scholarly journals Molecular genetic markers of the risk of tension-type headache and migraine chronization development

2021 ◽  
pp. 147-154
Author(s):  
S. A. Kostiuk ◽  
O. S. Poluyan ◽  
M. V. Simirski ◽  
I. P. Marjenko
Keyword(s):  
Risk Factors ◽  
Molecular Genetic ◽  
Tension Headache ◽  
Tension Type Headache ◽  
Pcr Analysis ◽  
Genetic Studies ◽  
Polymorphic Variants ◽  
Preprotachykinin Gene ◽  
Type Headache

Objective: to identify the molecular genetic criteria of the risk of tension-type headache and migraine chronization development.Materials and methods. The detection of the results for the determination of allelic variants was carried out by means of horizontal electrophoresis using a molecular weight marker. The determination of the genotypes of the polymorphic variants of genes was carried out using high resolution melting PCR analysis.Results. Based on the performed molecular genetic studies, it has been established that the statistically significant (p < 0.05) risk factors of tension-type headache chronization are: the identification of the A-allele and AA-genotype of the DBH3 polymorphism of the dopamine-beta-hydroxylase gene DBH, as well as the identification of the G-allele and the GG-genotype of the Intron3SNP polymorphism of the preprotachykinin gene TAC1. It has been found that the statistically significant (p < 0.05) risk factors of migraine chronization are: the identification of the A-allele, GA- and AA-genotypes of the G29A polymorphism of the serotonin transporter gene SLC6A4, as well as the identification of the G-allele and the GG-genotype of the rs7793277 polymorphism of the preprotachykinin gene TAC1.Conclusion. The detection of these polymorphisms of the dopamine and preprotachykinin genes in the blood serum increases the risk of tension headache chronization by 1.395–1.991 times; the risk of migraine chronization by 1.235–1.395 times.

History of Headache Research in Denmark

Cephalalgia ◽  
2001 ◽  
Vol 21 (7) ◽  
pp. 748-752 ◽  
Author(s):  
P Tfelt-Hansen
Keyword(s):  
Migraine With Aura ◽  
Tension Type Headache ◽  
Regional Cerebral Blood ◽  
Danish Population ◽  
Genetic Studies ◽  
History Of ◽  
Headache Clinic ◽  
Type Headache ◽  
Acute Headache ◽  
First Time

Headache research in Denmark started with the description in 1949 by Dalsgaard-Nielsen of the percutaneous nitroglycerin test. In 1976 Jes Olesen started The Copenhagen Acute Headache Clinic and from that time modern headache research began in Denmark. Specific changes in regional cerebral blood flow during attacks of migraine with aura, spreading oligaemia, were described for the first time in 1980. The first headache classification with operational diagnostic criteria was published in 1988 and used in a Danish population study from 1989. The lifetime prevalence of migraine was 8% in men and 25% in women. An intravenous nitroglycerin test was introduced in 1989 and has been developed as an experimental headache model. In 1993 it was suggested by Jes Olesen et al. that NO supersensitivity could be a possible molecular mechanism of migraine pain. Recent genetic studies have supported the distinction between migraine with aura and migraine without aura. From the middle of the 1980s the pathophysiology of tension-type headache has been investigated and recent results indicate central sensitization in patients with chronic tension-type headache.

Effect of Biofeedback Treatment on Sympathetic Function in Common Migraine and Tension-Type Headache

Cephalalgia ◽  
1993 ◽  
Vol 13 (3) ◽  
pp. 197-200 ◽  
Author(s):  
Licia Grazzi ◽  
Gennaro Bussone
Keyword(s):  
Behavioral Therapy ◽  
Plasma Catecholamines ◽  
Tension Headache ◽  
Tension Type Headache ◽  
Stress Indices ◽  
Electromyographic Biofeedback ◽  
Sympathetic Function ◽  
Behavioral Therapies ◽  
Biofeedback Treatment ◽  
Type Headache

