scholarly journals Open-source, partially 3D-printed, high-pressure (50-bar) liquid-nitrogen-cooled parahydrogen generator

2021 ◽  
Vol 2 (1) ◽  
pp. 49-62
Author(s):  
Frowin Ellermann ◽  
Andrey Pravdivtsev ◽  
Jan-Bernd Hövener
Keyword(s):  
Magnetic Resonance Imaging ◽  
High Pressure ◽  
Open Source ◽  
Liquid Nitrogen ◽  
Nuclear Polarization ◽  
Low Cost ◽  
3D Models ◽  
Resonance Imaging ◽  
3D Printed ◽  
Magnetic Resonance Imaging Mri

Abstract. The signal of magnetic resonance imaging (MRI) can be enhanced by several orders of magnitude using hyperpolarization. In comparison to a broadly used dynamic nuclear polarization (DNP) technique that is already used in clinical trials, the parahydrogen (pH2)-based hyperpolarization approaches are less cost-intensive, are scalable, and offer high throughput. However, a pH2 generator is necessary. Available commercial pH2 generators are relatively expensive (EUR 10 000–150 000). To facilitate the spread of pH2-based hyperpolarization studies, here we provide the blueprints and 3D models as open-source for a low-cost (EUR <3000) 50-bar liquid-nitrogen-cooled pH2 generator.

scholarly journals Open-source, 3D-printed, high-pressure (50 bar) liquid-nitrogen-cooled <i>para</i>-hydrogen generator

2020 ◽  
Author(s):  
Frowin Ellermann ◽  
Andrey Pravdivtsev ◽  
Jan-Bernd Hövener
Keyword(s):  
Magnetic Resonance Imaging ◽  
Open Source ◽  
Nuclear Polarization ◽  
Low Cost ◽  
3D Models ◽  
Para Hydrogen ◽  
Resonance Imaging ◽  
Hydrogen Generator ◽  
3D Printed ◽  
Magnetic Resonance Imaging Mri

Abstract. The signal of magnetic resonance imaging (MRI) can be enhanced by several orders of magnitude using hyperpolarization. In comparison to a broadly used Dynamic Nuclear Polarization (DNP) technique that is already used in clinical trials, the para-hydrogen (pH2) based hyperpolarization approaches are less cost-intensive, scalable and offer high throughput. However, a pH2 generator is necessary. Available commercial pH2 generators are relatively expensive (10,000–150,000 €). To facilitate the spread of pH2 hyperpolarization studies, here, we provide the blueprints and 3D-models as open-source for a low-cost (

Quantitative Muscle Ultrasound versus Magnetic Resonance Imaging in Duchenne Muscular Dystrophy

2020 ◽  
Author(s):  
Jun Hu ◽  
Li Jiang ◽  
Siqi Hong ◽  
Li Cheng ◽  
Qiao Wang ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Duchenne Muscular Dystrophy ◽  
Magnetic Resonance ◽  
Muscular Dystrophy ◽  
Low Cost ◽  
Muscle Thickness ◽  
Resonance Imaging ◽  
Magnetic Resonance Imaging Mri ◽  
The Right ◽  
Muscle Ultrasound

Abstract Background: Nowadays, it needs favorable biomarkers to follow up the disease progression and therapeutic responses of Duchenne muscular dystrophy (DMD). This study evaluates which one of Quantitative muscle ultrasound (QMUS) and magnetic resonance imaging (MRI) is suitable for the disease in China. Methods: Thirty-six boys with DMD engaged in the longitudinal observational cohort study, who used prednisone from baseline to 12th month. Muscle thickness (MT) and echo intensity (EI) of QMUS and T1-weighted MRI grading were measured in the right quadriceps femoris of the boys with DMD. Results: The scores of MT and EI of QMUS and T1-weighted MRI grading showed significant correlations with the clinical ones of muscle strength, timed testing, and quality of life. The scores of MT and EI of QMUS showed good correlations with the ones of T1-weighted MRI grading too (P<0.05). But 15 of 36 boys with DMD did not take MRI examinations for different reasons. Conclusions: QMUS and MRI can use as biomarkers for tracking DMD. Nevertheless, QMUS, because of its practical, low cost, and patient-friendly, applies for DMD widely than MRI in China. Keywords: Ultrasonography, Magnetic resonance imaging, Duchenne muscular dystrophy, Child

scholarly journals B0-Shimming Methodology for Affordable and Compact Low-Field Magnetic Resonance Imaging Magnets

