scholarly journals emm Types and Clusters of Group A Streptococcus Causing Acute Pharyngitis in Changwon Korea, 2018–2019

2021 ◽  
Vol 24 (4) ◽  
Keyword(s):  
Group A Streptococcus ◽  
Acute Pharyngitis ◽  
Group A

scholarly journals Positive Rate of Tests for Group a Streptococcus and Viral Features in Children with Acute Pharyngitis

Children ◽  
2021 ◽  
Vol 8 (7) ◽  
pp. 599
Author(s):  
Dasom Wi ◽  
Soo-Han Choi
Keyword(s):  
Laboratory Testing ◽  
Older Patients ◽  
Group A Streptococcus ◽  
Throat Culture ◽  
Acute Pharyngitis ◽  
Rapid Antigen Detection Test ◽  
Positive Rate ◽  
Group A ◽  
Centor Score ◽  
Low Prevalence

Group A streptococcus (GAS) is an important cause of acute pharyngitis. We investigated the positive rate of GAS tests and clinical viral features in children with acute pharyngitis. A retrospective review was conducted for patients <15 years old with both rapid antigen detection test (RADT) and throat culture results. Patients were excluded if they were diagnosed with influenza or had received antibiotics within two weeks before these tests. A total of 377 patients were eligible. The median age of patients was 3.5 years, and 45.4% of total patients were <3 years old. Among all patients, 68.7% had at least one viral feature, and 39% had more than two. The overall positiv rate for GAS was 11.4%. The GAS positive rate was significantly lower in patients <3 years old than in older patients (1.8% vs. 19.4%, p < 0.0001). The overall sensitivity and specificity of RADT were 75.0% (95% CI: 57.8–87.9) and 97.9% (95% CI: 95.8–99.2), respectively. The GAS positive rate was not significantly different between patients with and without viral features (12.4% vs. 9.3%, p = 0.4854). In patients aged 3–14 years, the GAS positive rate was not associated with the modified Centor score or the frequency of clinical viral features. Despite a low prevalence of GAS pharyngitis, testing for GAS was frequently performed in children <3 years old in this study. Appropriate use of laboratory testing for GAS pharyngitis and judicious prescription of antibiotics were imperative.

scholarly journals Rapid Group a Streptococcus Antigen Test (Radt) Usage and Expediency in Diagnosis and Treatment of Pharyngotonsillitis in Family Physician Practice

2015 ◽  
Vol 25 (2) ◽  
pp. 54-60
Author(s):  
Agnė Augulytė ◽  
Povilas Čepanauskas ◽  
Kazys Simanauskas
Keyword(s):  
Family Physician ◽  
Clinical Symptoms ◽  
Group A Streptococcus ◽  
Antigen Detection ◽  
Empiric Antibiotic Therapy ◽  
Physician Practice ◽  
Antigen Test ◽  
Throat Culture ◽  
Acute Pharyngitis ◽  
Group A

