scholarly journals Correlation of Reticulocyte Hemoglobin Equivalent (Ret-He) Levels and Iron Deficiency Anemia in CKD Patients Treating Regular Hemodialysis

2021 ◽  
Vol 8 (11) ◽  
pp. 10-16
Author(s):  
Husni Gunawan Hasibuan ◽  
Syafrizal Nasution ◽  
Radar Radius Tarigan
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Pearson Correlation ◽  
Clinical Pathology ◽  
Secondary Data ◽  
Deficiency Anemia ◽  
Sample Collection ◽  
Pathology Laboratory ◽  
Cross Sectional ◽  
Regular Hemodialysis

Background: Anemia appears in the early stages of CKD and its prevalence increases as kidney function declines. Ret-HE can be used to diagnose iron-deficiency anemia. Indonesia does not yet have appropriate research data on RET-He levels in CKD patients undergoing hemodialysis as a parameter to assess iron. Therefore, this study aims to examine the ability of RET-He as an alternative parameter to assess iron deficiency in hemodialysis patients. Method: This research is a correlation analytic study with a cross-sectional design, carried out in February-May 2021 at the Hemodialysis Installation of H. Adam Malik Hospital. Blood sample collection and examination are carried out at the Clinical Pathology Laboratory. Primary and secondary data were collected from interviews, questionnaires, or patient medical records. The data will be analyzed by Pearson correlation test using SPSS software. Results: A total of 41 samples consisted of 31 anemic patients and 10 anemic patients with normal RET-He levels. Demographic characteristics based on age group with an average of 47±13.28 years. The correlation of Ret-HE and TSAT levels in CKD patients undergoing hemodialysis shows a significance value of 0.000, so it can be concluded that there is a correlation between RET-HE and TSAT levels with a significance value of <0.05. According to the Pearson correlation number of 0.618 which is in the range of 0.61 to 0.80. Conclusion: There is a positive correlation between Ret-HE levels and iron deficiency anemia in CKD patients undergoing regular hemodialysis. Keywords: CKD, RET-HE, Hemodialysis.

scholarly journals INADEQUACIES IN THE TREATMENT OF IRON DEFICIENCY ANEMIA AMONG CHILDREN REGISTERED IN THE NATIONAL PROGRAM OF IRON SUPPLEMENTATION IN FLORIANOPOLIS, SANTA CATARINA, BRAZIL

2017 ◽  
Vol 26 (2) ◽  
Author(s):  
Francieli Cembranel ◽  
Arlete Catarina Tittoni Corso ◽  
David Alejandro González-Chica
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Ferrous Sulfate ◽  
Iron Supplementation ◽  
Secondary Data ◽  
Cross Sectional Study ◽  
Deficiency Anemia ◽  
National Program ◽  
Santa Catarina ◽  
Cross Sectional

ABSTRACT Objective: to identify inadequacies in the treatment of iron deficiency anemia among children enrolled in the National Program of Iron Supplementation (PNSF) and treated at public primary health centers in Florianópolis, Santa Catarina, Brazil. Method: a cross-sectional study was performed using secondary data obtained from the InfoSaúde system. Information was obtained on the ferrous sulfate dose prescribed for treating iron deficiency anemia, as well as demographic and anthropometric data of all children enrolled in the program in 2010. STATA 11.0 software was used in the analysis and p-values ≤ 0.05 were considered significant. Results: sixty-eight (68) of the 834 children enrolled in the program in 2010 were diagnosed as anemic; 58 of whom received an indication to use ferrous sulfate. Conclusion: children under six months of age (65.1%), living in economically deprived areas (66.7%) and with a height/age Z-score ≥ -1.0 (52.1%) were more prone to receive inadequate supplement dosage (<3 mg/kg/day). The results are relevant to educate health professionals about their role in effectively treating iron deficiency anemia.

scholarly journals TEA CONSUMPTION AND IRON-DEFICIENCY ANEMIA AMONG PREGNANT WOMAN IN BOGOR DISTRICT, INDONESIA

2019 ◽  
Vol 10 (2) ◽  
pp. 91-100
Author(s):  
Putri Bungsu Machmud ◽  
Ratna Djuwita Hatma ◽  
Ahmad Syafiq
Keyword(s):  
Iron Deficiency ◽  
Pregnant Women ◽  
Iron Deficiency Anemia ◽  
Serum Ferritin ◽  
Iron Status ◽  
Demographic Data ◽  
Secondary Data ◽  
Deficiency Anemia ◽  
Tea Consumption ◽  
Cross Sectional