2021 ◽  
Vol 9 ◽  
Author(s):  
Konstantin Wenzel ◽  
Hazem Alhamwey ◽  
Tom O’Reilly ◽  
Layla Tabea Riemann ◽  
Berk Silemek ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Field ◽  
Magnetic Resonance ◽  
Point Of Care ◽  
Low Cost ◽  
Field Measurements ◽  
Target Volume ◽  
Resonance Imaging ◽  
Low Field ◽  
Magnetic Resonance Imaging Mri

Low-field (B0 &lt; 0.2 T) magnetic resonance imaging (MRI) is emerging as a low cost, point-of-care alternative to provide access to diagnostic imaging technology even in resource scarce environments. MRI magnets can be constructed based on permanent neodymium-iron-boron (NdFeB) magnets in discretized arrangements, leading to substantially lower mass and costs. A challenge with these designs is, however, a good B0 field homogeneity, which is needed to produce high quality images free of distortions. In this work, we describe an iterative approach to build a low-field MR magnet based on a B0-shimming methodology using genetic algorithms. The methodology is tested by constructing a small bore (inner bore diameter = 130 mm) desktop MR magnet (&lt;15 kg) at a field strength of B0 = 0.1 T and a target volume of 4 cm in diameter. The configuration consists of a base magnet and shim inserts, which can be placed iteratively without modifying the base magnet assembly and without changing the inner dimensions of the bore or the outer dimensions of the MR magnet. Applying the shims, B0 field inhomogeneity could be reduced by a factor 8 from 5,448 to 682 ppm in the target central slice of the magnet. Further improvements of these results can be achieved in a second or third iteration, using more sensitive magnetic field probes (e.g., nuclear magnetic resonance based magnetic field measurements). The presented methodology is scalable to bigger magnet designs. The MR magnet can be reproduced with off-the-shelf components and a 3D printer and no special tools are needed for construction. All design files and code to reproduce the results will be made available as open source hardware.

scholarly journals Hyperpolarized 15N-labeled, deuterated tris(2-pyridylmethyl)amine as an MRI sensor of freely available Zn2+

2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Eul Hyun Suh ◽  
Jae Mo Park ◽  
Lloyd Lumata ◽  
A. Dean Sherry ◽  
Zoltan Kovacs
Keyword(s):  
Magnetic Resonance Imaging ◽  
Prostate Cancer ◽  
Magnetic Resonance ◽  
Metal Ion ◽  
Nuclear Polarization ◽  
Specific Probe ◽  
Resonance Imaging ◽  
Intact Cells ◽  
Human Prostate Tissue ◽  
Magnetic Resonance Imaging Mri

AbstractDynamic nuclear polarization (DNP) coupled with 15N magnetic resonance imaging (MRI) provides an opportunity to image quantitative levels of biologically important metal ions such as Zn2+, Mg2+ or Ca2+ using appropriately designed 15N enriched probes. For example, a Zn-specific probe could prove particularly valuable for imaging the tissue distribution of freely available Zn2+ ions, an important known metal ion biomarker in the pancreas, in prostate cancer, and in several neurodegenerative diseases. In the present study, we prepare the cell-permeable, 15N-enriched, d6-deuterated version of the well-known Zn2+ chelator, tris(2-pyridylmethyl)amine (TPA) and demonstrate that the polarized ligand had favorable T1 and linewidth characteristics for 15N MRI. Examples of how polarized TPA can be used to quantify freely available Zn2+ in homogenized human prostate tissue and intact cells are presented.

scholarly journals The Role of Magnetic Resonance Imaging in the Diagnosis of Fetal Malformations

2007 ◽  
Vol 1 (3) ◽  
pp. 60-76
Author(s):  
M Lituania ◽  
MP Fondelli ◽  
U Passamonti ◽  
L Saitta ◽  
A Cerchiaro ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Low Cost ◽  
Resonance Imaging ◽  
Additional Information ◽  
Diagnostic Potential ◽  
Delivery Planning ◽  
Fetal Malformations ◽  
The Central Nervous System ◽  
Magnetic Resonance Imaging Mri

Abstract Even if ultrasonography still remains the primary prenatal investigation technique for the assessment of fetal development, magnetic resonance imaging (MRI) plays an important role for the study of fetal morphology and pathology. MRI has been shown to be particularly useful for the evaluation of the central nervous system (CNS), the latter being a common site of pathology such as cerebral and spinal malformations. MRI is contributive in defining fetal neck, thoracic, abdominal, and pelvic masses. This can be especially helpful when differing opinions exists as to the etiology of a mass. Ultrasonography, a non invasive, low cost, real time technique, still represents the investigation of choice in prenatal screening, not only regarding the CNS. Nevertheless several cases need a diagnostic complement by means of MRI, that increases the diagnostic potential of ultrasound . The additional information from MRI is important in prenatal counseling, delivery planning and planning for pre- or postnatal intervention.

