scholarly journals Summary of the IADR Cariology Research, Craniofacial Biology, and Mineralized Tissue Groups Symposium, Iguaçu Falls, Brazil, June 2012: Gene-environment Interactions and Epigenetics in Oral Diseases: Enamel Formation and its Clinical Impact on Tooth Defects, Caries, and Erosion

2013 ◽  
Vol 1 (1) ◽  
pp. 19-24 ◽  
Author(s):  
Adriana Modesto ◽  
Ophir Klein ◽  
Livia M.A. Tenuta ◽  
Raquel F. Gerlach ◽  
Alexandre R. Vieira
Keyword(s):  
Environmental Factors ◽  
Oral Diseases ◽  
Mineralized Tissue ◽  
Enamel Formation ◽  
Individual Level ◽  
Gene Environment ◽  
Craniofacial Biology ◽  
The Many ◽  
The Individual ◽  
Insight Into

Characteristics of enamel may influence or modulate individual susceptibility to caries and erosion. These characteristics are defined during development, which is under strict genetic control, but can easily be modified in many ways by environmental factors. In the symposium, translational aspects of embryology, biochemistry, and genetics of amelogenesis were presented. The symposium provided unique insight into how basic sciences integrate with clinically relevant problems. The need for improved understanding of risks at the individual level, taking into consideration both environmental exposures and genetic background, was presented. The symposium was divided into four stepwise and interconnected topics as follows:  1) The Many Faces of Enamel Development; 2) Enamel Pathogenesis: Biochemistry Lessons; 3) Environmental Factors on Enamel Formation; and, 4) Genetic Variation in Enamel Formation Genes.

scholarly journals A Tale of Odds and Ratios: Political Preference Formation in Postindustrial Democracies

2021 ◽  
Author(s):  
David M. Wineroither ◽  
Rudolf Metz
Keyword(s):  
Social Stratification ◽  
Political Process ◽  
Environment Interaction ◽  
Preference Formation ◽  
Political Preference ◽  
Individual Level ◽  
Gene Environment Interaction ◽  
Gene Environment ◽  
Wide Range ◽  
The Individual

AbstractThis report surveys four approaches that are pivotal to the study of preference formation: (a) the range, validity, and theoretical foundations of explanations of political preferences at the individual and mass levels, (b) the exploration of key objects of preference formation attached to the democratic political process (i.e., voting in competitive elections), (c) the top-down vs. bottom-up character of preference formation as addressed in leader–follower studies, and (d) gene–environment interaction and the explanatory weight of genetic predisposition against the cumulative weight of social experiences.In recent years, our understanding of sites and processes of (individual) political-preference formation has substantially improved. First, this applies to a greater variety of objects that provide fresh insight into the functioning and stability of contemporary democracy. Second, we observe the reaffirmation of pivotal theories and key concepts in adapted form against widespread challenge. This applies to the role played by social stratification, group awareness, and individual-level economic considerations. Most of these findings converge in recognising economics-based explanations. Third, research into gene–environment interplay rapidly increases the number of testable hypotheses and promises to benefit a wide range of approaches already taken and advanced in the study of political-preference formation.

A Critical Review of Theories and Models of Technology Adoption and Acceptance in Information System Research

2015 ◽  
Vol 6 (4) ◽  
pp. 58-77 ◽  
Author(s):  
Ali Tarhini ◽  
Nalin Asanka Gamagedara Arachchilage ◽  
Ra'ed Masa'deh ◽  
Muhammad Sharif Abbasi
Keyword(s):  
Information System ◽  
Technology Adoption ◽  
Environmental Factors ◽  
Critical Review ◽  
Predictive Power ◽  
Theoretical Models ◽  
System Research ◽  
Information System Research ◽  
Individual Level ◽  
The Individual