Background. Anemia in pregnancy is an essential problem due to affect to not only the mother’s life but also to baby’s life. An iron deficiency causes about 75 percent of anemia during pregnancy. Objective. This study aimed to identify risk factors for iron deficiency among pregnant women and determine the possible link between iron status and tannin levels associated with tea consumption. Method. The population-based cross-sectional studies were conducted from secondary data of previous thesis-research in 2013, “Pengaruh Kadar Tanin pada Teh Celup terhadap Anemia Gizi Besi (AGB) pada Ibu Hamil di UPT Puskesmas Citeureup Kabupaten Bogor Tahun 2012”. The study population consisted of 94 randomly selected pregnant women. The inclusion criteria were pregnant women who participated in the previous study and have a complete antenatal care record. Demographic data were collected, including data on age, working status, gestational stage, time since last pregnancy, and parity. The information included nutritional variables, such as iron supplements, nutritional status, and iron intake. Also, data for tannin level grouped as low, medium, and high based on the frequency of daily tea consumption and tea-making habits. The linear model analysis was used to determine the influence of tea consumption on serum ferritin levels. Results. The results showed that time since last pregnancy (<2 years), parity (more than two children), reduced consumption of foods containing heme, and levels of tannin consumption (low, medium, or high) were predictors of iron-deficiency anemia. The results also suggested that tannin levels were inversely proportional to serum ferritin levels. Conclusion. Pregnant women who consumed tea with a low tannin level had the highest serum ferritin levels, whereas those who drank tea with medium and high tannin levels had the lowest serum ferritin levels.

Perbedaan Kadar Brain Derived Neurotropic Factor Neonatus Dari Ibu Hamil Normal Dan Anemia Defisiensi Besi

2018 ◽  
Vol 3 (3) ◽  
pp. 568
Author(s):  
Ainal Mardiah ◽  
Arni Amir ◽  
Andi Friadi ◽  
Ellyza Nasrul
Keyword(s):  
Iron Deficiency ◽  
Pregnant Women ◽  
Community Health ◽  
Health Center ◽  
Iron Deficiency Anemia ◽  
Community Health Center ◽  
Deficiency Anemia ◽  
Cross Sectional ◽  
Consecutive Sampling ◽  
Neurotropic Factor

<p><em>Iron deficiency anemia is anemia caused by iron deficiency in the blood. Maternal iron deficiency affects the low iron reserves in neonates </em><em>and it also influences on </em><em>Brain Derived Neurotropic Factor (BDNF) </em><em> which affects cognitive function.</em><em> </em><em>The purpose of this study was to determine the difference mean of BDNF in neonates from normal pregnant women and pregnant women with iron deficiency. </em><em>The design of this research was Cross Sectional</em><em> </em><em>design. This research was conducted in Community Health Center of Lubuk  Buaya, Ambacang Community Health Center, Community Health Center of Ikur Koto Health Center and Biomedical Laboratory of Andalas University on February 2017 to April 2018. There were 42 pregnant women was selected as sample e of this research. The samples were chosen by Consecutive Sampling. Then, the sample is divided into two groups: normal pregnant women and pregnant women with iron deficiency anemia. BDNF are examined by the ELISA. Next, the data were analyzed by using T test. The levels of BDNF neonates in normal pregnant group was 3.65(ng/ml) and the anemia pregnant group was 1.74(ng/ml) (p &lt;0.05). There was significant difference of BDNF levels in neonates from normal pregnant women and pregnant women with iron deficiency anemia. </em><em>The conclusion of this study is there is a difference of average BDNF in neonates from normal pregnant women and pregnant women with iron deficiency.</em></p><p> </p><p>Anemia defisiensi besi adalah anemia yang disebabkan karena kekurangan zat besi dalam darah. Defisiensi besi  maternal berdampak pada rendahnya cadangan besi pada neonatus dan berdampak terhadap ekspresi Brain Derived Neurotropic Factor (BDNF) yang berpengaruh pada fungsi kognitif. Tujuan penelitian ini adalah untuk mengetahui perbedaan rerata kadar BDNF pada neonatus dari ibu hamil normal dan ibu hamil defisiensi besi. Desain penelitian ini adalah Cross Sectional. Penelitian dilakukan di Puskesmas Lubuk Buaya, Puskesmas Ambacang, Puskesmas Ikur Koto dan Laboratorium Biomedik Universitas Andalas pada bulan Februari 2017 – Juli 2018. Sampel Penelitian adalah ibu hamil sebanyak 42 orang yang dipilih secara Consecutive Sampling, sampel dibagi menjadi dua kelompok yaitu ibu hamil normal dan ibu hamil anemia defisiensi besi. BDNF diperiksa dengan metode ELISA. Data dianalisa menggunakan uji T test. Kadar BDNF neonatus pada ibu kelompok normal adalah 3,65(ng/ml) dan kelompok ibu anemia adalah 1,74(ng/ml) (p&lt;0,05). Terdapat perbedaan bermakna kadar BDNF pada neonatus dari ibu hamil normal dan ibu anemia defisiensi besi. <em></em></p>

