scholarly journals HISTOPATOLOGIA DAS NEOPLASIAS INTRAEPITELIAIS CERVICAIS ASSOCIADAS AO PAPILOMAVÍRUS HUMANO

2021 ◽  
Author(s):  
Maria Fernanda Brandão ◽  
Larissa Dayelle Osternack ◽  
Samya Hamad Mehanna
Keyword(s):  
Cervical Cancer ◽  
Human Papilloma Virus ◽  
Carcinoma In Situ ◽  
Hpv 16 ◽  
Papilloma Virus ◽  
Ciclo Celular ◽  
Intraepithelial Neoplasms

Introdução: Neoplasias intraepiteliais cervicais (NICs) são lesões precursoras do carcinoma de células escamosas no colo uterino, categorizadas segundo a proporção epitelial afetada: baixo grau (NIC I), grau moderado (NIC II) e alto grau (NIC III), a última correspondendo ao carcinoma in situ. Infecções persistentes de subtipos oncogênicos de alto risco do papilomavírus humano (HPV) podem levar ao desenvolvimento das NICs, com potencial de progressão para câncer invasivo entre 10 e 20 anos. Objetivos: Descrever a histologia cervical, relacionada ao surgimento das NICs decorrentes da infecção pelo HPV. Material e Métodos: Pesquisa bibliográfica nas bases Pubmed e Scielo, utilizando descritores: “cervical cancer”, “cervical intraepithelial neoplasms” e “human papilloma virus”. Foram utilizados Robbins Patologia Básica 9ª Ed.; Junqueira e Carneiro Histologia Básica 12ª Ed. Resultados: A histologia do colo do útero apresenta poucas artérias espiraladas e grandes glândulas ramificadas, não sofre alterações significativas de espessura durante ciclos menstruais e possui três componentes. A ectocérvix se projeta para a vagina e possui epitélio estratificado pavimentoso não queratinizado. A endocérvix é revestida por tecido epitelial glandular colunar simples. Entre as duas regiões está a junção escamocolunar (JEC), ponto de mudança abrupta entre os epitélios. Após ectrópio, a JEC sofre metaplasia escamosa devido à irritação causada pela acidez vaginal, gerando a zona de transformação (ZT). Células-tronco de reserva sustentam a JEC, conduzem a metaplasia e são mais suscetíveis à infecção pelo HPV. A patogênese pelo HPV abrange infecção inicial na JEC que, se persistente, possibilita integração do genoma viral ao do hospedeiro. A expressão das oncoproteínas virais E6 e E7, somada à desregulação do ciclo celular, promove o desenvolvimento de displasia. A invasão do epitélio por subtipos de alto risco do HPV (16 e 18) é o principal fator no desenvolvimento das NICs e cânceres cervicais, seja escamoso ou adenocarcinoma. Ainda, condições genéticas, alimentares e ambientais são fatores de risco para desenvolvimento das NICs. A prevalência de HPV nos carcinomas cervicais pode alcançar 99,7%. Conclusão: As características morfológicas encontradas no colo uterino explicam sua relação com a infecção pelo HPV. Assim, destaca-se a importância do estudo desta histologia, possibilitando a compreensão da fisiopatogenia da doença.

Viral load of human papilloma virus 16 as a determinant for development of cervical carcinoma in situ: a nested case-control study

The Lancet ◽  
2000 ◽  
Vol 355 (9222) ◽  
pp. 2189-2193 ◽  
Author(s):  
Agnetha M Josefsson ◽  
Patrik KE Magnusson ◽  
Nathalie Ylitalo ◽  
Per Sørensen ◽  
Pernilla Qwarforth-Tubbin ◽  
...  
Keyword(s):  
Viral Load ◽  
Human Papilloma Virus ◽  
Carcinoma In Situ ◽  
Case Control Study ◽  
Case Control ◽  
Papilloma Virus ◽  
Nested Case Control ◽  
Human Papilloma Virus 16 ◽  
Control Study

scholarly journals Human Papilloma Virus Types 16/18 Distribution in Invasive Cervical Cancer: An Evidence for Vaccination in Bihar, India

2021 ◽  
pp. 59-68
Author(s):  
Rahul Kumar ◽  
Vinita Trivedi ◽  
Richa Chauhan ◽  
Akhtar Parwez ◽  
Biplab Pal ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
High Risk ◽  
Human Papilloma Virus ◽  
Vaccination Program ◽  
Hpv 16 ◽  
Tissue Samples ◽  
Papilloma Virus ◽  
Cancer Tissues ◽  
High Risk Hpv ◽  
Hpv 18