Previous research shows that selecting an appropriate theory or model has always remained a critical task for IS researchers. To the best of the authors' knowledge, there are few papers that review and compare the acceptance theories and models at the individual level. Hence, this article aims to overcome this problem by providing a critical review of eight of the most influential theories that have been used to predict and explain human behaviour towards adoption of various technologies at the individual level. This article also summarizes their evolution; highlight the key constructs, extensions, strengths, and criticisms from a selective list of published articles appeared in the literature related to IS. This review provides a holistic picture for future researchers in selecting appropriate single/multiple theoretical models/constructs based on their strengths and weaknesses and in terms of predictive power and path significance. It is concluded that a well-established theory should consider the personal, social, cultural, technological, organizational and environmental factors

Getting Ahead

Teen Spirit ◽  
2020 ◽  
pp. 132-143
Author(s):  
Paul Howe
Keyword(s):  
Free Market ◽  
Economic Behavior ◽  
Social Fabric ◽  
Individual Level ◽  
Economic Decision Making ◽  
Economic Trends ◽  
Individual Decisions ◽  
The Individual ◽  
Adolescent Society ◽  
Insight Into

This chapter assesses how the pervasive influence of the adolescent character provides insight into the workings of another sector of modern life relevant to us all: the economy. Less of a collective undertaking than politics, economic activity is guided primarily by individual decisions and actions in the free market system; so many of the relevant effects are seen first and foremost at the individual level. But these individual effects can multiply and cascade to generate patterns that do have important consequences for the general economic and social fabric. Emotions, misperceptions, intangible costs and benefits, influenced in many instances by underlying character traits, lead people to act in ways that the traditional models do not anticipate. As in other fields, it is only recently that some researchers have started to link personality to economic behavior in interesting and enlightening ways to dig deeper into what makes people tick when it comes to economic decision making and activity. When we combine some of these findings with ideas about the changing contours of character in the adolescent society, we can develop new understandings of some of the more salient economic trends of the past number of years.

“Reinventing the wheel, over and over again”. organizational learning, memory and forgetting in doing diversity work

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Marieke van den Brink
Keyword(s):  
Organizational Change ◽  
Organizational Learning ◽  
Performance Management ◽  
Research Question ◽  
Content Type ◽  
Individual Level ◽  
Management Plans ◽  
The Individual ◽  
Diversity Studies ◽  
Insight Into

Purpose The purpose of this paper is to advance knowledge of organizational change towards diversity by bringing together concepts from organizational learning and diversity studies. Design/methodology/approach This longitudinal study was conducted over two years. It involved interviews, observation of meetings and consultation of documentation and the analysis focused on organizational learning. The key research question was how do organizational members institutionalize their individual learning process to change in organizational cultures, routines and structures in a sustainable way? Findings The results showed that there had been learning at the individual level but this did not necessarily mean that participants had been able to transfer their learning into behaviour change. Research limitations/implications The research suggested that training alone may not be sufficient to promote effective organizational change regarding diversity. Additional measures are likely to be required, for example, including diversity targets in performance management plans and reviews. Practical implications In order to achieve greater diversity, organizations are likely to need to use a number of methods to supplement initial training. Social implications This research gives insight into how greater diversity may be achieved in organizations. Originality/value Previous literature understates the complexity of the change processes for enhanced diversity to be sustained in organizations. This study has originality in its focus on organizational learning.

The genetic epidemiology of parental discipline

2000 ◽  
Vol 30 (6) ◽  
pp. 1303-1313 ◽  
Author(s):  
TRACEY D. WADE ◽  
KENNETH S. KENDLER
Keyword(s):  
Environmental Factors ◽  
Structural Equation ◽  
Population Based ◽  
Shared Environment ◽  
Parental Genotype ◽  
Physical Discipline ◽  
Parental Discipline ◽  
Gene Environment ◽  
Two Factors ◽  
The Individual

