scholarly journals The Atopic March. A Literature Review

2014 ◽  
Vol 2 (3) ◽  
pp. 119-124 ◽  
Author(s):  
Juan F. Salazar-Espinosa.
Keyword(s):  
Risk Factors ◽  
Allergic Rhinitis ◽  
Food Allergies ◽  
Food Allergens ◽  
Atopic Diseases ◽  
Therapeutic Approaches ◽  
Th2 Response ◽  
Important Condition ◽  
Atopic March ◽  
Definition Of

The atopic march is defined as the progression of atopic diseases, generally during childhood, such as atopic dermatitis, asthma, allergic rhinitis and food allergies. The main risk factors for developing these atopic diseases include genetics, aeroallergens, food allergens, latefood introduction to the infant, and living in developing countries. The immunologic contributors to this problem include the Th2 response, epigenetics, and lack of certain factors like thymic stromal lymphopoietin (TSLP) and filaggrin. As a whole, the therapeutic approach has been changing during recent years because of the discovery of new factors involved in this problem. This article explains the definition of atopic march, the immunological pathway, clinical features, epidemiology and therapeutic approaches to create a context for the broader understanding of this important condition.

scholarly journals Frequency of self-reported allergies at a high-complexity referral hospital in Colombia, a tropical Latin American country

2021 ◽  
Vol 49 (5) ◽  
pp. 100-105
Author(s):  
Lucia C. Pérez-Herrera ◽  
Sergio Moreno-López ◽  
Daniel Peñaranda ◽  
Elizabeth Garcia ◽  
Edgardo Chapman ◽  
...  
Keyword(s):  
Risk Factors ◽  
Allergic Rhinitis ◽  
Latin American ◽  
Milk Protein ◽  
Allergic Diseases ◽  
Food Allergies ◽  
Food Allergens ◽  
Santa Fe ◽  
High Complexity ◽  
Study Population

Background: The frequency of allergic diseases in tropical Latin American populations is poorly understood, and certain particularities can impact their natural history and risk factors. Objective: The study aimed to determine the frequency of self-reported allergies (allergic dis-eases, drug, and food allergies) in patients who attended the Hospital Universitario Fundación Santa Fe de Bogotá, Colombia.Material and methods: A retrospective study was conducted to assess the frequency of self-reported allergies reported by all the patients who attended an allergy referral center between June and December 2019.Results: A total of 60978 patients were included. Allergic rhinitis was reported by 1.51% (n = 921), asthma by 1.28% (n = 782), and atopic dermatitis by 0.41% (n = 250) of the study population. A higher frequency of self-reported allergic diseases (rhinitis, asthma, and dermatitis) was found in the younger populations, while drug allergies were more frequently reported in adults. The most frequently self-reported drug allergies were penicillin allergy (4.07%, n = 2479), and non-steroidal anti-inflammatory drug (NSAID) allergy (1.85%, n = 1116). The most commonly reported food allergens included shellfish (0.58%), fruits (0.54%), cow’s milk protein (0.37%), and eggs (0.21%). Conclusion: The distribution of food allergens showed a higher frequency of shrimp and fruit allergies compared to previous studies on African, Asian, and Arabic tropical populations that describe a higher predominance of egg and milk allergies. Patients reporting allergic diseases should always be referred to the allergology department for confirmatory testing.

scholarly journals Clinical manifestations of atopy in children up to two years of age

2011 ◽  
Vol 68 (8) ◽  
pp. 690-695 ◽  
Author(s):  
Nevenka Ilic ◽  
Vesna Velickovic ◽  
Dragoljub Djokic ◽  
Nebojsa Rankovic ◽  
Gordana Kostic ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Clinical Manifestations ◽  
Allergic Diseases ◽  
Developed Countries ◽  
Specific Ige ◽  
Food Allergies ◽  
Atopic Diseases ◽  
Ige Antibodies ◽  
Total Ige

