scholarly journals Sheep Pox in North Western and North Central States of Nigeria

2021 ◽  
Vol 2 (2) ◽  
pp. 212-215
Author(s):  
S. A. Bida ◽  
F. K. Ramsey ◽  
C. O. Njoku ◽  
E. U. Eze ◽  
F. I. Eid
Keyword(s):  
Clinical History ◽  
Skin Lesions ◽  
Animal Production ◽  
Morphological Examination ◽  
North Central ◽  
Viral Isolation ◽  
Experimental Transmission ◽  
North Western

SHEEP pox in two northern states of Nigeria is reported. The disease produced nodules which became popular, vesicular and ulcerated on the skin. Lesions also developed in the respiratory, urogenital and alimentary organs The importance of the disease in animal production and its control are discussed. Viral isolation was not done but the disease was experimentally reproduced. Diagnosis was based on clinical history, experimental transmission and morphological examination

scholarly journals Implementation of the Dutch expertise centre for child abuse: descriptive data from the first 4 years

BMJ Open ◽  
2019 ◽  
Vol 9 (8) ◽  
pp. e031008 ◽  
Author(s):  
Rick Robert van Rijn ◽  
Marjo J Affourtit ◽  
Wouter A Karst ◽  
Mascha Kamphuis ◽  
Leonie C de Bock ◽  
...  
Keyword(s):  
Child Abuse ◽  
Child Protection ◽  
Implementation Process ◽  
Clinical History ◽  
Skin Lesions ◽  
Added Value ◽  
Likelihood Ratios ◽  
Cross Sectional ◽  
Healthcare Facilities ◽  
Dutch Child

ObjectiveCombined paediatric and forensic medical expertise to interpret physical findings is not available in Dutch healthcare facilities. The Dutch Expertise Centre for Child Abuse (DECCA) was founded in the conviction that this combination is essential in assessing potential physical child abuse. DECCA is a collaboration between the three paediatric hospitals and the Netherlands Forensic Institute. DECCA works with Bayes’ theorem and uses likelihood ratios in their conclusions.DesignWe present the implementation process of DECCA and cross-sectional data of the first 4 years.ParticipantsBetween 14 December 2014 and 31 December 2018, a total of 761 advisory requests were referred, all of which were included in this study. An advisee evaluation over the year 2015 was performed using a self-constructed survey to gain insight in the first experiences with DECCA.Results761 cases were included, 381 (50.1%) boys and 361 (47.4%) girls (19 cases (2.5%) sex undisclosed). Median age was 1.5 years (range 1 day to 20 years). Paediatricians (53.1%) and child safeguarding doctors (21.9%) most frequently contacted DECCA. The two most common reasons for referral were presence of injury/skin lesions (n=592) and clinical history inconsistent with findings (n=145). The most common injuries were bruises (264) and non-skull fractures (166). Outcome of DECCA evaluation was almost certainly no or improbable child abuse in 35.7%; child abuse likely or almost certain in 24.3%, and unclear in 12%. The advisee evaluations (response rate 50%) showed that 93% experienced added value and that 100% were (very) satisfied with the advice.ConclusionData show growing interest in the expertise of DECCA through the years. DECCA seems to be a valuable addition to Dutch child protection, since advisee value the service and outcome of DECCA evaluations. In almost half of the cases, DECCA concluded that child abuse could not be substantiated.

scholarly journals Trypanosoma cruzi infection associated with atypical clinical manifestation during the acute phase of the Chagas disease

2019 ◽  
Vol 12 (1) ◽  
Author(s):  
Lucia Rangel-Gamboa ◽  
Lirio López-García ◽  
Francisco Moreno-Sánchez ◽  
Irma Hoyo-Ulloa ◽  
María Elisa Vega-Mémije ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Chagas Disease ◽  
Acute Phase ◽  
Clinical Manifestations ◽  
Chronic Phase ◽  
Clinical History ◽  
Skin Lesions ◽  
Small Subunit ◽  
Serological Tests ◽  
Cutaneous Manifestations

