scholarly journals Correlation between TyG (Fasting Triglyceride-glucose) Index, TyG BMI Index & Liver Transaminases in Women with Polycystic Ovary Disease Syndrome

2021 ◽  
Vol 8 (5) ◽  
pp. 193-201
Author(s):  
Gayatri Chandrashekhar Gawade ◽  
Geeta Shripad Wadadekar ◽  
Meghana Khandu Padwal
Keyword(s):  
Polycystic Ovary ◽  
Study Groups ◽  
Nonalcoholic Fatty Liver ◽  
Tyg Index ◽  
Triglyceride Glucose Index ◽  
First Choice ◽  
Liver Transaminases ◽  
The Common ◽  
A Prospective Study ◽  
Surrogate Index

Background: Polycystic Ovary Disease Syndrome (PCOS) and NAFLD are interlinked with the common culprit i.e. Insulin resistance (IR). The triglyceride and glucose index (TyG) has been recommended as a reliable and simple surrogate index for IR. So we evaluated TyG index, TyG–BMI index as a marker of IR and its correlation with liver transaminases (ALT, AST) to detect NAFLD in women with PCOS. Aim and Objectives: Correlation of TyG index and TyG-BMI index and liver transaminases (ALT, AST) in study groups. Materials and methods: A prospective study was done on 25 participants (14 controls and 11cases of PCOS according to Rotterdam’s criteria). The TG, FBG, ALT and AST were analyzed on autoanlyzers. TyG -BMI index was calculated by the formula and correlation was done. Result: The ROC Curve showed the optimal cut off value for TyG index as 4.55 and TyG –BMI index in PCOS as 104.76. The positive linear regression was 2.55 for TyG index indicating that test was associated with IR. TyG index has shown the better performance as compared to TyG BMI index. No significant correlation was found between TyG index, TyG BMI index and transaminases. Conclusion: TG and FBG are inexpensive and routinely performed investigations. TyG index which can be easily calculated makes it the first choice screening alternative to detect risk of IR in PCOS women. Keywords: PCOS, TyG -BMI index, Nonalcoholic fatty liver disease, liver transaminases

scholarly journals The triglyceride-glucose index (TyG) and Nonalcoholic fatty liver in the Japanese population: a retrospective cross-sectional study

2020 ◽  
Author(s):  
Enqian Liu ◽  
Yaping Weng ◽  
Aiming Zhou ◽  
Chunlai Zeng
Keyword(s):  
Logistic Regression ◽  
Japanese Population ◽  
Inflection Point ◽  
Binary Logistic Regression ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Nonalcoholic Fatty Liver ◽  
Tyg Index ◽  
Triglyceride Glucose Index

Abstract Background: Evidences regarding the association between triglyceride-glucose index (TyG) and Nonalcoholic fatty liver (NAFLD) are controversial. Therefore, the goals of this research are to evaluate whether TyG is independently associated with NAFLD and the ability of TyG index to detect NAFLD in the Japanese population. Methods: The present study was a cross-sectional study. The data was downloaded from the DATADRYAD website. A total of 13178 participants was involved in a hospital in Japan from 2004 to 2015. The correlation between TyG and NAFLD was detected by using binary logistic regression and Generalized additive models. The likelihood ration test was used to examine the modification and interaction of subgroups. Furthermore, the ability of TyG to predict NAFLD was evaluated by using receiver operating characteristic (ROC) curves. The formula for the TyG index was ln [fasting triglyceride level (mg / dl) × fasting blood glucose level (mg / dl) / 2] Results: The average age of the selected participants was 43.36±8.89 years old, and about 51.02% of them were male. In fully-adjusted binary logistic regression model, TyG was positively related with the risk of NAFLD (Odds ratio (OR)=2.45, 95%CI 2.12-2.82). The relationship between TyG and NAFLD was a non-linear relationship, and its inflection point was 8.22. The effect sizes and the confidence intervals of the left and right sides of inflection point were 3.26(2.44 - 4.35) and 2.09 (1.72 - 2.54), respectively. By subgroup analysis, the stronger association was found in females, low GGT, non-obesity, non-visceral fat obesity (P for interaction <0.05). Among the total population, the AUC for TyG [0.810 (0.804 - 0.817)] was worse than ALT [ 0.829 (0.822 - 0.835)] but better than TG [ 0.799 (0.792 - 0.805)] and FPG [ 0.715 (0.707 - 0.722)]. A similar result was found for men. In the women, the AUC for the TyG was superior to ALT, FPG, and TG. Conclusion: The association between TyG and NAFLD is non-linear. TyG is stronger positively correlated to the risk of NAFLD when TyG is less than 8.22. TyG is helpful to identify individuals with NAFLD.

