scholarly journals Coumarin Derived Schiff Base Ligand-Synthesis, Characterization and Antimicrobial Study of its Metal Complexes.

2021 ◽  
Vol 23 (09) ◽  
pp. 160-167
Author(s):  
Syeda Haseen Buvabi ◽  
◽  
Vani Srinivasan ◽  
Dr. Manjunatha M ◽  
◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Schiff Base ◽  
Metal Complex ◽  
Metal Complexes ◽  
Schiff Base Ligand ◽  
Coumarin Derivative ◽  
Antimicrobial Action ◽  
Antimicrobial Study ◽  
Antimicrobial Studies ◽  
Phenylene Diamine

A novel ligand was synthesized from terephthalaldehyde and o-phenylene diamine and treated with coumarin derivative to form a New Schiff base. Co(II), Ni(II) and Cu(II) complexes of the ligand were synthesized. 1HNMR and LC-MS mass spectrometry studies were done. Antimicrobial studies were performed for the ligand and its metal complex with E.Coli and was found to be active. The ligand can be further modified and studied for its antimicrobial action in the future.

scholarly journals Synthesis, Characterization and Antimicrobial studies of Schiff base Ligand from amino acid L-arginine and its Cu(II), Ni(II),Co(II) complexesIJCTR.2019.130201

2020 ◽  
Vol 13 (2) ◽  
pp. 1-8
Author(s):  
R.K. Sree Devi ◽  
S. SudhaKumari
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Schiff Base Ligand ◽  
Metal Ion ◽  
Electronic Absorption Spectra ◽  
Magnetic Data ◽  
Azomethine Nitrogen ◽  
Diffusion Method ◽  
Significant Activity ◽  
Antimicrobial Studies

Transition metal complexes of Cu(II), Ni(II), Co(II) with a Schiff base Ligand (R,Z)-2-(2-hydroxy-3-methoxybenzylideneamino)-5-guanidinopentanoic acid (HMA-GPA) was synthesized by the condensation of 2-hydroxy-3-methoxybenzaldehyde and L- Arginine. These were characterized by elemental analysis IR, UV, magnetic susceptibility and molar conductivity measurements. The IR spectra of the Ligand HMA-GPA and the metal complexes suggest that the Ligand coordinates the metal ion through azomethine nitrogen, carboxylate Oxygen and Oxygen of the phenolic -OH group. The electronic absorption spectra and magnetic data indicate the Cu(II), Ni(II)complexes to be square planar and Co(II) complex to be octahedral. The metal complexes and the ligand were subjected to antimicrobial studies by Kirby Bayer Disc-diffusion method and found to have significant activity against the selected bacterial and fungal strains under study.

scholarly journals Synthesis, characterization, thermal, theoretical and antimicrobial studies of Schiff base ligand and its Co(II) and Cu(II) complexes

2020 ◽  
Vol 85 (2) ◽  
pp. 215-225 ◽  
Author(s):  
Palaniswamy Venkittapuram ◽  
Mahalakshmi Dhandapani ◽  
Jonekirubavathy Suyambulingam ◽  
Chitra Subramanian
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Schiff Base Ligand ◽  
Bacterial Species ◽  
Thermal Analyses ◽  
Fungal Species ◽  
Basis Sets ◽  
Chloride Salt ◽  
Antimicrobial Studies ◽  
Ft Ir

A Schiff base ligand L was synthesized by condensation of 1,2-diaminoethane with creatinine. The reaction of the ligand with metal chloride salt gives Co(II) and Cu(II) complexes. The synthesized ligand and its metal complexes were characterized by elemental analysis, FT-IR, NMR, UV?Vis, conductivity and magnetic susceptibility measurements as well as thermal analyses. Based on spectral data, tetrahedral geometries have been proposed for the Co(II) and Cu(II) complexes. The molar conductivity data show that the complexes are non-electrolytic in nature. In DFT studies, the geometry of the Schiff base ligand and its Co(II) and Cu(II) complexes were fully optimized using the B3LYP functional together with 6-31g(d,p) and LANL2DZ basis sets. The ligand and its metal complexes were tested against four bacterial species and two fungal species. The results revealed that the metal complexes are more potent against the microbes than the parent ligand.