Abstract Background Chagas disease (CD) is caused by the protozoan parasite Trypanosoma cruzi and is transmitted by triatomine insects. Clinical manifestations vary according to the phase of the disease. Cutaneous manifestations are usually observed in the acute phase (chagoma and Romaña’s sign) or after reactivation of the chronic phase by immunosuppression; however, a disseminated infection in the acute phase without immunosuppression has not been reported for CD. Here, we report an unusual case of disseminated cutaneous infection during the acute phase of CD in a Mexican woman. Methods Evaluation of the patient included a complete clinical history, a physical exam, and an exhaustive evaluation by laboratory tests, including ELISA, Western blot and PCR. Results Skin biopsies of a 50-year-old female revealed intracellular parasites affecting the lower extremities with lymphangitic spread in both legs. The PCR tests evaluated biopsy samples obtained from the lesions and blood samples, which showed a positive diagnosis for T. cruzi. Partial sequencing of the small subunit ribosomal DNA correlated with the genetic variant DTU II; however, serological tests were negative. Conclusions We present a case of CD with disseminated skin lesions that was detected by PCR and showed negative serological results. In Mexico, an endemic CD area, there are no records of this type of manifestation, which demonstrates the ability of the parasite to initiate and maintain infections in atypical tissues.

scholarly journals Evaluation of some effectiveness elements of the pig breeding industry in Bulgaria, through cluster analysis

2019 ◽  
Vol 35 (1) ◽  
pp. 25-33
Author(s):  
Ivelina Zapryanova
Keyword(s):  
Cluster Analysis ◽  
Central Region ◽  
Western Region ◽  
North Central Region ◽  
North Central ◽  
The North ◽  
South Central ◽  
North Eastern ◽  
Central Regions ◽  
North Western

An evaluation was made of the effectiveness elements of the pig breeding industry in Bulgaria in the period 2001-2016, through cluster analysis. The studied period was divided in 3 subperiods, each one with three similar groups (clusters). Through application of cluster analysis, the proximity of the different administration regions in the country was defined in accordance with certain indicators of the pig breeding effectiveness. It was found that in the first cluster for the period 2001-2006 fall North-Western and South-Western region. The North-Eastern and North-Central region form the second cluster. The South-Eastern and South-Central region fall mainly into the third cluster. In the first cluster for the period 2007-2011, the North-Western, South-Western and South-Central regions have a priority with the lowest number of sold animals. The North-Eastern and the North-Central region, forming a third cluster, remain with the highest effectiveness of the pig farming. After the end of 2013 an aggregation of the sector began. For the period 2012-2016, the second cluster is formed from three regions - North-Western, South-Western, and South-Central in 2013.

scholarly journals Clinical Study on Outcome of Treatment for Herpes Zoster

2021 ◽  
Author(s):  
Kishan Rasubhai Ninama ◽  
Rashmi Samir Mahajan ◽  
Atmakalyani Rashmi Shah ◽  
Apexa Prakash Jain
Keyword(s):  
Herpes Zoster ◽  
Lupus Erythematosus ◽  
De Novo ◽  
Clinical Manifestations ◽  
Pemphigus Vulgaris ◽  
Clinical History ◽  
Skin Lesions ◽  
Enzyme Linked Immunosorbent Assay ◽  
Oral Acyclovir ◽  
Varicella Zoster

