Evaluation of Oxidative Stress and Thiol-Disulfide Parameters According to the Body Mass Index in Adult Individuals

ABSTRACT BACKGROUND: Preeclampsia (PE) is a systemic pregnancy-related disorder characterized by hypertension, proteinuria, and edema. Free radicals seem to play an important role in the induction of endothelial dysfunction in PE. AIM: The aim of the present study was to investigate serum levels of nitric oxide (NO), peroxynitrite (ONOO−), paraoxonase (PON-1), malondialdehyde (MDA), and lipid profile in preeclamptic patients compared to the women with normal pregnancy. MATERIALS AND METHODS: A total of 68 pregnant women were recruited. They were divided into two groups - Group A, 40 women were a newly diagnosed with PE and Group B, 28 women with normal pregnancy. Anthropometric measurements including body mass index and blood pressure in accordance with biochemical measurements including NO, ONOO−, PON-1, MDA, and lipid profile were done for preeclamptic pregnant women compared to the controls. RESULTS: Pregnant women with pre-eclampsia illustrated insignificant differences in the age (31.22±2.87) compared to the age of control P > 0.05. There were significant changes in the body mass index (BMI) , type of delivery and smoking status of pregnant women with pre-eclampsia compared to the control P < 0.05. Both systolic and diastolic blood pressures were high in pregnant women with pre-eclampsia compared to the control P < 0.01. PON-1 and NO serum levels were significantly decreased (P < 0.01) while ONOO− and MDA serum levels were significantly increased in PE compared to the women with normal pregnancy. Conclusions: This study concluded that PE is associated with the augmentation of oxidative stress and reduction of endogenous antioxidant capacity regarding PON-1.

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P365 THE BODY MASS INDEX IS NOT A GOOD PREDICTOR OF THE LEVEL OF OXIDATIVE STRESS AND LIPOTOXICITY IN PATIENTS WITH MORBID OBESITY

Clinical Nutrition Supplements ◽

10.1016/s1744-1161(08)70427-7 ◽

2008 ◽

Vol 3 ◽

pp. 183-184

Author(s):

M. Murri-Pierri ◽

E. Garcia-Fuentes ◽

J.M. Garcia-Almeida ◽

J. Garcia-Arnes ◽

F. Vilchez ◽

...

Keyword(s):

Oxidative Stress ◽

Body Mass Index ◽

Morbid Obesity ◽

Body Mass ◽

Good Predictor ◽

The Body

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GLUTATHION AS AN IMPORTANT COMPONENT OF THIOSULFID SYSTEM OF INFERTILITY PATHOGENESIS IN OVERWEIGHT MEN

Annals of the Russian academy of medical sciences ◽

10.15690/vramn.v68i7.705 ◽

2013 ◽

Vol 68 (7) ◽

pp. 9-12 ◽

Cited By ~ 3

Author(s):

L. I. Kolesnikova ◽

O. A. Vanteeva ◽

N. A. Kurashova ◽

B. Ya. Vlasov

Keyword(s):

Oxidative Stress ◽

Body Mass Index ◽

Body Mass ◽

Antioxidant Defense System ◽

The Body ◽

Reduced Form ◽

Normal Body Mass Index ◽

Oxidized Glutathione ◽

Active Components ◽

Infertile Men

Aim: to study the glutathionic part of thiosulfid system and oxidative stress in infertile men with different body mass index. Patients and methods: examined 60 infertile men with normal and overweight, and 40 healthy men with proven fertility. Active components of the antioxidant defense system of the body was assessed by the level of reduced and oxidized glutathione by the method of PY Hissin, determination of TBA-active products was carried out by the method VB Gavrilova. In the analysis of inter-group differences for independent samples was used parametric Student criterion. Results: the oxidative stress in obese men was characterized by significant elevation of oxidized form of glutathione (GSSG) in comparison with its reduced form. We discussed our results in the context of GSSG «quantivalence» to numerous of cellular processes in the setting of metabolic disorders in infertile and obese men. The ratio of reduced glutathione to oxidized infertile men decreased by 1,5 times in patients with obesity and 1,2 times in those with normal body mass index. Conclusions: Glutathione is the most important link in the study of oxidative stress in men with infertility. Raising the level of oxidized glutathione is due to the presence of his additional functions that are implemented at higher values of body mass index, especially in association with infertility.

