scholarly journals Role of “Meshshringyadi Yog" in the management of Diabetic wound

2021 ◽  
Vol 12 (3) ◽  
pp. 726-729
Author(s):  
Archana B Kukade ◽  
Priyanka D Patil ◽  
Pradeep Kumar B Jondhale
Keyword(s):  
Diabetes Mellitus ◽  
Adverse Effects ◽  
Herbal Medicines ◽  
Modern Society ◽  
Hypoglycemic Agents ◽  
Diabetic Wound ◽  
Diabetes Mellitus Type Ii ◽  
Health Complications

Diabetes mellitus type II is a metabolic disorder and has become confront for   the   medical professionals to deal with   comprehensively and it becomes   thoughtful   problem of   modern society due to severe long- term health complications associated with it. Though   there    are abundant   hypoglycemic   agents available in the market, due to their adverse effects, herbal medicines are becoming  more  popular with better results and probable null adverse effects on body. Ayurvedic remedies for Diabetes Mellitus are the   oldest   among   all   the available therapies. Through various literary reviews  Meshshringi (Gymnema sylvestre, Robert Brown) Aamalaki (Emblica officinalis, Gaerthand) Vijaysar (Pterocarpus marsupium, Roxburgh) have shown marked  effect  in Diabetes mellitus and their  properties  also  shows  anti-inflammatory, antioxidant effects   also . This article   highlights a case of diabetic wound treated with Meshshringyadi- yog  with effective results. 

Patient with Diabetes Mellitus and Ocular Complications: A Brief review

2021 ◽  
pp. 141-145
Author(s):  
Naveen K L ◽  
Grinton Josvi Veigas ◽  
Ananya Bhattacharjee
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Action ◽  
Vision Loss ◽  
Ocular Complications ◽  
Autoimmune Destruction ◽  
Young Stage ◽  
Onset Of Diabetes ◽  
Heart Blood ◽  
Health Complications

Diabetes mellitus is metabolic disorder characterised by hyperglycaemia of human blood due to inadequate secretion and action of hormone insulin. Different classes of DM are Type-1, Type-2, neonatal, gestational and maturity onset of diabetes at young stage. The main pathologic cause for the DM is autoimmune destruction of β-cells and insulin deficiency due to resistance of insulin action caused by the abnormalities in metabolism of carbohydrates, protein and lipids which intern cause lack of insulin action on target tissues. Chronic stage of hyperglycaemia is associated with permanent damage, failure and dysfunction of various organs system, which includes heart, blood vessel, eyes, neurones and kidney. Long term DM may causes some health complications in patient such as nephropathy, neuropathy, retinopathy and other complications like peripheral vasculopathy and ischemia of heart. In current era ocular complications associated with DM are rapid and progressive, becoming world top most cause of morbidity. This article covers brief information regarding ocular complications and vision loss in patient with DM.

scholarly journals An Immediate and Long-Term Complication of COVID-19 May Be Type 2 Diabetes Mellitus: The Central Role of β-Cell Dysfunction, Apoptosis and Exploration of Possible Mechanisms

Cells ◽  
2020 ◽  
Vol 9 (11) ◽  
pp. 2475
Author(s):  
Melvin R. Hayden
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Cell Injury ◽  
Light And Electron Microscopy ◽  
Β Cell ◽  
Cell Dysfunction

The novel coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) was declared a pandemic by the WHO on 19 March 2020. This pandemic is associated with markedly elevated blood glucose levels and a remarkable degree of insulin resistance, which suggests pancreatic islet β-cell dysfunction or apoptosis and insulin’s inability to dispose of glucose into cellular tissues. Diabetes is known to be one of the top pre-existing co-morbidities associated with the severity of COVID-19 along with hypertension, cardiocerebrovascular disease, advanced age, male gender, and recently obesity. This review focuses on how COVID-19 may be responsible for the accelerated development of type 2 diabetes mellitus (T2DM) as one of its acute and suspected long-term complications. These observations implicate an active role of metabolic syndrome, systemic and tissue islet renin–angiotensin–aldosterone system, redox stress, inflammation, islet fibrosis, amyloid deposition along with β-cell dysfunction and apoptosis in those who develop T2DM. Utilizing light and electron microscopy in preclinical rodent models and human islets may help to better understand how COVID-19 accelerates islet and β-cell injury and remodeling to result in the long-term complications of T2DM.

scholarly journals Best Approach to Prevent Diabetic Nephropathy

2019 ◽  
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Nephropathy ◽  
Hypoglycemic Agents ◽  
Renal Outcome ◽  
Pathogenic Mechanisms ◽  
Type1 Diabetes ◽  
Outcome Trial ◽  
Almost All

The last two decades have witnessed a storm in our understanding of the pathogenesis of diabetic nephropathy. In parallel, the newly evolved hypoglycemic agents have shown different mechanisms of action that would effectively tackle the different pathogenic mechanisms involved in the development and progression of diabetic nephropathy. Several large prospective placebo controlled clinical trials have supported the significant impact of these different agents to withhold the progression of diabetic nephropathy. Almost all these trials involved type 2 diabetes mellitus (T2DM). However, most of these agents can additionally be used in type1 diabetes mellitus (T1DM) patients aiming at avoidance of long-term complications of this disease. The most recent of these trial, the DECLARE - TIMI 58 renal outcome trial, have additionally declared the preventive value of dapagliflozin in T2DM. In this review, we are going to discuss the most recent and relevant pathogenic mechanisms highlight the therapeutic and value of the early use of the different agents to prevent the development of diabetic nephropathy.

