scholarly journals One Health Approach: An Overview of Q Fever in Livestock, Wildlife and Humans in Asturias (Northwestern Spain)

Animals ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 1395
Author(s):  
Alberto Espí ◽  
Ana del Cerro ◽  
Álvaro Oleaga ◽  
Mercedes Rodríguez-Pérez ◽  
Ceferino M. López ◽  
...  
Keyword(s):  
One Health ◽  
Roe Deer ◽  
Q Fever ◽  
Close Contact ◽  
Acute Infection ◽  
Pcr Analysis ◽  
Wild Ungulates ◽  
Domestic Ruminants ◽  
Iberian Red Deer ◽  
Northwestern Spain

This study aimed to investigate the seroprevalence of C. burnetii in domestic ruminants, wild ungulates, as well as the current situation of Q fever in humans in a small region in northwestern Spain where a close contact at the wildlife–livestock–human interface exists, and information on C. burnetii infection is scarce. Seroprevalence of C. burnetii was 8.4% in sheep, 18.4% in cattle, and 24.4% in goats. Real-time PCR analysis of environmental samples collected in 25 livestock farms detected Coxiella DNA in dust and/or aerosols collected in 20 of them. Analysis of sera from 327 wild ungulates revealed lower seroprevalence than that found in domestic ruminants, with 8.4% of Iberian red deer, 7.3% chamois, 6.9% fallow deer, 5.5% European wild boar and 3.5% of roe deer harboring antibodies to C. burnetii. Exposure to the pathogen in humans was determined by IFAT analysis of 1312 blood samples collected from patients admitted at healthcare centers with Q fever compatible symptoms, such as fever and/or pneumonia. Results showed that 15.9% of the patients had IFAT titers ≥ 1/128 suggestive of probable acute infection. This study is an example of a One Health approach with medical and veterinary institutions involved in investigating zoonotic diseases.

Antibodies against Salmonella is associated with reduced reproductive success in female alpine chamois (Rupicapra rupicapra)

2008 ◽  
Vol 86 (10) ◽  
pp. 1111-1120 ◽  
Author(s):  
Maryline Pioz ◽  
Anne Loison ◽  
Philippe Gibert ◽  
Jean-Michel Jullien ◽  
Marc Artois ◽  
...  
Keyword(s):  
Reproductive Success ◽  
Bos Taurus ◽  
Q Fever ◽  
High Titer ◽  
Ovis Aries ◽  
Capra Hircus ◽  
Wild Ungulates ◽  
Rupicapra Rupicapra ◽  
Domestic Ruminants ◽  
Microbial Infections

Microbial infections that affect reproduction are poorly studied in wildlife because reproductive disorders usually go unnoticed. However, such infections are a major concern in domestic ungulates, which raises the question of their influence on reproductive success and population dynamics of wild ungulates. Three bacterial abortive infections are frequent in domestic ruminants: salmonellosis caused by Salmonella enterica serovar Abortusovis, enzootic abortion caused by Chlamydophila abortus , and Q fever caused by Coxiella burnetii . They induce abortions and neonatal mortality in sheep ( Ovis aries L., 1758), goat ( Capra hircus L., 1758), and cattle ( Bos taurus L., 1758). However, little information is known about these bacteria in wild ungulates, particularly in mountain ungulates that may share alpine pastures with infected domestic ruminants. We investigated the relationship between female serological status against Salmonella, Chlamydophila, and Coxiella and her reproductive success. From 1986 to 2003, the reproductive and serological statuses of 125 female chamois ( Rupicapra rupicapra (L., 1758)) aged 2–10 years were available. Reproductive success was the lowest for 2-year-old females and for females born at the highest density. Moreover, we showed for the first time in a wild ungulate population that females with high titer in antibodies against Salmonella experienced a decrease in their reproductive success. Titers in antibodies against Chlamydophila and Coxiella were not related to the reproductive success of female chamois.

scholarly journals SERO-MOLECULAR INVESTIGATION OF COXIELLA BURNETII INFECTION IN DOMESTIC RUMINANTS AND HUMANS AND ASSOCIATED RISK FACTORS BASED ON ‘ONE HEALTH’ PERSPECTIVES IN BANGLADESH