scholarly journals A Novel DNA and Dengue Virus Protein Binding of Antipyridine Based Copper and Zinc Metal Complexes through Molecular Docking Studies

2019 ◽  
Vol 31 (8) ◽  
pp. 1733-1736
Author(s):  
K.N. Gita ◽  
V. Chandrasekaran ◽  
P. Akilan
Keyword(s):  
Mass Spectrometry ◽  
Schiff Base ◽  
Binding Energy ◽  
Metal Complexes ◽  
Schiff Base Ligand ◽  
Grid Point ◽  
Docking Studies ◽  
Virus Protein ◽  
Human Dna ◽  
Ns3 Protease

The Cu(II) and Zn(II) complexes were synthesized using Schiff base ligand by refluxing with CuCl2 and ZnCl2. A Schiff base ligand (L) was synthesized by condensing o-vanillin and 4-aminoantipyrine. The synthesized ligand and metal complexes were characterized by IR and mass spectrometry. The synthesized Cu(II) and Zn(II) metal complexes were especially docked with human DNA (PDB I.D: 1BNA) and dengue protein virus (PDB ID: 2VBC) using auto dock software tools version 1.5.6 and pymol. The binding of the ligand and biomolecule in grid point value of x × y × z directions of 90 × 90 × 90 and a grid space group value of 0.380 Å. The binding energy values of Cu(II) and Zn(II) complexes were respectively -7.1 and -7.4 kcal mol–1 towards NS3 protease-helicase, while the binding energy values of Cu(II) and Zn(II) complexes were found to be -8.5 and -8.2 kcal mol–1, respectively towards B-DNA.

scholarly journals Synthesis, Characterization, and Antimicrobial Studies of N, O Donor Schiff Base Polymeric Complexes

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Shubhangi N. Kotkar ◽  
Harjeet D. Juneja
Keyword(s):  
Antimicrobial Activity ◽  
Schiff Base ◽  
Spectral Data ◽  
Elemental Analysis ◽  
Schiff Base Ligand ◽  
Antimicrobial Studies ◽  
Polymeric Complexes ◽  
Phenylene Diamine

A series of new polymeric complexes of Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) were prepared with a Schiff base ligand derived from condensation of 2,4-dihydroxy acetophenone and p-phenylene diamine and characterized by elemental analysis and IR and NMR spectral data. The antimicrobial activity of the Schiff base and its polymeric complexes have been studied.

scholarly journals Synthesis, Characterization and Biological Activity of ONO Donor Schiff Base and its Metal Complexes

2022 ◽  
Vol 34 (2) ◽  
pp. 389-394
Author(s):  
R. Nalini ◽  
S.M. Basavarajaiah ◽  
N.G. Yernale ◽  
K. Ramakrishna Reddy
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Biological Activity ◽  
Schiff Base ◽  
Metal Complexes ◽  
Schiff Base Ligand ◽  
Artemia Salina ◽  
Antimicrobial Action ◽  
Donor Ligand ◽  
Spectral Techniques

A new Schiff base ligand (E)-2-((7-hydroxy-4-methyl-2-oxo-2H-chromen-8-yl)methylene)-N-(5- methyl-3-phenyl-1H-indol-2-yl)hydrazine carboxamide (L) (3) was synthesized by the reaction of N-(5-methyl-3-phenyl-1H-indol-2-yl)hydrazinecarboxamide (1) and 7-hydroxy-4-methyl-2-oxo-2Hchromene- 8-carbaldehyde (2). The Cu(II), Co(II), Ni(II) and Zn(II) metal complexes (4a-d) were synthesized and its structural elucidation was done by different spectral techniques. The Schiff base (3) behaves as ONO donor ligand and forms the complexes of the sort [M(L)(Cl)(H2O)2] for Cu(II) (4a) and Zn(II) (4d) and [M(L)2] for Co(II) (4b) and Ni(II) (4c). Compounds (3) and (4a-d) were tested in vitro for antimicrobial action, cytotoxicity property against Artemia salina and anti-tuberculosis assay against Mycobacterium tuberculosis (ATCC 25177). The metal complexes showed very good biological activity.

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