilitation, Standard Exercise Program and Modified Oswastry Disability Index.

scholarly journals Limberg flap versus primary closure in the treatment of pilonidal sinus: a randomised clinical study

2021 ◽  
Vol 8 (8) ◽  
pp. 2388
Author(s):  
Devaprashanth M. ◽  
Srinivas N. M. ◽  
Akhihlandeshwari N.
Keyword(s):  
Clinical Study ◽  
Pilonidal Sinus ◽  
Primary Closure ◽  
Wound Dehiscence ◽  
Pilonidal Sinus Disease ◽  
Limberg Flap ◽  
Randomized Clinical Study ◽  
Routine Work ◽  
Group A ◽  
Group B

Background: Pilonidal sinus is a chronic disease usually involving the sacrococcygeal area. Various treatment modalities exist, yet few comparison studies exist to compare the efficacy of one modality over the other. Hence this randomized clinical study was undertaken as an attempt to compare the outcomes of pilonidal sinus following Limberg flap procedure and primary closure.Methods: 60 patients undergoing surgery for pilonidal sinus disease were considered for the study. 30 patients underwent excision and primary closure and 30 patients underwent Limberg flap repair. They were followed up for 1 year. Duration of hospital stay, duration of inability to work, postoperative infection, wound dehiscence, and postoperative recurrence in a follow up period were recorded. Descriptive statistics, chi- square tests and independent t-test are the statistical tools employed.Results: Mean age was 29.83±4.99 years. Male:female ratio was 5.66:1. The mean duration of hospitalization in group A was significantly less (p<0.05) than group B. The patients in group B returned early to routine work (21.56±3.92 days) as compared to 30.5±5.92 days in group A (p<0.05). 5 of 30 patients in group A and 2 of 30 in group B developed surgical site infection. (p>0.05. 4 patients developed wound dehiscence in group A only which was found to be statistically significant.Conclusions: Limberg flap in treatment of pilonidal sinus is associated with shorter hospitalization, early return to routine work and less wound dehiscence as compared with excision and primary closure. Wound infections are comparable with both the modalities.

scholarly journals Efficacy of Shankhapushpi Choorna on Borderline IQ in School Going Children - A Randomized Placebo Controlled Clinical Study

2020 ◽  
Vol 11 (3) ◽  
pp. 433-440
Author(s):  
Aswathi P Murali ◽  
Prathviraj Puranik ◽  
Nagaratna S Jartarghar
Keyword(s):  
Clinical Study ◽  
Objective Assessment ◽  
Indian Children ◽  
Post Test ◽  
Group A ◽  
Detailed Assessment ◽  
Group B ◽  
Trial Drug ◽  
Borderline Iq ◽  
Controlled Clinical Study

Objective: To study the concepts regarding Medha, Medhya and IQ. Detailed assessment of IQ level of school going children with 6-8 years of age group. To study the efficacy of Shankhapushpi Choorna in the enhancement of IQ of school going children with Borderline IQ. Design: Open randomized placebo controlled clinical study with pre and post-test design. Setting: O.P.D. of Sri Dharmasthala Manjunatheshwara College of Ayurveda and Hospital, Udupi and also nearby schools of Udupi. Interventions: A minimum of 40 children under borderline IQ were selected based on the inclusion and exclusion criteria. The selected children were randomly divided into 2 groups of 20 each. Group A (Trial Group) were treated with Shankhapushpi Choorna with dose of 5grams daily at night, after food with lukewarm milk for a duration of 60 days and Group B was administered with Placebo. The follow up period was 30 days after the intervention. Main outcome measures: The subjective criteria were based on the parameters of Grasping power, Memory power, Courage & Activity.  The values obtained using Malin’s Intelligence Scale for Indian Children (MISIC) were considered for objective assessment. Results: Over the duration of the study, the trial drug Shankhapushpi Choorna was seen to have a positive effect on all the subjective and objective parameters with statistically highly significant results. Conclusion: Shankhapushpi Choorna with the proper dosage according to the age definitely improves the Medha of children with borderline IQ. The drug can be used as both promotive as well as curative aspects in accordance with intelligence.