2021 ◽  
Vol 3, Issue 1 ◽  
Author(s):  
A. Chakrabartty ◽  
N. Nahar ◽  
M. S. Rahman ◽  
A. K. M. A. Rahman ◽  
A. S. Sarker ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coxiella Burnetii ◽  
One Health ◽  
Q Fever ◽  
Reproductive Disorders ◽  
Serum Samples ◽  
Factors Associated ◽  
Milk Samples ◽  
Domestic Ruminants ◽  
History Of

Background: Q-fever is an important zoonotic disease caused by the bacterium Coxiella burnetii with wide host range of mammals, birds and arthropods worldwide. The prevalence of C. burnetii infection has been reported in domestic ruminants in Bangladesh with no attention on the ‘One Health’ approach for the epidemiological investigation associated with risk factors for prevention of the disease. Objective: This study aimed to investigate the sero-molecular prevalence of Coxiella burnetii infection and associated risk factors in domestic ruminants and humans based on ‘One Health’ approach in Bangladesh Materials and Methods: This study on C. burnetii infection was conducted in cattle, goats and humans of the four randomly selected districts (Kurigram, Sirajgonj, Pabna and Mymensingh) in Bangladesh during the period from 2018 to 2021. A total of 162 and 172 serum samples respectively from cattle and goats with the reproductive disorders, 159 serum samples from human patients with pyrexia of unknown origin lasting over a period of three weeks and who were in close contact with animal, 119 milk samples from cows with reproductive disorders and 6 aborted materials from goat were collected from these selected districts for the detection of C. burnetii antibody by ELISA and DNA by PCR assay. The research was performed with the collaboration of OIE reference laboratory for Q fever, Friedrich-Loeffler-Institute, Germany. Results: The overall sero-prevalence of C. burnetii infection by ELISA was 3.01% in cattle, 7.6 % in goats and 0.63% in humans. The highest sero-positivity was recorded in cattle in Mymensingh (4.5%) in comparison to Pabna (2.8%), Kurigram (2.5%) and Sirajgonj (2.4%) districts. Risk factors associated with higher sero-positivity of C. burnetii infection was recorded in cattle with  5 years (4.4%) than 3 to 5 years (2.1%), indigenous (4.2%) than cross-bred (2.6%), history of retention of placenta (5.6%) than abortion (2.3%) and natural service (5.9%) than artificial insemination (2.3%). The sero-positivity of C. burnetii infection in goat showed highest in Kurigram (10.0%), followed by Sirajgonj (9.5%) and Mymensingh (9.3%) with no positive reactors in Pabna district. Risk factors associated with sero-positivity of C. burnetii infection in goats showed higher in > 2 years (14.1%) than up to 2 years (2.1%) age group and higher with the history of abortion (10.0%) than retention of placenta (4.2%). Risk factors associated with positivity of C. burnetii infection detected in milk samples of cows by ELISA showed an overall 21.85% positivity associated with history of reproductive disorders, with highest positivity in anestrus (33.3%), followed by retention of placenta (24.4%), abortion (21.7%) and lowest with repeat breeding (8.3%). In addition, higher positivity was recorded in cross-bred (24.2%) than in indigenous (12.5%) cattle. In case of humans, only one human patient (0.63%) had positive for IgG phase-II ELISA. C. burnetii DNA was detected in two sero-positive milk samples but all of the intermediate positive milk samples by ELISA were negative by PCR assay and even none of the aborted material of goat was positive in PCR and cell culture. Conclusions: This study recorded the prevalence and risk factors associated with the zoonotic C. burnetii infection in both the domestic ruminants and humans but still it is unrecognized and underestimated in both human and animal health and research in Bangladesh. The findings of this study support the further research on C. burnetii in both human and veterinary medicine under ‘One Health’ approach particularly targeting epidemiology on the agent, host and environment for the control and prevention of the disease in Bangladesh. Keywords: C. burnetii, Ruminants, Humans, ELISA, PCR, Sera, Milk, Prevalence, Risk factors, ‘One Health’ approach

