Role of Low Dose Mifepristone on Uterine Leiomyoma in Reproductive Age Group: A Prospective Study

2018 ◽  
Vol 6 (4) ◽  
pp. 372-378
Author(s):  
Varun Neha ◽  
◽  
Prasad Sudha ◽  
Kumar Ashok ◽  
◽  
...  
2013 ◽  
Vol 100 (3) ◽  
pp. S78 ◽  
Author(s):  
S. Prasad ◽  
N. Varun ◽  
A. Kumar ◽  
S. Prasad

Author(s):  
Manpreet Kaur ◽  
Rajiv Kamal Gupta ◽  
Simrat Jit Kaur ◽  
Panchampreet Kaur

Background: Leiomyomas are benign tumors of smooth muscle cells commonly encountered in women of reproductive age group. Aim of this study was to conduct a histopathological study of leiomyomas in hysterectomy specimens and to correlate them with clinical findings.Methods: A prospective study was done on 130 hysterectomy specimens clinically diagnosed as leiomyoma. The specimens were subjected to histopathological examination.Results: In this study, the most common age group was 31-50 years (87.69%). Most common complaint was menorrhagia (51.54%). In endometrium, the most common histopathological diagnosis was proliferative phase (46.15%) followed by endometrial hyperplasia (19.23%). The most common secondary change was hyalinization and the most common site was intramural (62.9%).Conclusions: Hysterectomy is a commonly performed procedure in the management of uterine leiomyomas. The ultimate diagnosis and prognosis depends on the histopathological examination; therefore, every operated specimen must be subjected to histopathology. 


2020 ◽  
Vol 05 (02) ◽  
pp. 44-47
Author(s):  
Sweety Singh ◽  
Rumpa Saha ◽  
Amita Suneja ◽  
Shukla Das ◽  
N P Singh

Author(s):  
Kusum V Shah ◽  
Sonal Goyal ◽  
Saket Kumar ◽  
Arti D Shah ◽  
Yash Rana

Pulmonary Lymphangioleiomyomatosis (LAM) is a rare disease, mostly seen in women of reproductive age group. Most common presentation is dyspnoea on exertion, may be associated with haemoptysis and chest pain. LAM is a cystic lung disease, with a poor prognosis and is difficult to treat. In this case reports, we discussed two patients who presented with dyspnoea and chest pain due to pneumothorax and were later diagnosed as case of LAM on clinical and radiological basis. Intercostal Chest tube Drainage (ICD) was inserted for resolution of pneumothorax and subsequently pleurodesis was done to prevent recurrent pneumothorax. In case of recurrent pneumothorax, LAM should be considered as a differential diagnosis. Pleurodesis can be considered to prevent recurrent pneumothorax.


Author(s):  
Pooja Subhash Kale ◽  
Sylvia Noronha

Background: Infertility is one of the most important and underappreciated reproductive health problems in developing countries. The aim of the present study was to evaluate the role of hysterolaparoscopy in infertility.Methods: It was observational prospective study. In this study, 50 patients in the age group of 20-40 years who are anxious to conceive formed the study group. All women were subjected to a detailed history taking followed by clinical examination.Results: Out of 50 cases studied, 30 (60%) were of primary infertility while, 20 (40%) were of secondary infertility. Laparoscopic findings were as follows, 28% had polycystic ovaries, 20% had endometriosis, 18% had tubal factors, 18% had adhesions, and 8% had fibroids while 4% had PID. Hysteroscopic findings were uterine septum in 16%, T shaped cavity in 14%, shaggy-hyperplastic endometrium in 10% while adhesions and polyps in 8% and 4% respectively. 16 women (32%) conceived after the procedure during the study period.Conclusions: It is concluded that while investigating the causes of female infertility combined simultaneous diagnostic laparoscopy and hysteroscopy with operative interventions wherever indicated should be performed in all infertile patients before treatment, especially in women with age more than 30 years.


2022 ◽  
Vol 13 (1) ◽  
pp. 129-135
Author(s):  
Lipika Ghosh ◽  
Abhijit Rakshit ◽  
Madhumita De

Background: Fibroid or uterine leiomyoma is the most common benign tumor of the uterus in the reproductive age group and found in one out of every four women. They are symptomatic in 50% of women, with the peak incidence occurring among women in their 30s or 40s. Fibroid can cause a variety of symptoms which include menstrual disturbances commonly menorrhagia and dysmenorrhea. It is a common indication of hysterectomy in Indians. An effective medical treatment option may reduce hysterectomy-associated morbidity and mortality. This study is undertaken to evaluate the efficacy and safety of medical management of myoma and contribution in the reduction of myoma size comparing the two drugs ulipristal and mifepristone. Aims and Objectives: The study was conducted to compare reduction of menorrhagia (By pictorial blood loss assessment chart score), reduction of fibroid size (using transvaginal ultrasonography), and improvement of hemoglobin (Hb) level. We are also evaluating safety or side effects using these drugs. Materials and Methods: The study includes 210 patients who are divided into two groups. Group A includes 105 patients who are treated with tablet Ulipristal Acetate 5 mg daily for 3 months and Group B includes 105 patients who are treated with tablet mifepristone 25 mg daily for 3 months. Results: Ulipristal and mifepristone both are effective in reduction of menorrhagia and improvement of Hb levels, but Ulipristal is more effective in reduction of size of uterine myoma than mifepristone after 3 months of treatment. Conclusion: Multicentric study over a larger population is required to reach a valid conclusion.


2019 ◽  
Vol 9 (2) ◽  
pp. 72-75
Author(s):  
Megalamane Supreetha ◽  
◽  
Preeti Ashok Utnal ◽  
Anantharamaiah Hemalatha ◽  
◽  
...  

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