Behavioral therapies such as biofeedback are commonly used to treat migraine and tension headache. Controlling sympathetic activity is effective for controlling the pain in both disturbances. A group of 26 common migraine patients and a group of 14 tension headache patients were treated by electromyographic biofeedback (EMG-BFB); blood samples were collected during the treatment (1st session; pre and post 10th session) and plasma catecholamines and cortisol measured to determine basal levels and changes induced by the behavioral therapy. The clinical efficacy of BFB treatment for tension headache and common migraine was confirmed. The basal values of the plasma stress indices were significantly different between the two groups, but did not change during treatment. The lack of correlation between the clinical improvement and the biological indices monitored indicates the need for further studies with standardized protocols in order to probe the mechanism of action of these effective behavioral therapies.

scholarly journals ROLE OF GENETIC PREDISPOSITION, GENE POLYMORPHISM OF GLUTATHIONE-S-TRANSFERASE (GSTT1, GSTM1, GSTP1) AND SOME ADVERSE FACTORS IN DEVELOPMENT OF BRONCHIAL ASTHMA IN CHILDREN – RESIDENTS OF RADIOACTIVELY CONTAMINATED AREAS

2021 ◽  
Vol 26 ◽  
pp. 449-463
Author(s):  
Ye. Stepanova ◽  
◽  
I. Kolpakov ◽  
V. Vdovenko ◽  
V. Zigalo ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Bronchial Asthma ◽  
Gene Deletion ◽  
Molecular Genetic ◽  
Glutathione S Transferase ◽  
Genetic Studies ◽  
Hereditary Predisposition ◽  
Gstm1 Gene ◽  
Polymorphic Variants ◽  
Asthma In Children

Objective: to determine the influence of hereditary predisposition, polymorphism of GSTT1, GSTM1, GSTP1 genes and environmental factors on the development of bronchial asthma in children – residents of radioactively contaminated areas. Materials and methods. School-age children-residents of radioactively contaminated areas with bronchial asthma, and those without clinical signs of respiratory pathology were examined. Genetic, medical, biological and social risk factors were determined based on the study of anamnestic data and medical records. Ventilation lung capacity was assessed by the method of computer spirometry. Molecular genetic studies were carried out using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) for further analysis. Results. Molecular genetic studies of the distribution of genotypes and frequencies of polymorphic variants of the genes GSTT1, GSTM1, GSTP1 were performed in children living under long-term intake of 137Cs by food chains. It was found that in children with BA the tendency to frequency of the deletion variant of the GSTT1 and GSTM1 genes in comparison with children without bronchial and pulmonary pathology was increased. The study of distributing the GSTP1 A313G gene polymorphic variants revealed in children with BA a significant increase in the frequency of AG-genotype, compared with the data of reference group. Adverse factors that increase the risk of developing bronchoobstructive disorders and the probability of their implementation in the form of bronchial asthma in children residents of RCA have been identified. It is established that among them the leading role is played by hereditary predisposition to this disease. On the part of the child, such negative factors were unfavorable conditions of fetal development, the presence of signs of exudative-catarrhal diathesis, manifestations of allergies and frequent respiratory diseases from the first months of life. It was found that the risk of developing BA was significantly increased in children with the GSTT1 and GSTM1 gene deletion genotypes; an increased risk of developing BA in children with a combination of the GSTP1 A313G gene polymorphism with deletion polymorphism of the GSTT1 or GSTM1 gene was determined. Сonclusion. Оne of the leading mechanisms, due to which there is a realization of hereditary predisposition to bronchial asthma in children living under constant intake of radionuclides with a long half-life, is the polymorphism of certain glutathione-S-transferase genes, namely, GSTT1, GSTM1 and A313G gene deletion polymorphism and GSTP1 gene polymorphism. Key words: children, radioactively contaminated areas, risk factors, bronchial asthma, glutathione-S-transferase gene polymorphism.

scholarly journals Acupuncture as a therapeutic option for tension-type headache: A Systematic Review

