scholarly journals Various Phytochemicals Present in Maida Lakdi Litsea glutinosa (Lour) acts in the Management of Waja ul Mafasil (Arthritis) in a Clinical Trials

2021 ◽  
Vol 9 (11) ◽  
pp. 1-8
Author(s):  
Zaibunnisa Begum ◽  
Noor Banu Noorein ◽  
Shenaz Begum Modi
Keyword(s):  
Wound Healing ◽  
Clinical Trials ◽  
Joint Pain ◽  
Classical Text ◽  
Functional Activities ◽  
Anti Oxidant ◽  
Anti Inflammatory ◽  
Traditional Practitioners ◽  
Litsea Glutinosa ◽  
Anti Fungal

Litsea glutinosa (Lour) Maida Lakdi is an evergreen tree belonging to family Lauraceae it is a native to India.1,2,3 Ethinomedically the bark is used by the traditional practitioners as a demulcent, emollient and in the treatment of diarrhea and dysentery. According to ancient Unani classical text books by our ancient scholars which was used for mostly bony diseaseslike Fracture (kasar), Joint pain(Hudaar), gout(Naqras), sciatica(lrqun nasa), anti inflammatory(Muhalil e Auram), spacity of nerves(Tashannunj e Asab), nervine tonic(Muqavi e Asab)etc. and now a days further activities were found by various scientific studies paving a way for multi functional activities like Anti oxidant , analgesic anti inflammatory, anti pyretic, anti microbial, anti bacterial, anti fungal anti helminthic, wound healing, hepatoprotective, nephro protective, anti infertility,anti hyperglycemic and anti hyperlipidemic.

A REVIEW OF PHYTOMORPHOLOGICAL, PHYTOCHEMICAL AND PHARMACOLOGICAL ACTIVITY ON IPOMOEA CARNEA

2021 ◽  
Vol 12 (4) ◽  
pp. 166-169
Author(s):  
Mahaveer Sing ◽  
Sravan P Kumar ◽  
Birendra Shrivastava ◽  
Pamula B Reddy ◽  
Suma Rohilla
Keyword(s):  
Wound Healing ◽  
Pharmacological Activity ◽  
Wild Plant ◽  
Toxicological Effects ◽  
Ipomoea Carnea ◽  
Anti Cancer ◽  
Anti Inflammatory ◽  
Anti Fungal

Ipomoea carnea Jacq. grows as wild plant in India. It is identified as a useful material for several applications including medicinal purposes. Different extracts of Ipomoea carnea plant possess anti-bacterial, anti-fungal, antioxidant, antimicrobial, anti-cancer, anti-convulsant, immune modulatory, antidiabetic, hepatoprotective, anti-inflammatory, anxiolytic, sedative, cardiovascular, inhibition and wound healing activities. However, some toxicological effects have been also reported. In this review the potential of phytochemical, pharmacological and other activities of Ipomoea carnea are discussed.

A review on phyto-pharmacology of Oxalis corniculata

2021 ◽  
Vol 24 ◽  
Author(s):  
Iqra Sarfraz ◽  
Azhar Rasul ◽  
Ghulam Hussain ◽  
Muhammad Ajmal Shah ◽  
Bushra Nageen ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Biological Activities ◽  
Chemical Constituents ◽  
Current Effort ◽  
Isolation And Characterization ◽  
Anti Cancer ◽  
Anti Oxidant ◽  
Anti Fungal ◽  
Warm Temperate

: Oxalis corniculata (Oxalidaceae) is a small decumbent and delicate appearing medicinal herb flourishing in warm temperate and tropical domains such as Pakistan and India. Main bioactive chemical constituents of Oxalis plant include several alkaloids, flavonoids, terpenoids, cardiac glycosides, saponins, phlobatannins along with steroids. Due to its polyphenolic, glycosides and flavonoid profile, it is proved to be protective in numerous ailments and exhibit various biological activities such as anti-fungal, anti-cancer, anti-oxidant, anti-bacterial, anti-diabetic, and cardioprotective. Moreover, bioactive phytochemicals from this plant possess significant wound healing potential. Our current effort intends to emphasize on the immense significance of this plant species, which have not been the subject matter of clinical trials and effective pharmacological studies, even though its favored usage has been stated. This review proposes that Oxalis corniculata possess potential for the cure of various diseases, however, further researches on isolation and characterization of bioactive compounds along with pre-clinical trials are compulsory to figure out its pharmacological applications.