EFFECT OF AROMATASE INIBITOR IN OVULATION INDUCTION IN FETILE WOMEN WITH POLYCYSTIC OVARY SYNDROME

2014 ◽  
pp. 86-93
Author(s):  
Minh Tam Le
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Ovulation Induction ◽  
Polycystic Ovary ◽  
Endometrial Thickness ◽  
Statistical Significance ◽  
Ovulation Rate ◽  
Normal Body Mass Index ◽  
Ovary Syndrome ◽  
Group I ◽  
First Choice

Backgrounds: Polycystic Ovary Syndrome (PCOS) is one of the most common causes of female infertility due to ovulation disorders. Clomiphene citrate (CC) is a first choice to restore ovulation but it has some side effects by estrogen receptor down-regulation. Aromatase inhibitor (AI) is a newer class of drugs which increases the production of endogenous FSH to stimulate ovulation. Subjects and methods: randomized control trial to compare 64 cases of infertile women with PCOS examined at the Hue University Hospital, alternately used AI (group I) or CC (group II) for ovulation induction from day 2 cycle. Follow-up follicle growth, endometrium and ovulation via ultrasound. Evaluation were done on 10th day cycle, day of hCG trigger and after administration of hCG. Results: Total of 64 PCOS cases distributed into 2 groups using alternatively AI and CC had similar characteristics with average age of 28.8 ± 4.6, the majority were primary infertility (84.4%), infertility duration was 2.6 ± 2.4 years, 85.9% had oligomenorrhrea or amenorrhea, normal body mass index accounts for 60.9% and 21.9% was lean. Evaluation of both groups on day 10 revealed no differences in the dominant follicle and endometrial thickness. Number of days until the follicle mature appears to be shorter in AI group (15.1 ± 2.9) compared to the CC group (16.5 ± 2.8) with statistical significance. The number of mature follicles in 2 groups were not different at a rate of 81.3% (AI) and 84.4% (CC) but a higher proportion of single mature follicle in the AI ​​group (71.9%) compared with the CC group (65.7%) and There is no case with 3-4 mature follicles in the AI group. The rate of thin endometrium (<8 mm) in the AI group (25%) was lower than the CC group (53.1%) with statistically significance and higher ovulation rate (68.8%) compared with the CC group (56.3%) but have not found statistically significant. Conclusion: Two drugs AI and CC potentially induce follicle development and ovulation similarly, but AI has the potential to be more effective than CC on factors such as the shorter stimulation duration, increasing rate of single follicle, limiting multiple pregnancies, improve endometrial thickness and higher ovulation rate. More researches are needed with a larger sample size to clarify the statistical significance of differences.

Relationship of triglyceride–glucose index with chronic limb-threatening ischemia in lower extremity peripheral artery disease

Vascular ◽  
2021 ◽  
pp. 170853812110183
Author(s):  
Arda Aybars Pala ◽  
Yusuf Salim Urcun
Keyword(s):  
Lower Extremity ◽  
High Density Lipoprotein ◽  
Peripheral Artery Disease ◽  
Density Lipoprotein ◽  
Peripheral Artery ◽  
Tyg Index ◽  
Triglyceride Glucose Index ◽  
Group 2 ◽  
Artery Disease ◽  
Group 1