Q fever: a rare but potentially life-threatening zoonotic disease

2021 ◽  
Vol 14 (2) ◽  
pp. e237155
Author(s):  
Pranav Mahajan ◽  
Kailash Pant ◽  
Shirin Majdizadeh
Keyword(s):  
Chronic Disease ◽  
Cardiovascular System ◽  
Q Fever ◽  
Acute Infection ◽  
Acute Illness ◽  
Unknown Aetiology ◽  
Severe Hepatitis ◽  
The Usa ◽  
Life Threatening ◽  
Acute Q Fever

Q fever can present as a fever of unknown aetiology and can be challenging to diagnose because of the rare incidence. It can present as an acute illness with manifestations, including influenza-like symptoms, hepatitis, pneumonia or chronic disease involving the cardiovascular system. We present a case of a 39-year-old woman in the USA, who developed acute Q fever with associated sepsis and severe hepatitis. She received treatment with recovery from acute infection but currently has symptoms of post Q fever syndrome.

scholarly journals Q fever prevention and vaccination: Australian livestock farmers' knowledge and attitudes to inform a One Health approach

One Health ◽  
2021 ◽  
Vol 12 ◽  
pp. 100232
Author(s):  
Md Rezanur Rahaman ◽  
Helen Marshall ◽  
Adriana Milazzo ◽  
Deane Crabb ◽  
Peng Bi
Keyword(s):  
One Health ◽  
Q Fever ◽  
Knowledge And Attitudes ◽  
Livestock Farmers

scholarly journals Questing one Brazilian query: reporting 16 cases of Q fever from Minas Gerais, Brazil

2006 ◽  
Vol 48 (1) ◽  
pp. 5-9 ◽  
Author(s):  
Paulo Sérgio Gonçalves da Costa ◽  
Marco Emilio Brigatte ◽  
Dirceu Bartolomeu Greco
Keyword(s):  
Phase I ◽  
Phase Ii ◽  
Fever Of Unknown Origin ◽  
Q Fever ◽  
Acute Infection ◽  
Case Series ◽  
Febrile Illness ◽  
Unknown Origin ◽  
Clinical Form ◽  
Chronic Q Fever

Q fever has been considered non-existing in Brazil where reports of clinical cases still cannot be found. This case-series of 16 patients is a result of a systematic search for such illness by means of clinical and serologic criteria. Serologic testing was performed by the indirect microimmunofluorescence technique using phase I/II C. burnetii antigens. Influenza-like syndrome was the most frequent clinical form (eight cases - 50%), followed by pneumonia, FUO (fever of unknown origin), mono-like syndrome (two cases - 12.5% each), lymphadenitis (one case - 6.3%) and spondylodiscitis associated with osteomyelitis (one case - 6.3%). The ages varied from four to 67 years old with a median of 43.5. All but one patient had positive serologic tests for phase II IgG whether or not associated with IgM positivity compatible with acute infection. One patient had both phase I and phase II IgG antibodies compatible with chronic Q fever. Seroconvertion was detected in 10 patients. Despite the known limitations of serologic diagnosis, the cases here reported should encourage Brazilian doctors to include Q fever as an indigenous cause of febrile illness.

scholarly journals The benefits of ‘One Health’ for pastoralists in Africa

2014 ◽  
Vol 81 (2) ◽  
Author(s):  
Helena Greter ◽  
Vreni Jean-Richard ◽  
Lisa Crump ◽  
Mahamat Béchir ◽  
Idriss O. Alfaroukh ◽  
...  
Keyword(s):  
Vaccination Coverage ◽  
Health Care Services ◽  
One Health ◽  
Q Fever ◽  
Animal Health ◽  
Added Value ◽  
Care Services ◽  
Mobile Pastoralists ◽  
Serological Studies ◽  
Health Studies

