Assessment of Knowledge, Attitude, and Practices of Nurses towards Pharmacovigilance and Adverse Drugs Reactions Monitoring and Reporting: Cross-Sectional Study in Lahore, Pakistan

Purpose: The purpose of the study is to determine nurses' current knowledge, attitudes and practices towards pharmacovigilance and adverse drug reactions monitoring and reporting. Methodology: A cross-sectional study was conducted. The target population 154 nurses who work in Tertiary Care Hospital, Lahore, Pakistan. The sample size was calculated by the “World Health Organization” online sample size calculator. A well-structured questionnaire on adverse drug reactions reporting was used for data collection. The data was analysed by using SPSS version 25. The Pearson correlation test used to assess the relationship between knowledge, attitudes, and practices regarding adverse drug reactions. Pearson correlation at p <0.05 consider as significant. The study results display in tables and charts. Findings: The study was carried out to assess the knowledge, attitude, and practice towards Pharmacovigilance and adverse drug reactions and reporting. 56.5% of nurses had a concept of pharmacovigilance. The 39.6% know the voluntary reporting system of adverse drug reaction. Only 36.4% nurses responded agree for policies and procedures should be developed for monitoring and reporting of adverse drug reaction. Unique Contribution To Theory, Practice And Policy: This study is a way of improving pharmacovigilance programs in the country, public awareness on reporting. This could be done to improve practice by advertising and encouraging patients to self-reporting to their nearest health facility. Public awareness could be done through social media. The responsible regulatory authority, with assistance from other relevant stakeholders, should design the reporting forms and make them easily available and accessible so that the public may use them for reporting adverse drug reaction. Keywords: Knowledge, Attitude, Practices, Nurses, Adverse Drug Reactions, Pharmacovigilance

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Knowledge, attitudes and practices of pharmacists about pharmacovigilance, Libya

Eastern Mediterranean Health Journal ◽

10.26719/2021.27.7.693 ◽

2021 ◽

pp. 693-697

Author(s):

Ahmed Atia ◽

Amal Botto ◽

Safia Alarbi

Keyword(s):

Adverse Drug Reactions ◽

Cross Sectional Study ◽

Drug Reactions ◽

Cross Sectional ◽

Attitudes And Practices ◽

Information Leaflets ◽

Level Of Knowledge ◽

Training Programmes ◽

Pharmacy Curriculum ◽

Knowledge Attitudes And Practices

Background: The concept of pharmacovigilance is not well known in Libya and its practice is still in the early stages. Aims: This study aimed to determine the knowledge, attitudes and practices of pharmacists in Tripoli, Libya about pharmacovigilance and the reporting of adverse drug reactions. Methods: A cross-sectional study was conducted from October 2019 to February 2020 of working pharmacists randomly selected from pharmacies in Tripoli. Participants were eligible for inclusion if they had a degree or diploma in pharmacy from a recognized university or institute. Data were collected using a validated self-administered questionnaire. Results: Of 500 pharmacists selected, 408 completed the questionnaire. The pharmacists’ knowledge of pharmacovigilance and reporting of adverse drug reactions was poor overall: only 28.9% correctly defined pharmacovigilance and 14.7% knew about the existence of a centre for pharmacovigilance in Libya. The attitudes of the pharmacists to pharmacovigilance was positive: 77.2% believed that pharmacovigilance needed to be included in the pharmacy curriculum and 73.0% said that they would practice pharmacovigilance if trained. Pharmacists depended mostly on drug information leaflets to update their knowledge on adverse drug reactions. Conclusion: Given the pharmacists’ low level of knowledge about pharmacovigilance but their readiness to become involved if trained, training programmes should be introduced for practising pharmacists to improve their knowledge and encourage their active participation in pharmacovigilance. Regulators need to reinforce the importance of reporting adverse drug reactions and implement pharmacovigilance policies in the Libyan health care system

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Prevalence and Characteristics of Adverse Drug Reaction among Patients in Jubail, Saudi Arabia

Journal of Pharmaceutical Research International ◽

10.9734/jpri/2021/v33i29a31570 ◽

2021 ◽

pp. 124-134

Author(s):

Hussain Alyousif ◽

Mohammed Tarawneh ◽

Zainab Al Madan ◽

Abdulmuhsen Hussein

Keyword(s):

