2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Danilo Sales Bocalini ◽  
Rafael da Silva Luiz ◽  
Kleiton Augusto Santos Silva ◽  
Andrey Jorge Serra ◽  
Renata Andrade Avila ◽  
...  

Despite the strong evidence on the cardiac and renal damages after chronic exposure to cigarette smoke, there is a paucity of data on its short-term effects. The study evaluated the short-term effects of cigarette smoking on left ventricular (LV) remodeling, in vitro myocardial and renal function. Female Wistar rats were randomized to control (C) and cigarette smoking rats for eight weeks. Physical capacity was assessed using an adapted model of exhaustive swim; left ventricle (LV) morphology and function were also evaluated. Renal function was assessed by creatinine clearance and urine protein. The in vitro myocardial performance was analyzed in isolated papillary muscles. Rats exhibited reduced physical capacity after short-term cigarette smoking. Although there was no change on LV function, reduced chamber diameter was found in the smoking group associated with an increased LV wall thickness. There was augmented cardiac mass compared to C that was confirmed by increased cardiomyocyte nucleus volume, but in vitro myocardial performance and renal function were unchanged. A short-term cigarette smoking induces cardiac remodeling without abnormalities in function. The smoking group still preserved renal function and in vitro myocardial performance. However, the reduced physical capacity may suggest an impairment of the cardiac reserve.


1996 ◽  
Vol 48 (6) ◽  
pp. 484-486 ◽  
Author(s):  
A. Clouter ◽  
C.E. Houghton ◽  
C.A. Bowskill ◽  
J.A. Hoskins ◽  
R.C. Brown

Author(s):  
I. Maskell ◽  
M. Ellis ◽  
R. Smithard

Full fat rapeseed is not usually used in livestock feeds because the extracted oil is too valuable. However in some circumstances it may be worthwhile using full fat rapeseed as a protein and energy supplement. Intact seeds are only poorly digested so it is necessary to physically disrupt the seed to allow efficient digestion. Milling the seeds may allow myrosinase catalysed hydrolysis of glucosinolates yielding products which adversely affect palatability and nutritive value. Dry extrusion offers a means of simultaneously crushing the seed and denaturing the myrosinase by high temperature (130°C). Previous short term studies with rats and pigs have indicated that extrusion may improve the nutritive value of diets containing 12.5% high glucosinolate rapeseed (HG-RS).The present work involved a production trial to study the longer term effects of diets containing 12.5% rapeseed and a metabolism study to investigate the digestion and short term effects of pig diets containing 25% rapeseed.


Author(s):  
Felix Fischer ◽  
Andreas Andris ◽  
Wolfgang Lippmann ◽  
Antonio Hurtado

The continuous generation of graphite dust particles in the core of a high-temperature reactor (HTR) is one of the key challenges of safety during its operation. The graphite dust particles emerge from relative movements between the fuel elements or from contact to the graphitic reflector structure and could be contaminated by diffused fission products from the fuel elements. They are distributed from the reactor core to the entire reactor coolant system. In case of a depressurization accident, a release of the contaminated dust into the confinement is possible. In addition, the contaminated graphite dust can decrease the life cycle of the coolant system due to chemical interactions. On one hand, the knowledge of the behavior of graphite dust particles under HTR conditions using helium as the flow medium is a key factor to develop an effective filter system for the discussed issue. On the other hand, it also provides a possibility to access the activity distribution in the reactor. The behavior can be subdivided into short-term effects like transport, deposition, remobilization and long-term effects like reactions with material surfaces. The Technische Universität Dresden has installed a new high-temperature test facility to study the short-term effects of deposition of graphite dust particles. The flow channel has a length of 5 m and a tube diameter of 0.05 m. With helium as the flow medium, the temperature can be up to 950 °C in the channel center and 120 °C on the sample surface, the Reynolds number can be varied from 150 up to 1000. The particles get dispersed into the accelerated and heated flow medium in the flow channel. Next, the aerosol is passing a 3 m long adiabatic section to ensure homogenous flow conditions. After passing the flow straightener, it enters the optically accessible measurement path made from quartz glass. In particular, this test facility offers the possibility to analyze the influence of the thermophoretic effect separately. For this, an optionally cooled sample can be placed in the measuring area. The thickness of the particle layer on the sample is estimated with a three-dimensional laser scanning microscope. The particle concentration above the sample is measured with an aerosol particle sizer (APS). Particle image velocimetry (PIV) detects the flow-velocity field and provides data to estimate the shear velocity. In combination with the measured temperature-field, all necessary information for the calculation of the particle deposition and particle relaxation times are available. The measurements are compared to results of theoretical works from the literature. The experimental database is relevant especially for computational fluid dynamics (CFD)-developers, for model development, and model verification. A wide range of phenomena like particle separation, local agglomeration of particles with a specific particle mass, and selective remobilization can be explained in this way. Thus, this work contributes to a realistic analysis of nuclear safety.


1995 ◽  
Vol 12 (3) ◽  
pp. 403-412 ◽  
Author(s):  
Josef Ammermüller ◽  
Reto Weiler ◽  
Ido Perlman

AbstractThe effects of dopamine on luminosity-type horizontal cells have been documented in different vertebrate retinas, both in vivo and in vitro. Some of these effects may reflect direct action of dopamine onto these cells, but indirect effects mediated by presynaptic neurons cannot be ruled out. Furthermore, direct effects of dopamine on horizontal cells may affect other, postsynaptic neurons in the outer plexiform layer. To test these possibilities, we studied the effects of dopamine on photoreceptors and all types of horizontal cells in the turtle (Pseudemys scripta elegans) retina. Receptive-field properties, responsiveness to light, and time course of light responses were monitored with intracellular recordings. Dopamine at a concentration of 40 μM exerted effects with two different time courses. “Short-term” effects were fully developed after 3 min of dopamine application and reversed within 30 min of washout of the drug. “Long-term” effects were fully developed after about 7–10 min and could not be washed out during the course of our experiments. Only the “short-term” effects were studied in detail in this paper. These were expressed in a reduction of the receptive-field size of all types of horizontal cells studied; L1 and L2 luminosity types as well as Red/Green and Yellow/Blue chromaticity types. The L1 horizontal cells did not exhibit signs of reduced responsiveness to light under dopamine, while in the L2 cells and the two types of chromaticity cells responsiveness decreased. None of the rods, long-wavelength-sensitive, or medium-wavelength-sensitive cones exhibited any apparent reduction in their receptive-field sizes or responsiveness to light. The present results suggest that the “short-term” effects of dopamine are not mediated by photoreceptors and are probably due to direct action of dopamine on horizontal cells.


2014 ◽  
Vol 446 (3) ◽  
pp. 720-725 ◽  
Author(s):  
Débora Levy ◽  
Jorge Luis Maria Ruiz ◽  
Andrea Turbuck Celestino ◽  
Suelen Feitoza Silva ◽  
Adilson Kleber Ferreira ◽  
...  

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