Introduction: Herpes Zoster (HZ) is caused by reactivation of Varicella Zoster Virus (VZV). It is characterised by occurrence of grouped vesicles on erythematous base which involves the entire dermatome innervated by a single spinal or cranial sensory ganglion and is associated with radicular pain. Antivirals (Acyclovir, Famciclovir and Valacyclovir) started within 72 hours of onset of lesions are the agents of choice. Aim: To study the clinical manifestations, comorbidities, efficacy and safety of Acyclovir, complications and sequelae associated with HZ. Materials and Methods: A 3-year longitudinal cohort study was conducted in 212 adult patients (>18 years of age) suffering with HZ in the Department of Dermatology, Dhiraj General Hospital, Pipariya, Gujarat, India. In this study 212 patients with HZ were prescribed oral Acyclovir in a dose of 800 mg 5 times a day for 7 days. All patients were analysed in terms of clinical manifestations, pre-existing co-morbidities and incidence of complications. The clinical history and findings were recorded in a prestructured proforma. All patients were subjected to cytological examination (Tzanck smear) and Human immunodeficiency viruses (HIV) testing Enzyme-Linked Immunosorbent Assay (ELISA). Diagnosis was made primarily on the basis of clinical findings and presence of multinucleated giant cells in Tzanck smear. All the patients were treated with Oral Acyclovir. Cases were followed-up fortnightly for six weeks and evaluated for relief of symptoms, treatment outcome and complications/sequelae. Results: Two hundred and twelve cases were studied. One hundred and forty-two cases were in the 4th and 5th decades of life. Sixty-three cases had comorbidities like diabetes mellitus in 31, autoimmune diseases like pemphigus vulgaris, systemic lupus erythematosus, rheumatoid arthritis and inflammatory bowel disease in 19 and AIDS in 8 cases. Five cases had malignancy/lymphomas and were receiving chemotherapy for the same. In the majority, HZ occurred de novo without any comorbidities. The most common dermatomes involved were cervical and thoracic. Out of 212 cases Oral Acyclovir 800 mg was well tolerated by 74. Most common complication was Postherpetic Neuralgia (PHN), seen in 80 cases. Conclusion: The treatment of HZ with Oral Acyclovir 800 mg 5 times a day for 7 days is efficacious for healing of skin lesions and also reduces the chances of PHN if instituted within 72 hours.

scholarly journals Morphological Description of Horses from the Pazyryk Burials in North-Western Altai

2020 ◽  
Vol 32 (4) ◽  
pp. 123-130
Author(s):  
Plasteeva N. ◽  
◽  
Dashkovskiy P. ◽  
Tishkin A. ◽  
◽  
...  
Keyword(s):  
Morphological Description ◽  
Morphological Examination ◽  
Distinctive Features ◽  
Local Characteristics ◽  
The North ◽  
Sayan Region ◽  
Burial Mounds ◽  
Morphological Differences ◽  
Young Horses ◽  
North Western

The results of morphological examination of horse remains from the Pazyryk burials the North-Western Altai indicate a high similarity of buried animals in the height at the withers, size and proportions of their bones. Only stallions were buried in the Khankarinsky Dol, Inskoy Dol and Chineta-II burial mounds. Horses from these mounds were morphologically similar to the horses from other Pazyryk burials. The distinctive features of the Pazyryk burials in North-Western Altai are the higher proportion of young horses in the burials and the absence of animals which are above 144 cm at the withers. However, Pazyryk horses from Khankarinsky Dol, Inskoy Dol and Chineta-II burial mounds differ significantly in the size and proportions of the bones from horses which belonged to the previous Arzhano-Mayemir period of the Sayan region and the Bulan-Koby culture of the Xiongnu-Xianbei-Rouran period of the Altai. The morphological differences illustrate local characteristics of animals in the past times.

scholarly journals Estimated incidence of noma “A biologic indicator of poverty” in north central Nigeria: A retrospective cross-sectional study

2019 ◽  
Author(s):  
Seidu A. Bello ◽  
John A. Adeoye ◽  
Ifeoluwa Oketade ◽  
Oladimeji A. Akadiri
Keyword(s):  
Multinomial Logistic Regression ◽  
Central Zone ◽  
Sub Saharan Africa ◽  
Cross Sectional ◽  
North Central ◽  
Period Prevalence ◽  
The North ◽  
Surgical Mission ◽  
Sub Saharan ◽  
North Western