scholarly journals Potential of natural astaxanthin in alleviating the risk of cytokine storm and improve health in COVID-19: A scoping review

2020 ◽  
Author(s):  
Jayanta Talukdar ◽  
Bhaskar Bhadra ◽  
Santanu Dasgupta ◽  
Vinod Nagle
Keyword(s):  
Clinical Trials ◽  
Inflammatory Cytokines ◽  
Scoping Review ◽  
Meta Analysis ◽  
Relevant Literature ◽  
Elevated Serum ◽  
Cytokine Release ◽  
Prisma Statement ◽  
Anti Oxidant ◽  
Anti Inflammatory

Abstract Background: Natural astaxanthin as a potent anti-oxidant and broad-spectrum anti-inflammatory bioactive molecule plays important role in modulating the immune response, speculated to be a potential supplement to alleviate cytokine release storm in COVID-19. Objective: Review of published literature to summarize the rationale for possible benefits of natural astaxanthin to support COVID-19 patients. Methods: Retrieved relevant literature from electronic databases including Google scholar, PubMed, Scopus, etc. and reviewed following Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) Statement. We adapted the article as scoping review. Results: Cytokine release syndrome (CRS) is reported as a common feature in COVID-19, which can lead to potentially fatal, hyper-inflammatory acute respiratory distress condition, diagnosed with elevated serum level of pro-inflammatory cytokines like IL-6, CRP, etc. that positively correlated with disease severity. Anti-inflammatory drug, like tocilizumab, etc. are under clinical trials as anti-CRS therapy. Astaxanthin can potentially alleviate CRS by regulating inflammatory cytokines by inhibiting the activities of NF-kB, TNF-α, JAK/STAT-3, etc. Available pre-clinical and clinical trials data support its excellent safety, and potential therapeutic and health benefits. Conclusions: Natural astaxanthin has tremendous potential as co-adjunctive supplement, desiring necessary clinical supports on its efficacy and beneficial against COVID-19.

scholarly journals Biological Activities and Phytochemical Constituents of Trailing Daisy Trilobata: A Review

2019 ◽  
Vol 9 (4-s) ◽  
pp. 888-892
Author(s):  
K Sai Prasanna ◽  
G Jyothi Reddy ◽  
M Kiran ◽  
K Thyaga Raju
Keyword(s):  
Skin Diseases ◽  
Biological Activities ◽  
Pharmacological Activities ◽  
Traditional System ◽  
Wedelia Trilobata ◽  
Anti Oxidant ◽  
Phytochemical Constituents ◽  
Anti Inflammatory ◽  
Anti Fungal ◽  
Natural Medicines

The traditional system of medicinal plants have been found to possess significant anti-inflammatory, antibacterial, anti-fungal, anti-diabetic, analgesic properties etc. Plant-derived drugs are used to cure mental illness, skin diseases, tuberculosis, diabetes, jaundice, hypertension, and cancer. Wedelia Trilobata belongs to family Asteraceae. Leaf, stem, and flower of Wedelia trilobata show anti-microbial, anti-oxidant and anti-inflammatory activity, analgesic activity. Phytochemical screening of the extract has been reported to show the presence of tannins, cardiac glycosides, flavonoids, terpenoids, phenols, saponins, and coumarins. Wedelia Trilobata is also used in reproductive problems, amenorrhea, chest cold, dry cough, and fever. The present review aims to the study was phytoconstituents, biological and pharmacological activities of Wedelia trilobata. This study suggested a possible use of Wedelia trilobata as a source of natural medicines as an anti-inflammatory, anti-oxidant, anti-microbial, hepatoprotective, antidiabetic agents. Keywords: Wedelia Trilobata, Trialing daisy trilobata, Complaya trilobata(L), Sphagneticola Trilobata, pharmacological review.