Background. Previous studies of parental discipline have identified little influence of heritability on parental control, and some influence of gene–environment correlations, shared environment and child temperament.Method. Using interview data from 2003 female twins from a population-based twin registry and 1472 of their parents, we examined reports of parental discipline from four perspectives: (1) father and mother reporting separately on the type of discipline they provided for their offspring; (2) each twin reporting on the type of discipline they received from their parents; (3) each parent reporting on the discipline provided by their spouse; and, (4) each twin reporting on the discipline they provided for their own offspring. Using factor analysis and univariate structural equation modelling, we examined the structure of parental discipline, and the genetic and environmental influences thereon.Results. The seven discipline items yielded two factors, physical discipline and limit setting, which were moderately positively correlated. Parents perceived discipline as largely a common environmental experience for the twins, whereas the twins indicated that discipline was influenced by unique environmental factors and the genotype of the child. Twins as parents indicated no influence of shared environment on discipline, with the majority of influence accounted for by non- shared environment and parental genotype.Conclusions. Parents recall providing similar discipline to their children, whereas children emphasize the differences in parental discipline. Sources of individual variation in parental discipline vary according to which family member report is examined. In total, parental discipline is partially influenced by the genotype of both the parent and child, and by environmental factors shared by the twins and unique to the individual.

The impact of overeducated and undereducated workers on establishment-level productivity

2016 ◽  
Vol 37 (2) ◽  
pp. 372-392 ◽  
Author(s):  
Philipp Grunau
Keyword(s):  
Spillover Effects ◽  
Point Of View ◽  
Educational Mismatch ◽  
Content Type ◽  
Individual Level ◽  
Hr Management ◽  
The Individual ◽  
The Impact ◽  
Level Performance ◽  
Insight Into

Purpose – Many contributions to the educational mismatch literature address the productivity effects of both excess and deficit educational attainments for workers at the individual level. Due to the limited transferability of their results to establishment-level performance, especially when allowing for the possibility of spillover effects from mismatched workers to their well-matched colleagues, from an employer’s point of view, it is highly important to know the net effect of educationally mismatched employees on productivity at the establishment level. The paper aims to discuss these issues. Design/methodology/approach – This paper analyses the impact of overeducated and undereducated workers among an establishment’s workforce on its productivity, providing first representative evidence for Germany. Using linked employer-employee data from Germany, the author estimates dynamic panel production functions using a system GMM estimator. Findings – The author finds that undereducated workers among an establishment’s workforce impair its (establishment-level) productivity, implying that an establishment’s HR management should avoid the recruitment of undereducated workers, at least if they follow a short-term personnel policy. The effect for overeducated employees is also negative, albeit small and insignificant. Originality/value – The consideration of the phenomena of over and undereducation from the employer’s point of view provides further insight into the consequences of educational mismatch.

scholarly journals Beyond duty hours: leveraging large-scale paging data to monitor resident workload

2019 ◽  
Vol 2 (1) ◽  
Author(s):  
Amit Kaushal ◽  
Laurence Katznelson ◽  
Robert A. Harrington
Keyword(s):  
Data Streams ◽  
Data Stream ◽  
Large Scale ◽  
Digital Data ◽  
Internal Medicine Residency Program ◽  
Duty Hours ◽  
Individual Level ◽  
Hospital Operations ◽  
The Individual ◽  
Insight Into

Abstract Monitoring and managing resident workload is a cornerstone of policy in graduate medical education, and the duty hours metric is the backbone of current regulations. While the duty hours metric measures hours worked, it does not capture differences in intensity of work completed during those hours, which may independently contribute to fatigue and burnout. Few such metrics exist. Digital data streams generated during the usual course of hospital operations can serve as a novel source of insight into workload intensity by providing high-resolution, minute-by-minute data at the individual level; however, study and use of these data streams for workload monitoring has been limited to date. Paging data is one such data stream. In this work, we analyze over 500,000 pages—two full years of pages in an academic internal medicine residency program—to characterize paging patterns among housestaff. We demonstrate technical feasibility, validity, and utility of paging burden as a metric to provide insight into resident workload beyond duty hours alone, and illustrate a general framework for evaluation and incorporation of novel digital data streams into resident workload monitoring.