ABSTRACTBackgroundNoma is a spreading and devouring disease which is believed to be native to Sub-Saharan Africa over the last decade due to poverty. Within this noma belt, most epidemiological reports regarding the disease have emanated from the north western region of Nigeria. However, our indigenous surgical mission encountered a substantial number of cases noteworthy of epidemiological representation in north central Nigeria.MethodsAll facial cleft and noma cases encountered within the 8 year study period were included into this study. Estimated incidence of the noma in the zone was calculated using the existing statistical model of Fieger et al (2003), which takes into account the expected differences based on age and location of the two patient groups using the multinomial logistic regression analysis. Period prevalence of noma was also calculated by simple division considering the population at risk of the disease in the zone.FindingsA total of 770 subjects were included in this study (orofacial cleft – 692, noma – 78). The incidence estimate of noma in the north central zone was 3.2 per 1000 with a range of 2.6 – 3.7 per 1000. The period prevalence of noma was1:125,000 children. The median age of noma patients was comparatively higher than the median age of facial cleft patients. The mean age of onset of noma was 5.9 ± 8.08 years which was lower than the average age of individuals in the noma group - 29.6 ± 18.84 years.ConclusionAlthough noma may be more prevalent in the north western region of Nigeria; substantial number of cases is still being encountered in the north central zone which calls for urgent attention of relevant health stakeholders regarding the management and rehabilitation of individuals affected.AUTHOR SUMMARYNoma, a devouring facial disease, is commonly associated with poverty and impoverished regions of the world especially Sub-Saharan Africa which is being termed the noma belt region of the world. Although literature established that noma is indeed a neglected disease, the degree of this neglect in north central Nigeria compared to other sub-regions is in fact alarming, as no report on the disease burden have been published till date. In this light, a retrospective, cross-sectional was conducted to provide epidemiological representation to the cases encountered within an eight year period at the Cleft and Facial Deformity Foundation (CFDF), an indigenous surgical mission. The incidence of noma was estimated from the known incidence of orofacial cleft using an existing multinomial logistic regression model while the period prevalence was calculated considering the population living below poverty line in the sub-region. This study extrapolates an incidence of 3.2 per 1000 and a period prevalence of 0.05 per 1000 persons. Notable is the finding that most individuals with noma were above thirty years of age and suffered varying degree of facial disfigurement resulting from the acute phase of the disease which started in their childhood. Therefore, we advocate public awareness on the disease presentation, risk factors and sequelae in the sub-region and identify the need to bolster the efforts of existing health facilities and indigenous surgical missions in the management and rehabilitation of individuals affected.

scholarly journals Lymphomatoid Papulosis in a Case of Atypical Secondary Syphilis

2019 ◽  
Vol 14 (4) ◽  
pp. e32-e33
Author(s):  
Xin (Peter) Mu ◽  
Ian Mazzetti
Keyword(s):  
Clinical History ◽  
Skin Lesions ◽  
Secondary Syphilis ◽  
Low Grade ◽  
Cutaneous Lesions ◽  
Syphilis Infection ◽  
Lymphomatoid Papulosis ◽  
History Of ◽  
Skin Biopsies ◽  
Syphilis Serology

AbstractLymphomatoid papulosis is an indolent cutaneous lymphoproliferative disorder that presents as recurrent self-resolving papulonodular skin lesions. Currently, there are no known causes for lymphomatoid papulosis and definitive diagnosis is only made histologically. A 64-year-old man presented with a 6-week history of bilateral leg pains, low-grade fevers, and a widespread eruption of painless erythematic papules. Despite testing positive for syphilis serology, he lacked the typical clinical history for classic syphilis and therefore, skin biopsies were performed to confirm the diagnosis. Unexpectedly, the skin biopsies revealed lymphomatoid papulosis which resolved with antibiotic treatments for syphilis. Considering the synchronous resolution of the patient’s syphilis infection and his cutaneous lesions, this is the first report of findings to suggest syphilis as a possible cause for lymphomatoid papulosis. Clinicians should appreciate the possibility of alternative diagnosis for cutaneous presentations in settings of confirmed syphilis infections. RESUMELa papulose lympho-matoïde est un trouble lymphoprolifératif cutané indolent qui se présente sous la forme de lésions cutanées papulonodulaires auto-résolutives récurrentes. Actuellement, il n’y a pas de causes connues de la papulose lymphomatoïde et le diagnostic définitif n’est posé que sur le plan histologique. Un homme de 64 ans a présenté une histoire de 6 semaines de douleurs bilatérales aux jambes, de fièvres de bas grade et d’éruptions généralisées de papules érythémateuses indolores. Malgré un test sérologique positif pour la syphilis, il n’avait pas les antécédents cliniques typiques de la syphilis classique et des biopsies cutanées ont donc été effectuées pour confirmer le diagnostic. De façon inattendue, les biopsies cutanées ont révélé une papulose lymphomatoïde qui s’est résorbée grâce à des traitements antibiotiques contre la syphilis. Compte tenu de la résolution synchrone de l’infection syphilitique du patient et de ses lésions cutanées, il s’agit du premier rapport de résultats suggérant que la syphilis est une cause possible de papulose lymphomatoïde. Les cliniciens devraient apprécier la possibilité d’un diagnostic alternatif pour les présentations cutanées dans les contextes d’infections syphilitiques confirmées.