2021 ◽  
Author(s):  
Camila Puton, Caio de Almeida Lellis ◽  
Caio Reis Borges ◽  
Giovanna Garcia de Oliveira
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Relaxation Training ◽  
Randomized Clinical Trials ◽  
Therapeutic Option ◽  
Control Process ◽  
Tension Headache ◽  
Primary Headache ◽  
Tension Type Headache ◽  
Type Headache

Introduction: Tension headache (TTS), the most common type of primary headache, is characterized by tightness pain, typically bilateral, lasting hours or days, significantly impairing daily activities. Objectives: To review the literature on the use of acupuncture in the management of TTS, evaluating its safety and efficacy. Design and setting: A systematic review conducted at the Pontifical Catholic University of Goiás. Methods: A systematic literature review was performed in the PubMed, EMBASE and Virtual Health Library databases, with the terms: “Tension-Type Headache AND Acupuncture”. Randomized studies and clinical trials published in the last 10 years were selected. Results: Two studies, one clinical trial and one randomized trial, concluded that combining acupuncture with another therapy involving movement, such as stretching, physical therapy techniques, or relaxation training, led to reduced pain intensity and improved quality of life in patients with TTS. In contrast, other randomized clinical trials concluded that relaxation training decreased the intensity, frequency of attacks, and adjunctive symptoms of headache (sleep and vitality) more than acupuncture. Finally, acupuncture was compared with the simulated control process in the prevention of TTS, but there were no statistically significant differences between the two groups evaluated. Conclusion: The literature indicated that the combination of acupuncture with other therapeutic options was safe and effective in the management and prevention of TTS. Studies with greater scientific rigor should be conducted for a better understanding of this therapeutic option.

scholarly journals Modern view on the problem of splint therapy in treatment of chronic tension type headache

2021 ◽  
Vol 38 (3) ◽  
pp. 61-67
Author(s):  
N. B. Astashina ◽  
N. L. Starikova ◽  
K. R. Valiakhmetova
Keyword(s):  
Health Status ◽  
Tension Headache ◽  
Tension Type Headache ◽  
Therapeutic Approaches ◽  
Chronic Tension Type Headache ◽  
Splint Therapy ◽  
Key Points ◽  
Conducting Research ◽  
Type Headache

The review presents the epidemiology of tension type headache. The key points of etiology, pathogenesis and clinical picture are described, modern therapeutic approaches to the treatment of chronic tension headache are considered. The data on the possibility of using prosthetic and splint therapy for correction of health status in patients with chronic tension type headache are presented. The necessity of conducting research aimed at determining the role of using occlusive splints and the significance of correcting occlusive relationships in chronic tension type headache is grounded.

Identification and certification of Bactrian and Arvan camels of Kazakh population using DNA technology// FUNDAMENTAL AND APPLIED SCIENTIFIC RESEARCH: сб.науч.тр./ OEAPS Inc.; редкол.: Флора Бертран (отв.ред.) [и др.]. - Берлин, Германия : OEAPS Inc., 2018. - С. 44-56.

2018 ◽  
Author(s):  
Elmira Kalybaevna Adil’bekova ◽  
Nuradin Alibaev ◽  
Arunas Svitojus
Keyword(s):  
Genetic Resources ◽  
Molecular Genetic ◽  
Structure Identification ◽  
Dna Microsatellites ◽  
Genetic Studies ◽  
Kazakh Population ◽  
Cytogenetic Monitoring ◽  
Dna Technology ◽  
First Time