Adverse Drug Reaction ◽

Saudi Arabia ◽

Drug Reaction ◽

Care Center ◽

Cross Sectional Study ◽

Royal Commission ◽

P Value ◽

Drug Reactions ◽

Cross Sectional ◽

Increased Risk

Introduction: Adverse Drug Reactions (ADRs) often causes prolonged hospitalization and have an increased risk of mortality. Adverse drug reaction can greatly affect the quality of life. It may lead to various undesired outcomes such as use of suboptimal alternative drugs, unnecessary investigations and delayed treatment. This study aims to evaluate the prevalence and characteristics of adverse drug reaction as well as, risk factors of allergic drug reactions among hospitalized patients at the secondary care center Royal Commission Hospital (RCH) in Jubail, Saudi Arabia. Methods: A cross-sectional study conducted at the RCH in Jubail, Saudi Arabia. The study included all patients admitted to RCH during the period from 2017 to 2019. All patients admitted to RCH during the study period were reviewed to identify those with at least one documented drug allergy incident. The data was collected by the study authors from the hospital medical electronic data system by using a structured questionnaire that consists of two sections. The main section is the one adapted from the Adverse Drug Reaction Probability Scale (Naranjo). Results: A total of 93 patients with reported ADR were recruited in the current study, more than half (55.91%) of them were females, with a mean age of 35.79 ± 21.18. There was a statistically significant (P-value 0.042) difference in the prevalence of ADR by gender, and the "definitely" identified ADR cases were all males. Besides, the correlation was also significant (P<0.05) between the prevalence of ADR and the use of specific antagonists as well as the committee action. The suspected medications for ADR were mainly antibiotics by 54%, particularly the third generation cephalosporins at 13%, followed by the penicillin subtype at 11%. Ceftriaxone was the highest at 13.54%, followed by vancomycin at 9.38%, and cefazolin at 8.33%. This was followed by analgesic class at 14%. Conclusion: ADRs reported in the current study were mainly probable, and the definite ones were within the reported prevalence globally. The maximum number of ADRs reported was with antibiotics. The majority of patients had recovered from the ADRs.

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Public knowledge, attitudes and practices related to antibiotic use and resistance in Singapore: a cross-sectional population survey

BMJ Open ◽

10.1136/bmjopen-2020-048157 ◽

2021 ◽

Vol 11 (9) ◽

pp. e048157

Author(s):

Jane M Lim ◽

Minh Cam Duong ◽

Alex R Cook ◽

Li Yang Hsu ◽

Clarence C Tam

Keyword(s):

Antibiotic Resistance ◽

Public Awareness ◽

Action Plan ◽

Antibiotic Use ◽

Cross Sectional Study ◽

Primary Care Doctor ◽

Public Knowledge ◽

Cross Sectional ◽

Attitudes And Practices ◽

Knowledge Attitudes And Practices

ObjectivesThe WHO’s Global Action Plan on Antimicrobial Resistance (AMR) includes increasing overall public awareness of appropriate antibiotic use and resistance as a key priority area. We aimed to measure public knowledge, attitudes and practices of antibiotics and antibiotic resistance in Singapore, as well as their healthcare-seeking behaviours relating to respiratory illnesses, providing baseline data against which to measure the progress of future interventions.DesignA cross-sectional study.SettingThe general population in Singapore.ParticipantsBetween May and June 2019, we conducted a survey via an online panel in Singapore with 706 respondents.ResultsOur findings indicated common misconceptions surrounding antibiotic effectiveness and mechanisms of antibiotic resistance—most participants thought that resistance occurs when our bodies become resistant to antibiotics (62.5%) or when antibiotics become less powerful (48.5%). In multivariable analyses, better knowledge scores were associated with more favourable antibiotic attitudes (β=0.29; 95% CI 0.20 to 0.37). In addition, more favourable attitude scores were associated with lower odds of both expecting (OR: 0.84, 95% CI 0.72 to 0.99) and being prescribed antibiotics by a primary care doctor (OR: 0.76, 95% CI 0.63 to 0.90).ConclusionsThis study presents important information about population perceptions towards antibiotics and antibiotic resistance in Singapore. Results from this study emphasise the importance of effective public communication strategies to promote responsible antibiotic use locally and should be used to inform future implementation of programmes and activities as laid out in Singapore’s National Strategic Action Plan on AMR.

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Adverse Drug Reaction Monitoring and Reporting Among Physicians and Pharmacists in Pakistan: A Cross-sectional Study

Current Drug Safety ◽

10.2174/1574886315666200427120322 ◽

2020 ◽

Vol 15 (2) ◽

pp. 137-146

Author(s):

Zaka Un Nisa ◽

Ayesha Zafar ◽

Fatima Zafar ◽

Sally Pezaro ◽

Farooq Sher

Keyword(s):

Adverse Drug Reaction ◽

Drug Reaction ◽

Health Care Professionals ◽

Positive Attitude ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Attitudes And Practices ◽

