The Permanence Properties of Flexible Urethan Foams

1964 ◽  
Vol 37 (1) ◽  
pp. 38-75 ◽  
Author(s):  
Samuel Steingiser ◽  
W. C. Darr ◽  
J. H. Saunders

Abstract The acceptance of urethan foam as a commercial product has hinged to an important extent on its permanence as a foam under all conditions of actual end use. Customer experience with commercial flexible urethan foams has confirmed the satisfactory service life of these materials. However, in the development of this industry, it was necessary to be able to predict the performance of experimental systems which later were to become fully commercial. Most often, this prediction had to be made very early, long before the materials were allowed to be put into end service. The common way to do this is by accelerated testing, wherein the time axis is condensed by stepping up the aging process well beyond any normal conditions. Considerable time and expense are saved in this kind of test; however, there is always the question that such an accelerated step-up of test conditions is not representative of actual use, and/or causes reactions in the sample which do not occur in normal use. It is important that these questionable features be reconciled before the intercomparability of accelerated and shelf-life testing is accepted.

2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Kang Luo ◽  
Sun Woo Lim ◽  
Yi Quan ◽  
Sheng Cui ◽  
Yoo Jin Shin ◽  
...  

Calcineurin inhibitors (CNIs) are the most popular immunosuppressants in organ transplantation, but nephrotoxicity is a major concern. The common mechanism underlying chronic CNI nephropathy is oxidative stress, and the process of chronic CNI nephropathy is similar to that of aging. Current studies provide evidence that antiaging Klotho protein plays an important role in protecting against oxidative stress, and its signaling is a target for preventing oxidative stress-induced aging process. In this review, we focus on the association between Klotho and oxidative stress and the protective mechanism of action of Klotho against oxidative stress in chronic CNI nephropathy. In addition, we discuss the delivery strategy for Klotho in CNI-induced nephropathy.


1928 ◽  
Vol 21 (1) ◽  
pp. 1-9
Author(s):  
David Eugene Smith

Our Attitude to the lnfinite.—It is not a matter of much moment that we should or should not teach the various methods of factoring an expression in the form of ax2 + bx + c. Most of the common methods are worthless when we come to the actual use of these factors in the theory of algebraic polynomials, and any application of the work to a “real” problem in algebra is rarely seen. What is said of this detail of elementary algebra may be said of various others; they have a value, bnt in many cases this value is relatively slight; each concerns a single unimportant muscle of the body algebraic, bnt it scarcely touches the soul.


2006 ◽  
Vol 87 (6) ◽  
pp. 1403-1421 ◽  
Author(s):  
Alexander O. Pasternak ◽  
Willy J. M. Spaan ◽  
Eric J. Snijder

Many positive-stranded RNA viruses use subgenomic mRNAs to express part of their genetic information. To produce structural and accessory proteins, members of the order Nidovirales (corona-, toro-, arteri- and roniviruses) generate a 3′ co-terminal nested set of at least three and often seven to nine mRNAs. Coronavirus and arterivirus subgenomic transcripts are not only 3′ co-terminal but also contain a common 5′ leader sequence, which is derived from the genomic 5′ end. Their synthesis involves a process of discontinuous RNA synthesis that resembles similarity-assisted RNA recombination. Most models proposed over the past 25 years assume co-transcriptional fusion of subgenomic RNA leader and body sequences, but there has been controversy over the question of whether this occurs during plus- or minus-strand synthesis. In the latter model, which has now gained considerable support, subgenomic mRNA synthesis takes place from a complementary set of subgenome-size minus-strand RNAs, produced by discontinuous minus-strand synthesis. Sense–antisense base-pairing interactions between short conserved sequences play a key regulatory role in this process. In view of the presumed common ancestry of nidoviruses, the recent finding that ronivirus and torovirus mRNAs do not contain a common 5′ leader sequence is surprising. Apparently, major mechanistic differences must exist between nidoviruses, which raises questions about the functions of the common leader sequence and nidovirus transcriptase proteins and the evolution of nidovirus transcription. In this review, nidovirus transcription mechanisms are compared, the experimental systems used are critically assessed and, in particular, the impact of recently developed reverse genetic systems is discussed.


1859 ◽  
Vol 9 ◽  
pp. 229-231

In a former Note addressed to the Royal Society (Proceedings, vol. ix. p. 150), I have alluded to some [new alkaloids which are pro­duced by the action of the bromides of triatomic alcohols upon the primary amidogen bases. I have since examined more minutely one of these bodies. At the common temperature, chloroform and aniline may be left in contact for a considerable time without any change becoming perceptible. Even at the temperature of boiling water scarcely any reaction takes place. But on exposing for ten or twelve hours a mixture of about equal volumes of chloroform and aniline in sealed tubes to a tem­perature of 180° or 190° C., a hard brown crystalline mass is ob­tained, which consists chiefly of the hydrochlorates of aniline and of a new crystalline base.