Background/Aim. Atopic diseases such as atopic dermatitis, allergic rhinitis and asthma have had increased prevalence during the past decade and nowadays occur in every third child in developed countries. The aim of the study was to determine frequency and type of atopic diseases at the age of two, as well as the importance the total IgE antibodies concentrations have in diagnosis and prognosis of the disease. Methods. The study involved 175 children up to two years of age. Allergy-like symptoms were found after surveying their parents and pediatric medical records. Using the fluorescence immunossay (FIA) method, total IgE antibodies concentrations and specific IgE antibodies (Phadiatop infant) were determined on an Immunocap 100 Dyagnostic System. Results. One or more allergy-like symptoms accounted for 57.7% of findings in children under the age of two, whilst in 19.4% the existence of IgE-related allergic diseases was found. Atopic diseases usually have clinical manifestations of atopic dermatitis (11.4%), IgE-bound wheezing/asthma (10.8%) and food allergies (7.4%), and to much lesser extent those of allergic rhinitis (3.4%) and urticaria (1.7%). The significantly higher total IgE antibodies concentrations were found in children with allergy-like symptoms (p < 0.0005) (cut-off 15.15 kU/L, sensitivity 76.5% specificity 71.6%). Conclusion. Almost 20% of two-year-old children have any of clinically manifested allergic diseases, with atopic dermatitis and IgE wheeze/asthma being predominant. The higher total IgE antibodies concentration is a good marker for sensitization in children with allergy-like symptoms.

scholarly journals Progress in the Analysis of Food Allergens through Molecular Biology Approaches

Cells ◽  
2019 ◽  
Vol 8 (9) ◽  
pp. 1073 ◽  
Author(s):  
Mariateresa Volpicella ◽  
Claudia Leoni ◽  
Maria C.G. Dileo ◽  
Luigi R. Ceci
Keyword(s):  
Geographical Area ◽  
Food Allergies ◽  
Structural Basis ◽  
Allergic Reactions ◽  
Food Protein ◽  
Food Allergens ◽  
Molecular Tools ◽  
Therapeutic Approaches ◽  
Age Range ◽  
Specific Food

Food allergies associated with class E immunoglobulins (IgE) are a serious health problem that affects between 1% and 10% of the population of developing countries, with a variability that depends on the geographical area and age range considered. These allergies are caused by a cross-link reaction between a specific food protein (the allergen) and the host IgE. Allergic reactions can range from mild itching to anaphylactic shock and there are no clues to predict the effects of an allergen. Strict avoidance of allergenic food is the only way to avoid possible serious allergic reactions. In the last 30 years a growing number of molecular studies have been conducted to obtain information on the diffusion of food allergens and to establish the structural basis of their allergenicity. At the same time, these studies have also allowed the development of molecular tools (mainly based on synthetic peptides and recombinant allergens) that can be of great help for diagnostic and therapeutic approaches of food allergies. Accordingly, this review focuses on advances in the study of food allergens made possible by molecular technologies and how results and technologies can be integrated for the development of a systematic food molecular allergology. The review may be of interest both to scientists approaching this field of investigation and to physicians who wish to have an update on the progress of research in diagnosis and therapy of food allergies.

scholarly journals Allergic rhinitis, asthma and atopic diseases: Bangladesh perspective

1970 ◽  
Vol 14 (2) ◽  
pp. 66-70 ◽  
Author(s):  
M Alamgir Chowdhury ◽  
ARM Lutful Kabir ◽  
Md Monjurul Alam
Keyword(s):  
Allergic Rhinitis ◽  
Treatment Modalities ◽  
Food Allergens ◽  
Atopic Diseases ◽  
Key Words Asthma ◽  
Research Activities ◽  
Different Types ◽  
Education And Awareness ◽  
Skin Prick Tests