‘One health’ is particularly suited to serve mobile pastoralists. Dinka pastoralists in Sudan inspired Calvin Schwabe to coin the term ‘one medicine’, indicating that there is no difference in paradigm between human and veterinary medicine. Our contemporary definition of ‘one health’ is any added value in terms of improved health of humans and animals or financial savings or environmental services resulting from a closer cooperation of human and animal health sectors. Here we present a summary of ‘one health’ studies with mobile pastoralists in Africa which were done in research partnership, demonstrating such an added value. Initial joint human and animal health studies revealed higher livestock vaccination coverage than in the pastoralist community, leading to joint animal and human vaccination intervention studies which demonstrated a better access to primary health care services for pastoralists in Chad. Further simultaneous animal and human serological studies showed that camel breeding was associated with human Q-fever seropositivity. In Borana communities in Ethiopia, human cases of  Mycobacterium bovis infection could be related to strains isolated from cattle. A challenge remained with regard to how to assess vaccination coverage in mobile populations. With the advent of mobile phones, health and demographic surveillance could be established for mobile pastoralists and their animals. This presents vast possibilities for surveillance and control of human and animal diseases. Pastoralists prefer a ‘one health’ approach and therefore contribute toward the validation of this concept by showing real added value of the cooperation between human and animal health services.

scholarly journals Pregnancy outcomes of Q fever : Prospective follow-up study on Reunion Island

2019 ◽  
Author(s):  
Yoan Mboussou ◽  
Julien Jaubert ◽  
Sophie Larrieu ◽  
Laura Atiana ◽  
Florence Naze ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Pregnancy Outcomes ◽  
Q Fever ◽  
Acute Infection ◽  
Reunion Island ◽  
Phase 2 ◽  
Follow Up Study ◽  
Réunion Island ◽  
Acute Q Fever

Abstract Background Q fever has been associated with perinatal complications. We conducted a prospective follow-up study to assess both the incidence of adverse pregnancy outcomes (APOs) associated with Coxiella burnetii infection and the contribution of Q fever to APOs. Methods Between May 1 and October 31, 2013, within the regional perinatal health care centre of Saint Pierre, Reunion island, we investigated unexplained miscarriages, stillbirths, preterm births or small-for-gestational age children. Seropositivity for C. burnetii antibodies was defined using indirect immunofluorescence for a phase 2 IgG titre ≥1:64. Acute Q fever was defined for a high phase 2 IgG titre ≥1:256 (compatible with recent or active infection) or the detection of C. burnetii genome in miscarriage products and placentas. Incidence rate ratios (IRR) for Q fever related APOs (taken as a composite outcome or individually) were assessed using Poisson regression models for dichotomous outcomes controlling major confounders. Results Over a 6-month period, 179 pregnant women suspected or diagnosed with an APO were investigated for Q fever, of whom 118 met the definition for an APO. Of these, 19 were seropositive and 10 presented a profile indicative of an acute infection. For three women with an acute Q fever, the chronology between the onset of infection, the APO (2 miscarriages, 1 preterm birth) and the seroconversion suggested causality in the pathogenesis. The cumulative incidence of Q fever related APOs was estimated between 2.2‰ and 5.2‰, whether causality was required or not. Both C. burnetii exposure and acute Q fever were independently associated with APOs (IRR 1.55, 95% CI 1.31-1.84; IRR 1.47, 95% CI 1.15-1.89, respectively). Conclusions In the endemic context of Reunion island, acute Q fever may lead to APOs. To limit the burden of Q fever on reproduction, pregnant women should be kept away from farms and avoid direct contact with ruminants.

scholarly journals SARS-CoV-2 / COVID-19: Salient Facts and Strategies to Combat Ongoing Pandemic

2020 ◽  
Vol 14 (3) ◽  
pp. 1663-1674
Author(s):  
Ranjit Sah ◽  
Nayanum Pokhrel ◽  
Zareena Fathah ◽  
Akihiko Ozaki ◽  
Divya Bhandari ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Prevention And Control ◽  
One Health ◽  
Close Contact ◽  
Mitigation Strategies ◽  
Virus Spread ◽  
Intermediate Hosts ◽  
Affected Person ◽  
Novel Coronavirus ◽  
And Control

