scholarly journals Báo Cáo Một Trường Hợp Ngộ Độc Asen Cấp Tính Được Trị Thành Công Tại Bệnh Viện Nhi Trung Ương

2021 ◽  
Vol 5 (2) ◽  
Author(s):  
Pham Thi Thanh Tam ◽  
Phan Viet Hai ◽  
Nguyen Thi Nga ◽  
Duong Dinh Cua ◽  
Nguyen Thi Mai
Keyword(s):  
Cell Cancer ◽  
Inorganic Arsenic ◽  
Cellular Respiration ◽  
Free Oxygen Radical ◽  
Free Oxygen ◽  
Arsenic Poisoning ◽  
Multiple Organs ◽  
History Of ◽  
Folk Remedies ◽  
Specific Symptoms

Arsenic is a poisoning metallic element, in which trivalent inorganic arsenic compounds are considered unique. Children can be exposed from arsenic containing water, food and folk remedies with unclear ingredients [1]. The main toxic mechanism of As3+ is inhibition of the pyruvate dehydrogenase (PDH) complex, which leads to decrease in acetyl-CoA production, decrease in cellular respiration and free oxygen radical (0-) and hydrogen peroxide (H202) are born, which make cytotoxic. Arsenic poisoning causes damage to multiple organs: keratosis of the skin, nail and squamous cell cancer, neuropathy, repolarization of the myocardium, liver damage and subsequent sequelaes [1], [2]. Arsenic poisoning has no specific symptoms, so it is easy to overlook, especially in children [2]. The epidemiological exploitation and history of poisoning drugs are very important to avoid missing arsenic poisoning. We report a case of successfully treated arsenic poisoning at the Vietnam National Children’s Hospital.

Screening for haemorrhagic disorders in paediatric patients by means of a questionnaire

2009 ◽  
Vol 29 (S 01) ◽  
pp. S87-S89 ◽  
Author(s):  
I. Music ◽  
M. Novak ◽  
B. Acham-Roschitz ◽  
W. Muntean
Keyword(s):  
Predictive Value ◽  
Laboratory Diagnosis ◽  
Von Willebrand Disease ◽  
Control Group ◽  
Older Children ◽  
Mild Disease ◽  
History Of ◽  
Von Willebrand ◽  
Specific Symptoms ◽  
Infants And Young Children

SummaryAim: In children, screening for haemorrhagic disorders is further complicated by the fact that infants and young children with mild disease in many cases most likely will not have a significant history of easy bruising or bleeding making the efficacy of a questionnaire even more questionable. Patients, methods: We compared the questionnaires of a group of 88 children in whom a haemorrhagic disorder was ruled out by rigorous laboratory investigation to a group of 38 children with mild von Willebrand disease (VWD). Questionnaires about child, mother and father were obtained prior to the laboratory diagnosis on the occasion of routine preoperative screening. Results: 23/38 children with mild VWD showed at least one positive question in the questionnaire, while 21/88 without laboratory signs showed at least one positive question. There was a trend to more specific symptoms in older children. Three or more positive questions were found only in VWD patients, but only in a few of the control group. The question about menstrual bleeding in mothers did not differ significantly. Sensitivity of the questionnaire for a hemostatic disorder was 0.60, while specifity was 0.76. The negative predictive value was 0.82, but the positive predictive value was only 0.52. Conclusions: Our small study shows, that a questionnaire yields good results to exclude a haemostatic disorder, but is not a sensitive tool to identify such a disorder.

scholarly journals Global Hypertrophic Calcification of Shoulder Joint Capsule

2021 ◽  
Vol 14 ◽  
pp. 117954762110253
Author(s):  
Abdulkarim Yousef Aldehaim ◽  
Abdurhman Saud Alarfaj
Keyword(s):  
Rheumatoid Arthritis ◽  
Shoulder Joint ◽  
Joint Capsule ◽  
Surgical Approaches ◽  
Contributing Factors ◽  
Severe Arthritis ◽  
History Of ◽  
Excellent Control ◽  
Specific Symptoms ◽  
Calcific Deposits