scholarly journals Targetoid Skin Lesions in a Child: Acute Hemorrhagic Oedema of Infancy and Its Differential Diagnosis

2019 ◽  
Vol 16 (5) ◽  
pp. 823
Author(s):  
Francesco Miconi ◽  
Lorenzo Cassiani ◽  
Emanuela Savarese ◽  
Federica Celi ◽  
Manuela Papini ◽  
...  
Keyword(s):  
Diagnostic Procedures ◽  
Clinical History ◽  
Skin Lesions ◽  
Small Vessel Vasculitis ◽  
Serological Tests ◽  
Systemic Involvement ◽  
Reactive Protein ◽  
Normal Platelet ◽  
Platelet Morphology ◽  
Dermatologic Manifestations

Acute hemorrhagic oedema of infancy (AHEI) is a cutaneous leukocytoclastic small-vessel vasculitis presenting with localized purpuric large skin plaques that are frequently associated with fever and oedema. It must be promptly differentiated from a number of diseases with similar dermatologic manifestations with potentially severe clinical courses that require adequate monitoring and prompt therapy to avoid the risk of a negative evolution. A 15-month-old girl with a negative personal medical clinical history was admitted for the sudden appearance of petechiae on the soft palate. The patient was moderately febrile during the following two days, with a maximum ear temperature of 38.3 °C. The fever disappeared on the third day, whereas the hemorrhagic rash progressively increased and extended to the limbs, face and auricles associated with a strong oedematous component. Moreover, on the second day of hospitalization, bilateral oedema of the metacarpophalangeal joints with joint pain appeared. The blood and serological tests showed an increase in C-reactive protein concentration (3.58 mg/dL) in the absence of leukocytosis and with a normal platelet count (180,000/mm3). The examination of the peripheral smear showed the presence of some large mononuclear elements with hyperbasophile cytoplasm. No alterations in platelet morphology were evidenced. The skin manifestations progressively diminished and disappeared spontaneously within 3 weeks, leaving no sequelae. Conclusion: This case shows the classic skin lesions of AHEI that require differentiation from those of more severe diseases that need prompt recognition and therapy. In this case, the age of the patient, the lack of systemic involvement and the favorable clinical course without therapy were typical. However, as these patients may present to the emergency department with an impressive clinical picture, the condition must be promptly diagnosed to avoid unnecessary diagnostic procedures and to reassure parents.

scholarly journals Erythema Ab Igne with Histological Features of Keratosis Lichenoides Chronica

2021 ◽  
pp. 184-189
Author(s):  
Asja Prohic ◽  
Selma Poparic ◽  
Adem Cemerlic ◽  
Aida Kapetanovic
Keyword(s):  
Heat Source ◽  
Prolonged Exposure ◽  
Heat Exposure ◽  
Clinical History ◽  
Skin Lesions ◽  
Histological Features ◽  
Malignant Skin ◽  
Erythema Ab Igne ◽  
Malignant Alteration ◽  
Rule Out

Erythema ab igne (EAI) is a localized, hyperpigmented and reticulated dermatosis at sites of chronic heat exposure. Within longstanding skin lesions of EAI, hyperkeratotic lesions may emerge and can potentially transform into pre-malignant or malignant skin lesions. A 55-year-old woman presented for the evaluation of multiple hyperkeratotic lesions along with a reticular patterned hyperpigmentation on her right knee, an area that had repeated and prolonged exposure to a heat source over a period of several months. Based on her clinical history and the physical examination of her lesions, she was diagnosed as having a hyperkeratotic form of EAI. A skin biopsy was performed to rule out malignant alteration, but the histopathological findings were supportive of keratosis lichenoides chronica.

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