scholarly journals IMMUNOMODULATORY Β-GLUCANS ENHANCE THE WOUND HEALING ABILITY OF CHLOROFORM FRACTION OF ACHYRANTHES ASPERA L

2021 ◽  
Author(s):  
Krishnaraju Venkatesan ◽  
Fazil Ahmad ◽  
Rasheed Ahemad Shaik ◽  
Kayamkani Abedulla Khan ◽  
Doaa Ahmed Ebrahim Radwan ◽  
...  
Keyword(s):  
Wound Healing ◽  
Positive Control ◽  
Excision Wound ◽  
Wound Model ◽  
Beta Glucans ◽  
Anti Oxidant ◽  
Anti Inflammatory ◽  
Rat Paw ◽  
Diabetic Wounds ◽  
Negative Controls

Introduction: Wound healing is a multifaceted biological process, and diabetic wounds add more complexity to it. In diabetic wounds, the combination of chloroform fractions of Achyranthes aspera L. (A.aspera) leaves with β-Glucans has not been investigated. The additive effect of these two (A.aspera + β-Glucans) would benefit the inflammatory phase of diabetic wounds, as improper treatment will lead to chronic injuries. Therefore, the goal of this research work was to assess the in-vivo wound healing and anti-inflammatory effects of a combination of chloroform fractions of A.aspera leaves and β-Glucans in a variety of wound models in STZ-induced diabetic rats. Methods: Preliminary phytochemical analyses of A.aspera were conducted to identify various phytoconstituents in the test extract. Acute and sub-acute dermal toxicity tests of A.aspera were carried out on mice and rats, respectively, to see whether there were any abnormalities. Excision and incision wound models, cotton pellet-induced granuloma models, rat paw edema and burn wounds were used to test wound healing and anti-inflammatory actions. To induce diabetes, streptozotocin (STZ) was administered intraperitoneally at a dosage of 65 mg/kg (i.p.). A.aspera (10% w/w) and β-Glucans (2% w/w) ointments were tested separately and in combination for wound healing activities. Silver sulfadiazine (1 % w/w) ointment was used to treat the positive control groups. Excision wound model rats that had been treated with basic ointment were used as negative controls, as were incision wound model rats that had not been treated. A.aspera (400 mg/kg, po) and β-Glucans (30 mg/kg, po) were tested separately and in combination for anti-inflammatory efficacy. Positive control groups were given indomethacin (10 mg/kg, po) for cotton pellet-induced granuloma and rat paw oedema models. Negative controls for both anti-inflammatory activity models were provided 2% Tween 80. The groups were made up of six rats, and the treatments were given topically and orally to assess wound healing and anti-inflammatory effects. The levels of hydroxyproline and hexosamine and the antioxidant enzymes (SOD and CAT) in the granulation tissue were measured in excision wound model. Healed excision wound skin was examined histopathologically. Results: The A.aspera and β-Glucans combination resulted in a significant percentage of wound contraction and a shorter epithelialization time (P<0.01). The combination was found to be the most effective, with the highest percentage of edema reduction (55 %; p<0.01). The combination also exhibited favourable hydroxylamine, hexosamine and anti-oxidant profiles supported by histopathology data. Conclusion: This research showed that the immunomodulatory effect of β-Glucans had significantly enhanced the wound healing, anti-inflammatory, and anti-oxidant potential of A.aspera in diabetic wounds.

scholarly journals An overview on synthesis and reactions of coumarin based compounds

2022 ◽  
Vol 11 (1) ◽  
pp. 29-42 ◽  
Author(s):  
Mahmoud S. Tolba ◽  
Mokhtar A. Abd ul-Malik ◽  
Adel M. Kamal El-Dean ◽  
Ahmed A. Geies ◽  
Shaban M. Radwan ◽  
...  
Keyword(s):  
Oxygen Atom ◽  
Food Additives ◽  
Synthetic Compounds ◽  
Significant Interest ◽  
Anti Oxidant ◽  
Anti Inflammatory ◽  
Anti Fungal ◽  
Anti Hiv ◽  
Natural And Synthetic