scholarly journals A Comparative Clinical Study on the Effect of Dhanyaka Kalka and Dhanyaka Avalehya with Anupana of Sharkara mixed Tandulodaka in Garbhini Chardi

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Upasana Nath ◽  
Kalpana Sharma
Keyword(s):  
Clinical Study ◽  
Large Scale ◽  
Symptomatic Relief ◽  
First Trimester ◽  
Comparative Clinical Study ◽  
Group A ◽  
Group B ◽  
Rice Water ◽  
Trial Drug ◽  
In Pregnancy

Garbhini Chardi (vomiting in pregnancy) is a blazing issue in obstetric enactment. About 50-60% of all pregnant females agonize from vomiting in pregnancy most apparently in first trimester. If not tackled effectively before or in time, it may affect the quality of life of pregnant woman and pregnancy consequences. Ayurvedic classics have described many formulations for management of Garbhini Chardi. In this study Dhanyaka kalka and Dhanyaka Avaleha was taken both with Anupana of Sharkara mixed Tandulodaka. Aim: To compare the effect of Dhanyaka Kalka and Dhanyaka Avaleha with Anupana of Sharkara mixed with Tandulodaka in Garbhini Chardi. Materials and Methods: Single blind clinical study with pre‑test and post‑test was designed. 60 patients complaining of Chardi in 1st trimester were randomly divided into the two groups: Group A and Group B, each comprising of 30 patients. Medicine used for Group A was Dhanyaka Kalka with Anupana of Sharkara Mixed Tandulodaka (rice, water or gruel) and medicine used for Group B was Dhanyaka Avaleha with Anupana of Sharkara mixed Tandulodaka. Those cases, which were in regular follow ups for 5 weeks were taken for clinical study. The criteria of assessment were mainly on the symptomatic relief. Intermediate follow ups were recorded at interval of two weeks. Results: In Group A, overall percentage relief in chief complains was calculated as 59.44% whereas in Group B this value was 66.5%. Conclusion: In present clinical study efficacy of Dhanyaka Avaleha has been proven beneficial in comparison to Dhanyaka Kalka. The trial drug is highly significant in the management of Garbhini Chardi. This study needs to be done on large scale and for longer duration.

scholarly journals A COMPARATIVE CLINICAL STUDY TO EVALUATE THE EFFECT OF VRIKSHAMLA TWAK KASHAYA AND DASHAMOOLA KASHAYA IN UDAVARTHINI YONIVYAPAT

2021 ◽  
Vol 9 (10) ◽  
pp. 2303-2309
Author(s):  
Sahana G ◽  
Shivale Digambar P ◽  
Kavitha B.K ◽  
Manju Parvathy
Keyword(s):  
Clinical Study ◽  
Sedentary Lifestyle ◽  
Research Work ◽  
Normal Function ◽  
Duration Of Treatment ◽  
Natural Event ◽  
Comparative Clinical Study ◽  
Group A ◽  
Group B ◽  
Trial Drug