Bangladesh is a developing country with 150 million population. About 20 to 25% of population is suffering from different types of allergic disorder. Few studies were carried out on asthma, allergic rhinitis and atopic conditions in Bangladesh. There are many indoor, outdoor, occupational and food allergens that trigger allergy. More over many pollutants, allergens are still unidentified in the poor and developing countries due to fund constrains for research activities. In addition to multiple known and unknown allergens, over population, un-hygienic living, poverty, lack of education and awareness, negligence to take treatment leads to increasing incidence of these diseases. Diagnostic facilities are yet depending on history and clinical examination for majority of our patients. Skin prick tests and IgE estimation are not available outside capital Dhaka as well as these are expensive too. Majority of our population can't afford them. Asthma and allergies are affecting the quality of life that has impact on national economy and development a lot. Treatment modalities and drugs available with the costs in our country are discussed. More evidence based studies and dissemination of ARIA, WHO and other guidelines to health professionals will be needed to improve the situation. Key words: Asthma, Allergic Rhinitis, Atopic DermatitisDOI: 10.3329/bjo.v14i2.3284 Bangladesh J of Otorhinolaryngology 2008; 14(2) : 66-70

scholarly journals Risk factors for atopic diseases and recurrent respiratory tract infections in children

2020 ◽  
Author(s):  
Hannah Maria Kansen ◽  
Melanie A. Lebbink ◽  
Joeri Mul ◽  
Francine C. van Erp ◽  
Martine van Engelen ◽  
...  
Keyword(s):  
Risk Factors ◽  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Respiratory Tract ◽  
Respiratory Tract Infections ◽  
Atopic Disease ◽  
Atopic Diseases ◽  
Tract Infections ◽  
Shared Risk ◽  
Recurrent Respiratory Tract Infections

Abstract Background The simultaneous increased prevalence of atopic diseases and decreased prevalence of infectious diseases might point to a link between the two entities. Past work mainly focused on either atopic diseases or recurrent infections. We aim to investigate whether risk factors for atopic diseases (i.e. asthma, allergic rhinitis, atopic dermatitis and/or food allergy) differ from risk factors for recurrent respiratory tract infections (RRTIs) in children. Methods Cross-sectional data were used from 5516 children aged 1-18 years who participated in an Electronic Portal for children between 2011 and 2019. Univariable/multivariable logistic regression analyses were performed to determine risk factors for any atopic disease and RRTIs. Results Children aged ≥5 years were more likely to have any atopic disease (adjusted Odds Ratio, OR, 1.49-2.80) and less likely to have RRTIs (OR 0.77-0.82) compared to children aged <5 years. Female sex (OR 0.72; 95% CI 0.64-0.82), low birth weight (OR 0.74; 95% CI 0.56-0.98) and dog ownership (OR 0.79; 95% CI 0.66-0.95) reduced the odds of any atopic disease, but not of RRTIs. Day care attendance (OR 1.31; 95% CI 1.09-1.58) was associated with RRTIs, but not with atopic diseases. A family history of asthma, allergic rhinitis, atopic dermatitis and RRTIs was significantly associated with the same entity in children, with OR varying from 1.58 (95% CI 1.36-1.84) in allergic rhinitis to 2.19 (95% CI 1.85-2.60) in asthma. Conclusions Risk factors for atopic diseases are distinct from risk factors for RRTIs, suggesting that the changing prevalence of both entities is not related to shared risk factors.

Popliteal entrapment syndrome and age

VASA ◽  
2012 ◽  
Vol 41 (4) ◽  
pp. 262-268 ◽  
Author(s):  
Schweizer ◽  
Hügli ◽  
Koella ◽  
Jeanneret
Keyword(s):  
Risk Factors ◽  
Leg Pain ◽  
Walking Distance ◽  
Therapeutic Approaches ◽  
Long Distance ◽  
Entrapment Syndrome ◽  
Long Distance Running ◽  
Popliteal Entrapment ◽  
Popliteal Entrapment Syndrome ◽  
Atherosclerotic Risk Factors

On the occasion of diagnosing a popliteal entrapment syndrome in a 59-year old man with no cardiovascular risk factors, who developed acute ischemic leg pain during long distance running, we give an overview on this entity with emphasis on patients’age. The different types of the popliteal artery compression syndrome are summarized. The diagnostic and therapeutic approaches are discussed. The most important clinical sign of a popliteal entrapment syndrome is the lack of atherosclerotic risk factors in patients with limited walking distance. Not only in young athletes but also in patients more than 50 years old the popliteal entrapment syndrome has to be taken into account.

