Observation of the Curative Effect of Sodium Hyaluronate Combined with Fuming Capsule on Dry Eye after Cataract Operation

Background. In recent years, the prevalence of allergic diseases of the anterior chamber of the eye has increased. They are often accompanied by the development of dry eye syndrome, which can complicate their course. Therefore, it is important to take a comprehensive approach to their diagnosis and treatment. The purpose was to study the effectiveness of 0.4% sodium hyaluronate (Gilays) in children with dry eye syndrome on the background of allergic diseases of the conjunctiva. Materials and methods. The study involved 42 patients (84 eyes) aged 3 to 18 years, who were examined and treated on the basis of Regional Eye Clinic. Patients were treated with local H-1 histamine blockers twice a day for 14 days, f necessary — with topical glucocorticoids by the scheme for 12 days. In the first group (21 patients, 42 eyes), the main treatment was added with the drugs containing 0.2% sodium hyaluronate, used topically 4 times a day for 14 days. In the second group (21 patients/42 eyes), 0.4% sodium hyaluronate (Gilays) was added to the treatment regimen. H-1 histamine blockers were not used systemically. Before starting therapy and 2 weeks later, the following values were evaluated: the changes in the anterior chamber of the eye using biomicroscopy, determination of lacrimal film rupture time, Schirmer 1 test, questionnaire. Conclusions. The use of sodium hyaluronate in the complex therapy of dry eye syndrome in allergic eye diseases is quite effective. The use of 0.4% sodium hyaluronate was more effective compared to the control group. It is advisable to use a questionnaire to communicate with the child, but it is necessary to refine the form of questions to eliminate as much as possible the subjectivity of the data.

Download Full-text

Clinical Efficacy of Sodium Hyaluronate Eye Drops Combined With Pranoprofen in the Treatment of Patients with Dry Eye

10.36468/pharmaceutical-sciences.spl.323 ◽

2021 ◽

Vol 83 (s5) ◽

Author(s):

Guang Yang ◽

Ya Ming Wang

Keyword(s):

Clinical Efficacy ◽

Dry Eye ◽

Sodium Hyaluronate ◽

Eye Drops

Download Full-text

Ingredients Acting as a Physical Barrier for the Prevention and Treatment of the Rhinovirus Infection

Applied Sciences ◽

10.3390/app10186511 ◽

2020 ◽

Vol 10 (18) ◽

pp. 6511

Author(s):

Lisa-Marie Sittek ◽

Thomas Michael Schmidts ◽

Peggy Schlupp

Keyword(s):

Xanthan Gum ◽

Artificial Saliva ◽

Treatment Options ◽

Plaque Assay ◽

Sodium Hyaluronate ◽

Curative Effect ◽

Cell Monolayers ◽

Prevention And Treatment ◽

The Common ◽

First Time

Although the common cold, usually caused by human rhinoviruses, is responsible for enormous damage to the economy and health every year, there are hardly any treatment options or prophylaxis for rhinovirus infections. In this work, the potential of a hydrogel complex, based on polymers and an aqueous extract of Icelandic moss in isla® medic lozenges (Engelhard Arzneimittel, Niederdorfelden, Germany), and two other hydrogels (based on solely xanthan gum or sodium hyaluronate) are investigated for the first time in order to prevent and treat rhinovirus infections. By means of rheological investigations, we demonstrate that isla® medic and containing polymers cause artificial saliva to thicken. Additionally, we demonstrate that the thickening results in the formation of a physical diffusion barrier, which leads to a significant reduction in plaques in a preventive plaque assay with rhinovirus 14 (RV-14). Furthermore, it is shown in a curative plaque assay that the hydrogel complex also has a curative effect on rhinovirus infections in that it reduces the spread of the RV-14-infection on H1-HeLa cell monolayers. Overall, polymer-based hydrogels and related products, such as isla® medic, could contribute to the prevention and treatment of rhinovirus infections.

Download Full-text

Efficacy and Safety of Sodium Hyaluronate/chondroitin Sulfate Preservative-free Ophthalmic Solution in the Treatment of Dry Eye: A Clinical Trial

Current Eye Research ◽

10.1080/02713683.2020.1849733 ◽

2020 ◽

pp. 1-11

Author(s):

Sandra Belalcázar-Rey ◽

Valeria Sánchez Huerta ◽

Juan C Ochoa-Tabares ◽

Samuel Altamirano Vallejo ◽

Abraham Soto-Gómez ◽

...

Keyword(s):

Clinical Trial ◽

Chondroitin Sulfate ◽

Dry Eye ◽

Sodium Hyaluronate ◽

Ophthalmic Solution ◽

Efficacy And Safety ◽

Preservative Free

Download Full-text

Effect of Hyaluronic Acid/Trehalose in Two Different Formulations on Signs and Symptoms in Patients with Moderate to Severe Dry Eye Disease

Journal of Ophthalmology ◽

10.1155/2018/4691417 ◽

2018 ◽

Vol 2018 ◽

pp. 1-7 ◽

Cited By ~ 4

Author(s):

Klemens Fondi ◽

Piotr A. Wozniak ◽

Doreen Schmidl ◽

Ahmed M. Bata ◽

Katarzyna J. Witkowska ◽

...

Keyword(s):

Hyaluronic Acid ◽

Dry Eye ◽

Sodium Hyaluronate ◽

Signs And Symptoms ◽

Dry Eye Disease ◽

Eye Disease ◽

Quality Of Sleep ◽

Pro Re Nata ◽

Breakup Time

Purpose. This randomized, observer-masked, crossover study investigated the effect of two hyaluronic acid/trehalose-based containing formulations, with different physical properties, on the signs and symptoms in patients with moderate to severe dry eye disease (DED). Methods. In one group, patients received a mixture of sodium hyaluronate and trehalose (HT, Thealoz Duo®) for use during the day. In the other group, patients received a more viscous formulation consisting of hyaluronic acid, trehalose, and carbomer (HTC-gel, Thealoz Duo Gel) to use pro re nata. Both groups used HTC-gel before going to bed. Clinical standard tests for DED were performed at the beginning and end of each one-week period. Further, patient satisfaction including quality of sleep was assessed using a visual analogue scale. Results. Corneal fluorescein and conjunctival lissamine green staining scores decreased, and tear breakup time (BUT) increased for both groups (p<0.001 each). Mean instillation frequency was 3.1 ± 2.6 drops/day when using HT and 1.9 ± 2.2 drops/day when using HTC-gel (p=0.02). A significant improvement in the quality of sleep was observed with both treatments (p=0.01). Conclusions. Our results show improvement in signs and symptoms of DED in both groups. While instillation of HTC-gel resulted in a lower instillation frequency, both formulations of trehalose showed good clinical efficacy. This trial is registered with NCT02980913.

Download Full-text