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191: Does the Body Mass Index Affect the Outcome Following Reconstruction of Orthotopic Neobladder?

The Journal of Urology ◽

10.1016/s0022-5347(18)30456-7 ◽

2007 ◽

Vol 177 (4S) ◽

pp. 64-64

Author(s):

Murugesan Manoharan ◽

Martha A. Reyes ◽

Alan M. Nieder ◽

Bruce R. Kava ◽

MarkS Soloway

Keyword(s):

Body Mass Index ◽

Body Mass ◽

The Body ◽

Orthotopic Neobladder

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The place of abdominal ultrasound in the follow up of patients with acute pancreatitis depending on the body mass index

Ultraschall in der Medizin - European Journal of Ultrasound ◽

10.1055/s-2008-1079789 ◽

2008 ◽

Vol 29 (S 1) ◽

Author(s):

A Popescu ◽

I Sporea ◽

S Bota ◽

M Danila ◽

R Sirli ◽

...

Keyword(s):

Body Mass Index ◽

Acute Pancreatitis ◽

Body Mass ◽

Abdominal Ultrasound ◽

The Body

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EFFECT OF BODY MASS INDEX ON PEAK EXPIRATORY FLOW RATE

International Journal of Medical and Biomedical Studies ◽

10.32553/ijmbs.v3i9.570 ◽

2019 ◽

Vol 3 (9) ◽

Author(s):

K. Subramanyam ◽

Dr. P. Subhash Babu

Keyword(s):

Body Mass Index ◽

Body Mass ◽

Peak Expiratory Flow ◽

Flow Rate ◽

Peak Expiratory Flow Rate ◽

Normal Weight ◽

The Body ◽

Health Care Centre ◽

Expiratory Flow ◽

Group B

Obesity has become one of the major health issues in India. WHO defines obesity as “A condition with excessive fat accumulation in the body to the extent that the health and wellbeing are adversely affected”. Obesity results from a complex interaction of genetic, behavioral, environmental and socioeconomic factors causing an imbalance in energy production and expenditure. Peak expiratory flow rate is the maximum rate of airflow that can be generated during forced expiratory manoeuvre starting from total lung capacity. The simplicity of the method is its main advantage. It is measured by using a standard Wright Peak Flow Meter or mini Wright Meter. The aim of the study is to see the effect of body mass index on Peak Expiratory Flow Rate values in young adults. The place of a study was done tertiary health care centre, in India for the period of 6 months. Study was performed on 80 subjects age group 20 -30 years, categorised as normal weight BMI =18.5 -24.99 kg/m2 and overweight BMI =25-29.99 kg/m2. There were 40 normal weight BMI (Group A) and 40 over weight BMI (Group B). BMI affects PEFR. Increase in BMI decreases PEFR. Early identification of risk individuals prior to the onset of disease is imperative in our developing country. Keywords: BMI, PEFR.

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Visual body processing’s associations to Body Mass Index and internalization of societal beauty ideals

10.31234/osf.io/vnhzm ◽

2020 ◽

Author(s):

Valentina Cazzato ◽

Elizabeth Walters ◽

Cosimo Urgesi

Keyword(s):

Body Mass Index ◽

Body Mass ◽

Visual Processing ◽

The Body ◽

Configural Processing ◽

Cultural Ideals ◽

Beauty Ideals ◽

Female Bodies ◽

Processing Mechanisms ◽

Attention To Detail

We examined whether visual processing mechanisms of the body of conspecifics are different in women and men and whether these rely on westernised socio-cultural ideals and body image concerns. Twenty-four women and 24 men performed a visual discrimination task of upright or inverted images of female or male bodies and faces (Experiment 1) and objects (Experiment 2). In Experiment 1, both groups of women and men showed comparable abilities in the discrimination of upright and inverted bodies and faces. However, the genders of the human stimuli yielded different effects on participants’ performance, so that male bodies and female faces appeared to be processed less configurally than female bodies and male faces, respectively. Interestingly, altered configural processing for male bodies was significantly predicted by participants’ Body Mass Index (BMI) and their level of internalization of muscularity. Our findings suggest that configural visual processing of bodies and faces in women and men may be linked to a selective attention to detail needed for discriminating salient physical (perhaps sexual) cues of conspecifics. Importantly, BMI and muscularity internalization of beauty ideals may also play a crucial role in this mechanism.