Adr Reporting ◽

Significant Difference

Background: The success of a reporting system of adverse drug reaction (ADR) depends on the knowledge, attitudes, and practices of the health care professionals. However, due to a lack of knowledge and poor contribution by healthcare workers, ADR remains underreported. To improve safety, proper identification and ADR reporting is necessary. Objective: This study was carried out to determine knowledge, attitude, and practices of ADR among physicians and pharmacists working in Pakistan and the factors which encourage and discourage effective reporting. Methods: A cross-sectional study was conducted using a pretested questionnaire. Questionnaires were distributed among 333 physicians and 34 pharmacists with a 95.5% response rate. The Statistical Package for Social Science (SPSS) was used for data analysis. Results: Pharmacists have more knowledge regarding ADR compared to physicians (47.1% vs. 13.8%, p < 0.001). Pharmacists also have a positive attitude compared to physicians (97.1% vs. 76.3%, p < 0.001). No significant difference was noticed in ADR practice by physicians and pharmacists (12.3% vs. 11.8, p = 0.92). The seriousness of ADR was the main factor that encouraged nearly all pharmacists to report, whereas among physician’s, seriousness and the unusualness of reaction, the new drug involvement, and confidence in diagnosis were the factors which encouraged them to report ADR. Conclusion: Overall, pharmacists had more knowledge and a positive attitude regarding ADR reporting compared to physicians, but practices of ADR reporting remained the same among both. Therefore, it is suggested that educational interventions, along with training programs, should be developed.

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Reporting on Adverse Drug Reactions: Knowledge, Attitudes and Practice Among Physicians Working at Healthcare Institutions in Al-Buraimi Governorate-Oman

Global Journal of Health Science ◽

10.5539/gjhs.v10n8p107 ◽

2018 ◽

Vol 10 (8) ◽

pp. 107

Author(s):

Tablib Salim Al Kablani ◽

Hilal Salim Al Shamsi ◽

Abdullah Ghthaith Almutairi

Keyword(s):

Adverse Drug Reactions ◽

Cross Sectional Study ◽

Drug Reactions ◽

Cross Sectional ◽

Medical Speciality ◽

Attitudes And Practices ◽

Adr Reporting ◽

Healthcare Profession ◽

Significant Difference ◽

Knowledge And Attitude

OBJECTIVE: The study aims to evaluate postgraduate resident physicians’ knowledge, attitudes and practices related to reporting adverse drug reactions (ADRs). It also aims to investigate the causes of poor ADR reporting and to suggest possible ways to improve the reporting methods.METHODS: A cross-sectional study was conducted using a self-administered questionnaire. The questionnaire sought to obtain the physicians’ demographic characteristics, knowledge and practices in relation to ADRs and to identify the factors that affect and encourage ADR reporting. The questionnaire was distributed to physicians (n=117) working at governmental healthcare institutions in Al-Buraimi governorate in Oman.RESULTS: The response rate was 80%. Median score for the knowledge components of ADR reporting was 5 (total score: 7); it was 5 (total score: 5) for the attitude components. No significant difference for the knowledge and attitude scores was found between gender, age group or physicians’ medical speciality. Eighty-four of the physicians (89.4%) knew about pharmacovigilance and serious ADRs. Eighty-eight of the physicians (93.6%) believed that reporting ADRs should be mandatory. No statistical differences were found between general practitioners and specialists who felt that ADR reporting should be either compulsory or voluntary (p=0.080). Seventy-eight of the physicians (83%) noted that the lack of awareness about the reporting procedures is the main reason for not reporting ADRs. In this regard, there were no statistically significant differences between physicians younger than 45 or older than 45 (p=0.835).CONCLUSION: Deficits in the practice of ADR reporting can be resolved in the future only if all physicians in the healthcare profession are aware of the importance of reporting ADRs, the reporting system and their obligation to report ADRs.

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Public Awareness Toward Coronavirus Disease-2019

Asia Pacific Journal of Public Health ◽

10.1177/1010539520949421 ◽

2020 ◽

Vol 32 (6-7) ◽

pp. 354-356

Author(s):

Izzeddin A. Bdair ◽

Mohammad N. Alshloul ◽

Gladys L. Maribbay

Keyword(s):

Public Awareness ◽

Cross Sectional Study ◽

Kingdom Of Saudi Arabia ◽

Cross Sectional ◽

Negative Attitudes ◽

Effective Measure ◽

Attitudes And Practices ◽

Positive Attitudes ◽

Global Issue ◽

Knowledge Attitudes And Practices

Background The emergence of the coronavirus disease 2019 (COVID-19) infection has become a global issue of concern. Since its occurrence, about 18 million cases have been reported globally and about 280 000 in the Kingdom of Saudi Arabia. Aim The aim of this study was to investigate the knowledge, attitudes, and practices of the general population toward COVID-19. Method A cross-sectional study was conducted. A questionnaire was built by the researchers that was composed of demographics, knowledge, attitudes, and practices sections. Results The sample was composed of 575 participants. The mean scores of knowledge, attitudes, and practices were 16.48 ± 2.90, 10.01 ± 2.18, and 8.91 ± 1.91, respectively. The Ministry of Health constitutes the main source of participants’ information. Conclusion The findings showed that participants have good knowledge, positive attitudes, and satisfactory practices toward COVID-19. Yet, areas of low knowledge and negative attitudes were noticed. However, further studies are recommended to design an effective measure to control the disease.

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