Background: Calcification around the shoulder joint usually occur inside or around the tendons of the rotator cuff. We herein report on a case of global hypertrophic calcification of shoulder joint capsule in a patient with Rheumatoid arthritis. Case Report: An 86 years-old male with a long-standing history of seropositive Rheumatoid arthritis. The treatment for his Rheumatoid arthritis included Methotrexate and Hydroxychloroquine initially, but due lack of control, adalimumab was added with excellent control of his arthritis. He has progressively experienced an increasing pain and stiffness in his shoulders, in addition to an increasing limitation of shoulder movement. Magnetic Resonance Imaging revealed severe arthritis with remoulding deformity with extensive capsular calcification, intra-articular loose-bodies. Discussion: This phenomenon of calcification of shoulder capsule has not been reported before. The pathophysiology of calcific tendinopathy of the shoulder remains controversial. The calcific deposits consist of poorly-crystallized hydroxyapatite. Conclusion: Global hypertrophic calcification of shoulder joint capsule is unique and unreported in the literature. We can postulate that the long-standing inflammation of the synovial lining of the capsules had a major part. Moreover, Diabetes Mellitus, smoking, and repetitive manoeuvres are recognized contributing factors as well for similar conditions. Genetic predisposition seems to play a role as well. We think all those have played part in the development of this unprecedented presentation. Management should be tailored to target specific symptoms for pain, rigidity, and decreasing calcification size. Several options are available, including Kinesiotherapy, electrotherapy modalities, iontophoresis, electroshock wave therapy, and finally surgical approaches for progressive and refractory cases.

Free-oxygen radical generation in ischaemic rat intestine using a tissue section chemiluminescent assay

1987 ◽  
Vol 15 (2) ◽  
pp. 289-289 ◽  
Author(s):  
JOHN P. LAVELLE ◽  
PATRICK B. COLLINS ◽  
ALAN H. JOHNSON ◽  
THOMAS F. GOREY
Keyword(s):  
Tissue Section ◽  
Oxygen Radical ◽  
Rat Intestine ◽  
Free Oxygen Radical ◽  
Free Oxygen ◽  
Radical Generation

The Association Between Alterations in Redox Homeostasis, Cortisol, and Commonly Used Objective and Subjective Markers of Fatigue in American Collegiate Football

2021 ◽  
pp. 1-7
Author(s):  
Benjamin A. McKay ◽  
Jace A. Delaney ◽  
Andrew Simpkin ◽  
Theresa Larkin ◽  
Andrew Murray ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
College Football ◽  
Oxygen Radical ◽  
Flight Time ◽  
Stress Index ◽  
Strength Index ◽  
Urinary Cortisol ◽  
Free Oxygen Radical ◽  
Free Oxygen ◽  
Oxidative Stress Index

Purpose: To assess associations between a free oxygen radical test (FORT), free oxygen radical defense test (FORD), oxidative stress index, urinary cortisol, countermovement jump (CMJ), and subjective wellness in American college football. Methods: Twenty-three male student athlete American college football players were assessed over 10 weeks: off-season conditioning (3 wk), preseason camp (4 wk), and in season (3 wk). Assessments included a once-weekly FORT and FORD blood sample, urinary cortisol sample, CMJ assessment including flight time, reactive strength index modified and concentric impulse, and a daily subjective wellness questionnaire. Linear mixed models analyzed the effect of a 2 within-subject SD change in the predictor variable on the dependent variable. The effects were interpreted using magnitude-based inference and are presented as standardized effect size (ES) ± 90% confidence intervals. Results: Small negative associations were observed between FORT–flight time, FORT–fatigue, FORT–soreness (ES range = −0.30 to −0.48), FORD–sleep (ES = 0.42 ± 0.29), and oxidative stress index soreness (ES = 0.56 ± 0.29). Small positive associations were observed between FORT–cortisol (ES = 0.36 ± 0.35), FORD–flight time, FORD reactive strength index modified and FORD–soreness (0.37–0.41), oxidative stress index concentric impulse (ES = 0.37 ± 0.28), and with soreness–concentric impulse, soreness–flight time, and soreness reactive strength index modified (0.33–0.59). Moderate positive associations were observed between cortisol–concentric impulse and cortisol–sleep (0.57–0.60). Conclusion: FORT/FORD was associated with CMJ variables and subjective wellness. Greater amounts of subjective soreness were associated with decreased CMJ performance, increased FORT and cortisol, and decreased FORD.