2016 ◽  
Vol 22 (6) ◽  
pp. 717-725 ◽  
Author(s):  
Shaik Ahmed Sanai ◽  
Vasu Saini ◽  
Ralph HB Benedict ◽  
Robert Zivadinov ◽  
Barbara E Teter ◽  
...  

The life expectancy and average age of persons with multiple sclerosis (MS) have increased significantly during the last two decades. The introduction of disease-modifying therapies and a better delineation and understanding of the superimposed comorbidities often diagnosed in MS patients are probably the most important factors accountable for the increase in aging MS population worldwide. Healthcare teams must therefore address the problems arising due to advancing age superimposed on this chronic neurologic disease. In this review, we focus on the physiology of aging, its effects on MS disease course, and the pathological and immunological changes associated with aging and disease progression. Additionally, we discuss the common comorbidities that occur in aging persons with MS that may arise either as a result of the aging process or from relentless chronic MS disease progression as well as the challenges on differentiating the two processes for a more appropriate therapeutic approach.


2021 ◽  
Author(s):  
Bryan Dodson ◽  
◽  
Harry Schwab ◽  

The application of accelerated testing theory is a difficult proposition, yet one that can result in considerable time and cost savings, as well as increasing a product's useful life. In Accelerated Testing: A Practitioner's Guide to Accelerated and Reliability Testing, readers are exposed to the latest, most practical knowledge available in this dynamic and important discipline. Authors Bryan Dodson and Harry Schwab draw on their considerable experience in the field to present comprehensive, insightful views in this book. Development and quality assurance tests are defined in detail and are presented from a practical viewpoint. Included are testing fundamentals, plans and models, and equipment and methods most commonly used in accelerated testing. Individuals seeking to evaluate and improve the design lives of components and systems will find this book a valuable reference, with special attention being paid to testing in the mobility industries.


2008 ◽  
Vol 375-376 ◽  
pp. 440-444
Author(s):  
Li Li Liu ◽  
Jian Xin Deng

Idea of functionally gradient material (FGM) theory was used to the design of ceramic nozzle. The purpose was to increase the erosion wear resistance at the entrance of the nozzle in dry sand blasting processes. The SiC/(W,Ti)C gradient ceramic nozzles fabricated by conventional hot pressing. The erosion behavior of the SiC/(W,Ti)C gradient ceramic nozzles were investigated in comparison with the common homologous ceramic nozzles. The experimental results have shown that the ceramic nozzles with a gradient structure have superior erosion wear resistance to that of the common homologous ceramic nozzles under the same test conditions. It was shown that the mechanical properties of the gradient ceramic nozzle materials were greatly improved in comparison with that of the common homologous nozzles. The surface Vickers hardness and indentation fracture toughness of gradient ceramic nozzle were greatly improved compared with that of the common homologous nozzles. Therefore, it is indicated that gradient structures in ceramic nozzles is an effective way to improve the erosion wear resistance of the common homologous nozzles.


1968 ◽  
Vol 41 (4) ◽  
pp. 843-853
Author(s):  
E. P. Percarpio ◽  
E. M. Bevilacqua

Abstract Skid resistance of tires on wet pavements in an important component of tire safety; it is important to evaluate it precisely under conditions which are pertinent to actual use. The closest approximations to practical conditions are provided by measures of side force coefficient or by locked wheel sliding, both of which are related to problems of vehicle control. However, both of these require that a test vehicle be provided with four identical tires, that a surface large enough to test on be available, and that all test conditions including the nature of the surface be reproducible. For any rational program of research, costs of comparing materials of tire and of road would mount astronomically unless a controlled laboratory test were available which is well correlated with field experience, so that many variables can be studied conveniently in the laboratory. Such a test is available in the applications of the Portable Skid Resistance Tester. Results with this apparatus have been shown to correlate well with those from tests of vehicles on roads over a range of road properties, correlations apparently being with properties of a patterned tire. The results have been further shown to be well correlated with accident statistics. This report will show that correlations with tests on vehicles are valid over a wide variation in rubber properties as well.


2016 ◽  
Vol 78 (5) ◽  
Author(s):  
Ashkan Nochian ◽  
Osman Mohd Tahir ◽  
Suhardi Maulan ◽  
Ali Reza Mikaeili

Landfills are the common method of waste disposal. A closed landfill site can be an eyesore land and cause environmental hazardous impacts on surrounding areas. A sustainable solution for redevelopment of a closed landfill site, returns the land to an attractive and beneficial after-use. This study aim to identify potential sustainable solutions and factors in the redevelopment of closed landfill sites. The paper critically reviews the literature regarding vital understanding of the redevelopment process. The study also analyzed the successful landfill redevelopment projects in a wide range of time and locations to suggest the best end-use option. Additionally, the study offers an approach for integrating the social, economic and environmental benefits through the sustainable redevelopment solution contributing to the universal sustainable development and green built environment.  


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