MO557EFFICIENCY OF FERRIC CARBOXYMALTOSE IN NON-DIALYSIS CKD PATIENTS AND ITS IMPACT ON KIDNEY FUNCTION: A PROSPECTIVE OBSERVATIONAL STUDY

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Marisa Roldão ◽  
Rachele Escoli ◽  
Hernâni Gonçalves ◽  
Karina Lopes
Keyword(s):  
Iron Deficiency ◽  
Observational Study ◽  
Kidney Function ◽  
Iron Deficiency Anemia ◽  
Serum Ferritin ◽  
Prospective Observational Study ◽  
Pearson Correlation ◽  
Deficiency Anemia ◽  
Ferric Carboxymaltose ◽  
Ckd Stage

Abstract Background and Aims Iron deficiency anemia occurs in the vast majority of patients with chronic kidney disease (CKD). The aim of this study was to investigate the efficacy of ferric carboxymaltose (FCM) iron deficiency anemia’s treatment in non-dialysis CKD patients and to clarify its impact on kidney function. Method Prospective observational study of non-dialysis CKD stage 3 to 5 patients, with anemia and iron deficiency treated with FCM from 01 January 2019 to 31 June 2020. FCM was administrated as a single IV infusion of 500mg or 1000mg. Baseline clinical, analytical and demographic data were recorded. FCM efficacy was evaluated by comparing hemoglobin (Hb), serum ferritin and transferrin saturation index (TSAT) 24 ± 8 weeks after the infusion with analytical values at baseline. Renal function was also assessed at baseline and at 24 ± 8 weeks using estimated glomerular filtration rate (eGFR), calculated by CKD-EPI formula. Statistical analysis was executed using SPSS (Version 23 for Mac OSX). Results The average age of 71 patients was 77.31 ± 9.68 years, 29 (40.8%) were male, 46 (64.8%) were diabetic and 41 (57.8%) had congestive heart failure. Sixteen (22.5%) patients had CKD stage 3, 41 (57.7%) stage 4 and 14 (19.7%) stage 5. Twenty-five (35.2%) patients were treated with 1000mg of FCM. At baseline, average hemoglobin level (Hb) was 10.16 ± 1.12g/dL, serum ferritin 83.25 ± 96.55µg/L, TSAT 14.48 ± 6.72mg/dL and eGFR 24.21± 13.09ml/min/1.73m2. At 24 ± 8 weeks, Hb showed an increase of 1.31 ± 1.49 g/dL (p=0.001) and TSAT 10.68 ± 10.40% (p=0.001). Serum ferritin showed also an increase of 4.75 ± 180.53µg/L but did not reach statistical significance. The increase in Hb was observed uniformly across all stages of CKD. A Pearson correlation revealed a positive correlation between the variation of Hb and eGFR during the study follow-up period (r=0.310, p=0.008). A subgroup analysis was performed, patients were classified in 2 groups according to FCM dose. At baseline, there was no age, comorbidities or eGFR difference among groups. Patients treated with 1000mg had lower Hb (p=0.03) and serum ferritin (p=0.01). At 24±8 weeks both groups showed increases in Hb (p=0.001) and TSAT (p=0.001). Patients treated with 1000mg showed also a significant increase in ferritin (p=0.004). The Pearson correlation confirmed a positive correlation between the variation of Hb and eGFR in the group of patients treated with 1000mg (r=0.467, p=0.019) but not in the group treated with 500mg. Conclusion FCM was effective in the treatment of iron deficiency anemia in non-dialysis CKD stage 3 to 5 patients. In our population, the increase of Hb levels correlated with an improvement in eGFR in patients treated with higher doses of FCM, suggesting a positive impact of FCM on kidney function.

