scholarly journals STEM CELLS IN REGENERATIVE MEDICINE: ACHIEVEMENTS AND PROSPECTS

2015 ◽  
pp. 4-8
Author(s):  
A. N. Lyzikov ◽  
B. B. Osipov ◽  
A. G. Skuratov ◽  
A. A. Prizentsov
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Regenerative Medicine ◽  
Cell Therapy ◽  
Embryonic Stem ◽  
Long Term Effects ◽  
Internet Resources ◽  
Analytical Review ◽  
Pros And Cons

Purpose: to analyze achievements and prospects of the application of stem cells in regenerative medicine. Material and methods. We performed analytical review of national and foreign literature, Internet resources in PubMed and others dealing with the apоplication of stem cells in regenerative medicine. Results. Rich experience of experimental and clinical application of stem cells in the treatment of cardiovascular, neurological, endocrine, hematological, autoimmune, traumatological, and other diseases has been gained by now. Conclusion. Notwithstanding the success and achievements in regenerative medicine during the recent years, a lot of problems and questions remain unsolved. The application of both embryonic stem cells and postnatal stem cells has its pros and cons. The exact mechanism of the effect of transplanted stem cells remains unclear. It is necessary to study long-term effects of stem cell therapy (in particular, the risk of oncogenesis).

scholarly journals Cardiac Stem Cell Therapy: An Overview

1970 ◽  
Vol 3 (1) ◽  
pp. 66-80
Author(s):  
AKMM Islam ◽  
AAS Majumder ◽  
F Doza ◽  
MM Rahman ◽  
H Jesmin
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Regenerative Medicine ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Adult Stem Cells ◽  
Embryonic Stem ◽  
Future Research ◽  
Wide Range ◽  
Life Threatening

Cardiovascular diseases are the major causes of mortality and morbidity throughout the world. Treatment of these diseases is often incomplete, suboptimal and far from permanent cure. One of the reasons behind this is the nature of heart as a terminally differentiated organ. Preclinical and clinical research in the last few decades has put a challenge to this conventional belief regarding the inability of regeneration of the cardiomyocytes. Embryonic, foetal and a wide range of adult stem cells have been used so far. Differentiation of adult somatic cells has lead to breakthrough discovery of induced pleuripotent stem cells which may be a potential solution of controversy over embryonic stem cell issue. Stem cells specially those of bone marrow origin are already being used in a limited scale to treat acute myocardial infarction, chronic myocardial ischaemia and cardiomyopathy with efficacy, feasibility and safety. Mesenchymal stem cells and adult cardiac stem cells are on the way to bedside use. skeletal myoblasts have been associated with life-threatening ventricular arrhythmia. Stem cells combined with tissue engineering have produced prosthetic tissue valves, and hope for manufacturing whole heart ex vivo in near future. However, like other rapidly evolving modalities, there are more questions than answers. Exact indications, patient selection, cell selection, timing of therapy, efficacy of repeated therapies, co-administration of growth factors, and genetic modification of stem cells are yet to be determined with precision. International community is coming forward with enthusiasm and vigor to explore the enormous potential of stem cell therapy and regenerative medicine. Future research will hopefully facilitate more versatile application of stem cells in treating the life-threatening and disabling ailments of mankind. Keywords: Stem cell; regenerative medicine DOI: 10.3329/cardio.v3i1.6429Cardiovasc. j. 2010; 3(1): 66-80

Regenerative medicine and traumatic brain injury: from stem cell to cell-free therapeutic strategies

2021 ◽  
Author(s):  
Lianxu Cui ◽  
Yasmeen Saeed ◽  
Haomin Li ◽  
Jingli Yang
Keyword(s):  
Traumatic Brain Injury ◽  
Stem Cells ◽  
Stem Cell ◽  
Brain Injury ◽  
Regenerative Medicine ◽  
Cell Therapy ◽  
Therapeutic Strategies ◽  
Study Data ◽  
Health Concern ◽  
Standardized Treatment

Traumatic brain injury (TBI) is a serious health concern, yet there is a lack of standardized treatment to combat its long-lasting effects. The objective of the present study was to provide an overview of the limitation of conventional stem cell therapy in the treatment of TBI and to discuss the application of novel acellular therapies and their advanced strategies to enhance the efficacy of stem cells derived therapies in the light of published study data. Moreover, we also discussed the factor to optimize the therapeutic efficiency of stem cell-derived acellular therapy by overcoming the challenges for its clinical translation. Hence, we concluded that acellular therapy possesses the potential to bring a breakthrough in the field of regenerative medicine to treat TBI.