Menstruation is a physiological, natural event in the reproductive stage of the female. Due to a sedentary lifestyle and lack of self-care, stress, untimely food and other factors, many gynaecological problems occur and one of the most common among them is Dysmenorrhea. Painful menstruation is the most common cause which disturbs the mental state of the woman also affecting her day to day activities during the cycle. Pain is the Pratyatma Lak- shana of Vata vikruti mentioned in Ayurveda. Artava Nishkramana is the normal function of Apana vayu which moves in Pratiloma gati and obstructs the pathway of Artava. In our Classics, most of the gynaecological prob- lems are discussed under Yonivyapat. Udavartini Yonivyapat can be co-related and defined as painful menstrua- tion i.e. Dysmenorrhea. Considering the prevalence of dysmenorrhea in the present era, the trial drug Vrikshamlatwak kashaya which possess the properties such as Shoolprashamana and Vatahara was selected to evaluate its effect in the management of Udavartini yonivyapat. Objectives: To compare and evaluate the effect of Vriksham- la Twak kashaya and Dashamoola kashaya in Udavarthini yonivyapat w.r.s primary dysmenorrhea. Methodolo- gy: This research work was a randomized comparative clinical study of 40 patients suffering from symptoms of Udavartini Yonivyapat, who were randomly selected and categorized into 2 groups of 20 patients each. Group A was treated with Vrikshamla Twak kashaya and group B with Dashamoola Kashaya. Both Kashayas were given in Apanakaala (before food) with Sukhoshna Jala as Anupana. Duration of Treatment: 10 days (Starting 7days before the commencement of cycle till 3rd day of the menstrual cycle) for 3 consecutive cycles. Results and In- terpretation- Both the groups showed statistically significant results. Statistically, there was no significant differ- ence between the groups. Conclusion: Both Vrikshamla Twak kashaya and Dashamoola Kashaya had an equal effect in treating Udavartini Yonivyapat. Keywords: Udavartini, Dysmenorrhea, Vrikshamla Twak Kashaya, Dashamoola kashaya.

scholarly journals Clinical study to evaluate the effectiveness of Narikela Lavana, Navasadara Yuktha Yavakshara in comparision with Surya and Navasadara Paneeya Kshara in the management of Cholelithiasis

2020 ◽  
Vol 5 (05) ◽  
pp. 39-45
Author(s):  
Nagaratna . ◽  
Srinivas Masalekar
Keyword(s):  
Clinical Study ◽  
Gall Bladder ◽  
Positive Result ◽  
Effective Treatment ◽  
Empty Stomach ◽  
Once Daily ◽  
Control Drug ◽  
Group A ◽  
Group B ◽  
Trial Drug

Cholelithiasis is a crystalline concretion formed within the gall bladder by accretion of bile components. Cholelithiasis can be considered as Pittashaya Ashmari, but there is no direct reference of this condition available in Ayurveda. In Ayurveda the effective treatment is Paneeya Kshara. Surya and Navasadara Paneeya Kshara is standard one and which is highly effective treatment in the management of Cholelithiasis but, persisting pain, presence of calculi has limited in its use. To overcome the lacunas present study has been carried out. This study was conducted at SJIIM Hospital Bengaluru and total of 40 patients were randomly allotted into two groups namely Group A with trial drug i.e. 2grams each of Narikela Lavana, Navasadara, Yava Kshara orally with Jala once daily in empty stomach in the morning, every day for 28 days and Group B with control drug i.e. 2grams of Surya and Navasadara Paneeya Kshara orally with Narikela Jala once daily in empty stomach in the morning, every day for 28 days. Assessment was made on Subjective and Objective parameters. Observations were made before the treatment and on 15th day and 30th day to know the efficacy of the treatment. The combination of Narikela Lavana, Navasadara Yuktha Yava Kshara showed a positive result.

Comparative Clinical study of Jatyadi Taila and Jatyadi Ghrita in the management of Dushta Vrana

2018 ◽  
Vol 3 (3) ◽  
Author(s):  
Rajendra Joshi ◽  
N. B. Mashetti ◽  
Rakesh Kumar Gujar
Keyword(s):  
Clinical Study ◽  
Burning Sensation ◽  
Normal Process ◽  
Surgical Practice ◽  
Local Factors ◽  
Significant Difference ◽  
Comparative Clinical Study ◽  
Group A ◽  
Contaminated Wound ◽  
Group B

