scholarly journals A Prospective Study to study the Efficacy and Side Effects of Ormeloxifene in Regression of Mastalgia and Fibroadenoma: Is It the Ideal Drug?

2016 ◽  
Vol 8 (1) ◽  
pp. 48-56
Author(s):  
Nidhi Gupta
Keyword(s):  
Side Effects ◽  
Prospective Study ◽  
Low Cost ◽  
Response To Therapy ◽  
Reproductive Age ◽  
Complete Relief ◽  
Age Group ◽  
Short Period ◽  
A Prospective Study ◽  
The Ideal

ABSTRACT Ormeloxifene (Centchroman) is a novel nonsteroidal, selective estrogen receptor modulator birth control pill which has also been used recently for the treatment of mastalgia and fibroadenoma. Fibroadenomas are the most common benign breast tumors in women but worrisome for women fearing cancer. Mastalgia whether cyclic or noncyclic may be severely incapacitating for women. This study aims to analyze the effect of this new drug on the regression of mastalgia and fibroadenoma as an alternative to presently available steroid-based drugs with significant side effects. Materials and methods This was a prospective study involving 100 women of reproductive age group (up to 35 years of age) attending the outpatient department (OPD) in Malhotra Nursing Home, Agra and Rainbow Hospital Pvt Ltd., Agra, India, from August 2011 to August 2014, complaining of mastalgia and/ or fibroadenoma and fulfilling the inclusion criteria. After informed consent, these women were divided into a mastalgia group who had mastalgia with or without nodularity and a fibroadenoma group having sizes 1.5 to 2 cm, single or multiple in one or both breasts. Ormeloxifene 30 mg on alternate days was administered for 3 months in both the groups. Patients were followed at 1, 2, 4, 8, 12 and 24 weeks to assess response to therapy. Clinical examination, change in nodularity by palpation, breast lump size by ultrasonography, change in visual analog score (VAS) and breast tenderness were monitored. Results were analyzed using ‘t’ test. Results A total of 100 patients were included in this study. Eighty percent women belonged to the age group 25 to 35 years with a mean age of 28, 31.2 and 27.2 years in groups IA, IB and group B respectively. Mean interval between drug therapy and onset of response was 6 ± 2 days in mastalgia group and 15 ± 2 days in fibroadenoma group. 97.6 to 100% of women in the mastalgia group reported complete relief at 12 weeks of therapy with a decrease in VAS score from 10 to 3 in the first week of therapy itself while 28% of fibroadenoma group reported complete relief at 12 weeks of therapy, partial relief in 31% and equivocal response in 41%. Side effects observed were allergic rash development (2%) and a delay in menstruation of 7 to 10 days (14%) during therapy. Conclusion Ormeloxifene is a novel nonsteroidal drug found to be effective in treatment of mastalgia and partially in treatment of fibroadenoma in a short period of 3 months. As compared to the drugs presently in use namely danazol and bromocriptine, ormeloxifene is safer as suggested by its side-effect profile and is cost-effective too. There is need for prospective large randomized studies to compare this low-cost drug with the standard but costly drugs being prescribed at present. How to cite this article Gupta N. A Prospective Study to Study the Efficacy and Side Effects of Ormeloxifene in Regression of Mastalgia and Fibroadenoma: Is it the Ideal Drug? J South Asian Feder Obst Gynae 2016;8(1):48-56.

scholarly journals Knowledge, attitude and practice of family planning among women of reproductive age group attending outpatient department in a tertiary centre of Northern India

2019 ◽  
Vol 8 (5) ◽  
pp. 1775 ◽  
Author(s):  
Mahvish Qazi ◽  
Najmus Saqib ◽  
Sachin Gupta
Keyword(s):  
Family Planning ◽  
Side Effects ◽  
Total Fertility Rate ◽  
Reproductive Age ◽  
Age Group ◽  
Contraceptive Methods ◽  
Women Of Reproductive Age ◽  
Jammu And Kashmir ◽  
Planning Methods ◽  
Family Planning Methods

