The effects of noncrystalline calcium phosphate glass on the healing of 1-wall intrabony defects in beagle dogs

The purpose of this study was to compare the bone regenerative effect of calcium phosphate glass and glass-ceramics in the system of CaO-CaF2-P2O5-MgO-ZnO, which is already reported that promoted the bone-like tissue formation in vitro and formed new bone in Sprague-Dawley rats. We prepared calcium phosphate glass and glass-ceramics with Ca/P ratio of 0.6 using the system CaO-CaF2-P2O5-MgO-ZnO and subsequently milled to 400 µm. 4×4 mm 1-wall intrabony defects of six beagle dogs were surgically created and used in this study. 8 weeks after transplantation of the prepared calcium phosphate glass and glass-ceramics in the experimental group 1 and 2, respectively, the animals were sacrificed. No root resorption or ankylosis were observed in all groups. It can be examined that the prepared glass-ceramics were more effective in alveolar bone regeneration with statistical signigicant difference. In cementum regeneration, both the prepared glass and glass-ceramics showed significantly different effect. However, there were no statistical significant difference neither in glass nor glass-ceramics in the amounts of junctional epithelium migration and connective tissue adhesion. Further study is required to control the flowability as well as reduce the absorption rate in vivo.

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Investigation of Bone Formation using Non-Crystalline Calcium Phosphate Glass in Beagle Dogs

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.240-242.391 ◽

2003 ◽

Vol 240-242 ◽

pp. 391-394 ◽

Cited By ~ 2

Author(s):

Yong Keun Lee ◽

H.S. Kim ◽

Kyoo Sung Cho ◽

Kyoung Nam Kim ◽

Seong Ho Choi

Keyword(s):

Calcium Phosphate ◽

Bone Formation ◽

Phosphate Glass ◽

Beagle Dogs

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Effect of Calcium Phosphate Glass Scaffold with Chitosan Membrane on the Healing of Alveolar Bone in 1 Wall Intrabony Defect in the Beagle Dogs

Bioceramics 17 - Key Engineering Materials ◽

10.4028/0-87849-961-x.851 ◽

2005 ◽

pp. 851-854

Author(s):

D.H. Min ◽

M.J. Kim ◽

J.H. Yun ◽

C.S. Kim ◽

Yong Keun Lee ◽

...

Keyword(s):

Calcium Phosphate ◽

Phosphate Glass ◽

Alveolar Bone ◽

Beagle Dogs ◽

Intrabony Defect ◽

Chitosan Membrane

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The Effects of Calcium Phosphate-Chitosan Block Bone Graft on the Periodontal Regeneration in One Wall Intrabony Defects in Beagle Dogs

Advanced Biomaterials VII - Key Engineering Materials ◽

10.4028/0-87849-436-7.393 ◽

2007 ◽

pp. 393-396

Author(s):

Sung Koo Kim ◽

Jung Seok Lee ◽

Gyung Joon Chae ◽

Ui Won Jung ◽

Yong Keun Lee ◽

...

Keyword(s):

Calcium Phosphate ◽

Bone Graft ◽

Periodontal Regeneration ◽

Beagle Dogs ◽

Intrabony Defects ◽

Block Bone Graft

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Investigation of bone formation using calcium phosphate glass cement in beagle dogs

Journal of Periodontal & Implant Science ◽

10.5051/jpis.2010.40.3.125 ◽

2010 ◽

Vol 40 (3) ◽

pp. 125 ◽

Cited By ~ 4

Author(s):

Seung-Bum Lee ◽

Ui-Won Jung ◽

Youna Choi ◽

Otgonbold Jamiyandorj ◽

Chang-Sung Kim ◽

...

Keyword(s):

Calcium Phosphate ◽

Bone Formation ◽

Phosphate Glass ◽

Beagle Dogs

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The Effects of Calcium Phosphate-Chitosan Block Bone Graft on the Periodontal Regeneration in One Wall Intrabony Defects in Beagle Dogs

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.342-343.393 ◽

2007 ◽

Vol 342-343 ◽

pp. 393-396

Author(s):

Sung Koo Kim ◽

Jung Seok Lee ◽

Gyung Joon Chae ◽

Ui Won Jung ◽

Yong Keun Lee ◽

...

Keyword(s):

Calcium Phosphate ◽

Periodontal Regeneration ◽

Combination Group ◽

Control Group ◽

Experimental Surgery ◽

Beagle Dogs ◽

Intrabony Defects ◽

Chitosan Membrane ◽

Experimental Group ◽

Block Bone Graft

This study evaluated periodontal repair and biomaterial reaction following implantation of a newly fabricated calcium phosphate chitosan block bone and chitosan membrane on the regeneration of 1- wall intrabony defects in the beagle dogs. The surgical control group received a flap operation only, while experimental group was treated with calcium phosphate chitosan block bone and/or chitosan membrane. All dogs were uneventful healing without any complication. The subjects were sacrificed 8 weeks after the experimental surgery, and a comparative histological and histometric examination was done. Chitosan membrane group significantly enhanced bone regeneration compared to control, CaP-chitosan block bone and combination group. Chitosan membrane remnants were observed in chitosan and combination group, while CaP-chitosan bone materials were resorbed completely. These results suggest that Chitosan membrnae significantly enhanced bone and cementum formation in advanced periodontal defects.

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