Association of Vitamin D Levels and Other Risk Factors with Asthma Exacerbations in Children

2020 ◽  
Keyword(s):  
Risk Factors ◽  
Vitamin D ◽  
Serum Vitamin ◽  
Persistent Asthma ◽  
Food Allergies ◽  
P Value ◽  
Serum Vitamin D ◽  
Asthma Exacerbations ◽  
Vitamin D Levels ◽  
Animal Dander

Background: The risk factors for asthma exacerbations are well understood. However, the effect of vitamin D levels on number of asthma exacerbations per year is not clearly studied. The objective of the study was to find out the association of serum vitamin D levels and asthma risk factors on asthma exacerbations. Methods: In this study, ninety-nine subjects from 5 to 15 years of age were recruited at an episode of acute exacerbation. It was a cross sectional study and carried out from 2012 to 2015. Pulmonary function test was done by spirometry. Asthma exacerbation was labeled when forced expiratory volume/ forced vital capacity (FEV1/FVC) ratio was less than 80% (American Thoracic Society). Global Initiative for Asthma (GINA) guidelines were used to classify asthma into mild, moderate and severe persistent asthma. Serum vitamin D levels were measured by chemiluminescence method. Pearson Chi-square test was applied and p value (p<0.05) was considered as statistically significant. Results: Children who had exposure to animal dander had significantly lower asthma exacerbations per year (p-value <0.046). There was no significant association between vitamin D levels and number of exacerbations per years (p-value <0.099). Asthma was prevalent in girls of low socioeconomic status (SES) compared to males. However, there was no significant association between smoke, exercise, home environment, food allergies, weather, pollen and dust with asthma exacerbations. Conclusion: Low levels of vitamin D were not associated with increased number of asthma exacerbations per year. However, children exposed to animal dander had lesser number of exacerbations per year (p-value <0.046). Keywords: Asthma; Vitamin D; Children; Exacerbations, Risk factors.

scholarly journals Effects of Age on Recovery of Olfactory Function After Endoscopic Sinus Surgery and Related Risk Factors

2021 ◽  
pp. 014556132110129
Author(s):  
Weiping Qi ◽  
Liang Feng ◽  
Fengyan Yang ◽  
Weihuan Ma
Keyword(s):  
Risk Factors ◽  
Allergic Rhinitis ◽  
Endoscopic Sinus Surgery ◽  
Nasal Polyps ◽  
Protective Factor ◽  
Olfactory Function ◽  
Sinus Surgery ◽  
The Poor ◽  
Related Risk ◽  
Good Improvement

Objectives: To study the effects of age on the olfactory function recovery of chronic rhinosinusitis patients after endoscopic sinus surgery and related risk factors. Methods: A total of 176 chronic rhinosinusitis (CRS) patients enrolled from February 2017 to October 2019 were divided into child, youth, middle-aged, and elderly groups. Their baseline data, T&T olfactory test score, visual analogue scale (VAS) olfactory score, sinus computed tomography (CT) Lund-Mackay score, and Lund-Kennedy score were compared. Based on postoperative olfactory function, they were divided into good and poor improvement groups. Results: Complication with nasal polyps, allergic rhinitis history, and sinus surgery history had significant differences among patients of different ages ( P < .05). Three months after surgery, T&T olfactory, VAS olfactory, Lund-Mackay, and Lund-Kennedy scores all rose with increasing age, with significant differences between any 2 groups ( P < .05). The improvement of postoperative olfactory function became poorer with aging ( P < .05). T&T and VAS olfactory scores had significant positive correlations with Lund-Mackay and Lund-Kennedy scores ( P < .001). Age, preoperative Lund-Mackay and Lund-Kennedy scores, complication with nasal polyps, allergic rhinitis history, sinus surgery history, and postoperative complications were risk factors for the poor improvement of postoperative olfactory function. Doctor-directed treatment was a protective factor for good improvement. Conclusions: The improvement of olfactory function of CRS patients after endoscopic sinus surgery declines with aging. Age, preoperative Lund-Mackay and Lund-Kennedy scores, complication with nasal polyps, allergic rhinitis history, sinus surgery history, and postoperative complications are risk factors for the poor improvement of postoperative olfactory function. Doctor-directed treatment is a protective factor for good improvement.

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