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A Comparative Analysis on Body Composition, Risk Factors of Metabolic Disease, and Arteriosclerosis According to the Body Mass Index of Female College Students

Korean Journal of Sports Science ◽

10.35159/kjss.2018.12.27.6.939 ◽

2018 ◽

Vol 27 (6) ◽

pp. 939-947

Author(s):

Chul-Soon Choi

Keyword(s):

Risk Factors ◽

College Students ◽

Metabolic Disease ◽

Body Mass Index ◽

Body Composition ◽

Comparative Analysis ◽

Body Mass ◽

The Body ◽

Female College Students ◽

Female College

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STEROID RECEPTOR PHENOTYPE, EXPRESSION OF HER-2/NEU, PD-1, PD-L1 AND LYMPHOCYTIC-MACROPHAGAL INFILTRATION OF ENDOMETRIAL CARCINOMAS: COMPARISON OF MODERN MOLECULAR BIOLOGICAL TYPES OF THE DISEASE (THE ROLE OF BODY MASS INDEX)

Problems in oncology ◽

10.37469/0507-3758-2020-66-1-71-78 ◽

2020 ◽

Vol 66 (1) ◽

pp. 71-78

Author(s):

Lev Bershteyn ◽

Aleksandr Ivantsov ◽

Aglaya Ievleva ◽

A. Venina ◽

I. Berlev

Keyword(s):

Body Mass Index ◽

Body Mass ◽

Tumor Tissue ◽

Immunohistochemical Analysis ◽

The Body ◽

Molecular Profile ◽

Total N ◽

Number Of Patients ◽

Her 2

The aim of this study was to evaluate steroid receptors’ status of tumor tissue in different molecular biological types of endometrial cancer (EC), subdivided according to the current classification, and their colonization by lymphocytic and macrophage cells, taking into account body mass index of the patients. Materials and methods: Material from treatment-naive patients with EC (total n = 229) was included; the number of sick persons varied depending on the method used. The average age of patients was close to 60 years, and about 90% of them were postmenopausal. It was possible to divide the results of the work into two main subgroups: a) depending on the molecular biological type of the tumor (determined on the basis of genetic and immunohistochemical analysis), and b) depending on the value of the body mass index (BMI). The latter approach was used in patients with EC type demonstrating a defective mismatch repair of the incorrectly paired nucleotides (MMR-D) and with a type without characteristic molecular profile signs (WCMP), but was not applied (due to the smaller number of patients) in EC types with a POLE gene mutation or with expression of the oncoprotein p53. According to the data obtained, when comparing various types of EC, the lowest values of Allred ER and PR scores were revealed for POLE-mutant and p53 types, while the “triple-negative” variant of the tumor (ER-, PR-, HER2/neu-) was most common in POLE-mutant (45.5% of cases) and WCMP (19.4%) types of EC. The p53+ type of EC is characterized by inclination to the higher expression of the macrophage marker CD68 and lymphocytic Foxp3, as well as mRNA of PD-1 and SALL4. In addition to the said above, for WCMP type of EC is peculiar, on the contrary, a decrease in the expression of lymphocytic markers CD8 (protein) and PD-L1 (mRNA). When assessing the role of BMI, its value of >30.0 (characteristic for obesity) was combined with an inclination to the increase of HER-2/neu expression in the case of MMR-D EC type and to the decrease of HER-2 /neu, FOXp3 and ER expression in WCMP type. Conclusions: The accumulated information (mainly describing here hormonal sensitivity of the tumor tissue and its lymphocytic-macrophage infiltration) additionally confirms our earlier expressed opinion that the differences between women with EC are determined by both the affiliation of the neoplasm to one or another molecular biological type (subdivided according to the contemporary classification), as well as by body mass value and (very likely) the associated hormonal and metabolic attributes.

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