Objectives Triglyceride-glucose index (TyG index), which is defined as the simple and novel marker of insulin resistance, is becoming increasingly important as a promising predictive marker for atherosclerotic diseases. Chronic limb-threatening ischemia is defined as the most advanced stage of the lower extremity peripheral artery disease, whose main cause is atherosclerosis and is associated in this respect with amputation, impaired quality of life, and mortality. The main purpose of the present study was to investigate the relation between the calculated TyG index values and chronic limb-threatening ischemia development. Methods A total of 296 patients who were diagnosed with lower extremity peripheral artery disease in our outpatient clinic between October 2018 and October 2020 were included in this study retrospectively. Two groups were formed by clinically staging the patients according to Rutherford Classification. Patients who did not develop chronic limb-threatening ischemia were classified as “Group 1” ( n = 224) and those who developed were classified as “Group 2” ( n = 72). Results The mean TyG index values that were calculated in Group 2 were significantly higher than in Group 1 (9.27 ± 0.31 vs. 9.00 ± 0.34, p < 0.001). In the multivariate logistic regression analysis conducted to determine the predictors of chronic limb-threatening ischemia development, C-reactive protein (OR [Odds Ratio]: 1.220, 95% CI [confidence interval]: 1.092–1.363, p < 0.001), high-density lipoprotein cholesterol (OR: 0.775, 95% CI: 0.715–0.839, p < 0.001) and TyG index (OR: 5.796, 95% CI: 2.050–16.382, p = 0.001) were identified as independent predictors. Receiver operating characteristic analysis revealed that the cut-off value of TyG index was 9.13 (area under the curve: 0.721, p < 0.001) with 70.8% sensitivity and 65.2% specificity. The TyG index was significantly correlated with Rutherford category, high-density lipoprotein cholesterol and mean platelet volume. Conclusions Chronic limb-threatening ischemia development may be predicted with the TyG index value, which is calculated easily from routine biochemical parameters, in patients diagnosed with lower extremity peripheral artery disease.

scholarly journals Diet-Induced Alteration of Microbiota and Development of Obesity, Nonalcoholic Fatty Liver Disease, and Diabetes: Study Protocol of a Prospective Study

10.2196/11553 ◽  
2019 ◽  
Vol 8 (6) ◽  
pp. e11553
Author(s):  
Martine Uittenbogaart ◽  
Wouter KG Leclercq ◽  
Danielle Bonouvrie ◽  
Marleen M Romeijn ◽  
Arijan APM Luijten ◽  
...  
Keyword(s):  
Liver Disease ◽  
Prospective Study ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Study Protocol ◽  
Fatty Liver Disease ◽  
Nonalcoholic Fatty Liver ◽  
A Prospective Study

scholarly journals Link between autoimmune hypothyroidism and polycystic ovary syndrome.

2020 ◽  
Vol 27 (09) ◽  
pp. 1804-1808
Author(s):  
Anam Rehman ◽  
Shireen Jawed ◽  
Amna Rashid Tariq
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Thyroid Function ◽  
Polycystic Ovary ◽  
Thyroid Autoimmunity ◽  
Study Groups ◽  
Thyroid Peroxidase ◽  
Ovary Syndrome ◽  
Cross Sectional ◽  
Autoimmune Hypothyroidism ◽  
Thyroid Peroxidase Antibody

Objectives: Polycystic ovary syndrome (PCOS) is a rampant endocrine disorder distressing women of child bearing age worldwide. Many current researches have detected the presence of some organ specific and non-specific autoantibodies in females with PCOS. Study Design: Cross Sectional study. Setting:  Aziz Fatimah Hospital, Faisalabad, Pakistan. Period: April to September 2017. Material & Methods: This study comprised of 88 female subjects of 17-35 years old. Participants were divided into four group’s i.e PCOS obese females, PCOS non-obese, obese females without PCOS and age matched controls. Thyroid function was evaluated by the measurement of serum TSH, FT3 and FT4 levels. Thyroid peroxidase antibody was detected as an indicator of thyroid autoimmunity. All parameters were measured by chemiluminescence immunoassay technique (CLIA). SPSS version 22 was used for the statistical analysis of the data. Results: Out of total 88 female participants, 38.6% were hypothyroid and 61.4% were euthyroid females. While on comparing the percentages of hypothyroidism among the study groups PCOS, non-PCOS patients and obese we found higher percentages of hypothyroidism among non-obese PCOS. Thyroid peroxidase antibody levels were higher in PCOS obese subjects. PCOS patients have 15 times more risk for hypothyroidism as compared to non-PCOS patients. Conclusion: Hypothyroidism was commonly found in PCOS patients with high levels of TPO-Antibody indicating that PCOS is an independent risk factor for hypothyroidism which suggests that evaluation of thyroid function and autoimmunity must be deliberated in PCOS patients.

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