scholarly journals Photodistributed sarcoidosis: a case report and approach to management

2018 ◽  
Vol 6 ◽  
pp. 2050313X1879687
Author(s):  
Cristina Olteanu ◽  
Brandon Worley ◽  
Iris Teo ◽  
Jillian Macdonald
Keyword(s):  
Case Report ◽  
Ionizing Radiation ◽  
Bone Pain ◽  
Prior Exposure ◽  
Systemic Involvement ◽  
Pruritic Rash ◽  
Cutaneous Involvement ◽  
Multiple Organs ◽  
History Of ◽  
Idiopathic Disease

Sarcoidosis is an idiopathic disease, characterized by non-caseating granulomas in multiple organs/tissues. Cutaneous involvement occurs in approximately one-quarter of patients with a wide variety of presenting morphologies. This case report describes a case of photodistributed sarcoidosis, a rare cutaneous variant, with systemic involvement. A 42-year-old man presented with a history of a pruritic, rash with photoexacerbated annular plaques along with arthralgias and bone pain. Compared to previous reports of photodistributed sarcoidosis, our case presented with annular plaques rather than papules, and there was no prior exposure to ionizing radiation. He was treated successfully with prednisone and hydroxychloroquine. It is important to include sarcoidosis in the differential of photodistributed dermatoses.

scholarly journals Overt Lower Gastrointestinal Bleeding and Pseudotumor: A Rare Presentation of Cytomegalovirus Infection

2017 ◽  
Vol 2017 ◽  
pp. 1-4 ◽  
Author(s):  
Akanksha Agrawal ◽  
Deepanshu Jain ◽  
Sameer Siddique
Keyword(s):  
Highly Active Antiretroviral Therapy ◽  
The Body ◽  
Cmv Infection ◽  
Rare Presentation ◽  
Multiple Organs ◽  
Highly Active ◽  
History Of ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome

Cytomegalovirus (CMV) is a ubiquitous organism which can infect multiple organs of the body. In an immunocompromised patient, it can have a myriad of gastrointestinal manifestations. We report a case of recurrent hematochezia and concomitant pseudotumor in an AIDS (acquired immunodeficiency syndrome) patient attributable to CMV infection. A 62-year-old man with a history of AIDS, noncompliant with highly active antiretroviral therapy (HAART), presented with bright red blood per rectum. Index colonoscopy showed presence of multiple ulcers, colonic stenosis, and mass-like appearing lesion. Biopsy confirmed CMV infection and ruled out malignancy. Cessation of dual antiplatelet therapy and compliance with HAART lead to clinical cessation of bleeding and endoscopic healing of ulcers with complete resolution of colon mass on follow-up colonoscopy.

scholarly journals Purine nucleoside phosphorylase: A new marker for free oxygen radical injury to the endothelial cell

Hepatology ◽  
1990 ◽  
Vol 11 (2) ◽  
pp. 193-198 ◽  
Author(s):  
Prakash N. Rao ◽  
Thomas R. Walsh ◽  
Leonard Makowka ◽  
Randy S. Rubin ◽  
Thomas Weber ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Purine Nucleoside Phosphorylase ◽  
Oxygen Radical ◽  
Purine Nucleoside ◽  
Free Oxygen Radical ◽  
Free Oxygen ◽  
Nucleoside Phosphorylase

scholarly journals Differential Diagnosis between the Varieties of Vasculitis Forms

2018 ◽  
Vol 6 (2) ◽  
pp. 1-8
Author(s):  
Joana Hankollari ◽  
Marsida Duli ◽  
Qamil Dika ◽  
Xhenila Duli ◽  
Indrit Bimi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Differential Diagnosis ◽  
Blood Vessel ◽  
Specific Form ◽  
The Body ◽  
Imaging Studies ◽  
Patient Assessment ◽  
Diagnostic Difficulties ◽  
History Of ◽  
Specific Symptoms