Background: India with 1.35 billion people is the second most populated country in the world next to China. Total fertility rate of India is 2.2 and the current total fertility rate of Jammu and Kashmir is 1.7 which is still lagging behind various states. This study was conducted to investigate the knowledge, attitude and practices of contraception in women of reproductive age in this set up.Methods: The present cross-sectional study was carried out in patients attending OPD (outpatient department) of Obstetrics and Gynecology at ASCOMS, Jammu, Jammu and Kashmir, India from 1st September 2017 to 31st August 2018. 200 married women aged between 18-49 years were included in this study. Socio-demographic characteristics of the women, their knowledge, attitude and practices on contraception were evaluated with the help of predesigned questionnaire.Results: Out of 200 women, maximum respondents belong to age group of 21-25 years (75.6%). Most of the contraceptive non-users belongs to age below 20 years (62.5%). Majority of respondents were Hindu (70.37%), maximum studied up to secondary level education (84.61%), 70.30% were housewives and 56.58% belongs to middle class. In 45% of respondents, media was the main source of information. Preferred spacing method was condom in 85% of cases. 68% women had knowledge of female sterilization. According to most women, family planning methods are meant for limitations of birth (43%) and 36% meant for spacing of birth. 80% women had positive attitude towards contraceptive usage. 50% experienced side effects with the use of contraceptives. The most common side effect was menstrual irregularities in 25% of cases. Most common reason for not using contraceptive methods among non-respondents were lack of knowledge in 50% of cases.Conclusions: The study showed that inspite of having good knowledge, utilization of contraceptives were less because of large family norm, religious myth, cultural and political barriers. Ignorance regarding use and side effects of various contraceptive methods is another reason for inadequate practice of family planning methods.

scholarly journals Clinical and aetiological spectrum of spontaneous pneumothorax in adults in Sub-Himalayan: a prospective study at tertiary care institute

2018 ◽  
Vol 4 (2) ◽  
pp. 22
Author(s):  
Ajay Sharma ◽  
Ashok Sharma ◽  
Pramod Jaret ◽  
Malay Sarkar ◽  
Sanjeev Sharma
Keyword(s):  
Pulmonary Tuberculosis ◽  
Prospective Study ◽  
Spontaneous Pneumothorax ◽  
Tertiary Care ◽  
Primary Spontaneous Pneumothorax ◽  
Age Group ◽  
Outcome Indicators ◽  
Secondary Spontaneous Pneumothorax ◽  
A Prospective Study ◽  
Aetiological Spectrum

<p class="abstract"><strong>Background:</strong> <span lang="EN-IN">The spontaneous pneumothorax has been classified as major cause of morbidity and mortality among respiratory diseases. The objectives of the study were to determine the incidence and aetiology of spontaneous pneumothorax and to assess the clinical profile of affected patients admitted in our institute</span>.</p><p class="abstract"><strong>Methods:</strong> <span lang="EN-IN">A hospital based prospective study was conducted in year 2011-12 in the Department of Medicine, IGMC Shimla (H.P.) India. During study period the total admissions were 7335 out of which 30 patients were diagnosed as spontaneous pneumothorax and treated as cases under study. The data was collected on proforma includes demographic profile, probable cause, clinical and outcome indicators of Spontaneous Pneumothorax, master chart framed and analysed into frequency percentage. </span><span lang="EN-IN"> </span></p><p class="abstract"><strong>Results:</strong> <span lang="EN-IN">Incidence of spontaneous pneumothorax was found to be 408.99/yr/100000 admissions in the department of medicine. Incidence of primary spontaneous pneumothorax was 81.79/yr/100000 admissions. Incidence of secondary spontaneous pneumothorax was 327.19/yr/100000 admissions. Majority of the patients of primary spontaneous pneumothorax were of the 20-29yrs age group. Higher proportions of cases were from male gender (93.33%). Secondary pneumothorax patients were mostly of 50 to 59 years age group. The predominant aetiology for secondary spontaneous pneumothorax was COPD (36.66%) followed by Pulmonary tuberculosis (33.33%)</span>.</p><p class="abstract"><strong>Conclusions:</strong> <span lang="EN-IN">Spontaneous pneumothorax was more common in men. The predominant aetiology for secondary spontaneous pneumothorax was COPD (36.66%) followed by pulmonary tuberculosis (33.33%). </span></p><p class="abstract"> </p>

scholarly journals Clinicopathological study of leiomyomas in hysterectomy specimens