Dushta Vrana is a common and frequently encountered problem faced in surgical practice. The presence of Dushta Vrana worsens the condition of the patient with different complications and may become fatal. Local factors on wound like slough, infection and foreign body, affect the normal process of healing. A healthy wound in a normal body heals earlier with a minimum scar as compared to a contaminated wound. Therefore in this study all the efforts are made to make a Dushta Vrana into a Shuddha Vrana. Once the Vrana becomes Shuddha, Ropana of the Vrana will start. The objective of the study was to evaluate the clinical efficacy of Jatyadi Taila and Jatyadi Ghrita in Dushta Vrana. Clinically diagnosed 60 Patients of Dushta Vrana were randomly divided into two groups, each consisting of 30 Patients. Group A were treated with the Jatyadi Taila and Group B was treated by Jatyadi Ghrita. The results observed was based on the relief obtained on the subjective and objective parameters taken for consideration for this study viz, size of ulcer, discharge, smell, pain, burning sensation, itching and granulation were found significant (P Lass Than 0.05). On the basis of assessment criteria and overall result of treatment, the patients of Jatyadi Taila group showed better results when compared to Jatyadi Ghrita group. Even though statistically there is no much significant difference between the two groups, but by seeing the effect on individual parameters (subjective and objective) and over all response, Jatyadi Taila seems to be effective when compared to Jatyadi Ghrita. It is having more Ropana qualities when compared to Shodhana.

scholarly journals Oral Tranexamic Acid for the Treatment of Melasma

2014 ◽  
Vol 10 (4) ◽  
pp. 40-43 ◽  
Author(s):  
D Karn ◽  
S KC ◽  
A Amatya ◽  
EA Razouria ◽  
M Timalsina
Keyword(s):  
Tranexamic Acid ◽  
Controlled Trial ◽  
Severity Index ◽  
Sustained Improvement ◽  
Treatment Measures ◽  
Group A ◽  
Group B ◽  
Novel Concept ◽  
High Treatment

Background Melasma poses a great challenge as its treatment is unsatisfactory and recurrence is high. Treatment of melasma using tranexamic acid (oral, topical or intralesional) is a novel concept. Objective To compare the efficacy of oral tranexamic acid with routine topical therapies for the treatment of melasma. Methods It is a prospective, interventional, randomized controlled trial conducted among 260 melasma patients. Patients were divided into two groups consisting of 130 patients each. First group (Group A) was given routine treatment measures and oral Tranexamic Acid while second group (Group B) was treated only with routine topical measures. Capsule Tranexamic Acid was prescribed at a dose of 250 mg twice a day for three months and cases were followed for three months. Response was evaluated on the basis of Melasma Assessment Severity Index (MASI). Mean scores between the two groups were then compared. Results Statistically significant decrease in the mean Melasma Assessment Severity Index from baseline to 8 and 12 weeks was observed among group A patients (11.08±2.91 vs 8.95±2.08 at week 8 and vs. 7.84±2.44 at week 12; p<0.05 for both). While among group B patients the decrease in mean score was significant at 8 weeks and insignificant at 12 weeks follow up (11.60±3.40 vs 9.9±2.61 at 8 weeks and vs. 9.26±3 at 12 weeks; p<0.05 for former but p>0.05 for later). Conclusion Addition of oral tranexamic acid provides rapid and sustained improvement in the treatment of melasma. DOI: http://dx.doi.org/10.3126/kumj.v10i4.10993 Kathmandu Univ Med J 2012;10(4):40-43

scholarly journals Multiple intravenous tranexamic acid doses in total knee arthroplasty in patients with rheumatoid arthritis: a randomized controlled study

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Bing-xin Kang ◽  
Hui Xu ◽  
Chen-xin Gao ◽  
Sheng Zhong ◽  
Jing Zhang ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Clinical Trial ◽  
Total Knee Arthroplasty ◽  
Blood Loss ◽  
Tranexamic Acid ◽  
Randomized Controlled ◽  
Group A ◽  
Total Knee ◽  
Group B ◽  
D Dimer