Kazakhstan is the center where Bactrians and Dromedaries can be raised, and hybridization between them has become widespread. Genetic resources of interspecies camel hybrids, raised in Kazakhstan, are represented by 30 generations.The most highly valuable in the conditions of Central Asia and Kazakhstan are transboundary camel breeds such as Kazakh Bactrian, Turkmen and Kazakh Dromedary, as well as new generations of camels Arada, Bainar and Baitur.At pure breeding of Kazakh Bactrian, genetic peculiarities are not taken into account, in view of the poor knowledge of this issue. To maintain the biodiversity, molecular genetic monitoring of the state of camel populations is required. Cytogenetic monitoring and certification are one of the promising areas for reliable camel genome assessment.Deep determination of Kazakh dairy camelsallele poolwas not carried out in Kazakhstan before. Genetic studies to optimize structure, identification and certification of valuable genotypes, as well as systematization of genetic resources in dairy camel breeding in Kazakhstan are urgent task.The aim of the study is identification, systematization and certification of genetic resources of Bactrian and Dromedary camels of Kazakh population using DNA technology. Genetic analysis of the typing results of the camels studied was carried out by 7 and 8 loci of DNA microsatellites. The material for the studies was DNA samples isolated from histological samples. The microsatellite loci were selected in accordance with the recommendations of the European Society of Genetics (FAO/ISAG).Identification and certification of Arvan and Kazakh Bactrian camels’ genetic resources using the microsatellite analysis of their genotype was carried outfor the first time. Breeding significance of Bactrian and Arvan camels of Kazakh population using DNA technologies was studied and determined. The obtained results of the study allowed evaluate camels at the level of the allelic profile.

Contingent Negative Variation in Childhood Migraine

Cephalalgia ◽  
1993 ◽  
Vol 13 (1) ◽  
pp. 42-43 ◽  
Author(s):  
Evelyn Besken ◽  
Raymund Pothmann ◽  
Gudrun Sartory
Keyword(s):  
Contingent Negative Variation ◽  
Intertrial Interval ◽  
Tension Headache ◽  
Tension Type Headache ◽  
Moderate Intensity ◽  
Button Press ◽  
Control Group ◽  
Childhood Migraine ◽  
Type Headache ◽  
Diagnostic Importance

Adult migraineurs without aura have an increased amplitude of the Contingent Negative Variation (CNV) between attacks. Given the potential diagnostic importance of this finding and the difficulties associated with diagnosing migraine in childhood it seemed important to assess CNV in children suffering from this disorder. Ninety-seven children aged between 8 and 14 years were recruited. Forty-two suffered from migraine, 34 from tension-type headache. Twenty-one healthy controls were also studied. CNV was recorded from Fz, Cz and Pz referenced to linked earlobes during 20 trials consisting of two tones of moderate intensity with an interstimulus interval (ISI) of 4 sec and an intertrial interval (ITI) of 10 to 14 sec. The second tone of each trial required a button press. EOG was recorded from the left eye. The 10 CNV responses with the least EOG artefact were selected and averaged. Children with migraine had a highly significantly more negative mean CNV amplitude at all three electrode sites than children with tension-type headache and also a more pronounced Post-Imperative-Negative-Variation (PINV). Migrainous children differed from controls only at Cz (ISI). There was also a highly significant increase of mean CNV amplitude and PINV at all three electrode sites in the control group compared to the tension headache group.

Neurobiology of Attention Deficit/Hyperactivity Disorder

2013 ◽  
pp. 1034-1047 ◽  
Author(s):  
Stephen V. Faraone ◽  
Joseph Biederman
Keyword(s):  
Risk Factors ◽  
Attention Deficit Hyperactivity Disorder ◽  
Attention Deficit ◽  
Molecular Genetic ◽  
Mechanisms Of Action ◽  
Genetic Studies ◽  
Hyperactivity Disorder ◽  
High Heritability ◽  
Adhd Medications ◽  
Very High

Attention deficit hyperactivity disorder (ADHD) is a prevalent, early onset and persistent, disorder of inattention, hyperactivity and impulsivity. The mechanisms of action of ADHD medications, neuroimaging studies and studies of monoamine systems and animal models suggest that dysregulation of catecholaminergic neurotransmission in cerebellar-corticostriatal circuits plays a key role in the pathophysiology of ADHD. The efficacy of ADHD medications likely arises from their differing profile of effects on a) dopaminergic and noradrenergic systems and b) the localization of these effects in prefrontal cortex and striatum ADHD has a very high heritability and although molecular genetic studies have found no causal common DNA variants yet, they have found strong evidence that rare duplications and deletions are risk factors for ADHD. Environmental risk factors, especially those that impact early neurodevelopment (i.e., exposure to cigarette smoking and alcohol during pregnancy), also influence susceptibility to ADHD.

scholarly journals Personalized Medicine in the Treatment of Atrial Fibrillation: Myth or Reality?