2018 ◽  
Vol 7 (4) ◽  
pp. 1509 ◽  
Author(s):  
Manpreet Kaur ◽  
Rajiv Kamal Gupta ◽  
Simrat Jit Kaur ◽  
Panchampreet Kaur
Keyword(s):  
Histopathological Examination ◽  
Reproductive Age ◽  
Benign Tumors ◽  
Histopathological Study ◽  
Histopathological Diagnosis ◽  
Age Group ◽  
Diagnosis And Prognosis ◽  
Common Complaint ◽  
A Prospective Study ◽  
Reproductive Age Group

Background: Leiomyomas are benign tumors of smooth muscle cells commonly encountered in women of reproductive age group. Aim of this study was to conduct a histopathological study of leiomyomas in hysterectomy specimens and to correlate them with clinical findings.Methods: A prospective study was done on 130 hysterectomy specimens clinically diagnosed as leiomyoma. The specimens were subjected to histopathological examination.Results: In this study, the most common age group was 31-50 years (87.69%). Most common complaint was menorrhagia (51.54%). In endometrium, the most common histopathological diagnosis was proliferative phase (46.15%) followed by endometrial hyperplasia (19.23%). The most common secondary change was hyalinization and the most common site was intramural (62.9%).Conclusions: Hysterectomy is a commonly performed procedure in the management of uterine leiomyomas. The ultimate diagnosis and prognosis depends on the histopathological examination; therefore, every operated specimen must be subjected to histopathology. 

A prospective study on patterns of topical steroids self‐use in dermatophytoses and determinants predictive of cutaneous side effects

2020 ◽  
Vol 33 (4) ◽  
Author(s):  
Ananta Khurana ◽  
Aastha Gupta ◽  
Kabir Sardana ◽  
Khushboo Sethia ◽  
Sanjeet Panesar ◽  
...  
Keyword(s):  
Side Effects ◽  
Prospective Study ◽  
Topical Steroids ◽  
Cutaneous Side Effects ◽  
A Prospective Study

Direct referral hearing aid provision in the over sixties age group

1991 ◽  
Vol 105 (10) ◽  
pp. 825-827 ◽  
Author(s):  
Maurice R. Hawthorne ◽  
Desmond A. Nunez ◽  
Graham P. Clarke ◽  
Desmond Robertshaw
Keyword(s):  
General Practitioner ◽  
Confidence Interval ◽  
Prospective Study ◽  
General Practitioners ◽  
Hearing Aid ◽  
Referral Letter ◽  
Age Group ◽  
Common Criterion ◽  
A Prospective Study ◽  
Direct Referral

AbstractA prospective study was designed in which General Practitioners were issued with a standard referral letter for hearing aid provision. Unknown to the General Practitioner an independent otolaryngologist assessment was obtained at the time of first attendance. Three hundred consecutive patients selected by General Practitioners applying these guidelines were seen in a designated hearing aid clinic staffed by audiological technicians of senior grade or above. Referral pro formata were incomplete in 75 patients who were not assessed. Ninety-four patients (31 per cent) (95 per cent confidence interval 29–36 per cent) were accepted by the audiologist. Obstructing wax was the most common criterion failed. Clinical agreement between audiologist and otolaryngologist was 57 per cent greater than chance. None of the cases of clinical disagreement altered treatment. A direct referral system as proposed could have processed only 31 per cent of 300 referrals. However, experienced technical staff reliably detected otological pathology and with aural toilet facilities 91 per cent of 225 patients (confidence interval 88–94 per cent) were aided.

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