Association of Iron Deficiency Anemia with Stroke Severity in patients with Acute Ischemic Stroke

2021 ◽  
Vol 15 (11) ◽  
pp. 3004-3006
Author(s):  
Rabia Rathore ◽  
Nasir Farooq Butt ◽  
Adil Iqbal ◽  
Hina Latif ◽  
Mariam Azeem ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Iron Deficiency ◽  
Acute Ischemic Stroke ◽  
Iron Deficiency Anemia ◽  
Descriptive Study ◽  
World Health ◽  
Deficiency Anemia ◽  
P Value ◽  
Stroke Severity ◽  
Cross Sectional

Aim: To study the relationship of Iron Deficiency anemia (IDA) with severity of acute ischemic stroke. Study Design: A cross-sectional descriptive study. Place & Duration of Study: Department of Medicine, Mayo Hospital, Lahore from March 2020 to February 2021 Methods: A descriptive study of cross-sectional type was done on 200 individuals who had acute ischemic stroke (AIS) and were hospitalized at Mayo Hospital Lahore. Consecutive non-probability convenience sampling method was used to gather the data. Severity of stroke was assessed at the time of admission using the National Institute of Health Stroke Scale, (NIHSS) at the same time blood complete examination along with peripheral blood film was done to diagnose anemia in these patients. Iron studies were done to diagnose iron deficiency anemia (IDA). P-value less than 0.05 was taken as significant. Results: About 200individuals presenting with AIS were enrolled in the research work. Anemia according to World Health Organization was seen in 80(40%) and was not present in 120(60%) patients. Among the subjects who had anemia, 16(20%) had a minor AIS, 23(28.75%) had a moderately severe AIS, and 41(51.25%) reported with a severe AIS, according to NIHSS criteria. A notable relationship was found to exist between anemia and stroke severity, (P-value 0.000). Conclusion: Anemia was a commonly found in individuals with acute stroke due to ischemia and had direct relation with severity of stroke. Keywords: Iron deficiency Anemia, severity, ischemic stroke.

Evaluation of serum electrolyte levels in iron deficiency anemia patients.

2021 ◽  
Vol 28 (05) ◽  
pp. 691-696
Author(s):  
Maryam Rafiq ◽  
Amna Arooj ◽  
Qurrat-ul-Ain Tahir ◽  
Nudrat Fayyaz ◽  
Afra Samad ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Serum Ferritin ◽  
Cross Sectional Study ◽  
Deficiency Anemia ◽  
Close Monitoring ◽  
Cross Sectional ◽  
Mean Values ◽  
Medical College ◽  
Complete Blood Counts

Objectives: To evaluate electrolytes levels in patients suffering from iron deficiency anemia and to compare it with patients without anemia. Study Design: Descriptive Cross Sectional study. Setting: Department of Pathology, Sahiwal Medical College Sahiwal. Period: November, 2019 to May, 2020. Material & Methods: After taking informed consent, five milliliter of blood was drawn from each patient. Blood sample was analyzed for electrolytes, complete blood counts and serum ferritin levels. Results were compared in normal and iron deficiency anemic groups. Results: A total of 287 clinically anemic suspects including 181 (63.0%) female and 106 (37.0%) male with mean age of patients as 36.11±12.23 were included in this study. A total of 205 (71.4%) of the suspects had anemia whereas frequency of anemia remained higher among females (78.5%) as compared to males (59.5%) in this study. On the basis of serum ferritin levels a total of 178 (62.0%) patients had iron deficiency. Mean values of Sodium (130.41±0.59) and Bicarbonate (24.10±0.31) remained low while mean Potassium (4.33±0.07) and Chloride (103.93±0.47) levels of Iron Deficiency Anemia (IDA) group remained high as compared to non-anemic group. Conclusion: Levels of sodium and bicarbonate are found to be on the lower side while potassium and chloride remained on higher side in patients with Iron deficiency Anemia in this study. Thus these findings indicate close monitoring of electrolytes to evade impediments during management of patients.

scholarly journals Analysis of the iron profile and the incidence of iron deficiency anemia in the third-trimester pregnant women in the coendemic areas of Bengkulu City, Indonesia

2019 ◽  
Author(s):  
Mohammad Zulkarnain ◽  
Rizka Muliani ◽  
Rico Januar Sitorus ◽  
Nurlaili Nurlaili
Keyword(s):  
Iron Deficiency ◽  
Pregnant Women ◽  
Iron Deficiency Anemia ◽  
Total Sample ◽  
Deficiency Anemia ◽  
P Value ◽  
Binary Logistic Regression Analysis ◽  
Third Trimester ◽  
Cross Sectional ◽  
The Third