The Role of Magnetic Resonance Imaging in the Evaluation of Neoplastic Lesions of the Breast

1989 ◽  
Vol 75 (1) ◽  
pp. 14-17
Author(s):  
Raffaele Petrillo ◽  
Luca Balzarini ◽  
Anna Bargellini ◽  
Cesare Bartoli ◽  
Errico Ceglia ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Low Cost ◽  
Cost Benefit ◽  
Needle Aspiration ◽  
Alternative Methods ◽  
Resonance Imaging ◽  
Cost Benefit Ratio ◽  
Magnetic Resonance Imaging Mri ◽  
The Moment

Thirty-seven patients were evaluated for suspected breast cancer by magnetic resonance imaging (MRI) using 0.5- and 1.5-Tesla. We esamined the patterns in breast images and the use of MRI in evaluating neoplasms. At the moment the cost/benefit ratio is unfavorable, mainly because of the availability of alternative methods of high accuracy and low cost, like mammography and ultrasonography. Furthermore fine needle aspiration biopsy is not possible with MRI. The widespread use of MRI for breast pathology seems not to be justified by the results obtained.

scholarly journals Contactless respiratory monitoring system for magnetic resonance imaging applications using a laser range sensor

2016 ◽  
Vol 2 (1) ◽  
pp. 719-722 ◽  
Author(s):  
Johannes W. Krug ◽  
Robert Odenbach ◽  
Axel Boese ◽  
Michael Friebe
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Imaging System ◽  
Human Subjects ◽  
Low Cost ◽  
Resonance Imaging ◽  
Laser Range ◽  
Range Sensor ◽  
Shallow Breathing ◽  
Magnetic Resonance Imaging Mri

AbstractDuring a magnetic resonance imaging (MRI) exam, a respiratory signal can be required for different purposes, e.g. for patient monitoring, motion compensation or for research studies such as in functional MRI. In addition, respiratory information can be used as a biofeedback for the patient in order to control breath holds or shallow breathing. To reduce patient preparation time or distortions of the MR imaging system, we propose the use of a contactless approach for gathering information about the respiratory activity. An experimental setup based on a commercially available laser range sensor was used to detect respiratory induced motion of the chest or abdomen. This setup was tested using a motion phantom and different human subjects in an MRI scanner. A nasal airflow sensor served as a reference. For both, the phantom as well as the different human subjects, the motion frequency was precisely measured. These results show that a low cost, contactless, laser-based approach can be used to obtain information about the respiratory motion during an MRI exam.

scholarly journals Survey on Identification of Alzheimer Disease Using Magnetic Resonance Imaging (MRI) Images

2019 ◽  
Vol 8 (11) ◽  
pp. 3564-3570
Keyword(s):  
Magnetic Resonance Imaging ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Magnetic Resonance ◽  
Early Detection ◽  
Low Cost ◽  
Tau Proteins ◽  
Resonance Imaging ◽  
Human Errors ◽  
Magnetic Resonance Imaging Mri

Alzheimer’s disease (AD) is a neuro-degenerative disorder which is characterised functional and cognitive deficits that take place progressively. Early detection of the AD is important for the therapy to be early and this may slow down the disease and its progression. For the purpose of bringing about an improvement to the incidence of early detection of the AD, there may be certain Normal Controls (NC) that is based on the structural analysis of Magnetic Resonance Imaging (MRI). In fact, an early detection of the AD by means of using an MRI can help both patients, as well as physicians, to a great extent since it is of a low cost and is also a procedure that is non-invasive providing objective diagnosis by avoiding human errors. This has been connected to the accumulation of the amyloid and the tau proteins found in the brain which is probably the commonest cause for a case of dementia and also accounts for almost 70% of cases of dementia. The MRI is an extremely promising technique in terms of detection of functional or structural brain differences observed among both these patient populations. For the purpose of this work, there had been a new survey that had been made for the identification of a new case of Alzheimer’s disease by means of using the MRI images.

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