scholarly journals Q Fever Vertebral Osteomyelitis Complicating Vertebroplasty

2021 ◽  
Vol 12 (1) ◽  
pp. e0007
Author(s):  
Karina Dorfman ◽  
◽  
Ayelet Eran ◽  
Nesrin Ghanem-Zoubi ◽  
◽  
...  
Keyword(s):  
Clinical Presentation ◽  
Q Fever ◽  
Acute Infection ◽  
Vertebral Osteomyelitis ◽  
Patient Treatment ◽  
Vascular Prostheses ◽  
Paravertebral Abscess ◽  
Long Duration ◽  
Chronic Q Fever ◽  
Culture Negative

Query (Q) fever is a zoonotic bacterial infection caused by Coxiella burnetii. In a minority of patients, chronic disease can occur after acute infection. Endocarditis and infections of aneurysms or vascular prostheses are the most common forms of chronic Q fever in adults. We report a case of an elderly female patient with chronic Q fever vertebral osteomyelitis at the site of her previous cement vertebroplasty, complicated by paravertebral abscess. Patient treatment required prolonged drainage in addition to the long duration of antibiotic treatment by doxycycline and hydroxychloroquine. Osteomyelitis is a rare clinical presentation in adults with chronic Q fever. However, it is important to consider Q fever in the differential diagnosis of culture-negative osteomyelitis, especially in countries where C. burnetii is endemic, such as Israel.

scholarly journals Questing one Brazilian query: reporting 16 cases of Q fever from Minas Gerais, Brazil

2006 ◽  
Vol 48 (1) ◽  
pp. 5-9 ◽  
Author(s):  
Paulo Sérgio Gonçalves da Costa ◽  
Marco Emilio Brigatte ◽  
Dirceu Bartolomeu Greco
Keyword(s):  
Phase I ◽  
Phase Ii ◽  
Fever Of Unknown Origin ◽  
Q Fever ◽  
Acute Infection ◽  
Case Series ◽  
Febrile Illness ◽  
Unknown Origin ◽  
Clinical Form ◽  
Chronic Q Fever

Q fever has been considered non-existing in Brazil where reports of clinical cases still cannot be found. This case-series of 16 patients is a result of a systematic search for such illness by means of clinical and serologic criteria. Serologic testing was performed by the indirect microimmunofluorescence technique using phase I/II C. burnetii antigens. Influenza-like syndrome was the most frequent clinical form (eight cases - 50%), followed by pneumonia, FUO (fever of unknown origin), mono-like syndrome (two cases - 12.5% each), lymphadenitis (one case - 6.3%) and spondylodiscitis associated with osteomyelitis (one case - 6.3%). The ages varied from four to 67 years old with a median of 43.5. All but one patient had positive serologic tests for phase II IgG whether or not associated with IgM positivity compatible with acute infection. One patient had both phase I and phase II IgG antibodies compatible with chronic Q fever. Seroconvertion was detected in 10 patients. Despite the known limitations of serologic diagnosis, the cases here reported should encourage Brazilian doctors to include Q fever as an indigenous cause of febrile illness.

Culture negative prosthetic valve endocarditis in chronic Q fever: An under-recognized entity

2013 ◽  
Vol 167 (5) ◽  
pp. e127-e128
Author(s):  
Promporn Suksaranjit ◽  
Kunatum Prasidthrathsint ◽  
Supawat Ratanapo ◽  
Narat Srivali ◽  
Wisit Cheungpasitporn ◽  
...  
Keyword(s):  
Prosthetic Valve ◽  
Q Fever ◽  
Prosthetic Valve Endocarditis ◽  
Chronic Q Fever ◽  
Culture Negative

scholarly journals Q Fever Endocarditis in Iran

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Pardis Moradnejad ◽  
Saber Esmaeili ◽  
Majid Maleki ◽  
Anita Sadeghpour ◽  
Monireh Kamali ◽  
...  
Keyword(s):  
Q Fever ◽  
Molecular Evidence ◽  
Tissue Samples ◽  
Duke Criteria ◽  
Chronic Q Fever ◽  
High Prevalence ◽  
The Mean ◽  
Polymerase Chain ◽  
Criteria For Diagnosis ◽  
Culture Negative

Abstract Patients with the underlying valvular heart disease are at the high risk of developing sub-acute or chronic endocarditis secondary to Coxiella burnetii. Q fever endocarditis is the most common manifestation along with persistent the infection. There is some serologic and molecular evidence of C. burnetii infection in humans and livestock in Iran. As it is possible to observe chronic Q fever in Iran, it seems necessary to study the prevalence of Q fever endocarditis in this country. In the present study, Infective Endocarditis (IE) patients (possible or definite based on Duke Criteria) hospitalized in Rajaie Cardiovascular Medical and Research Center were enrolled from August 2016 to September 2018. Culture-negative endocarditis patients were evaluated by Raoult criteria for diagnosis Q fever endocarditis. The serological results for brucellosis were negative for all subjects. All blood and tissue samples including valve samples were tested for C. burnetii infection using serology and Polymerase Chain Reaction (PCR). In this study, 126 patients who were admitted to the hospital were enrolled; of which 52 subjects were culture-negative IE. Among the participants, 16 patients (30.77%) were diagnosed with Q fever IE and underwent medical treatment. The mean age of patients was 46.6 years ranging from 23 to 69 years and 75% of them were male. Considering the high prevalence of Q fever IE, evaluation of the patients with culture-negative IE for C. burnetii infections was highly recommended.