Background. Group A streptococcus (S. pyogenes) is responsi- ble for 5 – 20% of cases of pharyngitis in adults and 15 to 20% of cases in children. Most common diagnostic tests are throat culture and rapid antigen detection testing (RADT). The modified Centor criteria can be used to help physicians decide which patients need no testing, throat culture/rapid antigen detection testing or empiric antibiotic therapy. Objective. Evaluate the rapid group A streptococcus antigen test (RADT) usage and expediency in family physician practice. Goals. To analyze children aged between 3 - 15 who suffers from acute pharyngitis ≥ 3 times per year and have ≥ 3 modified Centor criteria; to evaluate the ease of use of RADT in family phy- sician practice; to identify the correlation between RADT and the clinical symptoms of the acute pharyngitis and between the RADT and the blood test results; to evaluate the importance of RADT in diagnosing the acute pharyngitis and choosing treatment strategy. Methods. The study was accomplished in 2011-2013. 108 children aged between 3 and 15 and who suffers from acute pha- ryngitis > 2 times per year, plus have ≥ 3 modified Centor criteria were investigated. Prospectively all patients were tested by RADT. Also, the prescribed treatment and its effectiveness were analyzed. Statistical facts analysis was performed by using „SPSS 17.0“ and „MS Excel“ programs. Results. Girls suffer more often than boys from acute pha- ryngotonsillitis. The age average of patients was 7,22 ± 3,532. On average, patients appealed to doctor after 2-3 days of illness. RADT was positive in 32 (29.6%) children. Moreover, RADT was more often positive (42%) for children in 7-10 years old group, also for children who had 5 modified Centor criteria (62% of all positive cases). Conclusion. No statistically significant difference was obtained between the clinical symptoms and treatment effectiveness for children with a positive or negative result in RADT. However, all patients with positive RADT and who were taking Phenoxymethyl- penicillin recovered in 10 days. Moreover, obtained data shows that RADT test will facilitate the correct diagnosis and the tactics of selecting the treatment.

Etiology, clinical presentation, laboratory diagnostics, pathogenesis of impetigo and treatment methods

2020 ◽  
pp. 64-70
Author(s):  
Anastasiya Laknitskaya
Keyword(s):  
Streptococcus Pyogenes ◽  
Skin Diseases ◽  
Group A Streptococcus ◽  
Antibiotic Sensitivity ◽  
Antioxidant Defense System ◽  
Laboratory Diagnostics ◽  
Treatment Methods ◽  
Group A ◽  
The Individual

Currently, one of the priority medical and social problems is the optimization of treatment methods for pyoderma associated with Streptococcus pyogenes — group A streptococcus (GAS). To date, the proportion of pyoderma, the etiological factor of which is Streptococcus pyogenes, is about 6 % of all skin diseases and is in the range from 17.9 to 43.9 % of all dermatoses. Role of the bacterial factor in the development of streptococcal pyoderma is obvious. Traditional treatment complex includes antibacterial drugs selected individually, taking into account the antibiotic sensitivity of pathognomonic bacteria, and it is not always effective. Currently implemented immunocorrection methods often do not take into account specific immunological features of the disease, the individual, and the fact that the skin performs the function of not only a mechanical barrier, but it is also an immunocompetent organ. Such an approach makes it necessary to conduct additional studies clarifying the role of factors of innate and adaptive immunity, intercellular mediators and antioxidant defense system, that allow to optimize the treatment of this pathology.

Bilateral periorbital necrotising fasciitis associated with invasive group: a Streptococcus infection

2020 ◽  
Vol 13 (12) ◽  
pp. e236800
Author(s):  
Grace Anne McCabe ◽  
Thomas Hardy ◽  
Thomas Gordon Campbell
Keyword(s):  
Group A Streptococcus ◽  
Early Recognition ◽  
Skin Grafting ◽  
Final Diagnosis ◽  
Necrotising Fasciitis ◽  
Invasive Group ◽  
Group A ◽  
Tissue Microscopy ◽  
Periorbital Swelling ◽  
Multidisciplinary Teamwork

A previously independent 56-year-old immunocompetent woman presented with septic shock in the setting of periorbital swelling and diffuse infiltrates on chest imaging. Blood cultures were positive for growth of group A Streptococcus (GAS). Broad spectrum antimicrobials were initiated with the inclusion of the antitoxin agent clindamycin. Necrosis of periorbital tissue was noted and surgical consultation was obtained. Débridement of both eyelids with skin grafting was performed. GAS was isolated from wound cultures and also observed on periorbital tissue microscopy. The final diagnosis was bilateral periorbital necrotising fasciitis (PONF) associated with invasive GAS infection. The patient had a prolonged intensive care unit course with input from multiple specialist teams. This case demonstrates the importance of early recognition and treatment of PONF, the profound systemic morbidity caused by these infections, and illustrates successful multidisciplinary teamwork.

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