Severe acute respiratory syndrome coronavirus – 2 (SARS-CoV-2), an emerging novel coronavirus causing coronavirus disease 2019 (COVID-19) pandemic, has now rapidly spread to more than 215 countries and has killed nearly 0.75 million people out of more than 20 million confirmed cases as of 10th August, 2020. Apart from affecting respiratory system, the virus has shown multiple manifestations with neurological affections and damaging kidneys. SARS-CoV-2 transmission mainly occurs through close contact of COVID-19 affected person, however air-borne route is also now considered as dominant route of virus spread. The virus has been implicated to have originated from animals. Apart from bats, pangolins and others being investigates to play role in transmitting SARS-CoV-2 as intermediate hosts, the recent reports of this virus infection in other animals (cats, dogs, tigers, lions, mink) suggest one health approach implementation along with adopting appropriate mitigation strategies. Researchers are pacing to develop effective vaccines and drugs, few reached to clinical trials also, however these may take time to reach the mass population, and so till then adopting appropriate prevention and control is the best option to avoid SARS-CoV-2 infection. This article presents an overview on this pandemic virus and the disease it causes, with few recent concepts and advances.

Cases of Q fever detected in residents of the novosibirsk region hospitalized with suspection of infections transmitted by ticks

2021 ◽  
Vol 66 (4) ◽  
pp. 229-236
Author(s):  
E. I. Bondarenko ◽  
E. S. Filimonova ◽  
E. I. Krasnova ◽  
E. V. Krinitsina ◽  
S. E. Tkachev
Keyword(s):  
Causative Agent ◽  
Q Fever ◽  
Clinical Manifestations ◽  
Test Methods ◽  
Pcr Analysis ◽  
Laboratory Diagnostics ◽  
Novosibirsk Region ◽  
Complex Approach ◽  
Wide Range ◽  
The Republic

Coxiella burnetii is the causative agent of Q fever (coxiellosis), which, in addition to acute manifestations, often occurs in a latent form, is prone to chronic course and, in the absence of antibiotic therapy, has a high risk of disability or death. As a result of the presence of a wide range of clinical manifestations specific to other infectious diseases, the use of laboratory test methods (LTM) is required to make a diagnosis. The presence of Q fever anthropurgic foci in the Novosibirsk region was described in the 90s of the last century, but due attention to its laboratory diagnostics is not paid in this region. The aim of the study was to identify genetic and serological markers of the causative agent, C. burnetii, in patients of the Novosibirsk region who were admitted for treatment with fever with suspected tick-borne infections (TBIs). DNA marker of the causative agent of Q fever was detected in blood samples by real time PCR in 9 out of 325 patients. In three patients, the presence of C. burnetii DNA was confirmed by sequencing of the IS1111 and htpB gene fragments. In ELISA tests, antibodies against the causative agent of coxiellosis were detected in the blood sera of 4 patients with positive results of PCR analysis. Contact with tick was registered in 7 out of 9 patients who had C. burnetii DNA and lacked markers of other TBIs. Six people were infected in the Novosibirsk region, two suffered from tick’s bite in Altai, and one case was from the Republic of Kyrgyzstan. Thus, a complex approach using both PCR analysis and ELISA provided the identification of markers of the Q fever causative agent in patients admitted with suspected TBIs, thereby differentiating it from other infections. Contact with ticks in most cases suggests that infection with C. burnetii had a transmissible pathway.

A One Health Perspective on Q Fever

2019 ◽  
pp. 195-216
Author(s):  
Rita Cruz ◽  
Carmen Vasconcelos-Nobrega ◽  
Fernando Esteves ◽  
Catarina Coelho ◽  
Ana Sofia Ferreira ◽  
...  
Keyword(s):  
Public Health ◽  
Disease Control ◽  
One Health ◽  
Q Fever ◽  
Clinical Manifestations ◽  
Zoonotic Disease ◽  
Diagnostic Methods ◽  
Veterinary Public Health

Q fever, a widespread zoonotic disease caused by Coxiella burnetiid, produces a complex and polymorphic disease in humans. As a zoonotic disease, control in animals will influence the level of disease seen in humans, thus resulting in interesting one health perspectives for disease control. Here the authors describe the clinical manifestations in animals and humans, as well as the current diagnostic methods available and the strategies for disease control. A review on the published information regarding Q fever as a disease with impact for veterinary public health and public health is presented.

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