Stem Cells in Neurodegenerative Disorders - A broad Overview

2021 ◽  
Author(s):  
Fariha Khaliq
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Pluripotent Stem Cells ◽  
Neurodegenerative Disorder ◽  
Human Fibroblasts ◽  
Embryonic Stem ◽  
Different Types ◽  
Induced Pluripotent

Stem cell therapy is an approach to use cells that have the ability of self-renewal and to differentiate into different types of functional cells that are obtained from embryo and other postnatal sources to treat multiple disorders. These cells can be differentiated into different types of stem cells based on their specific characteristics to be totipotent, unipotent, multipotent or pluripotent. As potential therapy, pluripotent stem cells are considered to be the most interesting as they can be differentiated into different type of cells with similar characteristics as embryonic stem cells. Induced pluripotent stem cells (iPSCs) are adult cells that are reprogrammed genetically into stem cells from human fibroblasts through expressing genes and transcription factors at different time intervals. In this review, we will discuss the applications of stem cell therapy using iPSCs technology in treating neurodegenerative disorder such that Alzheimer’s disease (AD), Parkinson’s disease (PD), and Amyotrophic Lateral Sclerosis (ALS). We have also broadly highlighted the significance of pluripotent stem cells in stem cell therapy.

RESEARCH FINDINGS

2011 ◽  
Vol 15 (12) ◽  
pp. 43-44
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Kawasaki Disease ◽  
Regenerative Medicine ◽  
Embryonic Stem Cell ◽  
Human Embryonic Stem Cell ◽  
Embryonic Stem ◽  
Medicine Research ◽  
Research Findings ◽  
Cell Study

Singapore Scientists Lead Human Embryonic Stem Cell Study to Advance Regenerative Medicine Research. Singapore Scientists Discover Genetic Link in Kawasaki Disease. Stem Cells Engineered to Kill Cancer.

scholarly journals Magnetic Nanoparticles for Targeting and Imaging of Stem Cells in Myocardial Infarction

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Michelle R. Santoso ◽  
Phillip C. Yang
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Iron Oxide ◽  
Regenerative Medicine ◽  
Cell Therapy ◽  
Iron Oxide Nanoparticles ◽  
Stem Cell Therapy ◽  
Superparamagnetic Iron Oxide ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles

Stem cell therapy has broad applications in regenerative medicine and increasingly within cardiovascular disease. Stem cells have emerged as a leading therapeutic option for many diseases and have broad applications in regenerative medicine. Injuries to the heart are often permanent due to the limited proliferation and self-healing capability of cardiomyocytes; as such, stem cell therapy has become increasingly important in the treatment of cardiovascular diseases. Despite extensive efforts to optimize cardiac stem cell therapy, challenges remain in the delivery and monitoring of cells injected into the myocardium. Other fields have successively used nanoscience and nanotechnology for a multitude of biomedical applications, including drug delivery, targeted imaging, hyperthermia, and tissue repair. In particular, superparamagnetic iron oxide nanoparticles (SPIONs) have been widely employed for molecular and cellular imaging. In this mini-review, we focus on the application of superparamagnetic iron oxide nanoparticles in targeting and monitoring of stem cells for the treatment of myocardial infarctions.

scholarly journals Human therapeutic cloning, pitfalls and lack luster because of rapid developments in induced pluripotent stem cell technology

2014 ◽  
Vol 8 (1) ◽  
pp. 5-10
Author(s):  
Song Hua ◽  
Henry Chung ◽  
Kuldip Sidhu
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Regenerative Medicine ◽  
Somatic Cell ◽  
Pluripotent Stem Cells ◽  
Nuclear Transfer ◽  
Es Cells ◽  
Embryonic Stem ◽  
Therapeutic Cloning ◽  
Induced Pluripotent