scholarly journals Long-term serological follow-up after primary Coxiella burnetii infection in patients with vascular risk factors for chronic Q fever

2021 ◽  
Author(s):  
Sheila B. Buijs ◽  
Sanne K. Stuart ◽  
Jan Jelrik Oosterheert ◽  
Steffi Karhof ◽  
Andy I. M. Hoepelman ◽  
...  
Keyword(s):  
Risk Factors ◽  
Clinical Presentation ◽  
Q Fever ◽  
Vascular Risk Factors ◽  
Vascular Risk ◽  
Serological Testing ◽  
Chronic Q Fever ◽  
Lost To Follow Up

AbstractWe evaluated the long-term serological follow-up of patients with vascular risk factors for chronic Q fever that were previously Coxiellaburnetii seropositive. C. burnetii phase I IgG titers were reevaluated in patients that gave informed consent or retrospectively collected in patients already deceased or lost to follow-up. Of 107 patients, 25 (23.4%) became seronegative, 77 (72.0%) retained a profile of past resolved Q fever infection, and five (4.7%) developed chronic Q fever. We urge clinicians to stay vigilant for chronic Q fever beyond two years after primary infection and perform serological testing based on clinical presentation.

scholarly journals Chronic Q fever vertebral osteomyelitis, an underrecognized clinical entity

2021 ◽  
pp. 1-2
Author(s):  
S. B. Buijs ◽  
J. M. Weehuizen ◽  
J. J. Oosterheert ◽  
S. E. van Roeden
Keyword(s):  
Q Fever ◽  
Vertebral Osteomyelitis ◽  
Clinical Entity ◽  
Chronic Q Fever

scholarly journals Is There a Difference in Clinical Features, Microbiological Epidemiology and Effective Empiric Antimicrobial Therapy Comparing Healthcare-Associated and Community-Acquired Vertebral Osteomyelitis?

Antibiotics ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 1410
Author(s):  
Siegmund Lang ◽  
Astrid Frömming ◽  
Nike Walter ◽  
Viola Freigang ◽  
Carsten Neumann ◽  
...  
Keyword(s):  
Clinical Presentation ◽  
Vertebral Osteomyelitis ◽  
Empiric Antibiotic Therapy ◽  
Patient History ◽  
Coagulase Negative Staphylococci ◽  
Female Ratio ◽  
Empiric Antibiotic ◽  
Healthcare Associated ◽  
Male To Female ◽  
Culture Negative

Background: Empiric antibiotic therapy for suspected vertebral osteomyelitis (VO) should be initiated immediately in severely ill patients, and might be necessary for culture-negative VO. The current study aimed to identify differences between community-acquired (CA) and healthcare-associated (HA) VO in terms of clinical presentation, causative pathogens, and antibiotic susceptibility. Methods: Cases of adult patients with VO treated at a German university orthopaedic trauma center between 2000 and 2020 were retrospectively reviewed. Patient history was used to distinguish between CA and HA VO. Susceptibility of antibiotic regimens was assessed based on antibiograms of the isolated pathogens. Results: A total of 155 patients (with a male to female ratio of 1.3; and a mean age of 66.1 ± 12.4 years) with VO were identified. In 74 (47.7%) patients, infections were deemed healthcare-associated. The most frequently identified pathogens were Staphylococcus aureus (HAVO: 51.2%; CAVO: 46.8%), and Coagulase-negative Staphylococci (CoNS, HAVO: 31.7%; CAVO: 21.3%). Antibiograms of 45 patients (HAVO: n = 22; CAVO: n = 23) were evaluated. Significantly more methicillin-resistant isolates, mainly CoNS, were found in the HAVO cohort (27.3%). The highest rate of resistance was found for cefazolin (HAVO: 45.5%; CAVO: 26.1%). Significantly higher rates of resistances were seen in the HAVO cohort for mono-therapies with meropenem (36.4%), piperacillin–tazobactam (31.8%), ceftriaxone (27.3%), and co-amoxiclav (31.8%). The broadest antimicrobial coverage was achieved with either a combination of piperacillin–tazobactam + vancomycin (CAVO: 100.0%; HAVO: 90.9%) or meropenem + vancomycin (CAVO: 100.0%; HAVO: 95.5%). Conclusion: Healthcare association is common in VO. The susceptibility pattern of underlying pathogens differs from CAVO. When choosing an empiric antibiotic, combination therapy must be considered.

scholarly journals Chronic Q Fever in Alberta: A Case ofCoxiella burnetiiMycotic Aneurysm and Concomitant Vertebral Osteomyelitis