2019 ◽  
Vol 15 (1) ◽  
pp. 90-94
Author(s):  
V. I. Podzolkov ◽  
A. I. Tarzimanova
Keyword(s):  
Risk Factors ◽  
Atrial Fibrillation ◽  
Molecular Genetic ◽  
Modern Medicine ◽  
Therapeutic Drug ◽  
Genetic Studies ◽  
Genomic Studies ◽  
Familial Atrial Fibrillation ◽  
Life Threatening ◽  
Genetic Mechanisms

Due to the spectacular progress made in human genomic studies, molecular biology and genetics have become an essential part of modern medicine making it possible to early detect the risk factors and select the personalized treatment. The genetic studies have been widely used in the diagnosis and treatment of arrhythmias. Significant advances in the study of electrophysiological and genetic mechanisms of life-threatening arrhythmias have been achieved through studies of familial conditions with high risk of sudden cardiac death. However, the area of special interest for a practitioner is the identification of mutations associated with atrial fibrillation (AF). The novel methods enable us to study histological, structural, cellular and molecular causes of this arrhythmia. The two main directions of molecular genetic studies of AF are the identification of genetic mutations causing familial atrial fibrillation and the study of different genes polymorphism predisposing to arrhythmia in general population. Gene polymorphism screening helps both identify AF risk factors and predict its evolution from paroxysmal to chronic type. Emerging genetic studies provided explanation for the variable efficacy of antiarrhythmic drugs. It can be assumed that the clinical use of genetic methods will allow accurate and personalized selection of antiarrhythmics. Currently, therapeutic drug monitoring is widely recommended for a number of medications including cytostatics, aminoglycosides, anticonvulsants, and, by some researchers, antiarrhythmic and anticoagulant drugs. Medicine from the very beginning was intended to be personalized, but until recently it was a little more than a myth. The discovery of the human genome makes it possible to choose the most effective treatment with minimal adverse drug reactions for a particular patient.

Comparative Study with EMG, Pressure Algometry and Manual Palpation in Tension-Type Headache and Migraine

Cephalalgia ◽  
1994 ◽  
Vol 14 (6) ◽  
pp. 451-457 ◽  
Author(s):  
G Sandrini ◽  
F Antonaci ◽  
E Pucci ◽  
G Bono ◽  
G Nappi
Keyword(s):  
Mental Arithmetic ◽  
International Headache Society ◽  
Trapezius Muscle ◽  
Tension Headache ◽  
Tension Type Headache ◽  
Pressure Algometry ◽  
Manual Palpation ◽  
Type Headache ◽  
International Headache Society Classification ◽  
Headache Patients

According to International Headache Society classification criteria, the presence of pericranial muscle disorder in tension-type headache should be evaluated using one of the following methods: EMG, pressure algometry or manual palpation. The purpose of this study was to compare the results of these three methods in 15 patients with episodic tension-type headache, 29 with chronic tension-type headache and 22 presenting migraine without aura compared to those obtained in healthy individuals. Algometric and EMG recordings at the frontalis muscle during mental arithmetic were more impaired in episodic and chronic tension headache patients than in controls and migraine patients. Chronic tension headache patients were significantly impaired at the trapezius muscle in all three tests compared to controls. Our data indicate that when two or three tests were carried out the diagnostic capacity was significantly improved in comparison to only one test. Moreover, since a different pattern could be seen with pain and without pain, the existence of headache at the time of testing should be taken into consideration.

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