There is high incidence of cervical cancer in Bihar, India. Vaccination for cervical cancer in developed countries has played a crucial role in limiting the incidence rate of cervical cancer worldwide. In consideration of debate on clinical efficacy of Human Papilloma Virus (HPV) vaccine in India, study on the prevalence of high risk HPV 16/18 strains in different regions of the nation becomes very crucial. Few individual states have started vaccination but centralised vaccination program does not exist due to lack of sufficient genotypic study of Human Papilloma Virus in different parts of India. Bihar is the third most populous state of India and HPV 16/18 distribution has not been reported yet. The nationwide data of HPV 16/18will help to develop a unified centralised vaccination program. We carried out a distribution study of high risk HPV type 16 and 18 in cervical cancer patients attending a tertiary care hospital of Bihar, India.HPV 16/18 types were analysed in cervical cancer tissues (n = 96) of patients attending the regional cancer hospital of Bihar. Tissue samples were analysed for HPV 16 and HPV 18 using a Real Time PCR technique. The results suggest very high prevalence of HPV 16/18. HPV was identified in all the samples (96/96). About, 74 (77.08%) samples presented with HPV 16 whereas, 16 (16.67%) of the samples presented with HPV 18. 6 Co-infection was presented in 6 (6.25%) of the samples of cervical cancer tissues. HPV 16/18 prevalence is more in the women aged between 41 to 61 years.We report 100% prevalence of HPV16/18 in the cervical cancer tissue samples. A way to minimise this gynaecological concern would be to introduce prophylactic vaccines and early screening in the state of Bihar. The data generated would be crucial in drafting for community screening of HPV. We strongly emphasize the prophylactic HPV Vaccination against HPV 16 to control the alarming rate of cervical cancer in one of the most populous state of India, Bihar.

scholarly journals BLADDER CARCINOMA IN SITU WHICH HARBORED HUMAN PAPILLOMA VIRUS

1989 ◽  
Vol 80 (8) ◽  
pp. 1224-1227
Author(s):  
Tadaichi Kitamura ◽  
Yoshiaki Yogo ◽  
Naoto Doi ◽  
Tetsuo Ueki ◽  
Nobuo Moriyama ◽  
...  
Keyword(s):  
Human Papilloma Virus ◽  
Bladder Carcinoma ◽  
Carcinoma In Situ ◽  
Papilloma Virus

scholarly journals Perianal squamous cell carcinoma in-situ: a report of two human papilloma virus-negative cases

Cases Journal ◽  
2008 ◽  
Vol 1 (1) ◽  
pp. 114 ◽  
Author(s):  
James Shehan ◽  
Jeff F Wang ◽  
Susan Repertinger ◽  
Deba P Sarma
Keyword(s):  
Squamous Cell Carcinoma ◽  
Human Papilloma Virus ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Carcinoma In Situ ◽  
Papilloma Virus

scholarly journals PREVALENCE OF HUMAN PAPILLOMA VIRUS TYPES 16 AND 18 AMONG WOMEN WITH CERVICAL CANCER IN ALEPPO, SYRIA

2017 ◽  
Vol 9 (8) ◽  
pp. 90
Author(s):  
Ayman Dandal ◽  
Mohammad Yaser Abajy ◽  
Moustafa Alkhalaf ◽  
Ali Ibrahim
Keyword(s):  
Cervical Cancer ◽  
Squamous Cell ◽  
Carcinoma In Situ ◽  
Significant Risk ◽  
Squamous Cell Carcinomas ◽  
Control Group ◽  
Hpv 16 ◽  
Tissue Samples ◽  
Cervical Cancers

Objective: Cervical cancer is the second common type of cancer among women worldwide. Infection by certain types of human papillomavirus infection (HPV) such as HPV 16/18 has been considered as the most significant risk factor for the development of cervical cancer. This study was conducted to determine the prevalence HPV 16/18 in women with and without cervical cancer in Aleppo city, Syria.Methods: Paraffin embedded cervical tissue samples were collected from 113 patients and 40 controls (normal cervix), DNA was extracted and analyzed by PCR for the presence of HPV16/18. Out of 113 cases of cervical carcinoma, 25 cases (22.1%) were carcinoma in situ (CIS), 72 cases (63.7%) were squamous cell carcinomas (SCC) and 16 cases (14.2%) were adenocarcinoma (ADC).Results: HPV 16 and/or 18 DNA was detected in 84 (74.3%) cases out of 113 of cervical cancers, while it was found in only two of the 40 samples in the control group. At the same time, 9 out of 25 (36%) carcinoma in situ, 61 out of 72(84.72%) squamous cell carcinomas, and 14 out of 16 (87.5%) adenocarcinomas, were positive for HPV 16 and/or 18.Conclusion: The frequency of infection with HPV 16 and 18 is high among Syrian women and a vaccine against these two types may be effective in about 74% of cervical cancers in Syria.