2016 ◽  
Vol 2016 ◽  
pp. 1-3 ◽  
Author(s):  
William Stokes ◽  
Jack Janvier ◽  
Stephen Vaughan
Keyword(s):  
Coxiella Burnetii ◽  
Vascular Tissue ◽  
Open Repair ◽  
Q Fever ◽  
Vertebral Osteomyelitis ◽  
Abdominal Aortic ◽  
Chronic Q Fever ◽  
Life Threatening ◽  
History Of ◽  
Polymerase Chain

Chronic Q fever is a potentially life-threatening infection from the intracellular, Gram-negativeCoxiella burnetii. It presents most commonly as endocarditis or vascular infection in people with underlying cardiac or vascular disease. We discuss a case of a 67-year-old male withCoxiella burnetiivascular infection of a perirenal abdominal aortic graft. The patient had a history of an abdominal aortic aneurysm (AAA) repair 5 years earlier. He presented with a 12 × 6 × 8 cm perirenal pseudoaneurysm and concomitant L1, L2, and L3 vertebral body discitis. He underwent an open repair which revealed a grossly infected graft perioperatively. Q fever serology revealed phase I serological IgG titer of 1 : 2048 and phase II 1 : 1024 consistent with chronic Q fever. Polymerase chain reaction (PCR) on infected vascular tissue was positive forC. burnetii. The patient was started on doxycycline and hydroxychloroquine with good clinical response and decreasing serological titers. Recognizing chronic Q fever is a difficult task as symptoms are nonspecific, exposure risk is difficult to ascertain, and diagnosis is hidden from conventional microbiological investigations. Its recognition, however, is critical asC. burnetiiis inherently resistant to standard empiric therapies used in cardiovascular infections.

scholarly journals Q fever in Plymouth, 1972–88: A review with particular reference to neurological manifestations

1990 ◽  
Vol 105 (2) ◽  
pp. 391-408 ◽  
Author(s):  
S. Reilly ◽  
J. L. Northwood ◽  
E. O. Caul
Keyword(s):  
Complement Fixation Test ◽  
Q Fever ◽  
Acute Infection ◽  
Neurological Complications ◽  
Respiratory Involvement ◽  
Maximum Duration ◽  
Chronic Q Fever ◽  
High Phase

SUMMARYBetween 1972 and 1988 we have serologically confirmed 103Coxiella burnetiiinfections: 46 were acute, 5 were chronic, 52 represented past infections. Details of 61 cases are presented.Of acute cases 80 % had respiratory involvement; at least 63 % had pneumonias. The incidence (22%) of neurological complications was of particular interest; 40% of these patients had prolonged sequelae. One acutely ill patient died of fulminating hepatitis. Patients with pre-existing pathology or immunosuppression were especially susceptible toC. burnetii.In the absence of acute sera, the complement fixation test alone provided inadequate differentiation between recent and past Q fever: phase II titres persisted at ⋝ 80 for more than 1 year after the acute infection in 15 cases; maximum duration of persistence was 14 years. Three patients acquired high phase I titres.Only 5% of cases had chronic Q fever, but in view of the diverse sequelae observed in this series, we suggest that long-term serological and clinical follow-up of all cases of Q fever is fully justified.

scholarly journals One Health Approach: An Overview of Q Fever in Livestock, Wildlife and Humans in Asturias (Northwestern Spain)

Animals ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 1395
Author(s):  
Alberto Espí ◽  
Ana del Cerro ◽  
Álvaro Oleaga ◽  
Mercedes Rodríguez-Pérez ◽  
Ceferino M. López ◽  
...  
Keyword(s):  
One Health ◽  
Roe Deer ◽  
Q Fever ◽  
Close Contact ◽  
Acute Infection ◽  
Pcr Analysis ◽  
Wild Ungulates ◽  
Domestic Ruminants ◽  
Iberian Red Deer ◽  
Northwestern Spain

This study aimed to investigate the seroprevalence of C. burnetii in domestic ruminants, wild ungulates, as well as the current situation of Q fever in humans in a small region in northwestern Spain where a close contact at the wildlife–livestock–human interface exists, and information on C. burnetii infection is scarce. Seroprevalence of C. burnetii was 8.4% in sheep, 18.4% in cattle, and 24.4% in goats. Real-time PCR analysis of environmental samples collected in 25 livestock farms detected Coxiella DNA in dust and/or aerosols collected in 20 of them. Analysis of sera from 327 wild ungulates revealed lower seroprevalence than that found in domestic ruminants, with 8.4% of Iberian red deer, 7.3% chamois, 6.9% fallow deer, 5.5% European wild boar and 3.5% of roe deer harboring antibodies to C. burnetii. Exposure to the pathogen in humans was determined by IFAT analysis of 1312 blood samples collected from patients admitted at healthcare centers with Q fever compatible symptoms, such as fever and/or pneumonia. Results showed that 15.9% of the patients had IFAT titers ≥ 1/128 suggestive of probable acute infection. This study is an example of a One Health approach with medical and veterinary institutions involved in investigating zoonotic diseases.

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