Abstract Background We aimed to determine the efficacy and safety of multiple doses of intravenous tranexamic acid (IV-TXA) on perioperative blood loss in patients with rheumatoid arthritis (RA) who had undergone primary unilateral total knee arthroplasty (TKA). Methods For this single-center, single-blind randomized controlled clinical trial, 10 male and 87 female participants with RA, aged 50–75 years, who underwent unilateral primary TKA were recruited. The patients received one dose of 1 g IV-TXA 10 min before skin incision, followed by articular injection of 1.5 g tranexamic acid after cavity suture during the surgery. The patients were randomly assigned (1:1) into two groups and received an additional single dose of IV-TXA (1 g) for 3 h (group A) or three doses of IV-TXA (1 g) for 3, 6, and 12 h (group B) postoperatively. Primary outcomes were total blood loss (TBL), hidden blood loss (HBL), and maximum hemoglobin (Hb) level decrease. Secondary outcomes were transfusion rate and D-dimer levels. All parameters were measured postoperatively during inpatient hospital stay. Results The mean TBL, HBL, and maximum Hb level decrease in group B (506.1 ± 227.0 mL, 471.6 ± 224.0 mL, and 17.5 ± 7.7 g/L, respectively) were significantly lower than those in group A (608.8 ± 244.8 mL, P = 0.035; 574.0 ± 242.3 mL, P = 0.033; and 23.42 ± 9.2 g/L, P = 0.001, respectively). No episode of transfusion occurred. The D-dimer level was lower in group B than in group A on postoperative day 1 (P <  0.001), and the incidence of thromboembolic events was similar between the groups (P > 0.05). Conclusion In patients with RA, three doses of postoperative IV-TXA further facilitated HBL and Hb level decrease without increasing the incidence of adverse events in a short period after TKA. Trial registration The trial was registered in the Chinese Clinical Trial Registry (ChiCTR1900025013).

Effects of Diaphragmatic Breathing and Systematic Relaxation on Depression, Anxiety, Stress, and Glycemic Control in Type 2 Diabetes Mellitus

2021 ◽  
Author(s):  
Abhishek Yadav ◽  
Rajeev Mohan Kaushik ◽  
Reshma Kaushik
Keyword(s):  
Glycemic Control ◽  
Well Being ◽  
Depression And Anxiety ◽  
Diaphragmatic Breathing ◽  
Group A ◽  
Student’S T ◽  
Group B ◽  
Mental Well Being ◽  
Student’S T Test

Abstract This prospective study assessed the effects of diaphragmatic breathing and systematic relaxation on depression, anxiety, and stress levels, as well as glycemic control, in patients with type 2 diabetes mellitus (T2DM). One hundred patients with T2DM were randomly assigned to two equal groups: Group A patients received conventional treatment for T2DM, and Group B patients received conventional treatment for T2DM plus training in diaphragmatic breathing and systematic relaxation and home practice of these stress-management techniques for 6 months. Stress, depression, and anxiety levels, blood sugar, and glycated hemoglobin (HbA1c) were recorded at baseline and after 6 months of treatment in all patients. Baseline characteristics were compared using the chi-square test and student’s t test. Changes in mental well-being and glycemic status were assessed for their significance in each group using student’s t test and compared between two groups using one-way analysis of covariance (ANCOVA). Baseline levels of the respective change outcome and duration of diabetes were used as covariates in the ANCOVA. A significant decrease was seen in depression, anxiety, and stress scores in Group B, but in Group A only the stress score decreased after 6 months. A significant decline occurred in blood sugar (fasting, 2-hour postprandial, and random) and HbA1c in both groups after 6 months. There was a larger decrease in depression and anxiety scores and HbA1c in Group B than in Group A. The decrease in HbA1c was significantly correlated with the decrease in anxiety and stress scores in both groups and with the depression score in Group A. Thus, the addition of diaphragmatic breathing and systematic relaxation to conventional T2DM treatment appears to have led to improvement in mental well-being and glycemic control in patients with T2DM.

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