Vasculitis is an inflammation of the blood vessels. It can affect any blood vessel in the body by manifesting a variety of systemic, non-specific symptoms that make difficult the diagnosis of this pathology and especially its specific form. In front of any patient suspected of being affected by vasculitis, some questions are asked: Is the vasculitis or other pathology that camouflages, whether it is primary or secondary vasculitis, in which vessels this pathology extends, how can the diagnosis be confirmed and how can it be determined the type of vasculitis?The purpose of this study is to inform about the protocols to be followed to perform differential diagnosis of vasculitis types.This study is a review based on the research of world studies and literature regarding the recommendations for performing differential diagnosis among the variety of vasculitis forms.Primary patient assessment involves taking the history of the medications it uses, risk factors for infectious pathology, history of cardiac valve pathologies, and autoimmune pathologies. Then laboratory and imaging studies are carried out, aiming at setting the diagnosis, determining the affected organ and the degree of disease activity. And recently we refer to algorithms to make differential diagnosis between the varieties of vasculitis forms.Despite the diagnostic difficulties of vasculitis, the variety of its forms, the separation of responsibilities among many specialities, there are protocols that need to be followed rigorously to arrive at a safe diagnosis as well as auxiliary algorithms to distinguish the type of vasculitis.

scholarly journals Squamous Cell Metastasis of Cancer from Cervix to Breast: A Case Report

2021 ◽  
Author(s):  
Luisa Paulina Chafla Romero ◽  
Karen Alejandra Venegas ópez ◽  
Erik Vinicio Bolaños Donoso ◽  
Lizbeth Katherine Valverde Franco ◽  
Jessica Monserrate Reinoso Mora
Keyword(s):  
Squamous Cell ◽  
Cell Cancer ◽  
Malignant Neoplasms ◽  
Second Line ◽  
Squamous Cells ◽  
Cell Metastasis ◽  
History Of ◽  
Frequent Site ◽  
Cancer Of The Cervix ◽  
Stage Ivb

Squamous cell metastasis from cervical cancer to breast is an extremely rare entity, approximately 29 cases have been documented worldwide since 1947 and it is the second documented case in Ecuador, the incidence is very low, it represents only 1,2 of all malignant neoplasms of the breast, which limits the expertise in the diagnosis and treatment of this metastasis, with the outermost quadrant of the breasts being the most frequent site of presentation. We present the clinical case of a 46-year-old married woman with a history of stage IVB squamous cell cancer of the cervix, who received chemotherapy, a Paclitaxel/Carboplatin regimen for 6 cycles. There was no good response and we had radiotherapy and brachytherapy treatment. The second line of chemotherapy with monodroga Gemcitab is proposed, the scheme is completed for 8 cycles. There is no favorable response, so a second-line chemotherapy treatment with Ifosfomide is proposed. The same metastases are present in the breast as after imaging and pathology examinations, it is concluded that the patient presents cervical Ca squamous cell metastases (cancer) from the cervix, 6 months after the diagnosis of the deceased patient. Metastasis to the breast from a neoplasm of other organs is very rare, the incidence of which is very low and the prognosis is gloomy. Keywords: metastasis, squamous cells, cancer of the cervix. RESUMEN La metástasis de células escamosas de cáncer de cérvix a mama es una entidad extremadamente rara, se ha documentado a nivel mundial aproximadamente 29 casos desde 1947 y es el segundo caso documentado en el Ecuador, la incidencia es muy baja, representa tan solo el 1,2 de todas las neoplasias malignas de la mama, lo que limita la experticia en el diagnóstico y tratamiento de esta metástasis, siendo el sitio más frecuente de presentación el cuadrante superior externo de las mamas. Se presenta el caso clínico de una paciente de 46 años, casada, con antecedentes de cáncer de cérvix de células escamosas en estadio IVB por lo que recibió tratamiento de quimioterapia, esquema Paclitaxel/Carboplatino por 6 ciclos. No hubo buena respuesta y recibió tratamiento de radioterapia y braquiterapia. Se propone segunda línea de quimioterapia con monodroga Gemcitab, se completa el esquema por 8 ciclos. No existió respuesta favorable por lo que se propone tratamiento de segunda línea de quimioterapia con Ifosfomida. Presenta metástasis en mama la misma que posterior a exámenes de imagen y patología se concluye que la paciente presenta metástasis de células escamosas de Ca (cáncer) de Cérvix a mama, 6 meses posterior al diagnóstico la paciente fallece. La metástasis en la mama de una neoplasia de otros órganos es muy raro cuya incidencia es muy baja y de pronóstico sombrío. Palabras claves: metástasis, células escamosas, cáncer de cérvix.

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