scholarly journals Role of Microbiome in Modulating Immune Responses in Cancer

2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Mukulika Bose ◽  
Pinku Mukherjee
Keyword(s):  
Environmental Factors ◽  
Immune Responses ◽  
Disease Susceptibility ◽  
Cancer Susceptibility ◽  
Cancer Development ◽  
Complex Interactions ◽  
Gene Environment ◽  
Mechanisms Of Carcinogenesis ◽  
Insight Into

The complex interactions between genes and the environment play important roles in disease susceptibility and progression. One of the chronic diseases that is affected by this gene-environment interplay is cancer. However, our knowledge about these environmental factors remains limited. The microorganisms that inhabit our bodies have recently been acknowledged to play a crucial role as an environmental factor, to which we are constantly exposed. Studies have revealed significant differences in the relative abundance of certain microbes in cancer cases compared with controls. It has been reported that changes in the composition of normal gut microbiota can increase/decrease cancer susceptibility and progression by diverse mechanisms including, but not limited to, inflammation—a well-known hallmark of carcinogenesis. The microbiota can also affect the response to various treatments including immunotherapy. The microbiome-immune-cancer axis will continue to provide insight into the basic mechanisms of carcinogenesis. In this review, we provide a brief understanding of the mechanisms by which microbiota affects cancer development, progression, and treatment.

Precision (Personalized) Nutrition: Understanding Metabolic Heterogeneity

2020 ◽  
Vol 11 (1) ◽  
pp. 71-92 ◽  
Author(s):  
Steven H. Zeisel
Keyword(s):  
Bioactive Molecules ◽  
Personalized Nutrition ◽  
Dietary Recommendations ◽  
Individual Level ◽  
Diet Intake ◽  
Commercial Applications ◽  
Metabolic Heterogeneity ◽  
The Many ◽  
The Individual ◽  
Many Sources

People differ in their requirements for and responses to nutrients and bioactive molecules in the diet. Many inputs contribute to metabolic heterogeneity (including variations in genetics, epigenetics, microbiome, lifestyle, diet intake, and environmental exposure). Precision nutrition is not about developing unique prescriptions for individual people but rather about stratifying people into different subgroups of the population on the basis of biomarkers of the above-listed sources of metabolic variation and then using this stratification to better estimate the different subgroups’ dietary requirements, thereby enabling better dietary recommendations and interventions. The hope is that we will be able to subcategorize people into ever-smaller groups that can be targeted in terms of recommendations, but we will never achieve this at the individual level, thus, the choice of precision nutrition rather than personalized nutrition to designate this new field. This review focuses mainly on genetically related sources of metabolic heterogeneity and identifies challenges that need to be overcome to achieve a full understanding of the complex interactions between the many sources of metabolic heterogeneity that make people differ from one another in their requirements for and responses to foods. It also discusses the commercial applications of precision nutrition.

scholarly journals John Deakin Heaton and the ‘elusive civic pride of the Victorian middle class’

Urban History ◽  
2017 ◽  
Vol 45 (4) ◽  
pp. 595-615 ◽  
Author(s):  
SIMON MORGAN
Keyword(s):  
Middle Class ◽  
Professional Identity ◽  
Urban Governance ◽  
Town Hall ◽  
Individual Level ◽  
Civic Pride ◽  
Self Interest ◽  
The Matrix ◽  
The Individual ◽  
Insight Into

ABSTRACT:Civic pride is rarely studied at the individual level. The journals of Dr John Deakin Heaton provide a unique insight into the motivations of a man linked to many institutions and civic sites of Leeds, celebrated by historians as a progenitor of its famous town hall and the city's first university. This article uses those journals to investigate the matrix of family honour, Anglicanism and professional identity, tempered by self-interest, underpinning Heaton's desire to improve his native town. Its conclusions further justify the recent historiographical emphasis on associational culture and ritual in the study of urban governance.

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