Oxygen-containing heterocycles are largely distributed in natural and synthetic compounds. Coumarins are among the most famous heterocycles which possess one oxygen atom in their rings. Coumarins are classified as multifunctional scaffold and are used as anti-oxidant reagents, anti-inflammatory, anti-microbial, anti-fungal, anti-HIV active, analgesic, anti-histaminic, insecticides, dyes, herbicides, sensitizers, perfumes, cosmetics and food additives. Due to their diverse applications in industrial and pharmaceutical fields, many chemists have given significant interest to these compounds. Herein, the review highlights various methods for the synthesis and interactions of coumarin moiety as one of the most efficient categories of heterocycles.

scholarly journals UJI EFEK EKSTRAK DAUN LIDAH BUAYA (Aloe vera L.) TERHADAP PENYEMBUHAN LUKA INSISI KULIT KELINCI (Oryctolagus cuniculus)

2015 ◽  
Vol 3 (1) ◽  
Author(s):  
Christian A. Sewta ◽  
Christi Mambo ◽  
Jane Wuisan
Keyword(s):  
Wound Healing ◽  
Leaf Extract ◽  
Intestinal Tract ◽  
Aloe Vera ◽  
Rabbit Skin ◽  
Anti Oxidant ◽  
The Right ◽  
Tract Pain ◽  
Gastro Intestinal Tract ◽  
Anti Fungal

Abstract: Aloe vera has been used for thousands years to treat burns, hair loss, skin infections, sinus inflamation and gastro-intestinal tract pain. Previous researches showed that Aloe vera works effectively as anti-inflammatory, anti-pyretic, anti-fungal, anti-oxidant, anti-septic, anti-microbial, and anti-viral. This study aimed to evaluate the effect of aloe vera extract on wound healing in incised rabbit skin. This was an experimental study using 3 rabbits as test animals. The rabbits right and left backs were incised for 4 cm long and 2 mm deep. The wound on the right back was given aloe leaf extract , and the wound on the left back was not. The length of the wounds were measured everyday for 2 weeks. ResThe results showed that the wounds that were given aloe leaf extract dried and healed faster. Conclusion: Aloe vera extract accelerated wound healing in the incised rabbit skin.Keywords: aloe vera leaf extract, incision woundAbstrak: Lidah buaya digunakan sebagai bahan obat sejak beberapa ribu tahun yang lalu untuk mengobati luka bakar, rambut rontok, infeksi kulit, peradangan sinus, dan rasa nyeri pada saluran cerna. Beberapa peneliti terdahulu telah membuktikan bahwa Aloe vera berkhasiat sebagai antiinflamasi, antipiretik, antijamur, antioksidan, antiseptik, antimikroba, serta antivirus. Penelitian ini bertujuan untuk mengetahui efek pemberian ekstraksi lidah buaya terhadap penyembuhan luka insisi kulit kelinci. Penelitian ini mengunakan metode eksperimental, dengan menggunakan 3 ekor kelinci sebagai hewan uji. Punggung kanan dan kiri kelinci diinsisi sepanjang 4 cm dan kedalaman 2 mm. Luka pada punggung kanan diberi ekstrak daun lidah buaya sedangkan luka pada punggung kiri tidak diberi ekstrak daun lidah buaya. Pemberian ekstrak daun lidah buaya dan pengukuran panjang luka dilakukan setiap hari selama 2 minggu. Hasil penelitian memperlihatkan luka insisi kulit kelinci yang diberi ekstrak daun lidah buaya lebih cepat kering dan sembuh dibandingkan dengan luka insisi kulit kelinci yang tidak diberikan ekstrak daun lidah buaya. Simpulan: Pemberian ektrak daun lidah buaya memiliki efek untuk mempercepat penyembuhan luka insisi pada kulit kelinci.Kata kunci: ekstrak daun lidah buaya, luka insisi

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