scholarly journals Charms & Harms: Devil's Claw

2009 ◽  
Vol 1 (3) ◽  
pp. 238 ◽  
Author(s):  
Joanne Barnes
Keyword(s):  
Adverse Effects ◽  
Herbal Medicines ◽  
Term Treatment ◽  
Low Back ◽  
Efficacy And Safety ◽  
Short Term ◽  
Short Term Treatment ◽  
Acute Exacerbations ◽  
Long Term Adverse Effects

SUMMARY MESSAGE: There is evidence that Devil’s Claw can be an effective short-term treatment for acute exacerbations of low back pain and, to a lesser extent, in rheumatic and osteoarthritic conditions. Acute adverse effects reported in clinical trials were mild diarrhoea and flatulence. Long-term adverse effects have not been studied. As with all herbal medicines, Devil’s Claw products differ in their pharmaceutical quality, and the implications of this for efficacy and safety should be considered.

scholarly journals Role of Vidangadi Kwatha in Madhumeha (Diabetes Mellitus Type II)

2021 ◽  
Vol 05 (05) ◽  
Author(s):  
Premlata, Ram B ◽  
Vimlesh, . ◽  
Sachin Choudhary ◽  
Jitendra Khachariya
Keyword(s):  
Diabetes Mellitus ◽  
Diabetes Mellitus Type ◽  
Type Ii ◽  
Diabetes Mellitus Type Ii

scholarly journals TRANSFORMATION OF ADVERTISING UNDER THE INFLUENCE OF NEW TRENDS OF CONSUMPTION AS A SOCIAL ACTION

2021 ◽  
Author(s):  
Tetiana Reshetilova ◽  
◽  
Tetiana Kuvaieva ◽  
Keyword(s):  
Consumer Behavior ◽  
Social Action ◽  
Social Stratification ◽  
Modern Society ◽  
Modern Information Technology ◽  
Ambiguous Situation ◽  
The Impact ◽  
Selection Of

The article is devoted to the study of advertising transformation under the influence of new trends of consumption as a social action. It is highlighted that the current socio-economic situation is creating new subjects for the analysis of already well-known objects. The place and role of advertising in modern society is certainly based on its market principles in the past, but today it is necessary to take into account a set of influencing factors that were previously mutually exclusive but are now indivisible. The greatest influence is exerted by the socio-cultural aspect of consumer behavior, which is based on values and motivators that come from the lifestyle in a qualitatively new external environment. It means that they are not limited to market transactions. Moreover, in today's conditions, social stratification has receded into the background and is not among the main factors of influence. This transformation of understanding the practice of consumption allows to reasonably recruit and use advertising tools to increase their effectiveness. It is determined that during forming an advertising campaign it is necessary to consider the impact on consumer behavior of modern information technology, namely the selection of the necessary information from the large amount that is available. A large amount of information creates an ambiguous situation for the consumer. This requires the integration of advertising tools. It is established that the parallel use of several advertising media allows to carry out the influence similarly to the technology of purposeful management. The availability of technical means that quickly realize the desire can be recommended for both long-term brand communication and for the short term.

The Promising Role of Plant Tannins as Bioactive Antidiabetic Agents

2019 ◽  
Vol 26 (25) ◽  
pp. 4852-4884 ◽  
Author(s):  
Mohammed Ajebli ◽  
Mohamed Eddouks
Keyword(s):  
Diabetes Mellitus ◽  
Hypoglycemic Agents ◽  
Antidiabetic Activity ◽  
Glucose Lowering ◽  
Molecular Weights ◽  
Beneficial Effects ◽  
Pharmacological Studies ◽  
Glucose Lowering Effect ◽  
Available Information

Background:Plant tannins are polyphenolic substances with various molecular weights and a variable complexity. Due to the beneficial effects for controlling chronic disorders particularly diabetes mellitus, this class of secondary metabolites has gained more interest in the recent years.Objective:We aimed through this review to collect, analyze and discuss all available information related to the antidiabetic effect of isolated tannins (including both condensed and hydrolysable varieties) and tannin-rich plants as well as the possible mechanisms of action involved in this antidiabetic activity.Methods and Results:Our bibliographic research was conducted to gather more than 41 medicinal plants containing tannins and 19 isolated tannins and tannin-rich crud extracts which were revealed to possess glucose lowering effect according to pharmacological studies.Conclusion:Hence, according to findings of the present review, tannins could be useful for prevention and management of diabetes mellitus and its associated complications and these natural products could be promising compounds for the discovery of new hypoglycemic agents.

Stem Cells: A Golden Therapy for Diabetic Wound

2020 ◽  
Vol 16 ◽  
Author(s):  
Shubhangi Buchade ◽  
Shivani Desai ◽  
Ramesh Bhonde ◽  
Heena Kazi ◽  
Shivani Sainani ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Stem Cells ◽  
Stem Cell ◽  
Microvascular Complications ◽  
Foot Ulcer ◽  
Major Complication ◽  
Diabetic Wound ◽  
Organ Systems ◽  
The World

: Diabetes mellitus is the 7 th leading cause of death worldwide. Diabetes can affect the organ systems and lead to serious complication, majorly categorized as macrovascular complications, microvascular complications, and diabetic wound. Foot ulcer develops in 15-25% diabetic patient. In diabetic wound there is impairment in growth factor, neuropeptide, matrix metalloproteinases, angiogenesis, immune system. Many approaches are being experimented to manage this major complication of diabetic foot, but unfortunately with lesser success rate. Stem cell is an upcoming field which is being explored in the world of diabetes. Hence, this review is designed to understand the basic pathogenesis and complications of types of diabetes and the role of stem cells in diabetic wound and the benefits related to it.

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