AbstractBackground: Therapeutic cloning is the combination of somatic cell nuclear transfer (SCNT) and embryonic stem cell (ES) techniques to create specific ES cells that match those of a patient. Because ES cells derived by nuclear transfer (SCNT ES cells) are genetically identical to the donor, it will not generate rejection by the host’s immune system and thus therapeutically may be more acceptable. Induced pluripotent stem cells (iPS) are a type of pluripotent stem cell artificially derived from an adult somatic cell by inducing a forced expression of a set of specific pluripotent genes. In the past few years, rapid progress in reprogramming and iPS technology has been made, and it seems to shadow any progress made in SCNT programs.Objective: This review compares the application perspective of SCNT with that of iPS in regenerative medicine.Methods:We conducted a literature search using the MEDLINE (PubMed), Wiley InterScience, Springer, EBSCO, and Annual Reviews databases using the keywords “iPS”, “ES”, “SCNT” “induced pluripotent stem cells”, “embryonic stem cells”, “therapeutic cloning”, “regenerative medicine”, and “somatic cell nuclear transfer”. Only articles published in English were included in this review.Results: These two methods both have advantages and disadvantages. Nevertheless, by using SCNT to generate patient-specific cell lines, it eliminates complications by avoiding the use of viral vectors during iPS generation. Success in in vitro matured eggs from aged women and even differentiation of oocytes from germ stem cells will further enhance the application of SCNT in regenerative medicine.Conclusion: Human SCNT may be an appropriate mean of generating patient stem cell lines for clinical therapy in the near future.

Genetically-Modified Stem Cell in Regenerative Medicine and Cancer Therapy; A New Era

2021 ◽  
Vol 21 ◽  
Author(s):  
Ali Hassanzadeh ◽  
Somayeh Shamlou ◽  
Niloufar Yousefi ◽  
Marzieh Nikoo ◽  
Javad Verdi
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Cancer Therapy ◽  
Gene Delivery ◽  
Regenerative Medicine ◽  
Progenitor Cells ◽  
Embryonic Stem ◽  
In Vivo Studies ◽  
Cell Potential ◽  
Hematopoietic Stem

: Recently, genetic engineering by various strategies to stimulate gene expression in a specific and controllable mode is a speedily growing therapeutic approach. Genetic modification of human stem or progenitor cells, such as embryonic stem cells (ESCs), neural progenitor cells (NPCs), mesenchymal stem/stromal cells (MSCs), and hematopoietic stem cells (HSCs) for direct delivery of specific therapeutic molecules or genes has been evidenced as an opportune plan in the context of regenerative medicine due to their supported viability, proliferative features, and metabolic qualities. On the other hand, a large number of studies have investigated the efficacy of modified stem cells in cancer therapy using cells from various sources, disparate transfection means for gene delivery, different transfected yields, and wide variability of tumor models. Accordingly, cell-based gene therapy holds substantial aptitude for the treatment of human malignancy as it could relieve signs or even cure cancer succeeding expression of therapeutic or suicide transgene products; however, there exist inconsistent results in this regard. Herein, we deliver a brief overview of stem cell potential to use in cancer therapy and regenerative medicine and importantly discuss stem cells based gene delivery competencies to stimulate tissue repair and replacement in concomitant with their potential to use as an anti-cancer therapeutic strategy, focusing on the last two decades in vivo studies.

scholarly journals Assessment of Stem Cell Markers During Long-Term Culture of Mouse Embryonic Stem Cells

2004 ◽  
Vol 44 (1/2) ◽  
pp. 77-91 ◽  
Author(s):  
A. Berrill ◽  
H.L. Tan ◽  
S.C. Wuang ◽  
W.J. Fong ◽  
Andre B.H. Choo ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cells ◽  
Stem Cell Markers ◽  
Cell Markers ◽  
Long Term Culture

Stem cell therapy and research

2002 ◽  
Vol 10 (3) ◽  
pp. 359-367 ◽  
Author(s):  
ROBIN LOVELL-BADGE
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Embryonic Stem Cells ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Stem Cell Research ◽  
Embryonic Stem ◽  
Early Embryos ◽  
Wide Range ◽  
Potential Use

Stem cells are capable of regenerating tissue cells. They have an important potential use in a wide range of therapies, especially as an alternative to organ transplantation, with the advantage that they can be derived from the patient and thus avoid rejection. Embryonic stem cells are potentially capable of forming all kinds of cells. Their use is controversial however, because they are derived from early embryos and because, if they were to match the patient, they would have to be obtained using the same techniques that could, in theory, be used to produce cloned individuals. This article discusses the uses and problems of stem cell research and therapy.

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