Pregnant women are at risk for iron deficiency anemia especially pregnant women in malaria-endemic areas. This study aimed to analyze the profile of iron in the third trimester pregnant women with iron deficiency anemia in co-endemic area of Bengkulu city. This study was cross-sectional study with a total sample of 66 pregnant women who met the inclusion criteria. Examination profile of iron in pregnant women is done by taking blood specimen through the vena cubity. Profile iron includes examination sTfR levels, hepcidin, transferrin were examined by ELISA. Determination of iron deficiency anemia is based on the results of Hb, serum iron and TIBC. The results showed 39.4% of pregnant women experience iron deficiency anemia. There is an average difference between hepcidin levels with the incidence of iron deficiency anemia (p-value 0.031). Based on binary logistic regression analysis profile iron with irondeficiency anemia in pregnant women, hepcidin levels are predictors factors on the incidence of iron deficiency anemia (p-value 0.000, 95% CI .296-.709).

scholarly journals Effect of Maternal Iron Deficiency Anemia on the Iron Store of Newborns in Ethiopia

Anemia ◽  
2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Betelihem Terefe ◽  
Asaye Birhanu ◽  
Paulos Nigussie ◽  
Aster Tsegaye
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Serum Ferritin ◽  
Complete Blood Count ◽  
Iron Status ◽  
Hemoglobin Concentration ◽  
Deficiency Anemia ◽  
Iron Store ◽  
Cross Sectional ◽  
Iron Deficient

Iron deficiency anemia among pregnant women is a widespread problem in developing countries including Ethiopia, though its influence on neonatal iron status was inconsistently reported in literature. This cross-sectional study was conducted to compare hematologic profiles and iron status of newborns from mothers with different anemia status and determine correlation between maternal and neonatal hematologic profiles and iron status in Ethiopian context. We included 89 mothers and their respective newborns and performed complete blood count and assessed serum ferritin and C-reactive protein levels from blood samples collected from study participants. Maternal median hemoglobin and serum ferritin levels were 12.2 g/dL and 47.0 ng/mL, respectively. The median hemoglobin and serum ferritin levels for the newborns were 16.2 g/dL and 187.6 ng/mL, respectively. The mothers were classified into two groups based on hemoglobin and serum ferritin levels as iron deficient anemic (IDA) and nonanemic (NA) and newborns of IDA mothers had significantly lower levels of serum ferritin (P=0.017) and hemoglobin concentration (P=0.024). Besides, newborns’ ferritin and hemoglobin levels showed significant correlation with maternal hemoglobin (P=0.018;P=0.039) and ferritin (P=0.000;P=0.008) levels. We concluded that maternal IDA may have an effect on the iron stores of newborns.

scholarly journals Incidence of iron deficiency anemia among the children with febrile seizures.

2021 ◽  
Vol 29 (01) ◽  
pp. 121-125
Author(s):  
Samina Batool ◽  
Nadia Qamar ◽  
Akasha Islam ◽  
Saman Jamal ◽  
Qurat-ul-Ain Rana
Keyword(s):  
Socioeconomic Status ◽  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Rural Areas ◽  
Ferritin Level ◽  
Demographic Data ◽  
Febrile Seizures ◽  
Deficiency Anemia ◽  
Cross Sectional ◽  
Duration Of Symptoms

Objective: To determine frequency of iron deficiency anemia among the children having febrile seizures. Study Design: Descriptive Cross Sectional study. Setting: Pediatric Unit Allama Iqbal Memorial Teaching Hospital Sialkot. Period: September 2020 to February 2021. Material & Methods: Total 70 children were studied with age six months to 10 years with either gender presenting with febrile seizures. All data of the patients was documented including demographic data like age, gender, residential area, educational status, socioeconomic status and clinical findings at the time of presentation like fever, fits and duration of symptoms etc. Blood hemoglobin and ferritin level were tested of each patient to evaluate iron deficiency anemia. Results: There were 65.7% male and 34.3% female cases in this study. Age range of the patients was 6 months to 10 years with mean age of 4.36 ± 2.71 years. Most of the children (60%) were below three years of age. Mostly children belonged to low and middle socioeconomic status with the frequency of 42.8% and 45.7% respectively. Iron deficiency anemia was found in 38.6% cases. Majority of the mothers were illiterate (65%). There were 44.3% cases from rural areas and 55.7% from urban area. Conclusion:  Iron deficiency anemia is a common problem among children with febrile seizures, younger than 03 years and belonging to rural areas. Illiterate mothers, is an important risk factor of iron deficiency anemia in their children.

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