scholarly journals Caracterización clínica e histopatológica de la infección por Papiloma Virus humano de muestras de cérvix. Hospital Teodoro Maldonado Carbo “IESS” // Histopathological and clinical characterization of Human Papilloma Virus infection in cervical samples. Teodoro Maldonado Carbo “IESS”

Ciencia Unemi ◽  
2017 ◽  
Vol 10 (23) ◽  
pp. 105
Author(s):  
César Bedoya ◽  
Sunny Sánchez Giler ◽  
Dolores Zambrano ◽  
Alan Herrera ◽  
Alba Silva ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Human Papilloma Virus ◽  
Human Papilloma Virus Infection ◽  
Infectious Agent ◽  
Papilloma Virus ◽  
Detection Techniques ◽  
Cervical Biopsy ◽  
Para Determinar

El Virus del Papiloma Humano (HPV), posee una predilección por los tejidos poliestratificados, con persistencia en capas basales, de allí que a partir de ello es el agente etiológico del cáncer de cérvix, principalmente. Este tipo de cáncer es el segundo más frecuente en mujeres, alrededor del mundo. El HPV es único agente infeccioso oncogénico que lo provoca. Se realizó un trabajo para determinar la prevalencia del virus en mujeres, utilizando técnicas de detección de ADN mediante PCR, en tiempo real, a partir de biopsia de cérvix, además de establecer las características histopatológicas y clínicas relacionadas. La prevalencia fue del 30,67%, la presentación histopatológica más frecuentemente infectada fue el Cáncer de cérvix y el in situ.  Mientras más displásica es la histopatología del cérvix, más frecuente es la presentación del virus. Se demostró una asociación entre la exposición a la infección y la presencia de secreción vaginal blanquecina y la dispareunia. ABSTRACT Human Papilloma Virus (HPV) has a predilection for poly-stratified tissues, with persistence in the basal layers, hence mainly is the etiological agent of cervical cancer. Cervical cancer is the second most common cancer in women worldwide. HPV is unique oncogenic infectious agent that causes it. The objective of the study was to determine the prevalence of the virus in women, using DNA detection techniques through PCR, in real-time, from the cervical biopsy. In addition, the related histopathological and clinical characteristics were established. The prevalence was 30.67%, the most frequently infected histopathology presentation was cervical and in situ cancer. The more dysplastic the histopathology of the cervix, the more frequent the presentation of the virus. An association between exposure to infection and the presence of whitish vaginal discharge and dyspareunia was demonstrated.

scholarly journals Distribution of high risk Human Papilloma Virus genotypes among cervical cancer patients in a tertiary level hospital in Bangladesh

2019 ◽  
Vol 45 (2) ◽  
pp. 86-92
Author(s):  
Munira Jahan ◽  
Tania Islam ◽  
Sharmin Sultana ◽  
Monira Pervin ◽  
Prof. Ashrafunnessa ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
High Risk ◽  
Human Papilloma Virus ◽  
Cancer Patients ◽  
Hpv Infection ◽  
Multiple Infections ◽  
Hpv 16 ◽  
Papilloma Virus ◽  
Hpv Dna ◽  
Hpv 18

Background: Cervical cancer is one of the most common types of cancer affecting women worldwide. Persistent HPV infection plays a major role in cervical cancer. The risk of cervical cancer has increased in parallel with the incidence of certain genotypes of human papilloma virus (HPV). Methods: The study was aimed to detect the distribution of HPV genotypes among cervical cancer patients from a specialized hospital in Dhaka, Bangladesh. HPV DNA testing was done by polymerase chain reaction (PCR) using SPF-10 broad-spectrum primers followed by genotyping by reverse hybridization using the INNO-LIPA genotyping system at the Department of Virology, Bangabandhu Sheikh Mujib Medical University, Dhaka. Results: HPV 16 was more prevalent (72.0%) in cervical cancer patients from Bangladesh followed by type 18 (6.0%) and 45 (2.0%). Genotype 16 and 18 alone and as co-infection were detected in 88.0% cases. Multiple HPV infection was found in 20% patients. Along with high risk (HR) HPV 16, 18 and 45 HR HPV 56, 39, 31 and 58 were also prevalent in multiple infections. Conclusion: Thus the study concluded that HR HPV 16 and HPV 18 were more prevalent genotypes among cervical cancer patients in a specialised hospital in Bangladesh. Along with HR HPV 16 and HPV 18, HR HPV 45, 56, 39, 31 and 58 were also prevalent Bangladesh Med Res Counc Bull 2019; 45: 86-92

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